Can dietary antioxidants reduce the incidence of brain tumors?

Current Drug Metabolism

Volumn 12, Issue 6, 2011, Pages 587-593

  Sheweita, S A ^a   Sheikh, B Y ^b  

^a Alexandria University Faculty Of Science   (Egypt)

^b TAIBAH UNIVERSITY   (Saudi Arabia)

Author keywords

Antioxidants; Brain tumor; N nitrosamines; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; FREE RADICAL; GENISTEIN; NITROSAMINE; PROTEIN P53; TELOMERASE;

ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN TUMOR; CANCER INCIDENCE; CANCER PREVENTION; CANCER SURVIVAL; DIETARY INTAKE; DNA DAMAGE; ENVIRONMENTAL FACTOR; GLIOBLASTOMA; HUMAN; METABOLIC ACTIVATION; MORTALITY; NITROSATION; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS;

EID: 79957952408     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920011795713733     Document Type: Article

References (103)

1. Sheikh, B. Huge occipital myxomatous plexiform neurofibroma in the absence of neurofibromatosis. Neurosci. 2003, 8(3), 195-197 (Pubitemid 36818492)
2. Gurney, J.G.; Preston-Martin, S.; McDaniel, A.M.; Mueller, B.A.; Holly, E.A. Head injury as a risk factor for brain tumors in children: results from a multicenter case-control study. Epidemiol. 1996, 7, 485-489. (Pubitemid 26277692)
3. Bunin, G.R.; Kuitjen, R.R.; Buckley, J.D.; Rorke, L.B.; Meadows, A.T. Relation between maternal diet and subsequent primitive neuroectodermal tumors in young children. N. Engl. J. Med. 1993. 329, 536- 541. (Pubitemid 23232622)
4. Miyagi, K.; Mukawa, J.; Kinjo, N.; Horikawa, K.; Mekaru, S.; Nakasone, S.; Koga, H.; Higa, Y. Naito, M. Astrocytoma linked to familial ataxia telangiectasia. Acta Neurochir. 1995, 135, 87- 92.
5. Bondy, M.L.; Lustbader, E.D.; Buffler, P.A.; Schull, W.J.; Hardy, R.J. Strong, L.C. Genetic epidemiology of childhood brain tumors. Genet. Epidemiol. 1991, 8, 253-267
6. Shibui , S. Nomura, K. Statistical Analysis of Pineal Tumors Based on the Data of Brain Tumor Registry of Japan . Prog. Neurol. Surg. 2009, 23,1-11.
7. Smith, M.A., Friedlin, B., Gloeckler-Ries, L.A., Simon, R., Trends in reported incidence of primary malignant brain tumors in children in the United States. J. Natl. Cancer Inst. 1998, 90, 1269- 1277. (Pubitemid 28433471)
8. Ullrich NJ. Inherited disorders as a risk factor and predictor of neurodevelopmental outcome in pediatric cancer. Dev. Disabil. Res. Rev. 2008,14(3), 229-237.
9. Olshan, A.F.; Anderson, L.; Roman, E.; Fear, N.; Wolff, M.; Whyatt, R.; Vu, V. ; Diwan, B.A.; Potischman, N.; Hanson, J. Workshop to identify critical windows of exposure for children's health: cancer work group summary. Environ. Health Perspect. 2000, 108 (Suppl. 3), 595- 599.
10. Han, Y.Y.; Kano, H., Davis, D.L.; Niranjan, A.; Lunsford, L.D. Cell phone use and acoustic neuroma: the need for standardized questionnaires and access to industry data. Surg. Neurol. 2009. 72(3):216-222.
11. VandenBerg, S. The developing brain and cellular targets for neoplastic transformation. In: Brain Tumors, 2nd ed., Kaye, A.H., Laws Jr., E.R. (Eds.), Churchill Livingstone, London
12. Bien, E.; Stachowicz-Stencel, T.; Szalewska, M.; Krawczyk, M.; Synakiewicz A, Dubaniewicz-Wybieralska M, Zielinski P, Adamkiewicz-Drozynska E, Balcerska A. Poor-risk high-grade gliomas in three survivors of childhood acute lymphoblastic leukaemia- an overview of causative factors and possible therapeutic options. Childs Nerv. Syst. 2009, 25(5), 619-626
13. Ward, C.; Phipps, K.; de Sousa, C.; Butler, S. ; Gumley, D. Treatment factors associated with outcomes in children less than 3 years of age with CNS tumours. Childs Nerv. Syst. 2009, 25(6):663-668
14. Autrup, H. Transplacental transfer of genotoxins and transplacental carcinogenesis. Environ. Health Perspect. 1993, 101 (Suppl. 2), 33- 38. (Pubitemid 23290932)
15. Waalkes, M.P.; Liu, J.; Ward, J.M.; Powell D.A.; Diwan, B.A. Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment. Cancer Res. 2006, 66(3),1337-1345. (Pubitemid 43259912)
16. Denning, D.W.; Allen, R.; Wilkinson, A.P.; Morgan, M.R. Transplacental transfer of aflatoxin in humans. Carcinog. 1990, 11 (6), 1033- 1035. (Pubitemid 20207362)
17. Hansen, C.; Sorensen, L.D.; Asmussen, I.; Autrup, H. Transplacental exposure to tobacco smoke in human-adduct formation in placenta and umbilical cord vessels. Teratog. Carcinog. Mutagen. 1992, 12, 51- 60.
18. Ohgaki, H. Epidemiology of brain tumors. Meth. Mol. Biol. 2009, 472,323-342.
19. Mazumdar, M.; Liu, C.Y.; Wang, S.F.; Pan, P.C.; Wu, M.T.; Christiani, D.C. No association between parental or subject occupation and brain tumor risk. Am J Epidemiol. 2008, 167(8), 976-985.
20. Colt, J.S.; Blair, A. Parental occupational exposures and risk of childhood cancer. Environ. Health Perspect. 1998, 106 (Suppl. 3), 909- 925. (Pubitemid 28342335)
21. Sheweita, S.A. Drug-metabolizing enzymes: Mechanisms and Functions. A review. Cur. Drug Metab.. 2000, 1, 107-132.
22. Imai, T.; Takami, S.; Cho, Y.M.; Hirose, M.; ; Nishikawa, A. Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthraceneinduced carcinogenesis in rats. Toxicol. Lett. 2009, 185(3),160-167
23. Likhachev, A.J.; Alexandrov, V.A.; Anisimov, V.N.; Bespalov, V.G.; Korsakov, M.V.; Ovsyannikov, A.I.; Popovich, I.G.; Napalkov, N.P. ; Tomatis, L. Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-Nnitrosurea. Int. J. Cancer, 1983, 31, 779-784. (Pubitemid 13060785)
24. Rice, D. ; Barone Jr. S. Critical periods of vulnerability for the developing nervous system. Environ. Health Perspect. 2000, 108 (Suppl. 3), 511 -533.
25. Castro, D.J.; Baird, W.M.; Pereira, C.B.; Giovanini, J.; Löhr, C.V.; Fischer, K.A.; Yu Z; Gonzalez, F.J.; Krueger, S.K. and Williams D.E. Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene. Cancer Prev. Res. 2008, 1(2):128-134.
26. Donovan, P.J. Cell sensitivity to transplacental carcinogenesis by Nethyl- N-nitrosourea is greatest in early post-implantation development. Mutat. Res. 1999, 427, 47- 51. (Pubitemid 29238156)
27. Burgess, R.; Jenkins, R. ; Zhang, Z. Epigenetic changes in gliomas. Cancer Biol Ther., 2008, 7(9),1326-1334.
28. Kotliarov, Y.; Kotliarova, S.; Charong, N.; Li, A.; Walling, J.; Aquilanti, E.; Ahn, S.; Steed, M.E.; Su, Q.; Center, A.; Zenklusen, J.C. ; Fine, H.A. Correlation analysis between single-nucleotide polymorphism and expression arrays in gliomas identifies potentially relevant target genes. Cancer Res. 2009, 69(4),1596-1603.
29. Zhang, B. ; Pan, X. RDX induces aberrant expression of microRNAs in mouse brain and liver. Environ. Health Perspect. 2009, 117(2), 231-240.
30. Arshad H.; Ahmad Z. ; Hasan, S.H. Gliomas: Correlation of Histologic Grade, Ki67 and p53 Expression with Patient Survival. Asian Pac. J. Cancer Prev. 2010,11(6),1637-1640.
31. Broholm, H.; Born, P.W.; Guterbaum, D.; Dyrbye, H.; Laursen, H. Detecting chromosomal alterations at 1p and 19q by FISH and DNA fragment analysis-a comparative study in human gliomas. Clin. Neuropathol. 2008, 27(6), 378-387.
32. Sheikh, B.; Ohata, K.; El-Naggar A; ; Hakuba A. Extracranial to intracranial bypass using radial artery graft. J. Stroke Cerebrovas. Dises. 2002, 9 (2), 303-304
33. Karwacki, M.W.; Wočniak, W. Neurofibromatosis-an inborn genetic disorder with susceptibility to neoplasia. Review. Med. Wieku. Rozwoj. 2006, (3 Pt 2), 923-948.
34. Lijinsky, W.; Keefer, L.; Conrad, E.; Van de Bogart, R. Nitrosation of tertiary amines and some biologic implications. J. Nat. Cancer Inst. 1972. 49(5),1239-1249.
35. Krauss, M.; Hollender, J. Analysis of nitrosamines in wastewater: exploring the trace level quantification capabilities of a hybrid linear ion trap/orbitrap mass spectrometer. Ana. Chem. 2008, 80(3), 834-842. (Pubitemid 351206875)
36. Preussmann, R. Carcinogenic N-nitroso compounds and their environmental significance. Review. Naturwissenschaften. 1984, 71(1), 25-30. (Pubitemid 14184351)
37. Mostafa, M.H.; Sheweita, S.A.; O'Connor, P.J. The relationship between schistosomiasis and bladder cancer. A review. Clin. Microbiol. Rev. 1999, 12(1), 97-111. (Pubitemid 29055955)
38. Lambert, R.; Hainaut ,P. Esophageal cancer: cases and causes (part I). Endosco. 2007, 39(6), 550-555. (Pubitemid 46978049)
39. Dietrich, M.; Block, G.; Pogoda, J.M.; Buffler, P.; Hecht, S.; Preston-Martin S. A review: dietary and endogenously formed Nnitroso compounds and risk of childhood brain tumors. Cancer Causes Con., 2005, 16(6), 619-635. (Pubitemid 41110952)
40. Lijinsky, W.; Kovatch, R.M.; Saavedra, J.E. Nitrosation of tertiary amines and some biologic implications. Cancer Lett. 1992, 63(2),101-107
41. Sheweita, S.A.; Mostafa, M.H. N-nitroso compounds induce changes in carcinogen-metabolizing enzymes. Cancer lett. 1996, 106, 243-249. (Pubitemid 26325475)
42. Sheweita S.A. Glutathione alleviates the influence of Nnitrosamines on the activity of carcinogen-metabolizing enzymes in the liver of male mice. J Taibah University: Med. Sci., 2007, 1(1), 72-81.
43. Sheweita, S.A.; Mousa, N.; Newairy, A.A. N-nitrosodimethylamine induced changes in the activities of carcinogen-metabolizing enzymes in the liver of male mice: role of glutathione and gossypol as antioxidants. Afr. J. Biochem. Research 2007 1(5), 078-082.
44. Lv, C.L; Liu, Y.D.; Zhong R.G. Theoretical investigation of Nnitrosodimethylamine formation from dimethylamine nitrosation catalyzed by carbonyl compounds. J Phys Chem A. 2009, 113(4), 713-718.
45. Preston-Martin, S.; Pogoda, J.M.; Mueller, B.A.; Lubin, F.; Modan, B.; Holly, E.A.; Filippini, G.; Cordier, S.; Peris-Bonet, R.; Choi, W.; Little, J.; Arslan, A. Carcinogenic N-nitroso compounds and their environmental significance. Review Environ. Health Perspect. 1998, 106 (S3), 887- 892.
46. McKean-Cowdin, R.; Pogoda, J.M.; Lijinsky, W.; Holly, E.A.; Mueller, B.A.; Preston-Martin, S. Maternal prenatal exposure to nitrosatable drugs and childhood brain tumours. Int. J. Epidemiol. 2003, 32, 211 -217. (Pubitemid 36622265)
47. Druckrey, H.; Preussmann, R.; Ivankovic, S.; Schmähl, D.; Afkham, F.; Blum, G.; Mennel, H.D.; Mü ller, M.; Petropoulos, P.; Schneider,. H. Organotrope carcinogene Wirkungen bei verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Z. Krebsforsch 1967, 69,103-201.
48. Magee, P. The experimental basis for the role of nitroso compounds in human cancer. Cancer Surv. 1989, 8, 207-239. (Pubitemid 20035373)
49. International Agency for Research on Cancer (IARC) 1985. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, vol. 37, Tobacco Habits Other than Smoking: Betel-Quid and Areca-Nut Chewing; and Some Related Nitrosamines, IARC, Lyon, France.
50. International Agency for Research on Cancer (IARC) 1987. Monographs on the Evaluation of the Carcinogenic Risks to Humans, Supplement 7, Overall Evaluation of Carcinogenicity: An Updating of IARC Monographs, vol. 42, IARC, Lyon, France.
51. Sasaki, Y.F.; Sekihashi, K.; Izumiyama, F.; Nishidate, E.; Saga, A.; Ishida, K.; Tsuda, S. The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database. Crit. Rev. Toxicol. 2000, 30(6), 629-799.
52. Sekihashi, K.; Sasaki, T.; Yamamoto, A.; Kawamura, K.; Ikka, T.; Tsuda, S.; Sasaki, Y.F. A comparison of intraperitoneal and oral gavage administration in comet assay in mouse eight organs. Mutat. Res. 2001, 493(1-2):39-54. (Pubitemid 32544599)
53. Sekihashi, K.; Yamamoto, A.; Matsumura, Y.; Ueno, S, Watanabe- Akanuma, M.; Kassie, F.; Knasmüller, S.; Tsuda, S.; Sasaki, Y.F. Comparative investigation of multiple organs of mice and rats in the comet assay. Mutat. Res. 2002, 517(1-2), 53-75. (Pubitemid 34600993)
54. Sheweita, S.A.; Tilmisany, A.K. Cancer and phase II drugmetabolizing enzymes. Current Drug Metabolism. Cur. Drug. Metab. 2003, 4(1), 45-58. (Pubitemid 36131683)
55. Martelli, A.; Robbiano, L.; Gazzaniga, G.M.; Brambilla, G. Comparative study of DNA damage and repair induced by ten N-nitroso compounds in primary cultures of human and rat hepatocytes. Cancer Res. 1988, 48, 4144-4152.
56. Robbiano, L.; Martelli, A.; Allavena, A.; Mazzei, M.; Gazzaniga, G.M.; Brambilla. G. Formation of the N-nitroso derivatives of six b-adrenergic- blocking agents and their genotoxic effects in rat and human hepatocytes, Cancer Res. 1991, 51, 2273-2279.
57. Brambilla, G.; Robbiano, L.; Martelli, A.; Cajelli, E.; Allavena, A.A.; Mazzei, M.. Genotoxicity of N-nitrosochlordiazepoxide in cultured mammalians cells, Toxicol. Appl. Pharmacol., 1989, 97, 480-488. (Pubitemid 19094964)
58. Robbiano, L.; Mereto, E.; Corbu, C.; Brambilla, G. DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells. Mutat. Res. 1996, 368, 41-47. (Pubitemid 26156534)
59. Robbiano, L.; Carrozzino, R.; Bacigalupo, M.; Corbu, C.; Brambilla, G. Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue specific carcinogenic activity. Toxicol. 2002,179,115-128. (Pubitemid 35251813)
60. Montesano, R.; Magee, P.N. Comparative metabolism in vitro of nitrosamines in various animal species including man, in: R. Montesano, L. Tomatis (Eds.), Chemical Carcinogenesis Essays, IARC Scientific Publications No. 10, International Agency Research on Cancer, Lyon, France, 1974, pp. 39-56.
61. Burch, J.D.; Craib, K.J.P.; Choi, B.C.K.; Miller, A.B. Risch, H.A. Howe, G.R. An exploratory case-control study of brain tumors in adults. J. Natl. Cancer Inst. 1987, 78, 601-609. (Pubitemid 17063613)
62. Olshan, A.F.; Baird, P.A.; Teschke, K. Workshop to identify critical windows of exposure for children's health: cancer work group summary. Am. J. Hum. Genet. 1989, 44(5), 646-651.
63. Ward, M.H.; Pan, W.H.; Cheng, Y.J.; Li, F.H. Brinton, L.A.; Chen, C.J.; M.M. Hsu, I.H.; Chen, P.H.; Levine, C.S.; Yang, A. Dietary exposure to nitrite and nitrosamines and risk of nasopharyngeal carcinoma in Taiwan. Int. J. Cancer. 2000, 86, 603-609. (Pubitemid 30249868)
64. McKean-Cowdin, R.; Pogoda, J.M.; Lijinsky, W.; Holly, E.A.; Mueller, B.A.; Preston- Martin, S. Maternal prenatal exposure to nitrosatable drugs and childhood brain tumours. Int. J. Epidemiol.. 2003, 32(2), 211-217. (Pubitemid 36622265)
65. Carozza, S.E.; Olshan, A.F.; Faustman, E.M.; Gula, M.J.; Kolonel, L.N, Austin, D.F.; West, E.D.; Weiss, N.S.; Swanson, G.M. Maternal exposure to N-nitrosatable drugs as a risk factor for childhood brain tumours. Int. J. Epidemiol. 1995, 24(2), 308-312.
66. Zerilli, A.; Lucas, D.; Dreano, Y.; Picart, D.; Berthou, F. Effect of pyrazole and dexamethasone administration on cytochrome P450 2E1 and 3A isoforms in rat liver and kidney: lack of specificity of p-nitrophenol as a substrate of P450 2E1. Alcohol Clin. Exp. Res. 1998, 22(3), 652-657. (Pubitemid 28242471)
67. Yoo, J.S.H.; Ning, S.H.; Patten, C.; Yang, C.S. Metabolism and activation of N-nitrosodimethylamine by hamster and rat microsomes: comparative study with weanling and adult animals. Cancer Res. 1987, 47, 992-998. (Pubitemid 17027917)
68. Porubsky, P.R.; Meneely, K.M.; Scott, E.E. Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J. Biol. Chem. 2008, 283(48), 33698-33707.
69. Hong, J.; Yang, C.S. The nature of microsomal Nnitrosodimethylamine demethylase and its role in carcinogen activation. Carcinogen. 1985, 6, 1805-1809. (Pubitemid 16168995)
70. Carrière, V.; Berthou, F.; Baird, S., Belloc, C.; Beaune, P.; and de Waziers, I. Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype. Pharmacogenet. 1996, 6(3), 203-211 (Pubitemid 26226312)
71. Lo, H.W.; Cao, X.; Zhu, H.; Ali-Osman, F. Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clin. Cancer Res. 2008, 14(19), 6042-6054.
72. Metodiewa, D.; KoŠka, C. Reactive oxygen species and reactive nitrogen species: relevance to cyto(neuro)toxic events and neurologic disorders. An overview. Neurotox Res. 2000, 1(3),197-233.
73. Larouche, G.; Hales, B.F. The impact of human superoxide dismutase 1 expression in a mouse model on the embryotoxicity of hydroxyurea. Birth Defects Res A Clin. Mol. Teratol. 2009, 85(9),800-807.
74. Wang, X.; Perez, E.; Liu, R.; Yan, L.J.; Mallet, R.T; Yang, S.H. Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells. Brain Res. 2007, 1132(1), 1-9. (Pubitemid 46096455)
75. Augustyniak, A.; Michalak, K.; Skrzydlewska, E. The action of oxidative stress induced by ethanol on the central nervous system (CNS). Postepy. Hig. Med. Dosw. 2005, 59, 464-471.
76. Woźniak, B.; Woźniak, A.; Kasprzak, H.A.; Drewa, G.; Mila- Kierzenkowska, C.; Drewa, T.,; Planutis, G. Lipid peroxidation and activity of some antioxidant enzymes in patients with glioblastoma and astrocytoma. J. Neurooncol. 2007, 81(1), 221-216.
77. Zengin, E. Atukeren, P.; Kokoglu, E. Gumustas, M.K.; Zengin, U. Alterations in lipid peroxidation and antioxidant status in different types of intracranial tumors within their relative peritumoral tissues. Clin. Neurol. Neurosurg. 2009,111(4), 345-351.
78. Martín, V.; Herrera, F.; García-Santos, G.; Antolín, I.; Rodriguez- Blanco, J.; Rodriguez, C. Signaling pathways involved in antioxidant control of glioma cell proliferation. Free Rad. Biol. Med. 2007, 42(11), 1715-1722. (Pubitemid 46617150)
79. Pouliquen, D.; Olivier, C.; Hervouet, E.; Pedelaborde, F.; Debien, E.; Le Cabellec, M.T.; Gratas, C.; Homma, T.; Meflah, K.; Vallette, F.M.; Menanteau,, Dietary prevention of malignant glioma aggressiveness, implications in oxidant stress and apoptosis. J. Int. J. Cancer. 2008; 123(2), 288-295. (Pubitemid 351842012)
80. Sabarinathan, D.; Mahalakshmi, P.; Vanisree, A. Naringenin, a flavanone inhibits the proliferation of cerebrally implanted C6 glioma cells in rats. J. Chem. Biol. Interact. 2011, 189(1-2), 26-36.
81. DeLorenze, G.N.; McCoy, L.; Tsai, A.L.; and Quesenberry, C.P Jr; Rice, T.; Il'yasova, D.; Wrensch, M. Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma. BMC Cancer. 2010, 10, 215-220.
82. Ueno, M.; Inano, H.; Onoda, M.; Murase, H.; Ikota, N.; Kagiya, T.V.; Anzai, K. Modification of mortality and tumorigenesis by tocopherol- mono-glucoside (TMG) administered after X irradiation in mice and rats. Rad. Res. 2009,172(4), 519-524.
83. Bunin, G.R.; Gallagher, P.R.; Rorke-Adams, L.B.; Robison, LL, Cnaan, A. Maternal supplement, micronutrient, and cured meat intake during pregnancy and risk of medulloblastoma during childhood: a children's oncology group study. Cancer Epid. Biom. Prev. 2006,15(9),1660-1667 (Pubitemid 44497102)
84. Zaidi, S.M.; Banu, N. Antioxidant potential of vitamins A, E and C in modulating oxidative stress in rat brain. Clin. Chim. Acta. 2004, 340(1-2):229-233. (Pubitemid 38167528)
85. Hanimoglu, H.; Tanriverdi, T.; Kacira, T.; Sanus, G.Z.; Atukeren, P.; Aydin, S.; Tunali, Y.; Gumustas, K.; Kaynar, M.Y. Relationship between DNA damage and total antioxidant capacity in patients with transitional meningioma. Clin. Neurol. Neurosurg.. 2007,109(7), 561-566. (Pubitemid 47016754)
86. Aggarwal, S.; Subberwalm M., Kumarm, S.; Sharmam, M. Brain tumor and role of beta-carotene, a-tocopherol, superoxide dismutase and glutathione peroxidase. J. Cancer Res. Ther. 2006, 2(1), 24-27. (Pubitemid 43254000)
87. Caprile, T.; Salazar, K.; Astuya, A.; Cisternas, P.; Silva-Alvarez, C.; Montecinos H, Millán C, de Los Angeles García M, Nualart F. The Na+-dependent L-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids. J. Neurochem. 2009, 108(3), 563-577.
88. Dudek, H.; Farbiszewski, R.; Rydzewska, M.; Michno, T.; Kozαowski, A. Concentration of glutathione (GSH), ascorbic acid (vitamin C) and substances reacting with thiobarbituric acid (TBArs) in single human brain metastases]. Wiad Lek. 2005, 58(7-8),379-381.
89. Son, E.W.; Mo, S.J.; Rhee, D.K.; Pyo, S. Inhibition of gammairradiation induced adhesion molecules and NO production by alginate in human endothelial cells. Arch. Pharm. Res.. 2000, 10, 1073-1079.
90. Sirachainan, N.; Wongruangsri, S.; Kajanachumpol, S.; Pakakasama, S.; Visudtibhan, A.; Nuchprayoon, I.; Lusawat, A.; Phudhicharoenrat, S.; Shuangshoti, S.; Hongeng, S. Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children. Cancer Detect. Prev. 2008, 32(1), 72-78.
91. Leamon, C.P.; Reddy, J.A.; Vetzel, M.; Dorton, R.; Westrick, E.; Parker, N.; Wang, Y.; Vlahov, I. Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue. Cancer Res. 2008, 68(23), 9839-9844.
92. Sirachainan, N.; Wongruangsri, S.; Kajanachumpol, S.; Pakakasama, S.; Visudtibhan, A.; Nuchprayoon, I.; Lusawat, A.; Phudhicharoenrat, S.; Shuangshoti, S.; Hongeng S. Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children. Cancer Detect. Prev. 2008, 32(1),72-78.
93. Radad, K.; Moldzio, R.; Taha, M.; Rausch, W.D. Thymoquinone protects dopaminergic neurons against MPP(+) and rotenone. Phytother. Res. 2008, 45, 23-34.
94. El Tahir, K.E.; Ashour, M.M., al-Harbi, M.M. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen. Pharmacol. 1993, 24,1123-1131. (Pubitemid 23283080)
95. El-Alfy, T.; El-Fatatry, H.; Toama, M. Isolation and structure assignment of an anti-microbial principle from the volatile oil Nigella sativa L. Pharmazia; 1975, 30, 109-111.
96. Ali, B.H.; Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother. Res. 2003,17, 299-305. (Pubitemid 36565330)
97. Salomi, N.J.; Nair, S.C.; Jayawardhanan, K.K.; Varghese, C.D., Panikkar, K.R. Antitumour principles from Nigella sativa seeds. Cancer Lett. 1992, 63, 41-46.
98. Salomi, M.J.; Nair, S.C.; Panikkar, K.R Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice.. Nutr. Cancer 1991,16, 67-72.
99. Swamy, S.M.K.; Tan, B..K.H. Extraction, isolation and characterization of anti-tumor principle, alpha-Hederin, from the seeds of Nigella sativa. Planta Medica, 2001, 67, 29-32.
100. Gali-Muhtasib, H.; Diab-Assaf, M.; Boltze, C.; Al-Hmaira, J.; Hartig, R.; Roessner A. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53- dependent mechanism. Int. J. Oncol. 2004, 25, 857-866.
101. Yi, T.; Cho, S.G.; Yi, Z.; Pang, X.; Rodriguez, M.; Wang, Y.; Sethi, G.; Aggarwal, B.B.; Liu, M. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol. Cancer Ther. 2008, 7(7),1789-1796.
102. Gurung, R.L.; Lim, S.N.; Khaw, A.K.; Soon, J.F.; Shenoy, K.; Mohamed A.S.; Jayapal, M.; Sethu, S.; Baskar, R.; Hande, M.P. Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells. PLoS. One. 2010, 5(8), e12124-12129
103. Farah, I.O. Assessment of cellular responses to oxidative stress using MCF-7 breast cancer cells, black seed (N. Sativa L.) extracts and H2O2. Int. J. Environ. Res. Public. Health. 2005, 2(3-4), 411-419. (Pubitemid 47618950)