-
1
-
-
0009760969
-
-
Oxford Univ Press, Cary, NC, P.T. Anastas, L.G. Heine, T.C. Williamson (Eds.)
-
Green Chemistry Syntheses and Process (Part 1); Green Engineering (Part 2) 2000, Oxford Univ Press, Cary, NC. P.T. Anastas, L.G. Heine, T.C. Williamson (Eds.).
-
(2000)
Green Chemistry Syntheses and Process (Part 1); Green Engineering (Part 2)
-
-
-
3
-
-
0004255131
-
-
Elsevier, Amsterdam, The Netherlands, H. Bundgaard (Ed.)
-
Design of Prodrugs 1985, Elsevier, Amsterdam, The Netherlands. H. Bundgaard (Ed.).
-
(1985)
Design of Prodrugs
-
-
-
5
-
-
33845199621
-
-
RSC Pub, Cambridge, United Kingdom, J.H. Duffus, H.G. Worth (Eds.)
-
Fundamental Toxicology 2006, RSC Pub, Cambridge, United Kingdom. J.H. Duffus, H.G. Worth (Eds.).
-
(2006)
Fundamental Toxicology
-
-
-
8
-
-
33845947478
-
-
IUPAC/Wiley-VCH Verlag GmbH, Wenheim, Germany, J. Fischer, C.R. Ganellin (Eds.)
-
Analog-based Drug Discovery 2006, IUPAC/Wiley-VCH Verlag GmbH, Wenheim, Germany. J. Fischer, C.R. Ganellin (Eds.).
-
(2006)
Analog-based Drug Discovery
-
-
-
10
-
-
0003711096
-
-
Williams & Wilkins, Baltimore, MD, B.N. LaDu, H.G. Mandel, E.L. Way (Eds.)
-
Fundamentals of Drug Metabolism and Drug Disposition 1971, Williams & Wilkins, Baltimore, MD. B.N. LaDu, H.G. Mandel, E.L. Way (Eds.).
-
(1971)
Fundamentals of Drug Metabolism and Drug Disposition
-
-
-
11
-
-
84882500629
-
-
ACS, Washington, DC, D. Lednicer (Ed.)
-
Chronicles of Drug Discovery 1993, Vol. 3. ACS, Washington, DC. D. Lednicer (Ed.).
-
(1993)
Chronicles of Drug Discovery
, vol.3
-
-
-
13
-
-
84906441280
-
-
Elsevier, Oxford, United Kingdom, J. Taylor, D. Triggle (Eds.)
-
Comprehensive Medicinal Chemistry 2006, Vol. 1. Elsevier, Oxford, United Kingdom. J. Taylor, D. Triggle (Eds.).
-
(2006)
Comprehensive Medicinal Chemistry
, vol.1
-
-
-
14
-
-
0003409952
-
-
Lippincott Williams & Wilkins, Baltimore, MD, D.A. Williams, T.L. Lemke (Eds.)
-
Foye's Principles of Medicinal Chemistry 2002, Lippincott Williams & Wilkins, Baltimore, MD. 5th ed. D.A. Williams, T.L. Lemke (Eds.).
-
(2002)
Foye's Principles of Medicinal Chemistry
-
-
-
16
-
-
0032880426
-
The drug discovery factory-An inevitable evolutionary consequence of high-throughput parallel processing
-
Archer R. The drug discovery factory-An inevitable evolutionary consequence of high-throughput parallel processing. Nature Biotechnology 1999, 17:834.
-
(1999)
Nature Biotechnology
, vol.17
, pp. 834
-
-
Archer, R.1
-
17
-
-
18844382579
-
Drug-drug interactions and the cytochromes P450
-
Fontis Media, Lausanne, Switzerland, J.S. Lee, R.S. Obach, M.B. Fisher (Eds.)
-
Bachmann K.A., Ring B.J., Wrighton S.A. Drug-drug interactions and the cytochromes P450. Drug Metabolizing Enzymes-Cytochrome P450 and Other Enzymes in Drug Discovery and Development 2003, 311-336. Fontis Media, Lausanne, Switzerland. J.S. Lee, R.S. Obach, M.B. Fisher (Eds.).
-
(2003)
Drug Metabolizing Enzymes-Cytochrome P450 and Other Enzymes in Drug Discovery and Development
, pp. 311-336
-
-
Bachmann, K.A.1
Ring, B.J.2
Wrighton, S.A.3
-
18
-
-
0029894013
-
The properties of known drugs 1 molecular frameworks
-
Bemis G.W., Murcko M.A. The properties of known drugs 1 molecular frameworks. Journal of Medicinal Chemistry 1996, 39:2887-2893.
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, pp. 2887-2893
-
-
Bemis, G.W.1
Murcko, M.A.2
-
20
-
-
0033966357
-
Soft drug design-General principles and recent applications
-
Bodor N., Buchwald P. Soft drug design-General principles and recent applications. Medicinal Research Reviews 2000, 20:58-101.
-
(2000)
Medicinal Research Reviews
, vol.20
, pp. 58-101
-
-
Bodor, N.1
Buchwald, P.2
-
21
-
-
0038259177
-
Structure-based library design-Molecular modeling merges with combinatorial chemistry
-
Bohm H-J., Stahl M. Structure-based library design-Molecular modeling merges with combinatorial chemistry. Current Opinion in Chemical Biology 2000, 4:283-286.
-
(2000)
Current Opinion in Chemical Biology
, vol.4
, pp. 283-286
-
-
Bohm, H.-J.1
Stahl, M.2
-
23
-
-
77956104711
-
Combinatorial chemistry-Redefining the scientific method
-
Borman S. Combinatorial chemistry-Redefining the scientific method. Chem Eng News 2000, 78:53-65.
-
(2000)
Chem Eng News
, vol.78
, pp. 53-65
-
-
Borman, S.1
-
24
-
-
77956109866
-
Drug discovery-Filtering out failures early in the game
-
Brennan M.B. Drug discovery-Filtering out failures early in the game. Chem Eng News 2000, 78:63-73.
-
(2000)
Chem Eng News
, vol.78
, pp. 63-73
-
-
Brennan, M.B.1
-
26
-
-
36148959779
-
The use of bioisosteric groups in lead optimization
-
Chen X., Wang W. The use of bioisosteric groups in lead optimization. Ann Rep Med Chem 2003, 38:333-346.
-
(2003)
Ann Rep Med Chem
, vol.38
, pp. 333-346
-
-
Chen, X.1
Wang, W.2
-
27
-
-
0029926720
-
Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
-
Cheng S., Comer D.D., Williams J.P., Myers P.L., Boger D.L. Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules. Journal of the American Chemical Society 1996, 118:2567-2573.
-
(1996)
Journal of the American Chemical Society
, vol.118
, pp. 2567-2573
-
-
Cheng, S.1
Comer, D.D.2
Williams, J.P.3
Myers, P.L.4
Boger, D.L.5
-
28
-
-
33748482627
-
Drug transporters and their role in tissue distribution
-
Alwis D.P.
-
Dantzig, A.H., Hillgren, K.M., & Alwis, D.P. Drug transporters and their role in tissue distribution. Ann Rep Med Chem, 39, 279-291.
-
Ann Rep Med Chem
, vol.39
-
-
Dantzig, A.H.1
Hillgren, K.M.2
-
29
-
-
84882502330
-
Managing combinatorial chemistry information
-
Kluwer Academic Pub, Dordrecht, The Netherlands, P.M. Dean, A.L. Lewis (Eds.)
-
Davies K., White C. Managing combinatorial chemistry information. Molecular Diversity in Drug Design 1999, 175-196. Kluwer Academic Pub, Dordrecht, The Netherlands. P.M. Dean, A.L. Lewis (Eds.).
-
(1999)
Molecular Diversity in Drug Design
, pp. 175-196
-
-
Davies, K.1
White, C.2
-
30
-
-
0023936327
-
Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure
-
DesJarlais R.L., Sheriden R.P., Seibel G.L., Dixon J.S., Kuntz I.D. Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure. Journal of Medicinal Chemistry 1988, 31:722-729.
-
(1988)
Journal of Medicinal Chemistry
, vol.31
, pp. 722-729
-
-
DesJarlais, R.L.1
Sheriden, R.P.2
Seibel, G.L.3
Dixon, J.S.4
Kuntz, I.D.5
-
31
-
-
0034677966
-
Drug discovery-A historical perspective
-
Drews J. Drug discovery-A historical perspective. Science 2000, 287:1960-1969.
-
(2000)
Science
, vol.287
, pp. 1960-1969
-
-
Drews, J.1
-
33
-
-
0000601329
-
Chemotherapeutics-Scientific principles, methods and results
-
Ehrlich P. Chemotherapeutics-Scientific principles, methods and results. The Lancet 1913, 16:445-451.
-
(1913)
The Lancet
, vol.16
, pp. 445-451
-
-
Ehrlich, P.1
-
34
-
-
0018690561
-
Conformational analogus of dopamine-Synthesis and pharmacological activity of (E)- and (Z)-2-(3,4-dihydroxyphenyl)-cyclopropylamine hydrochlorides
-
Erhardt P.W., Gorczynski R.J., Anderson W.G. Conformational analogus of dopamine-Synthesis and pharmacological activity of (E)- and (Z)-2-(3,4-dihydroxyphenyl)-cyclopropylamine hydrochlorides. Journal of Medicinal Chemistry 1979, 22:907-911.
-
(1979)
Journal of Medicinal Chemistry
, vol.22
, pp. 907-911
-
-
Erhardt, P.W.1
Gorczynski, R.J.2
Anderson, W.G.3
-
35
-
-
84882506267
-
Renal vascular dopamine receptor topography-Structure-activity relationships that suggest the presence of a ceiling
-
ACS, Washington, DC, C. Kaiser, J.W. Kebabian (Eds.)
-
Erhardt P.W. Renal vascular dopamine receptor topography-Structure-activity relationships that suggest the presence of a ceiling. ACS Symposium Series, 224, Dopamine Receptors 1983, 275-280. ACS, Washington, DC. C. Kaiser, J.W. Kebabian (Eds.).
-
(1983)
ACS Symposium Series, 224, Dopamine Receptors
, pp. 275-280
-
-
Erhardt, P.W.1
-
36
-
-
0023152230
-
In search of the digitalis replacement
-
Erhardt P.W. In search of the digitalis replacement. Journal of Medicinal Chemistry 1987, 30:231-237.
-
(1987)
Journal of Medicinal Chemistry
, vol.30
, pp. 231-237
-
-
Erhardt, P.W.1
-
37
-
-
0023853680
-
Cardiotonic agents 3-A topographical model of the cardiac c-AMP phosphodiesterase receptor
-
Erhardt P.W., Hagedorn A.A., Sabio M. Cardiotonic agents 3-A topographical model of the cardiac c-AMP phosphodiesterase receptor. Molecular Pharmacology 1988, 33:1-13.
-
(1988)
Molecular Pharmacology
, vol.33
, pp. 1-13
-
-
Erhardt, P.W.1
Hagedorn, A.A.2
Sabio, M.3
-
38
-
-
0025784080
-
A topographical model for the cAMP phosphodiesterase III active site
-
Erhardt P.W., Chou Y-L. A topographical model for the cAMP phosphodiesterase III active site. Life Sciences 1991, 49:553-568.
-
(1991)
Life Sciences
, vol.49
, pp. 553-568
-
-
Erhardt, P.W.1
Chou, Y.-L.2
-
39
-
-
0000730705
-
Esmolol
-
ACS, Washington, DC, D. Lednicer (Ed.)
-
Erhardt P.W. Esmolol. Chronicles of Drug Discovery 1993, 191-206. ACS, Washington, DC. D. Lednicer (Ed.).
-
(1993)
Chronicles of Drug Discovery
, pp. 191-206
-
-
Erhardt, P.W.1
-
42
-
-
0036315253
-
Medicinal chemistry in the new millennium-A glance into the future
-
Erhardt P.W. Medicinal chemistry in the new millennium-A glance into the future. Pure and Applied Chemistry 2002, 74:703-785.
-
(2002)
Pure and Applied Chemistry
, vol.74
, pp. 703-785
-
-
Erhardt, P.W.1
-
43
-
-
79952753255
-
Selective beta-adrenergic receptor blocking agents
-
IUPAC/ Wiley-VCH Verlag GmbH, Weinheim, Germany, J. Fischer, C.R. Ganellin (Eds.)
-
Erhardt P.W., Matos L. Selective beta-adrenergic receptor blocking agents. Analog-based Drug Discovery 2006, 193-232. IUPAC/ Wiley-VCH Verlag GmbH, Weinheim, Germany. J. Fischer, C.R. Ganellin (Eds.).
-
(2006)
Analog-based Drug Discovery
, pp. 193-232
-
-
Erhardt, P.W.1
Matos, L.2
-
44
-
-
84889785401
-
Case study 'Esmolol Stat'
-
IUPAC/Wiley-VCH Verlag GmbH, Weinheim, Germany, J. Fischer, C.R. Ganellin (Eds.)
-
Erhardt P.W. Case study 'Esmolol Stat'. Analog-based Drug Discovery 2006, 233-246. IUPAC/Wiley-VCH Verlag GmbH, Weinheim, Germany. J. Fischer, C.R. Ganellin (Eds.).
-
(2006)
Analog-based Drug Discovery
, pp. 233-246
-
-
Erhardt, P.W.1
-
45
-
-
84882471450
-
Medicinal chemistry in the new millennium-A glance into the future
-
John Wiley & Sons, Hoboken, NJ, M.S. Chorghade (Ed.)
-
Erhardt P.W. Medicinal chemistry in the new millennium-A glance into the future. Drug Discovery and Development Volume 1 Drug Discovery 2006, 17-102. John Wiley & Sons, Hoboken, NJ. M.S. Chorghade (Ed.).
-
(2006)
Drug Discovery and Development Volume 1 Drug Discovery
, pp. 17-102
-
-
Erhardt, P.W.1
-
46
-
-
84882475409
-
Drug discovery-Historical perspective, current status and outlook
-
Oxford, United Kingdom, J. Taylor, D. Triggle (Eds.)
-
Erhardt P.W., Proudfoot J.R. Drug discovery-Historical perspective, current status and outlook. Comprehensive Medicinal Chemistry 2006, Vol. 1. Oxford, United Kingdom. J. Taylor, D. Triggle (Eds.).
-
(2006)
Comprehensive Medicinal Chemistry
, vol.1
-
-
Erhardt, P.W.1
Proudfoot, J.R.2
-
48
-
-
33748481963
-
The hit-to-lead process in drug discovery
-
Gillespie P., Goodnow R.A. The hit-to-lead process in drug discovery. Ann Rep Med Chem 2004, 39:293-304.
-
(2004)
Ann Rep Med Chem
, vol.39
, pp. 293-304
-
-
Gillespie, P.1
Goodnow, R.A.2
-
49
-
-
0021871375
-
A computational procedure for determining energetically favorable binding sites on biologically important macromolecules
-
Goodford P.J. A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. Journal of Medicinal Chemistry 1985, 28:849-857.
-
(1985)
Journal of Medicinal Chemistry
, vol.28
, pp. 849-857
-
-
Goodford, P.J.1
-
50
-
-
85086794785
-
Pharma challenged-Market shifts and generic competition create dynamic environment for drug developers
-
Grimley J. Pharma challenged-Market shifts and generic competition create dynamic environment for drug developers. Chem Eng News 2006, 4:17-28.
-
(2006)
Chem Eng News
, vol.4
, pp. 17-28
-
-
Grimley, J.1
-
51
-
-
0040914011
-
Rho;- sigma;- pi; Analysis-A method for the correlation of biological activity and chemical structure
-
Hansch C., Fujita T. rho;-σ-π Analysis-A method for the correlation of biological activity and chemical structure. Journal of the American Chemical Society 1964, 86:1616-1625.
-
(1964)
Journal of the American Chemical Society
, vol.86
, pp. 1616-1625
-
-
Hansch, C.1
Fujita, T.2
-
53
-
-
33846400442
-
Knowledge and intelligence in drug design
-
Hopkins A.L., Polinsky A. Knowledge and intelligence in drug design. Ann Rep Med Chem 2006, 41:425-437.
-
(2006)
Ann Rep Med Chem
, vol.41
, pp. 425-437
-
-
Hopkins, A.L.1
Polinsky, A.2
-
54
-
-
0026419319
-
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
-
Houghten R.A., Pinilla C., Blondelle S.E., Appel J.R., Dooley C.T., Cuervo J.H. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 1991, 354:84-86.
-
(1991)
Nature
, vol.354
, pp. 84-86
-
-
Houghten, R.A.1
Pinilla, C.2
Blondelle, S.E.3
Appel, J.R.4
Dooley, C.T.5
Cuervo, J.H.6
-
55
-
-
0037597387
-
Inhibition of proteinases
-
Oxford Univ Press, Oxford, United Kingdom, M. Sandler, H.J. Smith (Eds.)
-
Horl W.H., George P.M., Carrell R.W., Powers J.C., Zimmerman M., Markwardt F., et al. Inhibition of proteinases. Design of Enzyme Inhibitors as Drugs 1989, 573-649. Oxford Univ Press, Oxford, United Kingdom. M. Sandler, H.J. Smith (Eds.).
-
(1989)
Design of Enzyme Inhibitors as Drugs
, pp. 573-649
-
-
Horl, W.H.1
George, P.M.2
Carrell, R.W.3
Powers, J.C.4
Zimmerman, M.5
Markwardt, F.6
-
56
-
-
4243602926
-
Challenging times for patent office
-
Jacobs M. Challenging times for patent office. Chem Eng News 2000, 10:39-44.
-
(2000)
Chem Eng News
, vol.10
, pp. 39-44
-
-
Jacobs, M.1
-
57
-
-
0026730489
-
Structure-based strategies for drug-design and discovery
-
Kuntz I.D. Structure-based strategies for drug-design and discovery. Science 1992, 257:1078-1082.
-
(1992)
Science
, vol.257
, pp. 1078-1082
-
-
Kuntz, I.D.1
-
59
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews 1997, 23:3-25.
-
(1997)
Advanced Drug Delivery Reviews
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
60
-
-
0001936586
-
Clinical toxicity-Could it have been predicted? Premarketing experience
-
Quay Pub, Lancaster, PA, C.E. Lumley, S.R. Walker (Eds.)
-
Lumley C. Clinical toxicity-Could it have been predicted? Premarketing experience. Animal Toxicity Studies. Their Relevance for Man 1990, 49-57. Quay Pub, Lancaster, PA. C.E. Lumley, S.R. Walker (Eds.).
-
(1990)
Animal Toxicity Studies. Their Relevance for Man
, pp. 49-57
-
-
Lumley, C.1
-
61
-
-
0642301503
-
Challenges and prospects for computational aids to molecular diversity
-
Martin Y.C. Challenges and prospects for computational aids to molecular diversity. Perspect Drug Discov Res 1997, 7/8:159-172.
-
(1997)
Perspect Drug Discov Res
, pp. 159-172
-
-
Martin, Y.C.1
-
62
-
-
0032212346
-
Uptake of new technology in lead optimization for drug discovery
-
Merritt A.T. Uptake of new technology in lead optimization for drug discovery. Drug Discovery Today 1998, 3:505-510.
-
(1998)
Drug Discovery Today
, vol.3
, pp. 505-510
-
-
Merritt, A.T.1
-
63
-
-
0029994263
-
Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models
-
Metzger T.G., Paterlini M.G., Portoghese P.S., Ferguson D.M. Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models. Neurochemical Research 1996, 21:1287-1294.
-
(1996)
Neurochemical Research
, vol.21
, pp. 1287-1294
-
-
Metzger, T.G.1
Paterlini, M.G.2
Portoghese, P.S.3
Ferguson, D.M.4
-
64
-
-
1642401467
-
Pharmaceutical productivity-The imperative for new paradigms
-
Milne G.M. Pharmaceutical productivity-The imperative for new paradigms. Ann Rep Med Chem 2003, 38:383-396.
-
(2003)
Ann Rep Med Chem
, vol.38
, pp. 383-396
-
-
Milne, G.M.1
-
65
-
-
84882559289
-
Contemporary drug discovery
-
John Wiley & Sons, Hoboken, NJ, M.S. Chorghade (Ed.)
-
Mitscher L.A., Dutta A. Contemporary drug discovery. Drug Discovery and Development Volume 1 Drug Discovery 2006, 103-128. John Wiley & Sons, Hoboken, NJ. M.S. Chorghade (Ed.).
-
(2006)
Drug Discovery and Development Volume 1 Drug Discovery
, pp. 103-128
-
-
Mitscher, L.A.1
Dutta, A.2
-
66
-
-
33846390048
-
Genomic data mining and its impact on drug discovery
-
Nirmala N.R. Genomic data mining and its impact on drug discovery. Ann Rep Med Chem 2006, 41:319-330.
-
(2006)
Ann Rep Med Chem
, vol.41
, pp. 319-330
-
-
Nirmala, N.R.1
-
70
-
-
0032447736
-
Rational high-throughput screening in preclinical drug metabolism
-
Rodrigues A.D. Rational high-throughput screening in preclinical drug metabolism. Med Chem Res 1998, 8:422-433.
-
(1998)
Med Chem Res
, vol.8
, pp. 422-433
-
-
Rodrigues, A.D.1
-
71
-
-
0032572816
-
A scoring scheme for discriminating between drugs and nondrugs
-
Sadowski J., Kubinyi H. A scoring scheme for discriminating between drugs and nondrugs. Journal of Medicinal Chemistry 1998, 41:3325-3329.
-
(1998)
Journal of Medicinal Chemistry
, vol.41
, pp. 3325-3329
-
-
Sadowski, J.1
Kubinyi, H.2
-
72
-
-
0034606406
-
2,4,5-trisubstituted imidazoles-Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance-Part 1
-
Sarshar S., Zhang C., Moran E.J., Krane S., Rodarte J.C., Benbatoul K.D., et al. 2,4,5-trisubstituted imidazoles-Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance-Part 1. Bioorganic & Medicinal Chemistry Letters 2000, 10:2599-2601.
-
(2000)
Bioorganic amp; Medicinal Chemistry Letters
, vol.10
, pp. 2599-2601
-
-
Sarshar, S.1
Zhang, C.2
Moran, E.J.3
Krane, S.4
Rodarte, J.C.5
Benbatoul, K.D.6
-
73
-
-
33747777515
-
Trends in pharmaceutical innovation
-
Schmid E.F., Smith D.A. Trends in pharmaceutical innovation. Ann Rep Med Chem 2005, 40:431-441.
-
(2005)
Ann Rep Med Chem
, vol.40
, pp. 431-441
-
-
Schmid, E.F.1
Smith, D.A.2
-
75
-
-
0028587371
-
Synthesis and biological evaluation of a library containing potentially 1600 amides/esters-A strategy for rapid compound generation and screening
-
Smith P.W., Lai J.Y.Q., Whittington A.R., Cox B., Houston J.G., Stylli C.H., et al. Synthesis and biological evaluation of a library containing potentially 1600 amides/esters-A strategy for rapid compound generation and screening. Bioorganic & Medicinal Chemistry Letters 1994, 4:2821-2824.
-
(1994)
Bioorganic amp; Medicinal Chemistry Letters
, vol.4
, pp. 2821-2824
-
-
Smith, P.W.1
Lai, J.Y.Q.2
Whittington, A.R.3
Cox, B.4
Houston, J.G.5
Stylli, C.H.6
-
76
-
-
33750928793
-
Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential
-
Tomizawa K., Sugano K., Yamada H., Hori I. Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential. The Journal of Toxicological Sciences 2006, 31:315-324.
-
(2006)
The Journal of Toxicological Sciences
, vol.31
, pp. 315-324
-
-
Tomizawa, K.1
Sugano, K.2
Yamada, H.3
Hori, I.4
-
77
-
-
0037030653
-
Molecular properties that influence the oral bioavailability of drug candidates
-
Veber D.F., Johnson S.R., Cheng H.-Y., Smith B.R., Ward K.W., Kopple K.D. Molecular properties that influence the oral bioavailability of drug candidates. Journal of Medicinal Chemistry 2002, 45:2615-2623.
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, pp. 2615-2623
-
-
Veber, D.F.1
Johnson, S.R.2
Cheng, H.-Y.3
Smith, B.R.4
Ward, K.W.5
Kopple, K.D.6
-
79
-
-
0034040368
-
The impact of genomics-based technologies on drug safety evaluation
-
Waring J.E., Ulrich R.G. The impact of genomics-based technologies on drug safety evaluation. Annual Review of Pharmacologys 2000, 40:335-352.
-
(2000)
Annual Review of Pharmacologys
, vol.40
, pp. 335-352
-
-
Waring, J.E.1
Ulrich, R.G.2
-
80
-
-
0035953319
-
Property-based design-Optimization of drug absorption and pharmacokinetics
-
Waterbeemd H., van de, Smith D.A., Beaumont K., Walker D.K. Property-based design-Optimization of drug absorption and pharmacokinetics. Journal of Medicinal Chemistry 2001, 44:1313-1333.
-
(2001)
Journal of Medicinal Chemistry
, vol.44
, pp. 1313-1333
-
-
Waterbeemd, H.1
van de Smith, D.A.2
Beaumont, K.3
Walker, D.K.4
-
81
-
-
0013346210
-
Expanding and exploring cellular pathways for novel drug targets
-
Weir M.P., Overington J.P., Schwarz M. Expanding and exploring cellular pathways for novel drug targets. Ann Rep Med Chem 2002, 37:187-196.
-
(2002)
Ann Rep Med Chem
, vol.37
, pp. 187-196
-
-
Weir, M.P.1
Overington, J.P.2
Schwarz, M.3
-
82
-
-
85026053788
-
A glossary of terms used in medicinal chemistry
-
Wermuth C.G., Ganellin C.R., Lindberg P., Mitscher L.A. A glossary of terms used in medicinal chemistry. Pure and Applied Chemistry 1998, 70:1129-1143.
-
(1998)
Pure and Applied Chemistry
, vol.70
, pp. 1129-1143
-
-
Wermuth, C.G.1
Ganellin, C.R.2
Lindberg, P.3
Mitscher, L.A.4
-
83
-
-
8544219695
-
Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate
-
Yoo H.S., Park T.G. Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate. Journal of Controlled Release 2004, 100:247-256.
-
(2004)
Journal of Controlled Release
, vol.100
, pp. 247-256
-
-
Yoo, H.S.1
Park, T.G.2
-
84
-
-
0034606475
-
2,4,5-trisubstituted inmidazoles-Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance-Part 2
-
Zhang C., Sarshar S., Moran E.J., Krane S., Rodarte J.C., Benbatoul K.D., et al. 2,4,5-trisubstituted inmidazoles-Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance-Part 2. Bioorganic & Medicinal Chemistry Letters 2000, 10:2603-2605.
-
(2000)
Bioorganic amp; Medicinal Chemistry Letters
, vol.10
, pp. 2603-2605
-
-
Zhang, C.1
Sarshar, S.2
Moran, E.J.3
Krane, S.4
Rodarte, J.C.5
Benbatoul, K.D.6
|