-
1
-
-
37249006192
-
New links to the pathogene-sis of Crohn disease provided by genome-wide association scans
-
Mathew CG. (2008) New links to the pathogene-sis of Crohn disease provided by genome-wide association scans. Nat. Rev. Genet. 9:9-14.
-
(2008)
Nat. Rev. Genet
, vol.9
, pp. 9-14
-
-
Mathew, C.G.1
-
2
-
-
34248136828
-
Inflammatory bowel disease: Cause and immunobiology
-
Baumgart DC, Carding SR. (2007) Inflammatory bowel disease: cause and immunobiology. Lancet. 369:1627-1640.
-
(2007)
Lancet
, vol.369
, pp. 1627-1640
-
-
Baumgart, D.C.1
Carding, S.R.2
-
3
-
-
65349196054
-
Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease
-
Soderlund S, et al. (2009). Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease. Gastroenterol-ogy. 136:1561-1567.
-
(2009)
Gastroenterol-ogy
, vol.136
, pp. 1561-1567
-
-
Soderlund, S.1
-
4
-
-
25844459154
-
NF-kappa B: Linking inflammation and immunity to cancer development and progression
-
Karin M, Greten FR. (2005) NF-kappa B: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5:749-759.
-
(2005)
Nat. Rev. Immunol
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
5
-
-
0028979727
-
Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms
-
Tarmin L, et al. (1995) Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms. Cancer Res. 55:2035-2038.
-
(1995)
Cancer Res
, vol.55
, pp. 2035-2038
-
-
Tarmin, L.1
-
6
-
-
79957933972
-
Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat)
-
Furlan A, et al. (2011) Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat). Mol. Med. 17:353-362.
-
(2011)
Mol. Med
, vol.17
, pp. 353-362
-
-
Furlan, A.1
-
7
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 325:834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
-
8
-
-
77449116892
-
Acetylation goes global: The emergence of acetylation biology
-
Norris KL, Lee JY, Yao T P. (2009) Acetylation goes global: the emergence of acetylation biology. Sci. Signal. 2:pe76.
-
(2009)
Sci. Signal
, vol.2
-
-
Norris, K.L.1
Lee, J.Y.2
Yao, T.P.3
-
9
-
-
56049090769
-
Acetylation of non-histone proteins modulates cellular signalling at multiple levels
-
Spange S, Wagner T, Heinzel T, Kramer OH. (2009) Acetylation of non-histone proteins modulates cellular signalling at multiple levels. Int. J. Biochem. Cell Biol. 41:185-198.
-
(2009)
Int. J. Biochem. Cell Biol
, vol.41
, pp. 185-198
-
-
Spange, S.1
Wagner, T.2
Heinzel, T.3
Kramer, O.H.4
-
10
-
-
85047690640
-
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
-
Fuss IJ, et al. (2004) Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J. Clin. Invest. 113:1490-1497.
-
(2004)
J. Clin. Invest
, vol.113
, pp. 1490-1497
-
-
Fuss, I.J.1
-
11
-
-
0030209985
-
Disparate CD4+ lamina pro-pria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
-
Fuss IJ, et al. (1996) Disparate CD4+ lamina pro-pria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157:1261-1270.
-
(1996)
J. Immunol
, vol.157
, pp. 1261-1270
-
-
Fuss, I.J.1
-
12
-
-
0030029222
-
Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
-
Stuber E, Strober W, Neurath M. (1996) Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 183:693-698.
-
(1996)
J. Exp. Med
, vol.183
, pp. 693-698
-
-
Stuber, E.1
Strober, W.2
Neurath, M.3
-
14
-
-
34548125305
-
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
-
Acosta-Rodriguez EV, Napolitani G, Lanzavec-chia A, Sallusto F. (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8:942-9.
-
(2007)
Nat. Immunol
, vol.8
, pp. 942-949
-
-
Acosta-Rodriguez, E.V.1
Napolitani, G.2
Lanzavec-Chia, A.3
Sallusto, F.4
-
15
-
-
78650915985
-
Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis
-
Zhang X, et al. (2011) Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infect. Immun. 79:527-41.
-
(2011)
Infect. Immun
, vol.79
, pp. 527-541
-
-
Zhang, X.1
-
16
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou L, et al. (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8:967-74.
-
(2007)
Nat. Immunol
, vol.8
, pp. 967-974
-
-
Zhou, L.1
-
17
-
-
0037216498
-
Increased expression of in-terleukin 17 in inflammatory bowel disease
-
Fujino S, et al. (2003) Increased expression of in-terleukin 17 in inflammatory bowel disease. Gut. 52:65-70.
-
(2003)
Gut
, vol.52
, pp. 65-70
-
-
Fujino, S.1
-
18
-
-
29744450121
-
Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
-
Fuss IJ, et al. (2006) Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12:9-15.
-
(2006)
Inflamm. Bowel Dis
, vol.12
, pp. 9-15
-
-
Fuss, I.J.1
-
19
-
-
0030945106
-
Th1 and Th2 CD4+ cells in the pathogenesis of allergic diseases
-
Umetsu DT, DeKruyff RH. (1997) Th1 and Th2 CD4+ cells in the pathogenesis of allergic diseases. Proc. Soc. Exp. Biol. Med. 215:11-20.
-
(1997)
Proc. Soc. Exp. Biol. Med
, vol.215
, pp. 11-20
-
-
Umetsu, D.T.1
Dekruyff, R.H.2
-
20
-
-
0142053206
-
The immunological and genetic basis of inflammatory bowel disease
-
Bouma G, Strober W. (2003) The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3:521-33.
-
(2003)
Nat. Rev. Immunol
, vol.3
, pp. 521-533
-
-
Bouma, G.1
Strober, W.2
-
21
-
-
23244455992
-
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that af-fects epithelial tight junctions, apoptosis, and cell restitution
-
Heller F, et al. (2005) Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that af-fects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 129:550-64.
-
(2005)
Gastroenterology
, vol.129
, pp. 550-564
-
-
Heller, F.1
-
22
-
-
34548680982
-
Foxp3+ regulatory T cells: Selfishness under scrutiny
-
Stephens GL, Shevach EM. (2007) Foxp3+ regulatory T cells: selfishness under scrutiny. Immunity. 27:417-9.
-
(2007)
Immunity
, vol.27
, pp. 417-419
-
-
Stephens, G.L.1
Shevach, E.M.2
-
23
-
-
34247277666
-
Foxp3 in control of the regulatory T cell lineage
-
Zheng Y, Rudensky AY (2007) Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 8:457-62.
-
(2007)
Nat. Immunol
, vol.8
, pp. 457-462
-
-
Zheng, Y.1
Rudensky, A.Y.2
-
25
-
-
35348876040
-
IPEX, FOXP3 and regulatory T-cells: A model for autoimmunity
-
Ochs HD, Gambineri E, Torgerson TR. (2007) IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol. Res. 38:112-21.
-
(2007)
Immunol. Res
, vol.38
, pp. 112-121
-
-
Ochs, H.D.1
Gambineri, E.2
Torgerson, T.R.3
-
26
-
-
55949085986
-
Keeping things quiet: Roles of NuRD and Sin3 co-repressor complexes during mammalian development
-
McDonel P, Costello I, Hendrich B. (2009) Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development. Int. J. Biochem. Cell Biol. 41:108-16.
-
(2009)
Int. J. Biochem. Cell Biol
, vol.41
, pp. 108-116
-
-
McDonel, P.1
Costello, I.2
Hendrich, B.3
-
27
-
-
0033609055
-
Three proteins define a class of human histone deacetylases related to yeast Hda1p
-
Grozinger CM, Hassig CA, Schreiber SL. (1999) Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. U. S. A. 96:4868-73.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A
, vol.96
, pp. 4868-4873
-
-
Grozinger, C.M.1
Hassig, C.A.2
Schreiber, S.L.3
-
28
-
-
0035312289
-
The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
-
Feng Q, Zhang Y. (2001) The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev. 15:827-832.
-
(2001)
Genes Dev
, vol.15
, pp. 827-832
-
-
Feng, Q.1
Zhang, Y.2
-
29
-
-
58849088509
-
T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation
-
Chang S, Collins PL, Aune TM. (2008) T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. J. Immunol. 181:8372-81.
-
(2008)
J. Immunol
, vol.181
, pp. 8372-8381
-
-
Chang, S.1
Collins, P.L.2
Aune, T.M.3
-
30
-
-
33750964226
-
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes
-
Chen GY, Osada H, Santamaria-Babi LF, Kannagi R (2006) Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 103:16894-9.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A
, vol.103
, pp. 16894-16899
-
-
Chen, G.Y.1
Osada, H.2
Santamaria-Babi, L.F.3
Kannagi, R.4
-
32
-
-
33748428027
-
Histone deacetylase inhibitors induce antigen specific energy in lymphocytes: A comparative study
-
Edens RE, Dagtas S, Gilbert KM. (2006) Histone deacetylase inhibitors induce antigen specific energy in lymphocytes: a comparative study. Int. Immunopharmacol. 6:1673-81.
-
(2006)
Int. Immunopharmacol
, vol.6
, pp. 1673-1681
-
-
Edens, R.E.1
Dagtas, S.2
Gilbert, K.M.3
-
33
-
-
3042566927
-
The histone deacetylase inhibitor trichostatin A modulates CD4+ T cell responses
-
Moreira JM, Scheipers P, Sorensen P. (2003) The histone deacetylase inhibitor trichostatin A modulates CD4+ T cell responses. BMC Cancer. 3:30.
-
(2003)
BMC Cancer
, vol.3
, pp. 30
-
-
Moreira, J.M.1
Scheipers, P.2
Sorensen, P.3
-
34
-
-
34548134832
-
Mechanism of HDAC inhibitor FR235222-mediated IL-2 transcriptional repression in Jurkat cells
-
Matsuoka H, Fujimura T, Mori H, Aramori I, Mutoh S. (2007) Mechanism of HDAC inhibitor FR235222-mediated IL-2 transcriptional repression in Jurkat cells. Int. Immunopharmacol. 7:1422-32.
-
(2007)
Int. Immunopharmacol
, vol.7
, pp. 1422-1432
-
-
Matsuoka, H.1
Fujimura, T.2
Mori, H.3
Aramori, I.4
Mutoh, S.5
-
35
-
-
55149094300
-
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
-
Koenen HJ, et al. (2008) Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood. 112:2340-52.
-
(2008)
Blood
, vol.112
, pp. 2340-2352
-
-
Koenen, H.J.1
-
36
-
-
73449117582
-
Immunomodulatory effects of deacetylase inhibitors: Therapeutic targeting of FOXP3+ regulatory T cells
-
Wang L, de Zoeten EF, Greene MI, Hancock WW. (2009) Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat. Rev. Drug. Discov. 8:969-81.
-
(2009)
Nat. Rev. Drug. Discov
, vol.8
, pp. 969-981
-
-
Wang, L.1
de Zoeten, E.F.2
Greene, M.I.3
Hancock, W.W.4
-
37
-
-
35948980739
-
Deacetylase inhibition promotes the generation and function of regulatory T cells
-
Tao R, et al. (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13:1299-307.
-
(2007)
Nat. Med
, vol.13
, pp. 1299-1307
-
-
Tao, R.1
-
38
-
-
62849120700
-
Using his-tone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance
-
Wang L, Tao R, Hancock WW. (2009) Using his-tone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. Immunol. Cell Biol. 87:195-202.
-
(2009)
Immunol. Cell Biol
, vol.87
, pp. 195-202
-
-
Wang, L.1
Tao, R.2
Hancock, W.W.3
-
39
-
-
75449114277
-
Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice
-
de Zoeten EF, Wang L, Sai H, Dillmann WH, Hancock WW. (2010) Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology. 138:583-94.
-
(2010)
Gastroenterology
, vol.138
, pp. 583-594
-
-
de Zoeten, E.F.1
Wang, L.2
Sai, H.3
Dillmann, W.H.4
Hancock, W.W.5
-
40
-
-
57149099029
-
Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo
-
Bosisio D, et al. (2008) Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. J. Leukoc. Biol. 84:1540-8.
-
(2008)
J. Leukoc. Biol
, vol.84
, pp. 1540-1548
-
-
Bosisio, D.1
-
41
-
-
67650457697
-
Apicidin, the histone deacetylase inhibitor, suppresses Th1 polarization of murine bone marrow-derived dendritic cells
-
Jung ID, et al. (2009) Apicidin, the histone deacetylase inhibitor, suppresses Th1 polarization of murine bone marrow-derived dendritic cells. Int. J. Immunopathol. Pharmacol. 22:501-15.
-
(2009)
Int. J. Immunopathol. Pharmacol
, vol.22
, pp. 501-515
-
-
Jung, I.D.1
-
42
-
-
33846876336
-
Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function
-
Brogdon JL, et al. (2007) Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood. 109:1123-30.
-
(2007)
Blood
, vol.109
, pp. 1123-1130
-
-
Brogdon, J.L.1
-
43
-
-
70349737858
-
Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3
-
Sun Y, et al. (2009) Cutting edge: negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3. J. Immunol. 182:5899-903.
-
(2009)
J. Immunol
, vol.182
, pp. 5899-5903
-
-
Sun, Y.1
-
44
-
-
46749144173
-
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice
-
Reddy P, et al. (2008) Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J. Clin. Invest. 118:2562-73.
-
(2008)
J. Clin. Invest
, vol.118
, pp. 2562-2573
-
-
Reddy, P.1
-
45
-
-
33746499843
-
LPS regulates proinflam-matory gene expression in macrophages by altering histone deacetylase expression
-
Aung HT, et al. (2006) LPS regulates proinflam-matory gene expression in macrophages by altering histone deacetylase expression. FASEB J. 20:1315-27.
-
(2006)
FASEB J
, vol.20
, pp. 1315-1327
-
-
Aung, H.T.1
-
46
-
-
1542343955
-
Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators
-
Deng WG, Zhu Y, Wu KK. (2004) Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood. 103:2135-42.
-
(2004)
Blood
, vol.103
, pp. 2135-2142
-
-
Deng, W.G.1
Zhu, Y.2
Wu, K.K.3
-
47
-
-
31344446119
-
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression
-
Ito K, et al. (2006) Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J. Exp. Med. 203:7-13.
-
(2006)
J. Exp. Med
, vol.203
, pp. 7-13
-
-
Ito, K.1
-
48
-
-
78149283427
-
Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity
-
Maa MC, et al. (2010) Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity. J. Nutr. Biochem. 21:1186-92.
-
(2010)
J. Nutr. Biochem
, vol.21
, pp. 1186-1192
-
-
Maa, M.C.1
-
49
-
-
77951925741
-
Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue
-
Grabiec AM, et al. (2010) Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. J. Immunol. 184:2718-28.
-
(2010)
J. Immunol
, vol.184
, pp. 2718-2728
-
-
Grabiec, A.M.1
-
50
-
-
57349114027
-
Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
-
Choi Y, et al. (2008) Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Exp. Mol. Med. 40:574-81.
-
(2008)
Exp. Mol. Med
, vol.40
, pp. 574-581
-
-
Choi, Y.1
-
51
-
-
59849085588
-
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methy-lation
-
Lal G, et al. (2009) Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methy-lation. J. Immunol. 182:259-273.
-
(2009)
J. Immunol
, vol.182
, pp. 259-273
-
-
Lal, G.1
-
52
-
-
49649107703
-
DNA methylation controls Foxp3 gene expression
-
Polansky JK, et al. (2008) DNA methylation controls Foxp3 gene expression. Eur. J. Immunol. 38:1654-63.
-
(2008)
Eur. J. Immunol
, vol.38
, pp. 1654-1663
-
-
Polansky, J.K.1
-
53
-
-
32944462300
-
Rapid alteration of microRNA levels by histone deacetylase inhibition
-
Scott GK, Mattie MD, Berger CE, Benz SC, Benz CC. (2006) Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 66:1277-81.
-
(2006)
Cancer Res
, vol.66
, pp. 1277-1281
-
-
Scott, G.K.1
Mattie, M.D.2
Berger, C.E.3
Benz, S.C.4
Benz, C.C.5
-
54
-
-
53549097349
-
MicroRNAs: Key players in the immune system, differentiation, tumorigenesis and cell death
-
Schickel R, Boyerinas B, Park SM, Peter ME (2008) MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene. 27:5959-74.
-
(2008)
Oncogene
, vol.27
, pp. 5959-5974
-
-
Schickel, R.1
Boyerinas, B.2
Park, S.M.3
Peter, M.E.4
-
55
-
-
47849125676
-
MicroRNAs: New regulators of immune cell development and function
-
Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD. (2008) MicroRNAs: new regulators of immune cell development and function. Nat. Immunol. 9:839-45.
-
(2008)
Nat. Immunol
, vol.9
, pp. 839-845
-
-
Baltimore, D.1
Boldin, M.P.2
O'Connell, R.M.3
Rao, D.S.4
Taganov, K.D.5
-
56
-
-
70349774213
-
Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo
-
Faraco G, et al. (2009) Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo. Neurobiol. Dis. 36:269-79.
-
(2009)
Neurobiol. Dis
, vol.36
, pp. 269-279
-
-
Faraco, G.1
-
57
-
-
0037462725
-
Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65
-
Kiernan R, et al. (2003) Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J. Biol. Chem. 278:2758-66.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 2758-2766
-
-
Kiernan, R.1
-
58
-
-
4043088499
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten FR, et al. (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285-96.
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
-
59
-
-
38449110152
-
Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis
-
Shibata W, et al. (2007) Cutting edge: the IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis. J. Immunol. 179:2681-5.
-
(2007)
J. Immunol
, vol.179
, pp. 2681-2685
-
-
Shibata, W.1
-
60
-
-
34047173496
-
Epithelial NEMO links innate immunity to chronic intestinal inflammation
-
Nenci A, et al. (2007) Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446:557-61.
-
(2007)
Nature
, vol.446
, pp. 557-561
-
-
Nenci, A.1
-
61
-
-
0035979737
-
Duration of nuclear NF-kappaB action regulated by reversible acetylation
-
Chen L, Fischle W, Verdin E, Greene WC. (2001) Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science. 293:1653-7.
-
(2001)
Science
, vol.293
, pp. 1653-1657
-
-
Chen, L.1
Fischle, W.2
Verdin, E.3
Greene, W.C.4
-
62
-
-
0034802887
-
The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression
-
Ashburner BP, Westerheide SD, Baldwin AS Jr. (2001) The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol. 21:7065-77.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 7065-7077
-
-
Ashburner, B.P.1
Westerheide, S.D.2
Baldwin Jr., A.S.3
-
63
-
-
33744938927
-
Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation
-
Imre G, Gekeler V, Leja A, Beckers T, Boehm M. (2006) Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. Cancer Res. 66:5409-18.
-
(2006)
Cancer Res
, vol.66
, pp. 5409-5418
-
-
Imre, G.1
Gekeler, V.2
Leja, A.3
Beckers, T.4
Boehm, M.5
-
64
-
-
42549128138
-
Trichostatin A regulates hGCN5 expression and cell cycle on daudi cells in vitro
-
Liu H, et al. (2006) Trichostatin A regulates hGCN5 expression and cell cycle on daudi cells in vitro. J. Huazhong Univ. Sci. Technolog. Med. Sci. 26:534-7.
-
(2006)
J. Huazhong Univ. Sci. Technolog. Med. Sci
, vol.26
, pp. 534-537
-
-
Liu, H.1
-
65
-
-
33646851955
-
Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation
-
Takada Y, Gillenwater A, Ichikawa H, Aggarwal BB. (2006) Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation. J. Biol. Chem. 281:5612-22.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 5612-5622
-
-
Takada, Y.1
Gillenwater, A.2
Ichikawa, H.3
Aggarwal, B.B.4
-
66
-
-
42549114401
-
Histone deacetylases: Novel targets for prevention of colitis-associated cancer in mice
-
Glauben R, et al. (2008) Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut. 57:613-622.
-
(2008)
Gut
, vol.57
, pp. 613-622
-
-
Glauben, R.1
-
67
-
-
32644449048
-
Acetylation of Stat1 modulates NF-kappaB activity
-
Kramer OH, et al. (2006) Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev. 20:473-485.
-
(2006)
Genes Dev
, vol.20
, pp. 473-485
-
-
Kramer, O.H.1
-
68
-
-
33645775726
-
Histone hyperacetylation is associated with amelioration of experimental colitis in mice
-
Glauben R, et al. (2006) Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J. Immunol. 176:5015-22.
-
(2006)
J. Immunol
, vol.176
, pp. 5015-5022
-
-
Glauben, R.1
-
69
-
-
28644440158
-
Histone deacetylase inhibitors: Discovery and development as anticancer agents
-
Marks PA, Dokmanovic M. (2005) Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert Opin. Investig. Drugs. 14:1497-511.
-
(2005)
Expert Opin. Investig. Drugs
, vol.14
, pp. 1497-1511
-
-
Marks, P.A.1
Dokmanovic, M.2
-
70
-
-
77950860448
-
Inside HDAC with HDAC inhibitors
-
Bertrand P. (2010) Inside HDAC with HDAC inhibitors. Eur. J. Med. Chem. 45:2095-116.
-
(2010)
Eur. J. Med. Chem
, vol.45
, pp. 2095-2116
-
-
Bertrand, P.1
-
71
-
-
50849102708
-
The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice
-
Reilly CM, et al. (2008) The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. J. Autoimmun. 31:123-30.
-
(2008)
J. Autoimmun
, vol.31
, pp. 123-130
-
-
Reilly, C.M.1
-
72
-
-
70349385423
-
Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen- induced arthritis
-
Saouaf SJ, et al. (2009) Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen- induced arthritis. Exp. Mol. Pathol. 87:99-104.
-
(2009)
Exp. Mol. Pathol
, vol.87
, pp. 99-104
-
-
Saouaf, S.J.1
-
73
-
-
33646495294
-
The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo
-
Leoni F, et al. (2005) The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol. Med. 11:1-15.
-
(2005)
Mol. Med
, vol.11
, pp. 1-15
-
-
Leoni, F.1
-
74
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. (1995) Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281-90.
-
(1995)
J. Exp. Med
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
Stuber, E.4
Strober, W.5
-
75
-
-
0032538915
-
Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to in-terleukin 4
-
Boirivant M, Fuss IJ, Chu A, Strober W. (1998) Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to in-terleukin 4. J. Exp. Med. 188:1929-39.
-
(1998)
J. Exp. Med
, vol.188
, pp. 1929-1939
-
-
Boirivant, M.1
Fuss, I.J.2
Chu, A.3
Strober, W.4
-
76
-
-
79955552937
-
Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
-
Vojinovic J, et al. (2011) Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 63:1452-8.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1452-1458
-
-
Vojinovic, J.1
-
77
-
-
0034924839
-
Regulation of T-cell apoptosis in inflammatory bowel disease: To die or not to die, that is the mucosal question
-
Neurath MF, et al. (2001) Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question. Trends Immunol. 22:21-6.
-
(2001)
Trends Immunol
, vol.22
, pp. 21-26
-
-
Neurath, M.F.1
-
78
-
-
0034754480
-
Infliximab induces apo-ptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway
-
Lugering A, et al. (2001) Infliximab induces apo-ptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology. 121:1145-57.
-
(2001)
Gastroenterology
, vol.121
, pp. 1145-1157
-
-
Lugering, A.1
-
79
-
-
0344237231
-
A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
-
Tanaka T, et al. (2003) A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci. 94:965-73.
-
(2003)
Cancer Sci
, vol.94
, pp. 965-973
-
-
Tanaka, T.1
-
80
-
-
0142026072
-
Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice
-
Hegazi RA, et al. (2003) Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice. Inflamm. Bowel Dis. 9:230-36.
-
(2003)
Inflamm. Bowel Dis
, vol.9
, pp. 230-236
-
-
Hegazi, R.A.1
|