메뉴 건너뛰기




Volumn 17, Issue 5-6, 2011, Pages 426-433

Inhibition of histone deacetylases in inflammatory bowel diseases

Author keywords

[No Author keywords available]

Indexed keywords

6 (1,3 DIOXO 1H,3H BENZO[DE]ISOQUINOLIN 2 YL) N HYDROXYHEXANAMIDE; AZOXYMETHANE; DEXTRAN SULFATE; GIVINOSTAT; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 22; MICRORNA; NITROBENZENE DERIVATIVE; STAT3 PROTEIN; SYNAPTOTAGMIN I; TRICHOSTATIN A; VALPROIC ACID; VORINOSTAT;

EID: 79957944138     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00069     Document Type: Article
Times cited : (61)

References (81)
  • 1
    • 37249006192 scopus 로고    scopus 로고
    • New links to the pathogene-sis of Crohn disease provided by genome-wide association scans
    • Mathew CG. (2008) New links to the pathogene-sis of Crohn disease provided by genome-wide association scans. Nat. Rev. Genet. 9:9-14.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 9-14
    • Mathew, C.G.1
  • 2
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • Baumgart DC, Carding SR. (2007) Inflammatory bowel disease: cause and immunobiology. Lancet. 369:1627-1640.
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 3
    • 65349196054 scopus 로고    scopus 로고
    • Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease
    • Soderlund S, et al. (2009). Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease. Gastroenterol-ogy. 136:1561-1567.
    • (2009) Gastroenterol-ogy , vol.136 , pp. 1561-1567
    • Soderlund, S.1
  • 4
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappa B: Linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR. (2005) NF-kappa B: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5:749-759.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 5
    • 0028979727 scopus 로고
    • Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms
    • Tarmin L, et al. (1995) Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms. Cancer Res. 55:2035-2038.
    • (1995) Cancer Res , vol.55 , pp. 2035-2038
    • Tarmin, L.1
  • 6
    • 79957933972 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat)
    • Furlan A, et al. (2011) Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat). Mol. Med. 17:353-362.
    • (2011) Mol. Med , vol.17 , pp. 353-362
    • Furlan, A.1
  • 7
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 325:834-840.
    • (2009) Science , vol.325 , pp. 834-840
    • Choudhary, C.1
  • 8
    • 77449116892 scopus 로고    scopus 로고
    • Acetylation goes global: The emergence of acetylation biology
    • Norris KL, Lee JY, Yao T P. (2009) Acetylation goes global: the emergence of acetylation biology. Sci. Signal. 2:pe76.
    • (2009) Sci. Signal , vol.2
    • Norris, K.L.1    Lee, J.Y.2    Yao, T.P.3
  • 9
    • 56049090769 scopus 로고    scopus 로고
    • Acetylation of non-histone proteins modulates cellular signalling at multiple levels
    • Spange S, Wagner T, Heinzel T, Kramer OH. (2009) Acetylation of non-histone proteins modulates cellular signalling at multiple levels. Int. J. Biochem. Cell Biol. 41:185-198.
    • (2009) Int. J. Biochem. Cell Biol , vol.41 , pp. 185-198
    • Spange, S.1    Wagner, T.2    Heinzel, T.3    Kramer, O.H.4
  • 10
    • 85047690640 scopus 로고    scopus 로고
    • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    • Fuss IJ, et al. (2004) Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J. Clin. Invest. 113:1490-1497.
    • (2004) J. Clin. Invest , vol.113 , pp. 1490-1497
    • Fuss, I.J.1
  • 11
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina pro-pria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss IJ, et al. (1996) Disparate CD4+ lamina pro-pria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157:1261-1270.
    • (1996) J. Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1
  • 12
    • 0030029222 scopus 로고    scopus 로고
    • Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
    • Stuber E, Strober W, Neurath M. (1996) Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 183:693-698.
    • (1996) J. Exp. Med , vol.183 , pp. 693-698
    • Stuber, E.1    Strober, W.2    Neurath, M.3
  • 13
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver CT, Hatton RD, Mangan PR, Harrington LE. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25:821-52.
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 14
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez EV, Napolitani G, Lanzavec-chia A, Sallusto F. (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8:942-9.
    • (2007) Nat. Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavec-Chia, A.3    Sallusto, F.4
  • 15
    • 78650915985 scopus 로고    scopus 로고
    • Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis
    • Zhang X, et al. (2011) Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infect. Immun. 79:527-41.
    • (2011) Infect. Immun , vol.79 , pp. 527-541
    • Zhang, X.1
  • 16
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L, et al. (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8:967-74.
    • (2007) Nat. Immunol , vol.8 , pp. 967-974
    • Zhou, L.1
  • 17
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of in-terleukin 17 in inflammatory bowel disease
    • Fujino S, et al. (2003) Increased expression of in-terleukin 17 in inflammatory bowel disease. Gut. 52:65-70.
    • (2003) Gut , vol.52 , pp. 65-70
    • Fujino, S.1
  • 18
    • 29744450121 scopus 로고    scopus 로고
    • Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    • Fuss IJ, et al. (2006) Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12:9-15.
    • (2006) Inflamm. Bowel Dis , vol.12 , pp. 9-15
    • Fuss, I.J.1
  • 19
    • 0030945106 scopus 로고    scopus 로고
    • Th1 and Th2 CD4+ cells in the pathogenesis of allergic diseases
    • Umetsu DT, DeKruyff RH. (1997) Th1 and Th2 CD4+ cells in the pathogenesis of allergic diseases. Proc. Soc. Exp. Biol. Med. 215:11-20.
    • (1997) Proc. Soc. Exp. Biol. Med , vol.215 , pp. 11-20
    • Umetsu, D.T.1    Dekruyff, R.H.2
  • 20
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma G, Strober W. (2003) The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3:521-33.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 21
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that af-fects epithelial tight junctions, apoptosis, and cell restitution
    • Heller F, et al. (2005) Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that af-fects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 129:550-64.
    • (2005) Gastroenterology , vol.129 , pp. 550-564
    • Heller, F.1
  • 22
    • 34548680982 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells: Selfishness under scrutiny
    • Stephens GL, Shevach EM. (2007) Foxp3+ regulatory T cells: selfishness under scrutiny. Immunity. 27:417-9.
    • (2007) Immunity , vol.27 , pp. 417-419
    • Stephens, G.L.1    Shevach, E.M.2
  • 23
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y, Rudensky AY (2007) Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 8:457-62.
    • (2007) Nat. Immunol , vol.8 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 25
    • 35348876040 scopus 로고    scopus 로고
    • IPEX, FOXP3 and regulatory T-cells: A model for autoimmunity
    • Ochs HD, Gambineri E, Torgerson TR. (2007) IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol. Res. 38:112-21.
    • (2007) Immunol. Res , vol.38 , pp. 112-121
    • Ochs, H.D.1    Gambineri, E.2    Torgerson, T.R.3
  • 26
    • 55949085986 scopus 로고    scopus 로고
    • Keeping things quiet: Roles of NuRD and Sin3 co-repressor complexes during mammalian development
    • McDonel P, Costello I, Hendrich B. (2009) Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development. Int. J. Biochem. Cell Biol. 41:108-16.
    • (2009) Int. J. Biochem. Cell Biol , vol.41 , pp. 108-116
    • McDonel, P.1    Costello, I.2    Hendrich, B.3
  • 27
    • 0033609055 scopus 로고    scopus 로고
    • Three proteins define a class of human histone deacetylases related to yeast Hda1p
    • Grozinger CM, Hassig CA, Schreiber SL. (1999) Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. U. S. A. 96:4868-73.
    • (1999) Proc. Natl. Acad. Sci. U. S. A , vol.96 , pp. 4868-4873
    • Grozinger, C.M.1    Hassig, C.A.2    Schreiber, S.L.3
  • 28
    • 0035312289 scopus 로고    scopus 로고
    • The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
    • Feng Q, Zhang Y. (2001) The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev. 15:827-832.
    • (2001) Genes Dev , vol.15 , pp. 827-832
    • Feng, Q.1    Zhang, Y.2
  • 29
    • 58849088509 scopus 로고    scopus 로고
    • T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation
    • Chang S, Collins PL, Aune TM. (2008) T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. J. Immunol. 181:8372-81.
    • (2008) J. Immunol , vol.181 , pp. 8372-8381
    • Chang, S.1    Collins, P.L.2    Aune, T.M.3
  • 30
    • 33750964226 scopus 로고    scopus 로고
    • Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes
    • Chen GY, Osada H, Santamaria-Babi LF, Kannagi R (2006) Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 103:16894-9.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 16894-16899
    • Chen, G.Y.1    Osada, H.2    Santamaria-Babi, L.F.3    Kannagi, R.4
  • 32
    • 33748428027 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce antigen specific energy in lymphocytes: A comparative study
    • Edens RE, Dagtas S, Gilbert KM. (2006) Histone deacetylase inhibitors induce antigen specific energy in lymphocytes: a comparative study. Int. Immunopharmacol. 6:1673-81.
    • (2006) Int. Immunopharmacol , vol.6 , pp. 1673-1681
    • Edens, R.E.1    Dagtas, S.2    Gilbert, K.M.3
  • 33
    • 3042566927 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor trichostatin A modulates CD4+ T cell responses
    • Moreira JM, Scheipers P, Sorensen P. (2003) The histone deacetylase inhibitor trichostatin A modulates CD4+ T cell responses. BMC Cancer. 3:30.
    • (2003) BMC Cancer , vol.3 , pp. 30
    • Moreira, J.M.1    Scheipers, P.2    Sorensen, P.3
  • 34
    • 34548134832 scopus 로고    scopus 로고
    • Mechanism of HDAC inhibitor FR235222-mediated IL-2 transcriptional repression in Jurkat cells
    • Matsuoka H, Fujimura T, Mori H, Aramori I, Mutoh S. (2007) Mechanism of HDAC inhibitor FR235222-mediated IL-2 transcriptional repression in Jurkat cells. Int. Immunopharmacol. 7:1422-32.
    • (2007) Int. Immunopharmacol , vol.7 , pp. 1422-1432
    • Matsuoka, H.1    Fujimura, T.2    Mori, H.3    Aramori, I.4    Mutoh, S.5
  • 35
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    • Koenen HJ, et al. (2008) Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood. 112:2340-52.
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.1
  • 36
    • 73449117582 scopus 로고    scopus 로고
    • Immunomodulatory effects of deacetylase inhibitors: Therapeutic targeting of FOXP3+ regulatory T cells
    • Wang L, de Zoeten EF, Greene MI, Hancock WW. (2009) Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat. Rev. Drug. Discov. 8:969-81.
    • (2009) Nat. Rev. Drug. Discov , vol.8 , pp. 969-981
    • Wang, L.1    de Zoeten, E.F.2    Greene, M.I.3    Hancock, W.W.4
  • 37
    • 35948980739 scopus 로고    scopus 로고
    • Deacetylase inhibition promotes the generation and function of regulatory T cells
    • Tao R, et al. (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13:1299-307.
    • (2007) Nat. Med , vol.13 , pp. 1299-1307
    • Tao, R.1
  • 38
    • 62849120700 scopus 로고    scopus 로고
    • Using his-tone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance
    • Wang L, Tao R, Hancock WW. (2009) Using his-tone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. Immunol. Cell Biol. 87:195-202.
    • (2009) Immunol. Cell Biol , vol.87 , pp. 195-202
    • Wang, L.1    Tao, R.2    Hancock, W.W.3
  • 39
    • 75449114277 scopus 로고    scopus 로고
    • Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice
    • de Zoeten EF, Wang L, Sai H, Dillmann WH, Hancock WW. (2010) Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology. 138:583-94.
    • (2010) Gastroenterology , vol.138 , pp. 583-594
    • de Zoeten, E.F.1    Wang, L.2    Sai, H.3    Dillmann, W.H.4    Hancock, W.W.5
  • 40
    • 57149099029 scopus 로고    scopus 로고
    • Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo
    • Bosisio D, et al. (2008) Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. J. Leukoc. Biol. 84:1540-8.
    • (2008) J. Leukoc. Biol , vol.84 , pp. 1540-1548
    • Bosisio, D.1
  • 41
    • 67650457697 scopus 로고    scopus 로고
    • Apicidin, the histone deacetylase inhibitor, suppresses Th1 polarization of murine bone marrow-derived dendritic cells
    • Jung ID, et al. (2009) Apicidin, the histone deacetylase inhibitor, suppresses Th1 polarization of murine bone marrow-derived dendritic cells. Int. J. Immunopathol. Pharmacol. 22:501-15.
    • (2009) Int. J. Immunopathol. Pharmacol , vol.22 , pp. 501-515
    • Jung, I.D.1
  • 42
    • 33846876336 scopus 로고    scopus 로고
    • Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function
    • Brogdon JL, et al. (2007) Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood. 109:1123-30.
    • (2007) Blood , vol.109 , pp. 1123-1130
    • Brogdon, J.L.1
  • 43
    • 70349737858 scopus 로고    scopus 로고
    • Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3
    • Sun Y, et al. (2009) Cutting edge: negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3. J. Immunol. 182:5899-903.
    • (2009) J. Immunol , vol.182 , pp. 5899-5903
    • Sun, Y.1
  • 44
    • 46749144173 scopus 로고    scopus 로고
    • Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice
    • Reddy P, et al. (2008) Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J. Clin. Invest. 118:2562-73.
    • (2008) J. Clin. Invest , vol.118 , pp. 2562-2573
    • Reddy, P.1
  • 45
    • 33746499843 scopus 로고    scopus 로고
    • LPS regulates proinflam-matory gene expression in macrophages by altering histone deacetylase expression
    • Aung HT, et al. (2006) LPS regulates proinflam-matory gene expression in macrophages by altering histone deacetylase expression. FASEB J. 20:1315-27.
    • (2006) FASEB J , vol.20 , pp. 1315-1327
    • Aung, H.T.1
  • 46
    • 1542343955 scopus 로고    scopus 로고
    • Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators
    • Deng WG, Zhu Y, Wu KK. (2004) Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators. Blood. 103:2135-42.
    • (2004) Blood , vol.103 , pp. 2135-2142
    • Deng, W.G.1    Zhu, Y.2    Wu, K.K.3
  • 47
    • 31344446119 scopus 로고    scopus 로고
    • Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression
    • Ito K, et al. (2006) Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J. Exp. Med. 203:7-13.
    • (2006) J. Exp. Med , vol.203 , pp. 7-13
    • Ito, K.1
  • 48
    • 78149283427 scopus 로고    scopus 로고
    • Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity
    • Maa MC, et al. (2010) Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity. J. Nutr. Biochem. 21:1186-92.
    • (2010) J. Nutr. Biochem , vol.21 , pp. 1186-1192
    • Maa, M.C.1
  • 49
    • 77951925741 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue
    • Grabiec AM, et al. (2010) Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue. J. Immunol. 184:2718-28.
    • (2010) J. Immunol , vol.184 , pp. 2718-2728
    • Grabiec, A.M.1
  • 50
    • 57349114027 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
    • Choi Y, et al. (2008) Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Exp. Mol. Med. 40:574-81.
    • (2008) Exp. Mol. Med , vol.40 , pp. 574-581
    • Choi, Y.1
  • 51
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methy-lation
    • Lal G, et al. (2009) Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methy-lation. J. Immunol. 182:259-273.
    • (2009) J. Immunol , vol.182 , pp. 259-273
    • Lal, G.1
  • 52
    • 49649107703 scopus 로고    scopus 로고
    • DNA methylation controls Foxp3 gene expression
    • Polansky JK, et al. (2008) DNA methylation controls Foxp3 gene expression. Eur. J. Immunol. 38:1654-63.
    • (2008) Eur. J. Immunol , vol.38 , pp. 1654-1663
    • Polansky, J.K.1
  • 53
    • 32944462300 scopus 로고    scopus 로고
    • Rapid alteration of microRNA levels by histone deacetylase inhibition
    • Scott GK, Mattie MD, Berger CE, Benz SC, Benz CC. (2006) Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 66:1277-81.
    • (2006) Cancer Res , vol.66 , pp. 1277-1281
    • Scott, G.K.1    Mattie, M.D.2    Berger, C.E.3    Benz, S.C.4    Benz, C.C.5
  • 54
    • 53549097349 scopus 로고    scopus 로고
    • MicroRNAs: Key players in the immune system, differentiation, tumorigenesis and cell death
    • Schickel R, Boyerinas B, Park SM, Peter ME (2008) MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene. 27:5959-74.
    • (2008) Oncogene , vol.27 , pp. 5959-5974
    • Schickel, R.1    Boyerinas, B.2    Park, S.M.3    Peter, M.E.4
  • 56
    • 70349774213 scopus 로고    scopus 로고
    • Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo
    • Faraco G, et al. (2009) Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo. Neurobiol. Dis. 36:269-79.
    • (2009) Neurobiol. Dis , vol.36 , pp. 269-279
    • Faraco, G.1
  • 57
    • 0037462725 scopus 로고    scopus 로고
    • Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65
    • Kiernan R, et al. (2003) Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J. Biol. Chem. 278:2758-66.
    • (2003) J. Biol. Chem , vol.278 , pp. 2758-2766
    • Kiernan, R.1
  • 58
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten FR, et al. (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285-96.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1
  • 59
    • 38449110152 scopus 로고    scopus 로고
    • Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis
    • Shibata W, et al. (2007) Cutting edge: the IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis. J. Immunol. 179:2681-5.
    • (2007) J. Immunol , vol.179 , pp. 2681-2685
    • Shibata, W.1
  • 60
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci A, et al. (2007) Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446:557-61.
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1
  • 61
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF-kappaB action regulated by reversible acetylation
    • Chen L, Fischle W, Verdin E, Greene WC. (2001) Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science. 293:1653-7.
    • (2001) Science , vol.293 , pp. 1653-1657
    • Chen, L.1    Fischle, W.2    Verdin, E.3    Greene, W.C.4
  • 62
    • 0034802887 scopus 로고    scopus 로고
    • The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression
    • Ashburner BP, Westerheide SD, Baldwin AS Jr. (2001) The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol. 21:7065-77.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 7065-7077
    • Ashburner, B.P.1    Westerheide, S.D.2    Baldwin Jr., A.S.3
  • 63
    • 33744938927 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation
    • Imre G, Gekeler V, Leja A, Beckers T, Boehm M. (2006) Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. Cancer Res. 66:5409-18.
    • (2006) Cancer Res , vol.66 , pp. 5409-5418
    • Imre, G.1    Gekeler, V.2    Leja, A.3    Beckers, T.4    Boehm, M.5
  • 64
    • 42549128138 scopus 로고    scopus 로고
    • Trichostatin A regulates hGCN5 expression and cell cycle on daudi cells in vitro
    • Liu H, et al. (2006) Trichostatin A regulates hGCN5 expression and cell cycle on daudi cells in vitro. J. Huazhong Univ. Sci. Technolog. Med. Sci. 26:534-7.
    • (2006) J. Huazhong Univ. Sci. Technolog. Med. Sci , vol.26 , pp. 534-537
    • Liu, H.1
  • 65
    • 33646851955 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation
    • Takada Y, Gillenwater A, Ichikawa H, Aggarwal BB. (2006) Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation. J. Biol. Chem. 281:5612-22.
    • (2006) J. Biol. Chem , vol.281 , pp. 5612-5622
    • Takada, Y.1    Gillenwater, A.2    Ichikawa, H.3    Aggarwal, B.B.4
  • 66
    • 42549114401 scopus 로고    scopus 로고
    • Histone deacetylases: Novel targets for prevention of colitis-associated cancer in mice
    • Glauben R, et al. (2008) Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut. 57:613-622.
    • (2008) Gut , vol.57 , pp. 613-622
    • Glauben, R.1
  • 67
    • 32644449048 scopus 로고    scopus 로고
    • Acetylation of Stat1 modulates NF-kappaB activity
    • Kramer OH, et al. (2006) Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev. 20:473-485.
    • (2006) Genes Dev , vol.20 , pp. 473-485
    • Kramer, O.H.1
  • 68
    • 33645775726 scopus 로고    scopus 로고
    • Histone hyperacetylation is associated with amelioration of experimental colitis in mice
    • Glauben R, et al. (2006) Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J. Immunol. 176:5015-22.
    • (2006) J. Immunol , vol.176 , pp. 5015-5022
    • Glauben, R.1
  • 69
    • 28644440158 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Discovery and development as anticancer agents
    • Marks PA, Dokmanovic M. (2005) Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert Opin. Investig. Drugs. 14:1497-511.
    • (2005) Expert Opin. Investig. Drugs , vol.14 , pp. 1497-1511
    • Marks, P.A.1    Dokmanovic, M.2
  • 70
    • 77950860448 scopus 로고    scopus 로고
    • Inside HDAC with HDAC inhibitors
    • Bertrand P. (2010) Inside HDAC with HDAC inhibitors. Eur. J. Med. Chem. 45:2095-116.
    • (2010) Eur. J. Med. Chem , vol.45 , pp. 2095-2116
    • Bertrand, P.1
  • 71
    • 50849102708 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice
    • Reilly CM, et al. (2008) The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. J. Autoimmun. 31:123-30.
    • (2008) J. Autoimmun , vol.31 , pp. 123-130
    • Reilly, C.M.1
  • 72
    • 70349385423 scopus 로고    scopus 로고
    • Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen- induced arthritis
    • Saouaf SJ, et al. (2009) Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen- induced arthritis. Exp. Mol. Pathol. 87:99-104.
    • (2009) Exp. Mol. Pathol , vol.87 , pp. 99-104
    • Saouaf, S.J.1
  • 73
    • 33646495294 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo
    • Leoni F, et al. (2005) The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol. Med. 11:1-15.
    • (2005) Mol. Med , vol.11 , pp. 1-15
    • Leoni, F.1
  • 74
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. (1995) Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281-90.
    • (1995) J. Exp. Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 75
    • 0032538915 scopus 로고    scopus 로고
    • Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to in-terleukin 4
    • Boirivant M, Fuss IJ, Chu A, Strober W. (1998) Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to in-terleukin 4. J. Exp. Med. 188:1929-39.
    • (1998) J. Exp. Med , vol.188 , pp. 1929-1939
    • Boirivant, M.1    Fuss, I.J.2    Chu, A.3    Strober, W.4
  • 76
    • 79955552937 scopus 로고    scopus 로고
    • Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
    • Vojinovic J, et al. (2011) Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 63:1452-8.
    • (2011) Arthritis Rheum , vol.63 , pp. 1452-1458
    • Vojinovic, J.1
  • 77
    • 0034924839 scopus 로고    scopus 로고
    • Regulation of T-cell apoptosis in inflammatory bowel disease: To die or not to die, that is the mucosal question
    • Neurath MF, et al. (2001) Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question. Trends Immunol. 22:21-6.
    • (2001) Trends Immunol , vol.22 , pp. 21-26
    • Neurath, M.F.1
  • 78
    • 0034754480 scopus 로고    scopus 로고
    • Infliximab induces apo-ptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway
    • Lugering A, et al. (2001) Infliximab induces apo-ptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology. 121:1145-57.
    • (2001) Gastroenterology , vol.121 , pp. 1145-1157
    • Lugering, A.1
  • 79
    • 0344237231 scopus 로고    scopus 로고
    • A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    • Tanaka T, et al. (2003) A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci. 94:965-73.
    • (2003) Cancer Sci , vol.94 , pp. 965-973
    • Tanaka, T.1
  • 80
    • 0142026072 scopus 로고    scopus 로고
    • Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice
    • Hegazi RA, et al. (2003) Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice. Inflamm. Bowel Dis. 9:230-36.
    • (2003) Inflamm. Bowel Dis , vol.9 , pp. 230-236
    • Hegazi, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.