Effect of hesperetin against oxidative stress via ER-and TrkA-mediated actions in PC12 cells

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 10, 2011, Pages 5779-5785

  Hwang, Sam Long ^a   Yen, Gow Chin ^b,c  

^a Food Industry Research   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

ER; Hesperetin; Neuroprotection; PC12 cells; Receptor; TrkA

Indexed keywords

ER; HESPERETIN; NEUROPROTECTION; PC12 CELLS; RECEPTOR; TRKA;

AMINO ACIDS; BRAIN; HYDROGEN PEROXIDE; NEURODEGENERATIVE DISEASES; SIGNALING;

CELLS;

ESTROGEN RECEPTOR; HESPERETIN; HESPERIDIN; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT; PROTEIN TYROSINE KINASE;

ANIMAL; ARTICLE; CELL STRAIN; DRUG EFFECT; OXIDATIVE STRESS; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; HESPERIDIN; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION;

EID: 79957957524     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf104632a     Document Type: Article

References (40)

1. Mattson, M. P. Pathways towards and away from Alzheimer's disease. Nature 2004, 430, 631-639. (Pubitemid 39061671)
2. Warner, D. S.; Sheng, H.; Batinic-Haberle, I. Oxidants, antioxidants and the ischemic brain. J. Exp. Biol. 2004, 207, 3221-3231. (Pubitemid 39275296)
3. Oikawa, S.; Hirosawa, I.; Tada-Oikawa, S.; Furukawa, A.; Nishiura, K.; Kawanishi, S. Mechanism for manganese enhancement of dopamine-induced oxidative DNA damage and neuronal cell death. Free Radical Biol. Med. 2006, 41, 748-756. (Pubitemid 44163409)
4. Hwang, S.-L.; Yen, G.-C. Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoids-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide. J. Agric. Food Chem. 2009, 57, 2576-2582.
5. Erlund, I.; Meririnne, E.; Alfthan, G.; Aro, A Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J. Nutr. 2001, 131, 235-241. (Pubitemid 32115362)
6. Vauzour, D.; Vafeiadou, K.; Rice-Evans, C.; Williams, R. J.; Spencer, J. P. E. Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavonones in cortical neurons. J. Neurochem. 2007, 103, 1355-1367. (Pubitemid 47631805)
7. Liu, L.; Xu, D. M.; Cheng, Y. Y. Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells. J. Agric. Food Chem. 2008, 56, 824-829. (Pubitemid 351300251)
8. McEwen, B. S. Genome and hormones: gender differences in physiology invited review: estrogens effects on the brain: multiple sites and mechanisms. J. Appl. Physiol. 2001, 91, 2785-2801.
9. Alexaki, V. I.; Charalampopoulos, I.; Kampa, M.; Vassalou, H.; Theodoropoulos, P.; Stathopoulos, E. N.; Hatzoglou, A; Gravanis, A; Castanas, E. Estrogen exerts neuroptotective effects via membrane estrogen rceptors and rapid Akt/NOS activation. FASEB 2004, 18, 1594-1596 (doi: 10.1096/fj.04-1495fje) . (Pubitemid 39561644)
10. Watson, C. S.; Alyea, R. A.; Hawkins, B. E.; Thomas, M. L.; Cunningham, K. A.; Jakubas, A A Estradiol effects on the dopamine transporter-protein levels, subcellular location, and function. J. Mol. Signal. 2006, 1, 5 (doi: 10.1186/1750-2187-1-5). (Pubitemid 46979458)
11. Einat, H; Manji, H. K. Cellular plasticity cascades: gene-tobehavior pathways in animal models of bipolar disorder. Biol. Psychiatry 2006, 59, 1160-1171. (Pubitemid 43949143)
12. Han, B. H; D'Costa, A.; Back, S. A.; Parsadanian, M.; Patel, S.; Shah, A. R.; Gidday, J. M.; Srinivasan, A.; Deshmukh, M.; Holtzman, D. M. BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia. Neurobiol. Dis. 2000, 7, 38-53. (Pubitemid 30141818)
13. Lonze, B. E.; Ginty, D. D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35, 1951-1959.
14. St-Pierre, J.; Drori, S.; Uldry, M.; Silvaggi, J. M.; Rhee, J.; Jager, S.; Handschin, C; Zheng, K.; Lin, J.; Yang, W.; Simon, D. K.; Bachoo, R; Spiegelman, B. M. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006, 127, 397-408. (Pubitemid 44572377)
15. Greeve, I.; Hermans-Borgmeyer, I.; Brellinger, C; Kasper, D.; Gomez-Isla, T.; Behl, C; Levkau, B.; Nitsch, R. M. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J. Neurosci. 2000, 20, 7345-7352.
16. Lu, X.; Kambe, F.; Cao, X.; Kozaki, Y.; Kaji, T.; Ishii, T.; Seo, H. 3β-Hydroxysteroid-δ24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis. Endocrinology 2008, 149, 3267-3273. (Pubitemid 351919585)
17. Luciani, P.; Deledda, C; Rosati, F.; Benvenuti, S.; Cellai, I.; Dichiara, F.; Morello, M.; Vannelli, G B.; Danza, G; Serio, M.; Peri, A. Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures. Endocrinology 2008, 149, 4256-4266.
18. Takahashi, M.; Shibata, M.; Niki, E. Estimation of lipid peroxidation of live cells using a fluorescent probe, diphenyl-1-pyrenylphosphine. Free Radical Biol. Med. 2001, 31, 164-174. (Pubitemid 32607583)
19. Chen, X.; Shao, J.; Xiang, L.; Liu, X. Involvement of apoptosis in malathion-induced cytotoxicity in a grass carp (Ctenopharyngodon idellus) cell line. Comp. Biochem. Physiol. Part C 2006, 142, 36-45. (Pubitemid 43142052)
20. Maiti, S.; Chen, G Tamoxifen induction of aryl sulfotransferase and hydroxysteroid sulfotransferase in male and female rat liver and intestine. Drug Metab. Dispos. 2003, 31, 637-644. (Pubitemid 36444173)
21. Crespo, I.; García-Mediavilla, M. V.; Almar, M.; González, P.; Tuñón, M. J.; Sánchez-Campos, S.; González- Gallego, J. Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang liver cells. Food Chem. Toxicol. 2008, 46, 1555-1596.
22. Manthey, D.; Behl, C From structural biochemistry to expression profiling: neuroprotective activities of estrogen. Neurosci. 2006, 13, 845-850.
23. 2-induced cytotoxicity in PC12 cells. J. Agric. Food Chem. 2008, 56, 859-864. (Pubitemid 351300256)
24. Bedogni, B.; Pani, G; Colavitti, R.; Riccio, A; Borrello, S.; Murphy, M.; Smith, R; Eboli, M. L.; Galeotti, T. Redox regulation of cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor-dependent cell survival. J. Biol. Chem. 2003, 278, 16510-16519. (Pubitemid 36799511)
25. Mattson, M. P. Calcium and neurodegeneration. Aging Cell 2007, 6, 337-350.
26. 2+ wave propagation. Cell Death Differ. 2004, 11, 1265-1276. (Pubitemid 39591772)
27. 2+ and PI3-kinase. J. Neurochem. 2002, 80, 23-35.
28. 2-induced apoptosis of PC12 cells independent of ceramide formation. Neurol. Res. 2000, 22, 556-564.
29. Levin, E. S. Integration of the extranuclear and nuclear actions of estrogen. Mol. Endocrinol. 2005, 19, 1951-1959.
30. Chen, M. J.; Nguyen, T. V.; Pike, C J.; Russo-Neustadt, A A Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons. Cell Signal. 2007, 19, 114-128. (Pubitemid 44880248)
31. Bachis, A.; Major, E. O.; Mocchetti, I. Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. J. Neurosci. 2003, 23, 5715-5722. (Pubitemid 36807850)
32. Zeng, H; Chen, Q.; Zhao, B. Genistein ameliorates β-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis. Free Radical Biol. Med. 2004, 36, 180-188. (Pubitemid 38117236)
33. Qui, M. S.; Green, S. H. PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity. Neuron 1992, 9, 705-717.
34. Cowley, S.; Paterson, H; Kemp, P.; Marshall, C. J. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994, 17, 841-852. (Pubitemid 24187682)
35. Alexaki, V. I.; Charalampopoulos, I.; Kampa, M.; Nifli, A P.; Hatzoglou, A.; Gravanis, A; Castanas, E. Activation of membrane estrogen receptors induce pro-survival kinases. J. Steroid Biochem. Mol. Biol. 2006, 98, 97-110. (Pubitemid 43153782)
36. Pedram, A.; Razandi, M.; Atkenhead, M.; Hughes, C. C W.; Levin, E. R. Integration of the non-genomic and genomic actions of estrogen membrane-initiated signaling by steroid to transcription and cell biology. J. Biol. Chem. 2002, 277, 50768-50775. (Pubitemid 36042240)
37. 2 induce caspase-3-independent degradation of Akt/protein kinase B. J. Biol. Chem. 2002, 277, 42943-42952. (Pubitemid 35285672)
38. Michalski, B.; Fahnestock, M. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease. Brain Res. Mol. Brain Res. 2003, 111, 148-154. (Pubitemid 36332338)
39. Driggers, P. H; Segars, J. H. Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling. Trends Endocrinol. Metab. 2002, 13, 422-427.
40. Hayashi, S.; Yamaguchi, Y. Estrogen signaling pathway and hormonal therapy. Breast Cancer 2008, 15, 256-261.