메뉴 건너뛰기




Volumn 11, Issue 2, 2011, Pages 165-178

The Role of pharmacokinetics and pharmacodynamics in early drug development with reference to the cyclin-dependent kinase (Cdk) inhibitor - roscovitine

Author keywords

Agedependent kinetics; Anticancer drugs; Cdk inhibitor; Pharmacodynamics; Pharmacokinetics; Roscovitine; Toxicity

Indexed keywords

PROTOZOA; RATTUS;

EID: 79957949875     PISSN: 2075051X     EISSN: 20750528     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (11)

References (81)
  • 1
    • 0031472588 scopus 로고    scopus 로고
    • Role of pharmacokinetics and metabolism in drug discovery and development
    • Lin JH, Lu AY. Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol Rev 1997; 49:403-49.
    • (1997) Pharmacol Rev , vol.49 , pp. 403-449
    • Lin, J.H.1    Lu, A.Y.2
  • 2
    • 0036144662 scopus 로고    scopus 로고
    • Pharmacokinetic/ pharmacodynamic studies in drug product development
    • Meibohm B, Derendorf H. Pharmacokinetic/ pharmacodynamic studies in drug product development. J Pharm Sci 2002; 91:18-31.
    • (2002) J Pharm Sci , vol.91 , pp. 18-31
    • Meibohm, B.1    Derendorf, H.2
  • 3
    • 0034845384 scopus 로고    scopus 로고
    • Target concentration intervention: Beyond Y2K
    • Holford NH. Target concentration intervention: Beyond Y2K. Br J Clin Pharmacol 2001; 52:55-9.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 55-59
    • Holford, N.H.1
  • 4
    • 31344444671 scopus 로고    scopus 로고
    • Prediction of cytochrome p450- mediated hepatic drug clearance in neonates, infants and children:How accurate are available scaling methods?
    • Bjorkman S. Prediction of cytochrome p450- mediated hepatic drug clearance in neonates, infants and children:How accurate are available scaling methods? Clin Pharmacokinet 2006; 45:1-11.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 1-11
    • Bjorkman, S.1
  • 5
    • 20644465189 scopus 로고    scopus 로고
    • Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: Theophylline and midazolam as model drugs
    • Bjorkman S. Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: Theophylline and midazolam as model drugs. Br J Clin Pharmacol 2005; 59:691-704.
    • (2005) Br J Clin Pharmacol , vol.59 , pp. 691-704
    • Bjorkman, S.1
  • 6
    • 0024578538 scopus 로고
    • Cobalt in the environment and its toxicological implications
    • Domingo JL. Cobalt in the environment and its toxicological implications. Rev Environ Contam Toxicol 1989; 108:105-32.
    • (1989) Rev Environ Contam Toxicol , vol.108 , pp. 105-132
    • Domingo, J.L.1
  • 8
    • 34447094967 scopus 로고    scopus 로고
    • A census of mitotic cancer genes: New insights into tumor cell biology and cancer therapy
    • Perez de Castro I, de Carcer G, Malumbres M. A census of mitotic cancer genes: New insights into tumor cell biology and cancer therapy. Carcinogenesis 2007; 28:899-912.
    • (2007) Carcinogenesis , vol.28 , pp. 899-912
    • Perez de Castro, I.1    de Carcer, G.2    Malumbres, M.3
  • 9
    • 33747875152 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells
    • Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, et al. Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. Cancer Res 2006; 66:7509-15.
    • (2006) Cancer Res , vol.66 , pp. 7509-7515
    • Strock, C.J.1    Park, J.I.2    Nakakura, E.K.3    Bova, G.S.4    Isaacs, J.T.5    Ball, D.W.6
  • 10
    • 33845915536 scopus 로고    scopus 로고
    • Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5
    • Goodyear S, Sharma MC. Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5. Exp Mol Pathol 2007; 82:25-32.
    • (2007) Exp Mol Pathol , vol.82 , pp. 25-32
    • Goodyear, S.1    Sharma, M.C.2
  • 11
    • 0031569355 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling
    • Zhang Q, Ahuja HS, Zakeri ZF, Wolgemuth DJ. Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev Biol 1997; 183:222-33.
    • (1997) Dev Biol , vol.183 , pp. 222-233
    • Zhang, Q.1    Ahuja, H.S.2    Zakeri, Z.F.3    Wolgemuth, D.J.4
  • 12
    • 0033559980 scopus 로고    scopus 로고
    • The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis
    • Hakem A, Sasaki T, Kozieradzki I, Penninger JM. The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J Exp Med 1999; 189:957-68.
    • (1999) J Exp Med , vol.189 , pp. 957-968
    • Hakem, A.1    Sasaki, T.2    Kozieradzki, I.3    Penninger, J.M.4
  • 13
    • 0037034870 scopus 로고    scopus 로고
    • The subcellular localization of cyclin dependent kinase 2 determines the fate of mesangial cells: Role in apoptosis and proliferation
    • Hiromura K, Pippin JW, Blonski MJ, Roberts JM, Shankland SJ. The subcellular localization of cyclin dependent kinase 2 determines the fate of mesangial cells: Role in apoptosis and proliferation. Oncogene 2002; 21:1750-8.
    • (2002) Oncogene , vol.21 , pp. 1750-1758
    • Hiromura, K.1    Pippin, J.W.2    Blonski, M.J.3    Roberts, J.M.4    Shankland, S.J.5
  • 14
    • 2942572871 scopus 로고    scopus 로고
    • A Jekyll and Hyde kinase: Roles for Cdk5 in brain development and disease
    • Cruz JC, Tsai LH. A Jekyll and Hyde kinase: Roles for Cdk5 in brain development and disease. Curr Opin Neurobiol 2004; 14:390-4.
    • (2004) Curr Opin Neurobiol , vol.14 , pp. 390-394
    • Cruz, J.C.1    Tsai, L.H.2
  • 16
    • 33749164973 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory
    • Angelo M, Plattner F, Giese KP. Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. J Neurochem 2006; 99:353-70.
    • (2006) J Neurochem , vol.99 , pp. 353-370
    • Angelo, M.1    Plattner, F.2    Giese, K.P.3
  • 17
    • 0346119138 scopus 로고    scopus 로고
    • Role of Cdk5 in neuronal signaling, plasticity, and drug abuse
    • Bibb JA. Role of Cdk5 in neuronal signaling, plasticity, and drug abuse. Neurosignals 2003; 12:191-9.
    • (2003) Neurosignals , vol.12 , pp. 191-199
    • Bibb, J.A.1
  • 18
    • 0345166972 scopus 로고    scopus 로고
    • Cdk5 and the mystery of synaptic vesicle endocytosis
    • Nguyen C, Bibb JA. Cdk5 and the mystery of synaptic vesicle endocytosis. J Cell Biol 2003; 163:697-9.
    • (2003) J Cell Biol , vol.163 , pp. 697-699
    • Nguyen, C.1    Bibb, J.A.2
  • 19
    • 0036546687 scopus 로고    scopus 로고
    • Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity
    • Tomizawa K, Ohta J, Matsushita M, Moriwaki A, Li ST, Takei K, et al. Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J Neurosci 2002; 22:2590-7.
    • (2002) J Neurosci , vol.22 , pp. 2590-2597
    • Tomizawa, K.1    Ohta, J.2    Matsushita, M.3    Moriwaki, A.4    Li, S.T.5    Takei, K.6
  • 21
    • 0036710767 scopus 로고    scopus 로고
    • Pharmacological inhibitors of cyclin-dependent kinases
    • Knockaert M, Greengard P, Meijer L. Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci 2002; 23:417-25.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 417-425
    • Knockaert, M.1    Greengard, P.2    Meijer, L.3
  • 22
    • 0031028163 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinases by purine analogues: Crystal structure of human cdk2 complexed with roscovitine
    • De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH. Inhibition of cyclin-dependent kinases by purine analogues: Crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem 1997; 243:518-26.
    • (1997) Eur J Biochem , vol.243 , pp. 518-526
    • de Azevedo, W.F.1    Leclerc, S.2    Meijer, L.3    Havlicek, L.4    Strnad, M.5    Kim, S.H.6
  • 23
    • 0031037714 scopus 로고    scopus 로고
    • Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
    • Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 1997; 243:527-36.
    • (1997) Eur J Biochem , vol.243 , pp. 527-536
    • Meijer, L.1    Borgne, A.2    Mulner, O.3    Chong, J.P.4    Blow, J.J.5    Inagaki, N.6
  • 25
    • 24744461692 scopus 로고    scopus 로고
    • Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives
    • Tang L, Li MH, Cao P, Wang F, Chang WR, Bach S, et al. Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem 2005; 280:31220-9.
    • (2005) J Biol Chem , vol.280 , pp. 31220-31229
    • Tang, L.1    Li, M.H.2    Cao, P.3    Wang, F.4    Chang, W.R.5    Bach, S.6
  • 26
    • 0037058678 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)
    • McClue SJ, Blake D, Clarke R, Cowan A, Cummings L, Fischer PM, et al. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). Int J Cancer 2002; 102:463-8.
    • (2002) Int J Cancer , vol.102 , pp. 463-468
    • McClue, S.J.1    Blake, D.2    Clarke, R.3    Cowan, A.4    Cummings, L.5    Fischer, P.M.6
  • 27
    • 4444334494 scopus 로고    scopus 로고
    • Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis
    • Raynaud FI, Fischer PM, Nutley BP, Goddard PM, Lane DP, Workman P. Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis. Mol Cancer Ther 2004; 3:353-62.
    • (2004) Mol Cancer Ther , vol.3 , pp. 353-362
    • Raynaud, F.I.1    Fischer, P.M.2    Nutley, B.P.3    Goddard, P.M.4    Lane, D.P.5    Workman, P.6
  • 28
    • 0037325853 scopus 로고    scopus 로고
    • Deregulated degradation of the cdk inhibitor p27 and malignant transformation
    • Bloom J, Pagano M. Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol 2003; 13:41-7.
    • (2003) Semin Cancer Biol , vol.13 , pp. 41-47
    • Bloom, J.1    Pagano, M.2
  • 30
    • 0034607917 scopus 로고    scopus 로고
    • Initiation of human DNA replication in vitro using nuclei from cells arrested at an initiationcompetent state
    • Krude T. Initiation of human DNA replication in vitro using nuclei from cells arrested at an initiationcompetent state. J Biol Chem 2000; 275:13699-707.
    • (2000) J Biol Chem , vol.275 , pp. 13699-13707
    • Krude, T.1
  • 31
    • 0033594469 scopus 로고    scopus 로고
    • Cyclindependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells
    • Matsumoto Y, Hayashi K, Nishida E. Cyclindependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr Biol 1999; 9:429-32.
    • (1999) Curr Biol , vol.9 , pp. 429-432
    • Matsumoto, Y.1    Hayashi, K.2    Nishida, E.3
  • 32
    • 0037128933 scopus 로고    scopus 로고
    • Cyclindependent kinases govern formation and maintenance of the nucleolus
    • Sirri V, Hernandez-Verdun D, Roussel P. Cyclindependent kinases govern formation and maintenance of the nucleolus. J Cell Biol 2002; 15:969-81.
    • (2002) J Cell Biol , vol.15 , pp. 969-981
    • Sirri, V.1    Hernandez-Verdun, D.2    Roussel, P.3
  • 33
    • 14044257773 scopus 로고    scopus 로고
    • Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells
    • Wesierska-Gadek J, Gueorguieva M, Horky M. Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. Mol Cancer Ther 2005; 4:113-24.
    • (2005) Mol Cancer Ther , vol.4 , pp. 113-124
    • Wesierska-Gadek, J.1    Gueorguieva, M.2    Horky, M.3
  • 34
    • 57149083267 scopus 로고    scopus 로고
    • Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells
    • Wesierska-Gadek J, Wandl S, Kramer MP, Pickem C, Krystof V, Hajek SB. Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells. J Cell Biochem 2008; 105:1161-71.
    • (2008) J Cell Biochem , vol.105 , pp. 1161-1171
    • Wesierska-Gadek, J.1    Wandl, S.2    Kramer, M.P.3    Pickem, C.4    Krystof, V.5    Hajek, S.B.6
  • 35
    • 25444502962 scopus 로고    scopus 로고
    • In vitro activity of cyclindependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas
    • Lacrima K, Valentini A, Lambertini C, Taborelli M, Rinaldi A, Zucca E, et al. In vitro activity of cyclindependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas. Ann Oncol 2005; 16:1169-76.
    • (2005) Ann Oncol , vol.16 , pp. 1169-1176
    • Lacrima, K.1    Valentini, A.2    Lambertini, C.3    Taborelli, M.4    Rinaldi, A.5    Zucca, E.6
  • 36
    • 24744434754 scopus 로고    scopus 로고
    • Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells
    • Mohapatra S, Chu B, Zhao X, Pledger WJ. Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells. Cancer Res 2005; 65:7717-23.
    • (2005) Cancer Res , vol.65 , pp. 7717-7723
    • Mohapatra, S.1    Chu, B.2    Zhao, X.3    Pledger, W.J.4
  • 37
    • 0842329845 scopus 로고    scopus 로고
    • Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP
    • Kim EH, Kim SU, Shin DY, Choi KS. Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP. Oncogene 2004; 23:446-56.
    • (2004) Oncogene , vol.23 , pp. 446-456
    • Kim, E.H.1    Kim, S.U.2    Shin, D.Y.3    Choi, K.S.4
  • 38
    • 21144435503 scopus 로고    scopus 로고
    • A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival
    • Alvi AJ, Austen B, Weston VJ, Fegan C, MacCallum D, Gianella-Borradori A, et al. A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival. Blood 2005; 105:4484-91.
    • (2005) Blood , vol.105 , pp. 4484-4491
    • Alvi, A.J.1    Austen, B.2    Weston, V.J.3    Fegan, C.4    McCallum, D.5    Gianella-Borradori, A.6
  • 39
    • 0346327392 scopus 로고    scopus 로고
    • Dual action of cyclin-dependent kinase inhibitors: Induction of cell cycle arrest and apoptosis. A comparison of the effects exerted by roscovitine and cisplatin
    • Wesierska-Gadek J, Gueorguieva M, Horky M. Dual action of cyclin-dependent kinase inhibitors: Induction of cell cycle arrest and apoptosis. A comparison of the effects exerted by roscovitine and cisplatin. Pol J Pharmacol 2003; 55:895-902.
    • (2003) Pol J Pharmacol , vol.55 , pp. 895-902
    • Wesierska-Gadek, J.1    Gueorguieva, M.2    Horky, M.3
  • 41
    • 0034973788 scopus 로고    scopus 로고
    • Activation of p53 by roscovitine-mediated suppression of MDM2 expression
    • Lu W, Chen L, Peng Y, Chen J. Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 2001; 20:3206-16.
    • (2001) Oncogene , vol.20 , pp. 3206-3216
    • Lu, W.1    Chen, L.2    Peng, Y.3    Chen, J.4
  • 42
    • 1642373327 scopus 로고    scopus 로고
    • Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line
    • Abal M, Bras-Goncalves R, Judde JG, Fsihi H, De Cremoux P, Louvard D, et al. Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line. Oncogene 2004; 23:1737-44.
    • (2004) Oncogene , vol.23 , pp. 1737-1744
    • Abal, M.1    Bras-Goncalves, R.2    Judde, J.G.3    Fsihi, H.4    De Cremoux, P.5    Louvard, D.6
  • 43
    • 54249104991 scopus 로고    scopus 로고
    • Autophagy: A novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model
    • Lambert LA, Qiao N, Hunt KK, Lambert DH, Mills GB, Meijer L, et al. Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Res 2008; 68:7966-74.
    • (2008) Cancer Res , vol.68 , pp. 7966-7974
    • Lambert, L.A.1    Qiao, N.2    Hunt, K.K.3    Lambert, D.H.4    Mills, G.B.5    Meijer, L.6
  • 44
    • 27644591251 scopus 로고    scopus 로고
    • In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202
    • Raynaud FI, Whittaker SR, Fischer PM, McClue S, Walton MI, Barrie SE, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res 2005; 11:4875-87.
    • (2005) Clin Cancer Res , vol.11 , pp. 4875-4887
    • Raynaud, F.I.1    Whittaker, S.R.2    Fischer, P.M.3    McClue, S.4    Walton, M.I.5    Barrie, S.E.6
  • 46
    • 27144512221 scopus 로고    scopus 로고
    • Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo
    • Tirado OM, Mateo-Lozano S, Notario V. Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo. Cancer Res 2005; 65:9320-7.
    • (2005) Cancer Res , vol.65 , pp. 9320-9327
    • Tirado, O.M.1    Mateo-Lozano, S.2    Notario, V.3
  • 47
    • 33845317656 scopus 로고    scopus 로고
    • Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor
    • Iurisci I, Filipski E, Reinhardt J, Bach S, Gianella-Borradori A, Iacobelli S, et al. Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor. Cancer Res 2006; 66:10720-8.
    • (2006) Cancer Res , vol.66 , pp. 10720-10728
    • Iurisci, I.1    Filipski, E.2    Reinhardt, J.3    Bach, S.4    Gianella-Borradori, A.5    Iacobelli, S.6
  • 48
    • 0038519961 scopus 로고    scopus 로고
    • Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo
    • Maggiorella L, Deutsch E, Frascogna V, Chavaudra N, Jeanson L, Milliat F, et al. Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo. Cancer Res 2003; 63:2513-7.
    • (2003) Cancer Res , vol.63 , pp. 2513-2517
    • Maggiorella, L.1    Deutsch, E.2    Frascogna, V.3    Chavaudra, N.4    Jeanson, L.5    Milliat, F.6
  • 49
    • 0842287427 scopus 로고    scopus 로고
    • Analysis of roscovitine using novel high performance liquid chromatography and UV-detection method: Pharmacokinetics of roscovitine in rat
    • Vita M, Meurling L, Pettersson T, Cruz-Siden M, Siden A, Hassan M. Analysis of roscovitine using novel high performance liquid chromatography and UV-detection method: pharmacokinetics of roscovitine in rat. J Pharm Biomed Anal 2004; 34:425-31.
    • (2004) J Pharm Biomed Anal , vol.34 , pp. 425-431
    • Vita, M.1    Meurling, L.2    Pettersson, T.3    Cruz-Siden, M.4    Siden, A.5    Hassan, M.6
  • 50
    • 18044385804 scopus 로고    scopus 로고
    • Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat
    • Vita M, Abdel-Rehim M, Olofsson S, Hassan Z, Meurling L, Siden A, et al. Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat. Eur J Pharm Sci 2005; 25:91-103.
    • (2005) Eur J Pharm Sci , vol.25 , pp. 91-103
    • Vita, M.1    Abdel-Rehim, M.2    Olofsson, S.3    Hassan, Z.4    Meurling, L.5    Siden, A.6
  • 52
    • 14044274202 scopus 로고    scopus 로고
    • Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse
    • Nutley BP, Raynaud FI, Wilson SC, Fischer PM, Hayes A, Goddard PM, et al. Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse. Mol Cancer Ther 2005; 4:125-39.
    • (2005) Mol Cancer Ther , vol.4 , pp. 125-139
    • Nutley, B.P.1    Raynaud, F.I.2    Wilson, S.C.3    Fischer, P.M.4    Hayes, A.5    Goddard, P.M.6
  • 53
    • 1842637406 scopus 로고    scopus 로고
    • Pharmacokinetic model of R-roscovitine and its metabolite in healthy male subjects
    • De la Motte S, Gianella-Borradori A. Pharmacokinetic model of R-roscovitine and its metabolite in healthy male subjects. Int J Clin Pharmacol Ther 2004; 42:232-9.
    • (2004) Int J Clin Pharmacol Ther , vol.42 , pp. 232-239
    • de la Motte, S.1    Gianella-Borradori, A.2
  • 54
    • 33846254185 scopus 로고    scopus 로고
    • A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC 202; R-Roscovitine), administered twice daily for 7 days every 21 days
    • Benson C, White J, De Bono J, O'Donnell A, Raynaud F, Cruickshank C, et al. A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC 202; R-Roscovitine), administered twice daily for 7 days every 21 days. Br J Cancer 2007; 96:29-37.
    • (2007) Br J Cancer , vol.96 , pp. 29-37
    • Benson, C.1    White, J.2    De Bono, J.3    O'Donnell, A.4    Raynaud, F.5    Cruickshank, C.6
  • 56
    • 12444313584 scopus 로고    scopus 로고
    • In vitro glycosidation potential towards olomoucine-type cyclin-dependent kinase inhibitors in rodent and primate microsomes
    • Cervenkova K, Belejova M, Chmela Z, Rypka M, Riegrova D, Michnova K, et al. In vitro glycosidation potential towards olomoucine-type cyclin-dependent kinase inhibitors in rodent and primate microsomes. Physiol Res 2003; 52:467-74.
    • (2003) Physiol Res , vol.52 , pp. 467-474
    • Cervenkova, K.1    Belejova, M.2    Chmela, Z.3    Rypka, M.4    Riegrova, D.5    Michnova, K.6
  • 57
    • 40849142330 scopus 로고    scopus 로고
    • Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (r-roscovitine) in vitro and in vivo
    • McClue SJ, Stuart I. Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (r-roscovitine) in vitro and in vivo. Drug Metab Dispos 2008; 36:561-70.
    • (2008) Drug Metab Dispos , vol.36 , pp. 561-570
    • McClue, S.J.1    Stuart, I.2
  • 58
    • 33748462267 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
    • Rossi AG, Sawatzky DA, Walker A, Ward C, Sheldrake TA, Riley NA, et al. Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med 2006; 12:1056-64.
    • (2006) Nat Med , vol.12 , pp. 1056-1064
    • Rossi, A.G.1    Sawatzky, D.A.2    Walker, A.3    Ward, C.4    Sheldrake, T.A.5    Riley, N.A.6
  • 59
    • 67849119262 scopus 로고    scopus 로고
    • The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1
    • Duffin R, Leitch AE, Sheldrake TA, Hallett JM, Meyer C, Fox S, et al. The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1. FEBS Lett 2009; 583:2540-6.
    • (2009) FEBS Lett , vol.583 , pp. 2540-2546
    • Duffin, R.1    Leitch, A.E.2    Sheldrake, T.A.3    Hallett, J.M.4    Meyer, C.5    Fox, S.6
  • 60
    • 66749113138 scopus 로고    scopus 로고
    • The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD
    • Li L, Wang H, Kim J, Pihan G, Boussiotis V. The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle 2009; 8:1794-802.
    • (2009) Cell Cycle , vol.8 , pp. 1794-1802
    • Li, L.1    Wang, H.2    Kim, J.3    Pihan, G.4    Boussiotis, V.5
  • 61
    • 0037446980 scopus 로고    scopus 로고
    • The lethal effects of pharmacological cyclindependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
    • Yu C, Rahmani M, Dai Y, Conrad D, Krystal G, Dent P, et al. The lethal effects of pharmacological cyclindependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res 2003; 63:1822-33.
    • (2003) Cancer Res , vol.63 , pp. 1822-1833
    • Yu, C.1    Rahmani, M.2    Dai, Y.3    Conrad, D.4    Krystal, G.5    Dent, P.6
  • 62
    • 0036379564 scopus 로고    scopus 로고
    • Central nervous system prophylaxis in haematological malignancies
    • Wellwood J, Taylor K. Central nervous system prophylaxis in haematological malignancies. Intern Med J 2002; 32:252-8.
    • (2002) Intern Med J , vol.32 , pp. 252-258
    • Wellwood, J.1    Taylor, K.2
  • 63
    • 50949094104 scopus 로고    scopus 로고
    • Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain
    • Sallam H, Jimenez P, Song H, Vita M, Cedazo-Minguez A, Hassan M. Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain. Pharmacol Res 2008; 58:32-7.
    • (2008) Pharmacol Res , vol.58 , pp. 32-37
    • Sallam, H.1    Jimenez, P.2    Song, H.3    Vita, M.4    Cedazo-Minguez, A.5    Hassan, M.6
  • 64
    • 0026949519 scopus 로고
    • Pharmacokinetics in immature animals: A review
    • Nouws JF. Pharmacokinetics in immature animals: A review. J Anim Sci 1992; 70:3627-34.
    • (1992) J Anim Sci , vol.70 , pp. 3627-3634
    • Nouws, J.F.1
  • 65
    • 0030776172 scopus 로고    scopus 로고
    • Expression and inducibility of P450 enzymes during liver ontogeny
    • Rich KJ, Boobis AR. Expression and inducibility of P450 enzymes during liver ontogeny. Microsc Res Tech 1997; 39:424-35.
    • (1997) Microsc Res Tech , vol.39 , pp. 424-435
    • Rich, K.J.1    Boobis, A.R.2
  • 68
    • 0025048342 scopus 로고
    • Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study
    • Butt AM, Jones HC, Abbott NJ. Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study. J Physiol 1990; 429:47-62.
    • (1990) J Physiol , vol.429 , pp. 47-62
    • Butt, A.M.1    Jones, H.C.2    Abbott, N.J.3
  • 69
    • 33846828462 scopus 로고    scopus 로고
    • Cdk5 Modulation of mitogenactivated protein kinase signaling regulates neuronal survival
    • Zheng YL, Li BS, Kanungo J, Kesavapany S, Amin N, Grant P, et al. Cdk5 Modulation of mitogenactivated protein kinase signaling regulates neuronal survival. Mol Biol Cell 2007; 18:404-13.
    • (2007) Mol Biol Cell , vol.18 , pp. 404-413
    • Zheng, Y.L.1    Li, B.S.2    Kanungo, J.3    Kesavapany, S.4    Amin, N.5    Grant, P.6
  • 70
    • 0033781267 scopus 로고    scopus 로고
    • Activity and regulation of p35/ Cdk5 kinase complex
    • Nikolic M, Tsai LH. Activity and regulation of p35/ Cdk5 kinase complex. Methods Enzymol 2000; 325:200-13.
    • (2000) Methods Enzymol , vol.325 , pp. 200-213
    • Nikolic, M.1    Tsai, L.H.2
  • 71
    • 0032508698 scopus 로고    scopus 로고
    • p35, the neuronal-specific activator of cyclindependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
    • Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH. p35, the neuronal-specific activator of cyclindependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J Biol Chem 1998; 273:24057-64.
    • (1998) J Biol Chem , vol.273 , pp. 24057-24064
    • Patrick, G.N.1    Zhou, P.2    Kwon, Y.T.3    Howley, P.M.4    Tsai, L.H.5
  • 72
    • 2342494271 scopus 로고    scopus 로고
    • P35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons
    • Kesavapany S, Amin N, Zheng YL, Nijhara R, Jaffe H, Sihag R, et al. P35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons. J Neurosci 2004; 24:4421-31.
    • (2004) J Neurosci , vol.24 , pp. 4421-4431
    • Kesavapany, S.1    Amin, N.2    Zheng, Y.L.3    Nijhara, R.4    Jaffe, H.5    Sihag, R.6
  • 73
    • 0037665145 scopus 로고    scopus 로고
    • Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials
    • Meijer L, Raymond E. Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. Acc Chem Res 2003; 36:417-25.
    • (2003) Acc Chem Res , vol.36 , pp. 417-425
    • Meijer, L.1    Raymond, E.2
  • 74
    • 63849246351 scopus 로고    scopus 로고
    • Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
    • Phelps MA, Lin TS, Johnson AJ, Hurh E, Rozewski DM, Farley KL, et al. Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Blood 2009; 113:2637-45.
    • (2009) Blood , vol.113 , pp. 2637-2645
    • Phelps, M.A.1    Lin, T.S.2    Johnson, A.J.3    Hurh, E.4    Rozewski, D.M.5    Farley, K.L.6
  • 75
    • 0033951730 scopus 로고    scopus 로고
    • Assessing permeability alterations of the blood-bone marrow barrier due to total body irradiation: In vivo quantification with contrast enhanced magnetic resonance imaging
    • Daldrup-Link HE, Link TM, Rummeny EJ, August C, Konemann S, Jurgens H, et al. Assessing permeability alterations of the blood-bone marrow barrier due to total body irradiation: In vivo quantification with contrast enhanced magnetic resonance imaging. Bone Marrow Transplant 2000; 25:71-8.
    • (2000) Bone Marrow Transplant , vol.25 , pp. 71-78
    • Daldrup-Link, H.E.1    Link, T.M.2    Rummeny, E.J.3    August, C.4    Konemann, S.5    Jurgens, H.6
  • 76
    • 75749085170 scopus 로고    scopus 로고
    • An age-dependent pharmacokinetic study of intravenous and oral mycophenolate mofetil in combination with tacrolimus for GVHD prophylaxis in pediatric allogeneic stem cell transplantation recipients
    • Bhatia M, Militano O, Jin Z, Figurski M, Shaw L, Moore V, et al. An age-dependent pharmacokinetic study of intravenous and oral mycophenolate mofetil in combination with tacrolimus for GVHD prophylaxis in pediatric allogeneic stem cell transplantation recipients. Biol Blood Marrow Transplant 2010; 16:333-43.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 333-343
    • Bhatia, M.1    Militano, O.2    Jin, Z.3    Figurski, M.4    Shaw, L.5    Moore, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.