메뉴 건너뛰기




Volumn 20, Issue 1, 2009, Pages 7-14

Thioguanine pharmacokinetics in induction therapy of children with acute myeloid leukemia

Author keywords

Acute myeloid leukemia; Childhood; Pharmacokinetics; Thioguanine

Indexed keywords

CYTARABINE; DOXORUBICIN; ETOPOSIDE; HEMOGLOBIN; METHOTREXATE; TIOGUANINE;

EID: 57349184592     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32831bc086     Document Type: Article
Times cited : (13)

References (29)
  • 2
    • 0027973369 scopus 로고
    • The cytotoxicity of thioguanine vs mercaptopurine in acute lymphoblastic leukemia
    • Adamson PC, Poplack DG, Balis FM. The cytotoxicity of thioguanine vs mercaptopurine in acute lymphoblastic leukemia. Leuk Res 1994; 18: 805-810.
    • (1994) Leuk Res , vol.18 , pp. 805-810
    • Adamson, P.C.1    Poplack, D.G.2    Balis, F.M.3
  • 3
    • 0022551875 scopus 로고
    • Oral 6-mercaptopurine in childhood leukemia: Parent drug pharmacokinetics and active metabolite concentrations
    • Lennard L, Keen D, Lilleyman JS. Oral 6-mercaptopurine in childhood leukemia: parent drug pharmacokinetics and active metabolite concentrations. Clin Pharmacol Ther 1986; 40:287-292.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 287-292
    • Lennard, L.1    Keen, D.2    Lilleyman, J.S.3
  • 4
    • 0031874260 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine
    • Erb N, Harms DO, Janka-Schaub G. Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine. Cancer Chemother Pharmacol 1998; 42:266-272.
    • (1998) Cancer Chemother Pharmacol , vol.42 , pp. 266-272
    • Erb, N.1    Harms, D.O.2    Janka-Schaub, G.3
  • 5
    • 0141923920 scopus 로고    scopus 로고
    • Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: Results of the randomized trial COALL-92
    • Harms DO, Gobel U, Spaar HJ, Graubner UB, Jorch N, Gutjahr P, et al. Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92. Blood 2003; 102:2736-2740.
    • (2003) Blood , vol.102 , pp. 2736-2740
    • Harms, D.O.1    Gobel, U.2    Spaar, H.J.3    Graubner, U.B.4    Jorch, N.5    Gutjahr, P.6
  • 6
    • 34547770299 scopus 로고    scopus 로고
    • Substitution of oral and intravenous thioguanine for mercaptopurine in a treatment regimen for children with standard risk acute lymphoblastic leukemia: A collaborative Children's Oncology Group/National Cancer Institute pilot trial (CCG-1942)
    • Jacobs SS, Stork LC, Bostrom BC, Hutchinson R, Holcenberg J, Reaman GH, et al. Substitution of oral and intravenous thioguanine for mercaptopurine in a treatment regimen for children with standard risk acute lymphoblastic leukemia: a collaborative Children's Oncology Group/National Cancer Institute pilot trial (CCG-1942). Pediatr Blood Cancer 2007; 49:250-255.
    • (2007) Pediatr Blood Cancer , vol.49 , pp. 250-255
    • Jacobs, S.S.1    Stork, L.C.2    Bostrom, B.C.3    Hutchinson, R.4    Holcenberg, J.5    Reaman, G.H.6
  • 7
    • 33749515604 scopus 로고    scopus 로고
    • Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: A randomised trial
    • Vora A, Mitchell CD, Lennard L, Eden TO, Kinsey SE, Lilleyman J, et al. Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet 2006; 368:1339-1348.
    • (2006) Lancet , vol.368 , pp. 1339-1348
    • Vora, A.1    Mitchell, C.D.2    Lennard, L.3    Eden, T.O.4    Kinsey, S.E.5    Lilleyman, J.6
  • 8
    • 1842365260 scopus 로고
    • Purine and purine nucleoside antimetabolites
    • Chabner BW, Collins JM, editors, Philadelphia: J.B. Lippincott;
    • McCormack J, Johns D. Purine and purine nucleoside antimetabolites. In: Chabner BW, Collins JM, editors. Cancer chemotherapy; principles and practice. Philadelphia: J.B. Lippincott; 1990, pp. 234-250.
    • (1990) Cancer chemotherapy; principles and practice , pp. 234-250
    • McCormack, J.1    Johns, D.2
  • 9
    • 28544443076 scopus 로고    scopus 로고
    • Longterm results in children with AML: NOPHO-AML Study Group-report of three consecutive trials
    • Lie SO, Abrahamsson J, Clausen N, Forestier E, Hasle H, Hovi L, et al. Longterm results in children with AML: NOPHO-AML Study Group-report of three consecutive trials. Leukemia 2005; 19:2090-2100.
    • (2005) Leukemia , vol.19 , pp. 2090-2100
    • Lie, S.O.1    Abrahamsson, J.2    Clausen, N.3    Forestier, E.4    Hasle, H.5    Hovi, L.6
  • 10
    • 0020534019 scopus 로고
    • Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?
    • Zimm S, Collins JM, Riccardi R, O'Neill D, Narang PK, Chabner B, et al. Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered? N Engl J Med 1983; 308:1005-1009.
    • (1983) N Engl J Med , vol.308 , pp. 1005-1009
    • Zimm, S.1    Collins, J.M.2    Riccardi, R.3    O'Neill, D.4    Narang, P.K.5    Chabner, B.6
  • 11
    • 0019415898 scopus 로고
    • Clinical pharmacology of oral thioguanine in acute myelogenous leukemia
    • Brox LW, Birkett L, Belch A. Clinical pharmacology of oral thioguanine in acute myelogenous leukemia. Cancer Chemother Pharmacol 1981; 6:35-38.
    • (1981) Cancer Chemother Pharmacol , vol.6 , pp. 35-38
    • Brox, L.W.1    Birkett, L.2    Belch, A.3
  • 12
    • 0024818659 scopus 로고
    • Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia
    • Lennard L, Lilleyman JS. Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia. J Clin Oncol 1989; 7:1816-1823.
    • (1989) J Clin Oncol , vol.7 , pp. 1816-1823
    • Lennard, L.1    Lilleyman, J.S.2
  • 13
    • 0025195675 scopus 로고
    • 6 Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia
    • Schmiegelow K, Bruunshuus I. 6 Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia. Cancer Chemother Pharmacol 1990; 26:288-292.
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 288-292
    • Schmiegelow, K.1    Bruunshuus, I.2
  • 14
    • 0023001398 scopus 로고
    • Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia
    • Sulh H, Koren G, Whalen C, Soldin S, Zipursky A, Greenberg M. Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia. Clin Pharmacol Ther 1986; 40:604-609.
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 604-609
    • Sulh, H.1    Koren, G.2    Whalen, C.3    Soldin, S.4    Zipursky, A.5    Greenberg, M.6
  • 15
    • 33646676254 scopus 로고    scopus 로고
    • Optimal treatment intensity in children with Down syndrome and myeloid leukaemia: Data from 56 children treated on NOPHO-AML protocols and a review of the literature
    • Abildgaard L, Ellebaek E, Gustafsson G, Abrahamsson J, Hovi L, Jonmundsson G, et al. Optimal treatment intensity in children with Down syndrome and myeloid leukaemia: data from 56 children treated on NOPHO-AML protocols and a review of the literature. Ann Hematol 2006; 85:275-280.
    • (2006) Ann Hematol , vol.85 , pp. 275-280
    • Abildgaard, L.1    Ellebaek, E.2    Gustafsson, G.3    Abrahamsson, J.4    Hovi, L.5    Jonmundsson, G.6
  • 16
    • 0038487005 scopus 로고    scopus 로고
    • Treatment stratification based on initial in vivo response in acute myeloid leukaemia in children without Down's syndrome: Results of NOPHO-AML trials
    • Lie SO, Abrahamsson J, Clausen N, Forestier E, Hasle H, Hovi L, et al. Treatment stratification based on initial in vivo response in acute myeloid leukaemia in children without Down's syndrome: results of NOPHO-AML trials. Br J Haematol 2003; 122:217-225.
    • (2003) Br J Haematol , vol.122 , pp. 217-225
    • Lie, S.O.1    Abrahamsson, J.2    Clausen, N.3    Forestier, E.4    Hasle, H.5    Hovi, L.6
  • 17
    • 0026465403 scopus 로고
    • High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample
    • Lennard L, Singleton HJ. High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample. J Chromatogr 1992; 583:83-90.
    • (1992) J Chromatogr , vol.583 , pp. 83-90
    • Lennard, L.1    Singleton, H.J.2
  • 18
    • 33748182877 scopus 로고    scopus 로고
    • Doxorubicin pharmacokinetics is correlated to the effect of induction therapy in children with acute myeloid leukemia
    • Palle J, Frost BM, Peterson C, Gustafsson G, Hellebostad M, Kanerva J, et al. Doxorubicin pharmacokinetics is correlated to the effect of induction therapy in children with acute myeloid leukemia. Anticancer Drugs 2006; 17:385-392.
    • (2006) Anticancer Drugs , vol.17 , pp. 385-392
    • Palle, J.1    Frost, B.M.2    Peterson, C.3    Gustafsson, G.4    Hellebostad, M.5    Kanerva, J.6
  • 19
    • 33749028696 scopus 로고    scopus 로고
    • Etoposide pharmacokinetics in children treated for acute myeloid leukemia
    • Palle J, Britt-Marie F, Goran G, Marit H, Jukka K, Eva L, et al. Etoposide pharmacokinetics in children treated for acute myeloid leukemia. Anticancer Drugs 2006; 17:1087-1094.
    • (2006) Anticancer Drugs , vol.17 , pp. 1087-1094
    • Palle, J.1    Britt-Marie, F.2    Goran, G.3    Marit, H.4    Jukka, K.5    Eva, L.6
  • 20
    • 0034819143 scopus 로고    scopus 로고
    • 6-Thioguanine in children with acute lymphoblastic leukaemia: Influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations
    • Lancaster DL, Patel N, Lennard L, Lilleyman JS. 6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations. Br J Clin Pharmacol 2001; 51:531-539.
    • (2001) Br J Clin Pharmacol , vol.51 , pp. 531-539
    • Lancaster, D.L.1    Patel, N.2    Lennard, L.3    Lilleyman, J.S.4
  • 21
    • 0027276221 scopus 로고
    • Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?
    • Lennard L, Davies HA, Lilleyman JS. Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia? Br J Cancer 1993; 68:186-190.
    • (1993) Br J Cancer , vol.68 , pp. 186-190
    • Lennard, L.1    Davies, H.A.2    Lilleyman, J.S.3
  • 22
    • 0032533637 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of oral methotrexate and mercaptopurine in children with lower risk acute lymphoblastic leukemia: A joint children's cancer group and pediatric oncology branch study
    • Balis FM, Holcenberg JS, Poplack DG, Ge J, Sather HN, Murphy RF, et al. Pharmacokinetics and pharmacodynamics of oral methotrexate and mercaptopurine in children with lower risk acute lymphoblastic leukemia: a joint children's cancer group and pediatric oncology branch study. Blood 1998; 92:3569-3577.
    • (1998) Blood , vol.92 , pp. 3569-3577
    • Balis, F.M.1    Holcenberg, J.S.2    Poplack, D.G.3    Ge, J.4    Sather, H.N.5    Murphy, R.F.6
  • 23
    • 18944404989 scopus 로고    scopus 로고
    • AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity
    • Creutzig U, Reinhardt D, Diekamp S, Dworzak M, Stary J, Zimmermann M. AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity. Leukemia 2005; 19:1355-1360.
    • (2005) Leukemia , vol.19 , pp. 1355-1360
    • Creutzig, U.1    Reinhardt, D.2    Diekamp, S.3    Dworzak, M.4    Stary, J.5    Zimmermann, M.6
  • 25
    • 0026808789 scopus 로고
    • Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: Experience on Pediatric Oncology Group AML Study 8498
    • Ravindranath Y, Abella E, Krischer JP, Wiley J, Inoue S, Harris M, et al. Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498. Blood 1992; 80:2210-2214.
    • (1992) Blood , vol.80 , pp. 2210-2214
    • Ravindranath, Y.1    Abella, E.2    Krischer, J.P.3    Wiley, J.4    Inoue, S.5    Harris, M.6
  • 27
    • 0031847470 scopus 로고    scopus 로고
    • Thioguanine versus mercaptopurine for therapy of childhood lymphoblastic leukaemia: A comparison of haematological toxicity and drug metabolite concentrations
    • Lancaster DL, Lennard L, Rowland K, Vora AJ, Lilleyman JS. Thioguanine versus mercaptopurine for therapy of childhood lymphoblastic leukaemia: a comparison of haematological toxicity and drug metabolite concentrations. Br J Haematol 1998; 102:439-443.
    • (1998) Br J Haematol , vol.102 , pp. 439-443
    • Lancaster, D.L.1    Lennard, L.2    Rowland, K.3    Vora, A.J.4    Lilleyman, J.S.5
  • 28
    • 0036304389 scopus 로고    scopus 로고
    • Leucocyte versus erythrocyte thioguanine nucleotide concentrations in children taking thiopurines for acute lymphoblastic leukaemia
    • Lancaster DL, Patel N, Lennard L, Lilleyman JS. Leucocyte versus erythrocyte thioguanine nucleotide concentrations in children taking thiopurines for acute lymphoblastic leukaemia. Cancer Chemother Pharmacol 2002; 50:33-36.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 33-36
    • Lancaster, D.L.1    Patel, N.2    Lennard, L.3    Lilleyman, J.S.4
  • 29
    • 0031423875 scopus 로고    scopus 로고
    • Patterns of azathioprine metabolites in neutrophils, lymphocytes, reticulocytes, and erythrocytes: Relevance to toxicity and monitoring in recipients of renal allografts
    • Bergan S, Bentdal O, Sodal G, Brun A, Rugstad HE, Stokke O. Patterns of azathioprine metabolites in neutrophils, lymphocytes, reticulocytes, and erythrocytes: relevance to toxicity and monitoring in recipients of renal allografts. Ther Drug Monit 1997; 19:502-509.
    • (1997) Ther Drug Monit , vol.19 , pp. 502-509
    • Bergan, S.1    Bentdal, O.2    Sodal, G.3    Brun, A.4    Rugstad, H.E.5    Stokke, O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.