Characteristics and PD-1 expression of peripheral CD4+CD127 loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients

Virology Journal

Volumn 8, Issue , 2011, Pages

  Shen, Tao ^a   Zheng, Jiajia ^a   Liang, Hua ^b   Xu, Chunhui ^a   Chen, Xiangmei ^a   Zhang, Ting ^a   Xu, Qiang ^a   Lu, Fengmin ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; APOPTOSIS REGULATORY PROTEIN; CD45 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; INTERLEUKIN 7 RECEPTOR ALPHA; LEUKOCYTE ANTIGEN; PDCD1 PROTEIN, HUMAN;

ADULT; ARTICLE; CD4+ CD127+ CD25+ FOXP3+ REGULATORY T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY T LYMPHOCYTE; NONHUMAN; PERSISTENT VIRUS INFECTION; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; BIOSYNTHESIS; CHEMISTRY; GENE EXPRESSION PROFILING; IMMUNOLOGY; MIDDLE AGED; T LYMPHOCYTE SUBPOPULATION;

HEPATITIS C VIRUS;

ADULT; ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, CD45; APOPTOSIS REGULATORY PROTEINS; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; HEPATITIS C, CHRONIC; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 79957953513     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-8-279     Document Type: Article

References (40)

1. Hepatitis C virus (HCV) infection: a systemic disease. A Craxi G Laffi AL Zignego, Mol Aspects Med 2008 29 85 95 10.1016/j.mam.2007.09.017 18177700
2. Hepatitis C treatment: current and future perspectives. S Munir S Saleem M Idrees A Tariq S Butt B Rauff A Hussain S Badar M Naudhani Z Fatima M Ali L Ali M Akram M Aftab B Khubaib Z Awan, Virol J 2010 7 296 10.1186/1743-422X-7-296 21040548
3. IL28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: the future of personalized HCV therapies. PJ Clark AJ Thompson JG McHutchison, Am J Gastroenterol 2010 106 38 45 20924369
4. HCV drug discovery aimed at viral eradication. RF Schinazi L Bassit C Gavegnano, J Viral Hepat 2010 17 77 90 10.1111/j.1365-2893.2009.01246.x 20040045
5. Pegylated interferons alpha2a and alpha2b in the treatment of chronic hepatitis C. A Aghemo MG Rumi M Colombo, Nat Rev Gastroenterol Hepatol 2010 7 485 494 10.1038/nrgastro.2010.101 20644567
6. Adaptive immune responses in acute and chronic hepatitis C virus infection. DG Bowen CM Walker, Nature 2005 436 946 952 10.1038/nature04079 16107834 (Pubitemid 41191670)
7. HCV persistence and immune evasion in the absence of memory T cell help. A Grakoui NH Shoukry DJ Woollard JH Han HL Hanson J Ghrayeb KK Murthy CM Rice CM Walker, Science 2003 302 659 662 10.1126/science.1088774 14576438 (Pubitemid 37310924)
8. Analysis of successful immune responses in persons infected with hepatitis C virus. F Lechner DK Wong PR Dunbar R Chapman RT Chung P Dohrenwend G Robbins R Phillips P Klenerman BD Walker, J Exp Med 2000 191 1499 1512 10.1084/jem.191.9.1499 10790425 (Pubitemid 30257347)
9. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. JD Fontenot MA Gavin AY Rudensky, Nat Immunol 2003 4 330 336 12612578 (Pubitemid 36432314)
10. An essential role for Scurfin in CD4+CD25+ T regulatory cells. R Khattri T Cox SA Yasayko F Ramsdell, Nat Immunol 2003 4 337 342 12612581 (Pubitemid 36432315)
11. Mechanisms of suppression by suppressor T cells. H von Boehmer, Nat Immunol 2005 6 338 344 10.1038/ni1180 15785759 (Pubitemid 41716770)
12. Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. H Ebinuma N Nakamoto Y Li DA Price E Gostick BL Levine J Tobias W Kwok KM Chang, J Virol 2008 82 5043 5053 10.1128/JVI.01548-07 18337568 (Pubitemid 351657064)
13. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. T Boettler HC Spangenberg C Neumann-Haefelin E Panther S Urbani C Ferrari HE Blum F von Weizsäcker R Thimme, J Virol 2005 79 7860 7867 10.1128/JVI.79.12.7860-7867.2005 15919940 (Pubitemid 40756821)
14. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. R Cabrera Z Tu Y Xu RJ Firpi HR Rosen C Liu DR Nelson, Hepatology 2004 40 1062 1071 10.1002/hep.20454 15486925 (Pubitemid 39425561)
15. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. AH Sharpe EJ Wherry R Ahmed GJ Freeman, Nat Immunol 2007 8 239 245 10.1038/ni1443 17304234 (Pubitemid 46745373)
16. PD-1 and its ligands in T-cell immunity. ME Keir LM Francisco AH Sharpe, Curr Opin Immunol 2007 19 309 314 10.1016/j.coi.2007.04.012 17433872 (Pubitemid 46687017)
17. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. H Nishimura T Okazaki Y Tanaka K Nakatani M Hara A Matsumori S Sasayama A Mizoguchi H Hiai N Minato T Honjo, Science 2001 291 319 322 10.1126/science.291. 5502.319 11209085 (Pubitemid 32096320)
18. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. H Nishimura M Nose H Hiai N Minato T Honjo, Immunity 1999 11 141 151 10.1016/S1074-7613(00)80089-8 10485649 (Pubitemid 29428807)
19. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. GJ Freeman AJ Long Y Iwai K Bourque T Chernova H Nishimura LJ Fitz N Malenkovich T Okazaki MC Byrne HF Horton L Fouser L Carter V Ling MR Bowman BM Carreno M Collins CR Wood T Honjo, J Exp Med 2000 192 1027 1034 10.1084/jem.192.7.1027 11015443
20. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. S Urbani B Amadei D Tola M Massari S Schivazappa G Missale C Ferrari, J Virol 2006 80 11398 11403 10.1128/JVI.01177-06 16956940 (Pubitemid 44706581)
21. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. L Golden-Mason B Palmer J Klarquist JA Mengshol N Castelblanco HR Rosen, J Virol 2007 81 9249 9258 10.1128/JVI.00409-07 17567698 (Pubitemid 47311467)
22. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. H Radziewicz CC Ibegbu ML Fernandez KA Workowski K Obideen M Wehbi HL Hanson JP Steinberg D Masopust EJ Wherry JD Altman BT Rouse GJ Freeman R Ahmed A Grakoui, J Virol 2007 81 2545 2553 10.1128/JVI.02021-06 17182670 (Pubitemid 46447020)
23. PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. D Franceschini M Paroli V Francavilla M Videtta S Morrone G Labbadia A Cerino MU Mondelli V Barnaba, J Clin Invest 2009 119 551 564 10.1172/JCI36604 19229109
24. PD-1 tempers Tregs in chronic HCV infection. H Radziewicz RM Dunham A Grakoui, J Clin Invest 2009 119 450 453 10.1172/JCI38661 19306502
25. Central memory and effector memory T cell subsets: function, generation, and maintenance. F Sallusto J Geginat A Lanzavecchia, Annu Rev Immunol 2004 22 745 763 10.1146/annurev.immunol.22.012703.104702 15032595 (Pubitemid 38680440)
26. Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi. TL Humphreys LA Baldridge SD Billings JJ Campbell SM Spinola, Infect Immun 2005 73 3896 3902 10.1128/IAI.73.7.3896-3902.2005 15972475 (Pubitemid 40923127)
27. CD27- CD4+ memory T cells define a differentiated memory population at both the functional and transcriptional levels. A Schiott M Lindstedt B Johansson-Lindbom C Borrebaeck, Immunology 2004 113 363 370 10.1111/j.1365-2567. 2004.01974.x 15500623 (Pubitemid 39472153)
28. The CD27- subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo. R De Jong M Brouwer B Hooibrink T Van der Pouw-Kraan F Miedema RA Van Lier, Eur J Immunol 1992 22 993 999 10.1002/eji.1830220418 1348033
29. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. F Sallusto D Lenig R Forster M Lipp A Lanzavecchia, Nature 1999 401 708 712 10.1038/44385 10537110
30. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. M Miyara Y Yoshioka A Kitoh T Shima K Wing A Niwa C Parizot C Taflin T Heike D Valeyre A Mathian T Nakahata T Yamaguchi T Nomura M Ono Z Amoura G Gorochov S Sakaguchi, Immunity 2009 30 899 911 10.1016/j.immuni.2009.03.019 19464196
31. Frequency of naturally-occurring regulatory T cells is reduced in patients with ST-segment elevation myocardial infarction. G Sardella L De Luca V Francavilla D Accapezzato M Mancone MI Sirinian F Fedele M Paroli, Thromb Res 2007 120 631 634 10.1016/j.thromres.2006.12.005 17261328 (Pubitemid 47094917)
32. Rapamycin, and not cyclosporin A preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells. JJ Coenen HJ Koenen E van Rijssen LB Hilbrands I Joosten, Blood 2006 107 1018 1023 16210336 (Pubitemid 43156300)
33. CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells. HJ Koenen E Fasse I Joosten, J Immunol 2005 174 7573 7583 15944257 (Pubitemid 40806261)
34. Regulatory T cells and immune tolerance. S Sakaguchi T Yamaguchi T Nomura M Ono, Cell 2008 133 775 787 10.1016/j.cell.2008.05.009 18510923 (Pubitemid 351707693)
35. CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. RM Dunham B Cervasi JM Brenchley H Albrecht A Weintrob B Sumpter J Engram S Gordon NR Klatt I Frank DL Sodora DC Douek M Paiardini G Silvestri, J Immunol 2008 180 5582 5592 18390743
36. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. N Seddiki B Santner-Nanan J Martinson J Zaunders S Sasson A Landay M Solomon W Selby SI Alexander R Nanan A Kelleher Fazekas de St Groth B, J Exp Med 2006 203 1693 1700 10.1084/jem.20060468 16818676 (Pubitemid 44036275)
37. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. SJ Ha SN Mueller EJ Wherry DL Barber RD Aubert AH Sharpe GJ Freeman R Ahmed, J Exp Med 2008 205 543 555 10.1084/jem.20071949 18332181 (Pubitemid 351439302)
38. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. CL Day DE Kaufmann P Kiepiela JA Brown ES Moodley S Reddy EW Mackey JD Miller AJ Leslie C DePierres Z Mncube J Duraiswamy B Zhu Q Eichbaum M Altfeld EJ Wherry HM Coovadia PJ Goulder P Klenerman R Ahmed GJ Freeman BD Walker, Nature 2006 443 350 354 10.1038/nature05115 16921384 (Pubitemid 44435155)
39. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. C Boni P Fisicaro C Valdatta B Amadei P Di Vincenzo T Giuberti D Laccabue A Zerbini A Cavalli G Missale A Bertoletti C Ferrari, J Virol 2007 81 4215 4225 10.1128/JVI.02844-06 17287266 (Pubitemid 46586915)
40. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. A Penna M Pilli A Zerbini A Orlandini S Mezzadri L Sacchelli G Missale C Ferrari, Hepatology 2007 45 588 601 10.1002/hep.21541 17326153 (Pubitemid 46450610)