20-Aminosteroids as a novel class of selective and complete androgen receptor antagonists and inhibitors of prostate cancer cell growth

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 19, 2010, Pages 6960-6969

  Fousteris, Manolis A ^a,c   Schubert, Undine ^b   Roell, Daniela ^b   Roediger, Julia ^b   Bailis, Nikolaos ^a   Nikolaropoulos, Sotiris S ^c   Baniahmad, Aria ^b   Giannis, Athanassios ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c UNIVERSITY OF PATRAS   (Greece)

Author keywords

Aminosteroids; Androgen receptor; Antihormone; Prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; ANTINEOPLASTIC AGENT; BICALUTAMIDE; BIOLOGICAL MARKER; CELL NUCLEUS RECEPTOR; FLUTAMIDE; HORMONE RECEPTOR BLOCKING AGENT; MUTANT PROTEIN; N (TERT BUTYLSULFINYL) 20 3BETA (TERT BUTYLDIMETHYLSILYLOXY)PREGN 5 EN 20 AMINE; N (TERT BUTYLSULFINYL) 3BETA (TERT BUTYLDIMETHYLSILYLOXY) 20 (1 METHYL 2 PROPENYL)PREGN 5 EN 20 AMINE; N (TERT BUTYLSULFINYL) 3BETA (TERT BUTYLDIMETHYLSILYLOXY)PREGN 5 EN 20 AMINE; N (TERT BUTYLSULFINYL) 3BETA (TERT BUTYLDIMETHYLSILYLOXY)PREGN 5 EN 20 IMINE; NILUTAMIDE; PROSTATE SPECIFIC ANTIGEN; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CELL AGING; CELL GROWTH; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; GROWTH INHIBITION; HORMONE DEPENDENCE; HUMAN; HUMAN CELL; PROSTATE CANCER; PROTEIN EXPRESSION; RECEPTOR BLOCKING; TRANSACTIVATION; WILD TYPE;

ANDROGEN RECEPTOR ANTAGONISTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; MOLECULAR CONFORMATION; MUTATION; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEREOISOMERISM; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR MARKERS, BIOLOGICAL;

EID: 77956651385     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.029     Document Type: Article

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