DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells

Mutation Research - Genetic Toxicology

Volumn 368, Issue 1, 1996, Pages 41-47

  Robbiano, Luigi ^a   Mereto, Eugenio ^a   Corbu, Carlo ^a   Brambilla, Giovanni ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Alkaline elution technique; DNA damaging activity; N nitroso compound; Primary cultures of human kidney cell; Primary cultures of rat kidney cell

Indexed keywords

BIS(2 HYDROXYETHYL)NITROSAMINE; DIETHYLNITROSAMINE; DIMETHYLNITROSAMINE; DIPROPYLNITROSAMINE; NITROSAMINE; NITROSO DERIVATIVE; NITROSOMORPHOLINE; STREPTOZOCIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; KIDNEY CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029887466     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(96)90038-5     Document Type: Article

References (21)

1. Bartsch, H. and R. Montesano (1984) Relevance of nitrosamines to human cancer. Carcinogenesis, 5, 1381-1393.
2. Bogovski, P. and S. Bogovski (1981) Animal species in which N-nitroso compounds induce cancer. Int. J. Cancer, 27, 471-474.
3. Brambilla, G., M. Cavanna, S. Parodi, L. Sciabà, A. Pino and L. Robbiano (1978) DNA damage in liver, colon, stomach, lung and kidney of BALB/c mice treated with 1,2-dimethylhydrazine. Int. J. Cancer, 22, 174-180.
4. Bruggeman, LM., J.J.W.M. Mertens, J.H.M. Temmink, M.C. Lans, R.M.E. Vos and P.J. van Bladeren (1989) Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies. Toxicol. In Vitro, 3, 261-269.
5. Druckrey, H., R. Preussman, S. Ivankovic and D. Schmahl (1967) Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an Bd-Ratten. Z. Krebsforsch., 69, 103-201.
6. Harris, C.C. (1987) Human tissues and cells in carcinogenesis research. Cancer Res., 47, 1-10.
7. Heidelberger, C. (1975) Chemical carcinogenesis. Annu. Rev. Biochem. 44, 79-121.
8. Hiasa, Y., M. Ohshima, C. Iwata and T. Tanikake (1979) Histopathological studies on renal tubular cell tumors in rat treated with N-ethyl-N-hydroxyethylnitrosamine. Gann, 70, 817-819.
9. Hsu, I.C., C.C. Harris, M.M. Lipsky, S. Snyder and B.F. Trump (1987) Cell and species differences in metabolic activation of chemical carcinogens. Mutation Res., 177, 1-7.
10. IARC (1978) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 17, Some N-nitroso Compounds, IARC, Lyon.
11. IARC (1987) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Suppl. 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, IARC, Lyon.
12. Kastner, S., M. Soose and H. Stolte (1993) Human kidney cells in vitro pharmacotoxicity, in: V. Rogiers, W. Sonck, E. Shephard and A. Vercruysse (Eds.), Human Cells in Vitro Pharmaco-Toxicology, Vubpress, Bruxelles, pp. 197-238.
13. Kohn, K.W., L.C. Erickson, R.A.G. Ewig and C.A. Friedman (1976) Fractionation of DNA from mammalian cells by alka-line elution. Biochemistry, 15, 4629-4637.
14. Langenbach, R., S. Nesnow and J.M. Rice (1983) Organ and Species Specificity in Chemical Carcinogenesis, Plenum Press, New York.
15. Magee, P.N. and J.M. Barnes (1967) Carcinogenic nitroso compounds. Adv. Cancer Res., 10, 163-246.
16. Martelli, A., L. Robbiano, G.M. Gazzaniga and G. Brambilla (1988) Comparative study of DNA damage and repair induced by ten W-nitroso compounds in primary cultures of human and rat hepatocytes. Cancer Res., 48, 4144-4152.
17. Miller, E.C. (1978) Some current perspectives on chemical carcinogenesis in humans and experimental animals. Cancer Res., 38, 1479-1496.
18. Rogiers, V., W. Sonck, E. Shephard and A. Vercruysse (1993) Human cells in in vitro pharmaco-toxicology. Present status within Europe, Vubpress, Bruxelles.
19. Rümke, C.L. and H. De Jonge (1964) Desing, statistical analysis and interpretation, in: D.R. Laurence and A.L. Bacharach (Eds.), Evaluation of Drug Activities: Pharmacometrics, Academic Press, New York, pp. 80-82.
20. Scott, D., S.M. Galloway, R.R. Marshall, M. Ishidate Jr., D. Brusick, J. Ashby and B.C. Myhr (1991) International Commission for Protection against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A Report from ICPEMC Task Group 9. Mutation Res., 257, 147-204.
21. Weinberg, R.A. (1989) Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis. Cancer Res., 49, 3713-3721.