N-linked peptidoresorc[4]arene-based receptors as noncompetitive inhibitors for α-chymotrypsin

Journal of Organic Chemistry

Volumn 76, Issue 11, 2011, Pages 4396-4407

  Dacquarica, Ilaria ^a   Cerreto, Antonella ^a   Delle Monache, Giuliano ^a   Subrizi, Fabiana ^a   Boffi, Alberto ^a   Tafi, Andrea ^b   Forli, Stefano ^b,c   Botta, Bruno ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BENZYL ESTERS; DIPEPTIDE; ELECTROSTATIC INTERACTIONS; FUNCTIONALIZED; N-LINKED; NEW SERIES; PROTEIN SURFACE;

BIOSYNTHESIS; CARBOXYLIC ACIDS; ESTERIFICATION; ESTERS; HYDROGENATION; IONIC STRENGTH; STEREOCHEMISTRY;

ENZYME INHIBITION;

CARBOXYLIC ACID; CHYMOTRYPSIN A; PEPTIDORESORC[4]ARENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CIRCULAR DICHROISM; ENANTIOSELECTIVITY; ENZYME ACTIVITY; HYDROGENATION; HYDROPHOBICITY; IONIC STRENGTH; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STATIC ELECTRICITY; STEREOCHEMISTRY; SURFACE PROPERTY;

ANIMALS; CALIXARENES; CATALYTIC DOMAIN; CATTLE; CHYMOTRYPSIN; DRUG EVALUATION, PRECLINICAL; HUMANS; MODELS, MOLECULAR; NITROGEN; OSMOLAR CONCENTRATION; PEPTIDES, CYCLIC; PHENOLS; PROTEASE INHIBITORS; SERUM ALBUMIN; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 79957827357     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo102592f     Document Type: Article

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