Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1- and cathepsin B-independent necrosis

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Welin, Amanda ^a   Eklund, Daniel ^a   Stendahl, Olle ^a   Lerm, Maria ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; EARLY SECRETORY ANTIGENIC TARGET 6; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; ESAT 6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS;

ARTICLE; BACTERIAL VIRULENCE; CELL DEATH; CELL MEMBRANE; CELL PERMEABILIZATION; CELL VIABILITY; CONTROLLED STUDY; DNA DETERMINATION; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME RELEASE; HOST CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG TUBERCULOSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOCYTE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; INTRACELLULAR SPACE; MACROPHAGE; METABOLISM; MICROBIOLOGY; NECROSIS; PATHOLOGY; PHAGOCYTOSIS; SECRETION;

BACILLI (CLASS); CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CASPASE 1; CATHEPSIN B; CELL DEATH; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-1BETA; INTRACELLULAR SPACE; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; NECROSIS; PHAGOCYTOSIS;

EID: 79957554114     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020302     Document Type: Article

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