Selecting the optimal cell for kidney regeneration: Fetal, adult or reprogrammed stem cells

Organogenesis

Volumn 7, Issue 2, 2011, Pages

  Harari Steinberg, Orit ^a   Pleniceanu, Oren ^a   Dekel, Benjamin ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Kidney regeneration; Kidney stem cells; Renal progenitors; Reprogramming; Surface markers; Tissue specific stem cells

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CD133 ANTIGEN; CD24 ANTIGEN;

ANGIOGENESIS; BONE MARROW CELL; CELL DIFFERENTIATION; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; CHORIOALLANTOIS; EMBRYONIC STEM CELL; ENDOTHELIAL PROGENITOR CELL; EPITHELIAL MESENCHYMAL TRANSITION; FETAL STEM CELL; GENE EXPRESSION; GLOMERULUS FILTRATION RATE; HEMANGIOBLAST; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOGENICITY; KIDNEY CELL CULTURE; KIDNEY DEVELOPMENT; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY REGENERATION; MESENCHYMAL STEM CELL; MULTIPOTENT STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; REVIEW; STEM CELL; STEM CELL TRANSPLANTATION; STROMA; TISSUE REGENERATION; UPREGULATION; VESSEL; ADULT STEM CELL; ANIMAL; CYTOLOGY; KIDNEY; NUCLEAR REPROGRAMMING; PHYSIOLOGY; REGENERATION;

ADULT STEM CELLS; ANIMALS; FETAL STEM CELLS; HUMANS; KIDNEY; MULTIPOTENT STEM CELLS; NUCLEAR REPROGRAMMING; REGENERATION;

EID: 79957551904     PISSN: 15476278     EISSN: 15558592     Source Type: Journal    
DOI: None     Document Type: Review

References (115)

1. Fang J, Mensah GA, Croft JB, Keenan NL. Heart failure-related hospitalization in the US 1979 to 2004. J Am Coll Cardiol 2008; 52:428-34. (Pubitemid 352040814)
2. Farag YM, Gaballa MR. Diabesity: an overview of a rising epidemic. Nephrol Dial Transplant 2010; 26:28-35.
3. Trivedi H. Cost implications of caring for chronic kidney disease: are interventions cost-effective? Adv Chronic Kidney Dis 2010; 17:265-70.
4. Pleniceanu O, Harari-Steinberg O, Dekel B. Concise review: Kidney stem/progenitor cells: differentiate, sort out or reprogram? Stem Cells 2010; 28:1649-60.
5. Amabile G, Meissner A. Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends Mol Med 2009; 15:59-68.
6. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105:369-77. (Pubitemid 32455343)
7. Gupta S, Verfaillie C, Chmielewski D, Kim Y, Rosenberg ME. A role for extrarenal cells in the regeneration following acute renal failure. Kidney Int 2002; 62:1285-90.
8. Fang TC, Alison MR, Cook HT, Jeffery R, Wright NA, Poulsom R. Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury. J Am Soc Nephrol 2005; 16:1723-32. (Pubitemid 41716478)
9. Krause D, Cantley LG. Bone marrow plasticity revisited: Protection or differentiation in the kidney tubule? J Clin Invest 2005; 115:1705-8. (Pubitemid 40979707)
10. Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, et al. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest 2005; 115:1743-55. (Pubitemid 40979713)
11. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004; 428:664-8. (Pubitemid 38524810)
12. Sugimoto H, Mundel TM, Sund M, Xie L, Cosgrove D, Kalluri R. Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci USA 2006; 103:7321-6. (Pubitemid 43727831)
13. C Chade AR, Zhu XY, Krier JD, Jordan KL, Textor SC, Grande JP, et al. Endothelial progenitor cells homing and renal repair in experimental renovascular disease. Stem Cells 28:1039-47.
14. Tögel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation- independent mechanisms. Am J Physiol Renal Physiol 2005; 289:31-42.
15. Li B, Cohen A, Hudson TE, Motlagh D, Amrani DL, Duffield JS. Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury. Circulation 121:2211-20.
16. Sangidorj O, Yang SH, Jang HR, Lee JP, Cha RH, Kim SM, et al. Bone marrow-derived endothelial progenitor cells confer renal protection in a murine chronic renal failure model. Am J Physiol Renal Physiol 2010; 299:325-35.
17. Dekel B, Shezen E, Even-Tov-Friedman S, Katchman H, Margalit R, Nagler A, et al. Transplantation of human hematopoietic stem cells into ischemic and growing kidneys suggests a role in vasculogenesis but not tubulogenesis. Stem Cells 2006; 24:1185-93. (Pubitemid 44464686)
18. Dekel B, Hochman E, Sanchez MJ, Maharshak N, Amariglio N, Green AR, et al. Kidney, blood and endothelium: developmental expression of stem cell leukemia during nephrogenesis. Kidney Int 2004; 65:1162-9. (Pubitemid 38406954)
19. Dekel B, Metsuyanim S, Garcia AM, Quintero C, Sanchez MJ, Izraeli S. Organ-injury-induced reactivation of hemangioblastic precursor cells. Leukemia 2008; 22:103-13.
20. Bi B, Schmitt R, Israilova M, Nishio H, Cantley LG. Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol 2007; 18:2486-96. (Pubitemid 47378865)
21. Fine LG. First heal thyself: rescue of dysfunctional endothelial progenitor cells restores function to the injured kidney. Am J Pathol.176:1586-7.
22. Magnasco A, Corselli M, Bertelli R, Ibatici A, Peresi M, Gaggero G, et al. Mesenchymal stem cells protective effect in adriamycin model of nephropathy. Cell Transplant 2008; 17:1157-67.
23. Choi S, Park M, Kim J, Hwang S, Park S, Lee Y. The role of mesenchymal stem cells in the functional improvement of chronic renal failure. Stem Cells Dev 2009; 18:521-9.
24. Togel FE, Westenfelder C. Mesenchymal stem cells: A new therapeutic tool for AKI. Nat Rev Nephrol 6:179-83.
25. Humphreys BD, Bonventre JV. Mesenchymal stem cells in acute kidney injury. Annu Rev Med 2008; 59:311-25. (Pubitemid 351287940)
26. Behr L, Hekmati M, Lucchini A, Houcinet K, Faussat AM, Borenstein N, et al. Evaluation of the effect of autologous mesenchymal stem cell injection in a large-animal model of bilateral kidney ischaemia reperfusion injury. Cell Prolif 2009; 42:284-97.
27. Slack JM. Origin of stem cells in organogenesis. Science 2008; 322:1498-501.
28. Kondo M, Wagers AJ, Manz MG, et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol 2003; 21:759-806. (Pubitemid 37174547)
29. Blanpain C, Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol 2009; 10:207-17.
30. Barker N, van de Wetering M, Clevers H. The intestinal stem cell. Genes Dev 2008; 22:1856-64. (Pubitemid 352008634)
31. Alison MR, Islam S. Attributes of adult stem cells. J Pathol 2009; 217:144-60.
32. Herzlinger D, Koseki C, Mikawa T, et al. Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction. Development 1992; 114:565-72.
33. Cobaleda C, Jochum W, Busslinger M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 2007; 449:473-7. (Pubitemid 47509547)
34. Zhou Q, Brown J, Kanarek A, et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008; 455:627-32.
35. Reidy KJ, Rosenblum ND. Cell and molecular biology of kidney development. Semin Nephrol 2009; 29:321-37.
36. Dressler GR. Advances in early kidney specification, development and patterning. Development 2009; 136:3863-74.
37. Schedl A. Renal abnormalities and their developmental origin. Nat Rev Genet 2007; 8:791-802. (Pubitemid 47429212)
38. Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, et al. Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J 2006; 25:5214-28. (Pubitemid 44658538)
39. Boyle S, Misfeldt A, Chandler KJ, Deal KK, Southard- Smith EM, Mortlock DP, et al. Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev Biol 2008; 313:234-45. (Pubitemid 350298313)
40. Mugford JW, Sipilä P, McMahon JA, McMahon AP. Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol 2008; 324:88-98.
41. Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, et al. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008; 3:169-81.
42. Metsuyanim S, Pode-Shakked N, Schmidt-Ott KM, Keshet G, Rechavi G, Blumental D, et al. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Stem Cells 2008; 26:1808-17.
43. Rosenblum ND. Developmental biology of the human kidney. Semin Fetal Neonatal Med 2008; 13:125-32. (Pubitemid 351474625)
44. Hartman HA, Lai HL, Patterson LT. Cessation of renal morphogenesis in mice. Dev Biol 2007; 310:379-87. (Pubitemid 47496040)
45. Fishman MP, Melton DA. Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int J Dev Biol 2002; 46:201-7. (Pubitemid 34288702)
46. Vincent SD, Buckingham ME. How to make a heart: the origin and regulation of cardiac progenitor cells. Curr Top Dev Biol 90:1-41.
47. Heath JK. Transcriptional networks and signaling pathways that govern vertebrate intestinal development. Curr Top Dev Biol 90:159-92.
48. Challen GA, Martinez G, Davis MJ, Taylor DF, Crowe M, Teasdale RD, et al. Identifying the molecular phenotype of renal progenitor cells. J Am Soc Nephrol 2004; 15:2344-57. (Pubitemid 39159334)
49. Dekel B, Metsuyanim S, Schmidt-Ott KM, Fridman E, Jacob-Hirsch J, Simon A, et al. Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney. Cancer Res 2006; 66:6040-9.
50. Sebire NJ, Vujanic GM. Paediatric renal tumours: recent developments, new entities and pathological features. Histopathology 2009; 54:516-28.
51. Pode-Shakked N, Metsuyanim S, Rom-Gross E, Mor Y, Fridman E, Goldstein I, et al. Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population. J Cell Mol Med 2009; 13:1792-808.
52. Metsuyanim S, Harari-Steinberg O, Buzhor E, Omer D, Pode-Shakked N, Ben-Hur H, et al. Expression of stem cell markers in the human fetal kidney. PLoS One 2009;4:6709.
53. Lazzeri E, Crescioli C, Ronconi E, Mazzinghi B, Sagrinati C, Netti GS, et al. Regenerative potential of embryonic renal multipotent progenitors in acute renal failure. J Am Soc Nephrol 2007; 18:3128-38. (Pubitemid 350223972)
54. Brockes JP. Amphibian limb regeneration: Rebuilding a complex structure. Science 1997; 276:81-7. (Pubitemid 27161247)
55. Raya A, Koth CM, Büscher D, Kawakami Y, Itoh T, Raya RM, et al. Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proc Natl Acad Sci USA 2003; 100:11889-95. (Pubitemid 37205900)
56. Zupanc GK. Adult neurogenesis and neuronal regeneration in the central nervous system of teleost fish. Brain Behav Evol 2001; 58:250-75. (Pubitemid 34458032)
57. Elger M, Hentschel H, Litteral J, Wellner M, Kirsch T, Luft FC, et al. Nephrogenesis is induced by partial nephrectomy in the elasmobranch Leucoraja erinacea. J Am Soc Nephrol 2003; 14:1506-18. (Pubitemid 36687052)
58. Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, et al. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature 470:95-100.
59. Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R. Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development 2006; 133:151-61. (Pubitemid 43169329)
60. Amcheslavsky A, Jiang J, Ip YT. Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 2009; 4:49-61.
61. Zhang Y, Li TS, Lee ST, Wawrowsky KA, Cheng K, Galang G, et al. Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One 5:12559.
62. Miles DK, Kernie SG. Activation of neural stem and progenitor cells after brain injury. Prog Brain Res 2006; 157:187-97.
63. Mu X, Peng H, Pan H, Huard J, Li Y. Study of muscle cell dedifferentiation after skeletal muscle injury of mice with a Cre-Lox system. PLoS One 6:16699.
64. Abbate M, Brown D, Bonventre JV. Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia. Am J Physiol 1999; 277:454-63.
65. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008; 2:284-91. (Pubitemid 351298594)
66. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004; 429:41-6. (Pubitemid 38620543)
67. Vogetseder A, Karadeniz A, Kaissling B, Le Hir M. Tubular cell proliferation in the healthy rat kidney. Histochem Cell Biol 2005; 124:97-104. (Pubitemid 41429764)
68. Vogetseder A, Palan T, Bacic D, Kaissling B, Le Hir M. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. Am J Physiol Cell Physiol 2007; 292:807-13.
69. Vogetseder A, Picard N, Gaspert A, Walch M, Kaissling B, Le Hir M. Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells. Am J Physiol Cell Physiol 2008; 294:22-8.
70. Bussolati B, Bruno S, Grange C, Buttiglieri S, Deregibus MC, Cantino D, et al. Isolation of renal progenitor cells from adult human kidney. Am J Pathol 2005; 166:545-55. (Pubitemid 40189050)
71. + lin- multipotent stem/progenitor cells from adult mouse kidney. J Am Soc Nephrol 2006; 17:3300-14.
72. Oliver JA, Maarouf O, Cheema FH, Martens TP, Al-Awqati Q. The renal papilla is a niche for adult kidney stem cells. J Clin Invest 2004; 114:795-804. (Pubitemid 39578738)
73. Kitamura S, Yamasaki Y, Kinomura M, Sugaya T, Sugiyama H, Maeshima Y, et al. Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney. Faseb J 2005; 19:1789-97. (Pubitemid 41598763)
74. Gupta S, Verfaillie C, Chmielewski D, Kren S, Eidman K, Connaire J, et al. Isolation and characterization of kidney-derived stem cells. J Am Soc Nephrol 2006; 17:3028-40. (Pubitemid 44707763)
75. Sagrinati C, Netti GS, Mazzinghi B, Lazzeri E, Liotta F, Frosali F, et al. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol 2006; 17:2443-56. (Pubitemid 44300960)
76. Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LM, et al. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci USA 2009; 106:6685-90.
77. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-90.
78. - metastatic colon cancer cells initiate tumors. J Clin Invest 2008; 118:2111-20.
79. Weigmann A, Corbeil D, Hellwig A, Huttner WB. Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci USA 1997; 94:12425-30. (Pubitemid 27492544)
80. van de Rijn M, Heimfeld S, Spangrude GJ, Weissman IL. Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. Proc Natl Acad Sci USA 1989; 86:4634-8. (Pubitemid 19164604)
81. Droz D, Rousseau-Merck MF, Jaubert F, Diebold N, Nezelof C, Adafer E, et al. Cell differentiation in Wilms' tumor (nephroblastoma): an immunohistochemical study. Hum Pathol 1990; 21:536-44. (Pubitemid 20165148)
82. Natali PG, Nicotra MR, Sures I, Santoro E, Bigotti A, Ullrich A. Expression of c-kit receptor in normal and transformed human nonlymphoid tissues. Cancer Res 1992; 52:6139-43.
83. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126:663-76. (Pubitemid 44233629)
84. Laiosa CV, Stadtfeld M, Xie H, de Andres-Aguayo L, Graf T. Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity 2006; 25:731-44. (Pubitemid 46107288)
85. Choi J, Costa ML, Mermelstein CS, Chagas C, Holtzer S, Holtzer H. MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes. Proc Natl Acad Sci USA 1990; 87:7988-92.
86. Ki Kim JB, Greber B, Araúzo-Bravo MJ, Meyer J, Park KI, Zaehres H, et al. Direct reprogramming of human neural stem cells by OCT4. Nature 2009; 461:649-3.
87. Efe JA, Hilcove S, Kim J, Zhou H, Ouyang K, Wang G, et al. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol.13:215-22.
88. Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LI. Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell 2005; 8:109-16. (Pubitemid 40058010)
89. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 2008; 26:795-7. (Pubitemid 351961456)
90. Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 2008; 26:1269- 75.
91. Lin SL, Chang DC, Chang-Lin S, Lin CH, Wu DT, Chen DT, et al. Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. Rna 2008; 14:2115-24.
92. Lin SL, Chang DC, Lin CH, Ying SY, Leu D, Wu DT. Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Res 39:1054-65.
93. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature 1997; 385:810-3. (Pubitemid 27106068)
94. Gurdon JB, Melton DA. Nuclear reprogramming in cells. Science 2008; 322:1811-5.
95. Hochedlinger K, Jaenisch R. Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature 2002; 415:1035-8. (Pubitemid 34193452)
96. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008; 451:141-6.
97. Chang CW, Lai YS, Pawlik KM, Liu K, Sun CW, Li C, et al. Polycistronic lentiviral vector for "hit and run"reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells 2009; 27:1042-9.
98. Staerk J, Dawlaty MM, Gao Q, Maetzel D, Hanna J, Sommer CA, et al. Reprogramming of human peripheral blood cells to induced pluripotent stem cells. Cell Stem Cell 7:20-4.
99. Hu Q, Friedrich AM, Johnson LV, Clegg DO. Memory in induced pluripotent stem cells: reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation. Stem Cells 28:1981-91.
100. Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol 28:848-55.
101. Quattrocelli M, Palazzolo G, Floris G, Schöffski P, Anastasia L, Orlacchio A, et al. Intrinsic cell memory reinforces myogenic commitment of pericyte-derived iPSCs. J Pathol 223:593-603.
102. Kramer J, Steinhoff J, Klinger M, Fricke L, Rohwedel J. Cells differentiated from mouse embryonic stem cells via embryoid bodies express renal marker molecules. Differentiation 2006; 74:91-104. (Pubitemid 43376169)
103. Kim D, Dressler GR. Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. J Am Soc Nephrol 2005; 16:3527-34. (Pubitemid 46211273)
104. Vigneau C, Polgar K, Striker G, Elliott J, Hyink D, Weber O, et al. Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo. J Am Soc Nephrol 2007; 18:1709-20. (Pubitemid 46870308)
105. Bruce SJ, Rea RW, Steptoe AL, Busslinger M, Bertram JF, Perkins AC. In vitro differentiation of murine embryonic stem cells toward a renal lineage. Differentiation 2007; 75:337-49. (Pubitemid 46802153)
106. Kobayashi T, Tanaka H, Kuwana H, Inoshita S, Teraoka H, Sasaki S, et al. Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. Biochem Biophys Res Commun 2005; 336:585-95. (Pubitemid 41267268)
107. Batchelder CA, Lee CC, Matsell DG, Yoder MC, Tarantal AF. Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors. Differentiation 2009; 78:45-56.
108. Nakane A, Kojima Y, Hayashi Y, Kohri K, Masui S, Nishinakamura R. Pax2 overexpression in embryoid bodies induces upregulation of integrin alpha8 and aquaporin-1. In Vitro Cell Dev Biol Anim 2009; 45:62-8.
109. Jones DL, Wagers AJ. No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol 2008; 9:11-21.
110. Zhou Q, Melton DA. Extreme makeover: converting one cell into another. Cell Stem Cell 2008; 3:382-8.
111. Caplan AI. Why are MSCs therapeutic? New data: new insight. J Pathol 2009; 217:318-24.
112. Yeagy BA, Cherqui S. Kidney repair and stem cells: a complex and controversial process. Pediatr Nephrol.
113. Hagiwara M, Shen B, Chao L, Chao J. Kallikrein-modified mesenchymal stem cell implantation provides enhanced protection against acute ischemic kidney injury by inhibiting apoptosis and inflammation. Hum Gene Ther 2008; 19:807-19.
114. Caimi PF, Reese J, Lee Z, Lazarus HM. Emerging therapeutic approaches for multipotent mesenchymal stromal cells. Curr Opin Hematol.17:505-13.
115. Hanna J, Saha K, Pando B, van Zon J, Lengner CJ, Creyghton MP, et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009; 462:595-601.