Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 4, 2010, Pages 875-881

  Campanero, Miguel Angel ^a   Escolar, Manuel ^a   Perez, Guiomar ^a   Garcia Quetglas, Emilio ^a   Sadaba, Belen ^a   Azanza, Jose Ramon ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Diosmetin; Diosmin; HPLC MS MS; Pharmacokinetic studies

Indexed keywords

7 ETHOXYCOUMARIN; BETA GLUCURONIDASE; DAFLON; DIOSMETIN; DIOSMIN; FORMIC ACID; METHANOL; SULFATASE; TERT BUTYL METHYL ETHER;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; ION TRAP LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PH; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION STUDY;

ADMINISTRATION, ORAL; ATMOSPHERIC PRESSURE; CARDIOVASCULAR AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DIOSMIN; DRUG STABILITY; FLAVONOIDS; GLUCURONIDASE; HUMANS; HYDROLYSIS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SULFATASES; TANDEM MASS SPECTROMETRY;

EID: 72149114602     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.09.012     Document Type: Article

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