Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD)

Journal of Medicinal Chemistry

Volumn 54, Issue 10, 2011, Pages 3492-3499

  Pesnot, Thomas ^a   Kempter, Julia ^a,b   Schemies, Jörg ^b   Pergolizzi, Giulia ^a   Uciechowska, Urszula ^c   Rumpf, Tobias ^b   Sippl, Wolfgang ^c   Jung, Manfred ^b   Wagner, Gerd K ^a,d  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE DERIVATIVE; SIRTUIN 1; SIRTUIN 2; SIRTUIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; NAD; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RECOMBINANT FUSION PROTEINS; SIRTUIN 1; SIRTUIN 2;

EID: 79957683610     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1013852     Document Type: Article

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40. When ligand selectivity is discussed, it is important to note that the SIRT1 and SIRT2 enzymes used in this study have been labeled with different tags (SIRT1 with GST; SIRT2 with His). In principle, the different tags could influence the selectivity of sirtuin inhibitors, although there are no previous reports in the literature for such an effect.