Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold

Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2002, Pages 177-188

  Ohkanda, J ^a   Lockman, J W ^a   Kothare, M A ^a   Qian, Y ^a   Blaskovich, M A ^b   Sebti, S M ^b   Hamilton, A D ^a  

^a YALE UNIVERSITY   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL 3 (2 MERCAPTO)BENZYLAMINO 3' METHOXYCARBONYLBIPHENYL; 2 PHENYL 3 (4 MERCAPTO)BENZYLAMINO 3' CARBOXYLBIPHENYL; 2 PHENYL 3 (N (1 (4 AMINOBENZYL) 1H IMIDAZOL 5 YL)METHYL)AMINO 3' METHOXYCARBONYLBIPHENYL; 2 PHENYL 3 (N (1 (4 CYANOBENZYL) 1H IMIDAZOL 5 YL)METHYL)AMINO 3' CARBOXYLBIPHENYL; 2 PHENYL 3 (N (1 (4 CYANOBENZYL) 1H IMIDAZOL 5 YL)METHYL)AMINO 3' METHOXYCARBONYLBIPHENYL; 2 PHENYL 3 (N (1 (4 NITROBENZYL) 1H IMIDAZOL 5 YL)METHYL)AMINO 3' CARBOXYLBIPHENYL; 2 PHENYL 3 (N (1 (4 NITROBENZYL) 1H IMIDAZOL 5 YL)METHYL)AMINO 3' METHOXYCARBONYLBIPHENYL; 2 PHENYL 3 (N (1H IMIDAZOL 5 YL)METHYLAMINO 3' METHOXYCARBONYLBIPHENYL; 2 PHENYL 4 (3 MERCAPTOETHYLCARBONYL)AMINO 3' METHOXYCARBONYLBIPHENYL; 4 N [2 AMINO 3 MERCAPTOPROPYL]AMINO 3' (2H TETRAZOL 5 YL)BIPHENYL TRIFLUOROACETATE; GERANYLTRANSFERASE; GUANOSINE TRIPHOSPHATASE; IMIDAZOLE DERIVATIVE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; TETRAPEPTIDE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONCOGENE H RAS;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; ANIMALS; BLOTTING, WESTERN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GENES, RAS; HYDROPHOBICITY; MICE; MOLECULAR MIMICRY; OLIGOPEPTIDES; PROTEIN ISOPRENYLATION; RAP1 GTP-BINDING PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 0037011910     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0103099     Document Type: Article

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