Kidney repair and stem cells: A complex and controversial process

Pediatric Nephrology

Volumn 26, Issue 9, 2011, Pages 1427-1434

  Yeagy, Brian A ^a   Cherqui, Stephanie ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Acute kidney disease; Bone marrow stem cells; Chronic kidney disease; Kidney injury; Repair

Indexed keywords

CELL DIFFERENTIATION; CELL FRACTIONATION; CELL PROLIFERATION; CELL REGENERATION; CONFERENCE PAPER; ENGRAFTMENT; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; KIDNEY CELL; KIDNEY DYSFUNCTION; KIDNEY INJURY; MESANGIUM CELL; MESENCHYMAL STEM CELL; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; STEM CELL MOBILIZATION;

ACUTE DISEASE; ANIMALS; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; HUMANS; KIDNEY; KIDNEY DISEASES; REGENERATION; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 80052288641     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-011-1789-x     Document Type: Conference Paper

References (65)

1. C Hopkins J Li F Rae MH Little 2009 Stem cell options for kidney disease J Pathol 217 265 281 19058290 10.1002/path.2477 1:STN:280: DC%2BD1M%2FgsFKqsQ%3D%3D
2. C Roufosse HT Cook 2008 Stem cells and renal regeneration Nephron Exp Nephrol 109 e39 45 18560247 10.1159/000139989 1:STN:280:DC%2BD1cvotl2jtg%3D%3D
3. A Benigni M Morigi G Remuzzi 2010 Kidney regeneration Lancet 375 1310 1317 20382327 10.1016/S0140-6736(10)60237-1 1:CAS:528:DC%2BC3cXksFCltr0%3D
4. SL Chen WW Fang F Ye YH Liu J Qian SJ Shan JJ Zhang RZ Chunhua LM Liao S Lin JP Sun 2004 Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction Am J Cardiol 94 92 95 15219514 10.1016/j.amjcard. 2004.03.034 (Pubitemid 38813459)
5. BE Strauer M Brehm T Zeus M Kostering A Hernandez RV Sorg G Kogler P Wernet 2002 Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans Circulation 106 1913 1918 12370212 10.1161/01.CIR.0000034046.87607.1C (Pubitemid 35176294)
6. EM Horwitz DJ Prockop LA Fitzpatrick WW Koo PL Gordon M Neel M Sussman P Orchard JC Marx RE Pyeritz MK Brenner 1999 Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta Nat Med 5 309 313 10086387 10.1038/6529 1:CAS:528:DyaK1MXhsVSltLk%3D (Pubitemid 29124367)
7. L Mazzini F Fagioli R Boccaletti K Mareschi G Oliveri C Olivieri I Pastore R Marasso E Madon 2003 Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans Amyotroph Lateral Scler Other Motor Neuron Disord 4 158 161 13129802 10.1080/14660820310014653 (Pubitemid 37184884)
8. ON Koc J Day M Nieder SL Gerson HM Lazarus W Krivit 2002 Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH) Bone Marrow Transplant 30 215 222 12203137 10.1038/sj.bmt.1703650 1:STN:280:DC%2BD38vktl2lsg%3D%3D (Pubitemid 35023593)
9. R Poulsom SJ Forbes K Hodivala-Dilke E Ryan S Wyles S Navaratnarasah R Jeffery T Hunt M Alison T Cook C Pusey NA Wright 2001 Bone marrow contributes to renal parenchymal turnover and regeneration J Pathol 195 229 235 11592103 10.1002/path.976 1:STN:280:DC%2BD3Mrktlertg%3D%3D (Pubitemid 32899033)
10. ME De Broe 2005 Tubular regeneration and the role of bone marrow cells: 'stem cell therapy'-a panacea? Nephrol Dial Transplant 20 2318 2320 16188893 10.1093/ndt/gfi164 (Pubitemid 41548854)
11. T Ito A Suzuki E Imai M Okabe M Hori 2001 Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodeling J Am Soc Nephrol 12 2625 2635 11729231 1:STN:280:DC%2BD3Mnot1Whtg%3D%3D (Pubitemid 33115409)
12. B Li T Morioka M Uchiyama T Oite 2006 Bone marrow cell infusion ameliorates progressive glomerulosclerosis in an experimental rat model Kidney Int 69 323 330 16408122 10.1038/sj.ki.5000083 1:STN:280:DC%2BD28%2FitVOhtA%3D%3D (Pubitemid 43323083)
13. K Syres F Harrison M Tadlock JV Jester J Simpson S Roy DR Salomon S Cherqui 2009 Successful treatment of the murine model of cystinosis using bone marrow cell transplantation Blood 114 2542 2552 19506297 10.1182/blood-2009-03- 213934 1:CAS:528:DC%2BD1MXht1Wktr3E
14. B Li A Cohen TE Hudson D Motlagh DL Amrani JS Duffield 2010 Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury Circulation 121 2211 2220 20458011 10.1161/CIRCULATIONAHA.109.928796
15. M Morigi B Imberti C Zoja D Corna S Tomasoni M Abbate D Rottoli S Angioletti A Benigni N Perico M Alison G Remuzzi 2004 Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure J Am Soc Nephrol 15 1794 1804 15213267 10.1097/01.ASN.0000128974.07460. 34 (Pubitemid 38822058)
16. P Semedo PM Wang TH Andreucci MA Cenedeze VP Teixeira MA Reis A Pacheco-Silva NO Camara 2007 Mesenchymal stem cells ameliorate tissue damages triggered by renal ischemia and reperfusion injury Transplant Proc 39 421 423 17362746 10.1016/j.transproceed.2007.01.036 1:CAS:528:DC%2BD2sXjtFGgtbk%3D (Pubitemid 46386253)
17. JS Duffield KM Park LL Hsiao VR Kelley DT Scadden T Ichimura JV Bonventre 2005 Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells J Clin Invest 115 1743 1755 16007251 10.1172/JCI22593 1:CAS:528:DC%2BD2MXlvF2qtr0%3D (Pubitemid 40979713)
18. F Lin A Moran P Igarashi 2005 Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney J Clin Invest 115 1756 1764 16007252 10.1172/JCI23015 1:CAS:528:DC%2BD2MXlvF2qtro%3D (Pubitemid 40979714)
19. G Stokman JC Leemans N Claessen JJ Weening S Florquin 2005 Hematopoietic stem cell mobilization therapy accelerates recovery of renal function independent of stem cell contribution J Am Soc Nephrol 16 1684 1692 15829714 10.1681/ASN.2004080678 1:CAS:528:DC%2BD2MXls1eiu7o%3D (Pubitemid 41716474)
20. G Stokman JC Leemans I Stroo I Hoedemaeker N Claessen GJ Teske JJ Weening S Florquin 2008 Enhanced mobilization of bone marrow cells does not ameliorate renal fibrosis Nephrol Dial Transplant 23 483 491 17989101 10.1093/ndt/gfm607 1:CAS:528:DC%2BD1cXhvVemtLo%3D (Pubitemid 351767621)
21. EL Herzog DS Krause 2006 Engraftment of marrow-derived epithelial cells: the role of fusion Proc Am Thorac Soc 3 691 695 17065375 10.1513/pats.200605- 109SF (Pubitemid 44788226)
22. PJ Quesenberry JM Aliotta 2008 The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles Stem Cell Rev 4 137 147 18665337 10.1007/s12015-008-9036-y 1:CAS:528:DC%2BD1cXht1Sqsb%2FO
23. PJ Quesenberry G Colvin G Dooner M Dooner JM Aliotta K Johnson 2007 The stem cell continuum: cell cycle, injury, and phenotype lability Ann NY Acad Sci 1106 20 29 17360803 10.1196/annals.1392.016 (Pubitemid 47443052)
24. S Gupta C Verfaillie D Chmielewski Y Kim ME Rosenberg 2002 A role for extrarenal cells in the regeneration following acute renal failure Kidney Int 62 1285 1290 12234298 10.1111/j.1523-1755.2002.kid569.x
25. F Cornacchia A Fornoni AR Plati A Thomas Y Wang L Inverardi LJ Striker GE Striker 2001 Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors J Clin Invest 108 1649 1656 11733560 1:CAS:528: DC%2BD3MXovVCgsLo%3D (Pubitemid 33144875)
26. MB Rookmaaker AM Smits H Tolboom K Van 't Wout AC Martens R Goldschmeding JA Joles AJ Van Zonneveld HJ Grone TJ Rabelink MC Verhaar 2003 Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis Am J Pathol 163 553 562 12875975 10.1016/S0002-9440(10)63683-8 (Pubitemid 36909417)
27. MS Szczypka AJ Westover SG Clouthier JL Ferrara HD Humes 2005 Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury Stem Cells 23 44 54 15625121 10.1634/stemcells.2004-0111 1:CAS:528:DC%2BD2MXhtVygu78%3D (Pubitemid 40105290)
28. S Kale A Karihaloo PR Clark M Kashgarian DS Krause LG Cantley 2003 Bone marrow stem cells contribute to repair of the ischemically injured renal tubule J Clin Invest 112 42 49 12824456 1:CAS:528:DC%2BD3sXlt1Krt70%3D (Pubitemid 38056374)
29. TC Fang WR Otto J Rao R Jeffery T Hunt MR Alison HT Cook NA Wright R Poulsom 2008 Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2-induced acute tubular injury Cell Prolif 41 575 591 18616694 10.1111/j.1365-2184.2008.00545.x 1:CAS:528:DC%2BD1cXps1Ont7s%3D
30. M Haq J Norman SR Saba G Ramirez H Rabb 1998 Role of IL-1 in renal ischemic reperfusion injury J Am Soc Nephrol 9 614 619 9555664 1:CAS:528:DyaK1cXisVCnt7c%3D
31. DK Ysebaert KE De Greef A De Beuf AR Van Rompay S Vercauteren VP Persy ME De Broe 2004 T cells as mediators in renal ischemia/reperfusion injury Kidney Int 66 491 496 15253695 10.1111/j.1523-1755.2004.761-4.x 1:CAS:528: DC%2BD2cXmvVegs7w%3D (Pubitemid 38981984)
32. NS Patel PK Chatterjee R Di Paola E Mazzon D Britti A De Sarro S Cuzzocrea C Thiemermann 2005 Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion J Pharmacol Exp Ther 312 1170 1178 15572648 10.1124/jpet.104.078659 1:CAS:528: DC%2BD2MXitVOgsrY%3D (Pubitemid 40293778)
33. JV Bonventre A Zuk 2004 Ischemic acute renal failure: an inflammatory disease? Kidney Int 66 480 485 15253693 10.1111/j.1523-1755.2004.761-2.x 1:CAS:528:DC%2BD2cXmvVegs78%3D (Pubitemid 38981982)
34. M Bensidhoum A Chapel S Francois C Demarquay C Mazurier L Fouillard S Bouchet JM Bertho P Gourmelon J Aigueperse P Charbord NC Gorin D Thierry M Lopez 2004 Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment Blood 103 3313 3319 14715641 10.1182/blood-2003-04-1121 1:CAS:528:DC%2BD2cXjslKgsbw%3D (Pubitemid 38525658)
35. EH Javazon KJ Beggs AW Flake 2004 Mesenchymal stem cells: paradoxes of passaging Exp Hematol 32 414 425 15145209 10.1016/j.exphem.2004.02.004 1:CAS:528:DC%2BD2cXktVCqtrg%3D (Pubitemid 38624325)
36. PC Baer H Geiger 2010 Mesenchymal stem cell interactions with growth factors on kidney repair Curr Opin Nephrol Hypertens 19 1 6 19838114 10.1097/MNH.0b013e328333062c 1:CAS:528:DC%2BD1MXhsFentr7O
37. U Kunter S Rong Z Djuric P Boor G Muller-Newen D Yu J Floege 2006 Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis J Am Soc Nephrol 17 2202 2212 16790513 10.1681/ASN.2005080815 1:CAS:528:DC%2BD28XosFaltrY%3D (Pubitemid 44141910)
38. F Togel A Cohen P Zhang Y Yang Z Hu C Westenfelder 2009 Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury Stem Cells Dev 18 475 485 18564903 10.1089/scd.2008.0092
39. BF Schrijvers A Flyvbjerg AS De Vriese 2004 The role of vascular endothelial growth factor (VEGF) in renal pathophysiology Kidney Int 65 2003 2017 15149314 10.1111/j.1523-1755.2004.00621.x 1:CAS:528:DC%2BD2cXltFKgs7c%3D (Pubitemid 38669987)
40. B Bi R Schmitt M Israilova H Nishio LG Cantley 2007 Stromal cells protect against acute tubular injury via an endocrine effect J Am Soc Nephrol 18 2486 2496 17656474 10.1681/ASN.2007020140 (Pubitemid 47378865)
41. AV Vanikar HL Trivedi A Feroze KV Kanodia SD Dave PR Shah 2010 Effect of co-transplantation of mesenchymal stem cells and hematopoietic stem cells as compared to hematopoietic stem cell transplantation alone in renal transplantation to achieve donor hypo-responsiveness Int Urol Nephrol 10.1007/s11255-009-9659-1O
42. M Huls FG Russel R Masereeuw 2008 Insights into the role of bone marrow-derived stem cells in renal repair Kidney Blood Press Res 31 104 110 18354259 10.1159/000121387 1:CAS:528:DC%2BD1cXltFymsLk%3D (Pubitemid 351630067)
43. E Ronconi C Sagrinati ML Angelotti E Lazzeri B Mazzinghi L Ballerini E Parente F Becherucci M Gacci M Carini E Maggi M Serio GB Vannelli L Lasagni S Romagnani P Romagnani 2009 Regeneration of glomerular podocytes by human renal progenitors J Am Soc Nephrol 20 322 332 19092120 10.1681/ASN.2008070709 1:CAS:528:DC%2BD1MXjtFCrtL8%3D
44. A Maeshima S Yamashita Y Nojima 2003 Identification of renal progenitor-like tubular cells that participate in the regeneration processes of the kidney J Am Soc Nephrol 14 3138 3146 14638912 10.1097/01.ASN.0000098685. 43700.28 (Pubitemid 37509291)
45. JA Oliver O Maarouf FH Cheema TP Martens Q Al-Awqati 2004 The renal papilla is a niche for adult kidney stem cells J Clin Invest 114 795 804 15372103 1:CAS:528:DC%2BD2cXnslWiurs%3D (Pubitemid 39578738)
46. B Bussolati S Bruno C Grange S Buttiglieri MC Deregibus D Cantino G Camussi 2005 Isolation of renal progenitor cells from adult human kidney Am J Pathol 166 545 555 15681837 10.1016/S0002-9440(10)62276-6 1:CAS:528: DC%2BD2MXitVGms7o%3D (Pubitemid 40189050)
47. D Appel DB Kershaw B Smeets G Yuan A Fuss B Frye M Elger W Kriz J Floege MJ Moeller 2009 Recruitment of podocytes from glomerular parietal epithelial cells J Am Soc Nephrol 20 333 343 19092119 10.1681/ASN.2008070795 1:CAS:528:DC%2BD1MXjtFCrtLw%3D
48. ML Sequeira Lopez DR Chernavvsky T Nomasa L Wall M Yanagisawa RA Gomez 2003 The embryo makes red blood cell progenitors in every tissue simultaneously with blood vessel morphogenesis Am J Physiol Regul Integr Comp Physiol 284 R1126 1137 12626371 1:CAS:528:DC%2BD3sXjtlyktrw%3D
49. A Spyridonidis A Schmitt-Graff T Tomann A Dwenger M Follo D Behringer J Finke 2004 Epithelial tissue chimerism after human hematopoietic cell transplantation is a real phenomenon Am J Pathol 164 1147 1155 15039204 10.1016/S0002-9440(10)63203-8 (Pubitemid 38387782)
50. D Krause LG Cantley 2005 Bone marrow plasticity revisited: protection or differentiation in the kidney tubule? J Clin Invest 115 1705 1708 16007248 10.1172/JCI25540 1:CAS:528:DC%2BD2MXlvF2qsbk%3D (Pubitemid 40979707)
51. F Anjos-Afonso EK Siapati D Bonnet 2004 In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions J Cell Sci 117 5655 5664 15494370 10.1242/jcs.01488 1:CAS:528: DC%2BD2cXhtFagur%2FL (Pubitemid 40012211)
52. M Okabe M Ikawa K Kominami T Nakanishi Y Nishimune 1997 'Green mice' as a source of ubiquitous green cells FEBS Lett 407 313 319 9175875 10.1016/S0014-5793(97)00313-X 1:CAS:528:DyaK2sXivFyrsrY%3D (Pubitemid 27199450)
53. ES Swenson JG Price T Brazelton DS Krause 2007 Limitations of green fluorescent protein as a cell lineage marker Stem Cells 25 2593 2600 17615263 10.1634/stemcells.2007-0241 1:CAS:528:DC%2BD2sXht1CltLzP (Pubitemid 47582752)
54. M Broekema MC Harmsen JA Koerts AH Petersen MJ van Luyn G Navis ER Popa 2005 Determinants of tubular bone marrow-derived cell engraftment after renal ischemia/reperfusion in rats Kidney Int 68 2572 2581 16316332 10.1111/j.1523-1755.2005.00728.x (Pubitemid 43251002)
55. M St-Louis RM Tanguay 1997 Mutations in the fumarylacetoacetate hydrolase gene causing hereditary tyrosinemia type I: overview Hum Mutat 9 291 299 9101289 10.1002/(SICI)1098-1004(1997)9:4<291::AID-HUMU1>3.0.CO;2-9 1:CAS:528:DyaK2sXis1Grsrw%3D (Pubitemid 27157647)
56. M Grompe 2001 The pathophysiology and treatment of hereditary tyrosinemia type 1 Semin Liver Dis 21 563 571 11745044 10.1055/s-2001-19035 1:CAS:528:DC%2BD38XislCjsQ%3D%3D (Pubitemid 33131048)
57. M Grompe S Lindstedt M al-Dhalimy NG Kennaway J Papaconstantinou CA Torres-Ramos CN Ou M Finegold 1995 Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I Nat Genet 10 453 460 7545495 10.1038/ng0895-453 1:CAS:528:DyaK2MXnsVWksrs%3D
58. PK Held M Al-Dhalimy H Willenbring Y Akkari S Jiang Y Torimaru S Olson WH Fleming M Finegold M Grompe 2006 In vivo genetic selection of renal proximal tubules Mol Ther 13 49 58 16216560 10.1016/j.ymthe.2005.09.004 1:CAS:528:DC%2BD2MXhtlShsrnO (Pubitemid 41763482)
59. D Cosgrove DT Meehan JA Grunkemeyer JM Kornak R Sayers WJ Hunter GC Samuelson 1996 Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome Genes Dev 10 2981 2992 8956999 10.1101/gad.10.23.2981 1:CAS:528:DyaK28XnsV2ms7s%3D (Pubitemid 26412525)
60. H Sugimoto TM Mundel M Sund L Xie D Cosgrove R Kalluri 2006 Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease Proc Natl Acad Sci USA 103 7321 7326 16648256 10.1073/pnas.0601436103 1:CAS:528:DC%2BD28XkslOrsrg%3D (Pubitemid 43727831)
61. EI Prodromidi R Poulsom R Jeffery CA Roufosse PJ Pollard CD Pusey HT Cook 2006 Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome Stem Cells 24 2448 2455 16873763 10.1634/stemcells.2006-0201 1:CAS:528:DC%2BD28Xht12hsbbK (Pubitemid 44674305)
62. K Katayama M Kawano I Naito H Ishikawa Y Sado N Asakawa T Murata K Oosugi M Kiyohara E Ishikawa M Ito S Nomura 2008 Irradiation prolongs survival of Alport mice J Am Soc Nephrol 19 1692 1700 18480315 10.1681/ASN.2007070829 1:CAS:528:DC%2BD1cXhtFensrvN
63. KL Andrews JL Mudd C Li JH Miner 2002 Quantitative trait loci influence renal disease progression in a mouse model of Alport syndrome Am J Pathol 160 721 730 11839593 10.1016/S0002-9440(10)64892-4 1:CAS:528:DC%2BD38XitVCkur8%3D (Pubitemid 34160350)
64. S Cherqui C Sevin G Hamard V Kalatzis M Sich MO Pequignot K Gogat M Abitbol M Broyer MC Gubler C Antignac 2002 Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis Mol Cell Biol 22 7622 7632 12370309 10.1128/MCB.22.21.7622-7632.2002 1:CAS:528: DC%2BD38XotVKhsbY%3D
65. N Nevo M Chol A Bailleux V Kalatzis L Morisset O Devuyst MC Gubler C Antignac 2010 Renal phenotype of the cystinosis mouse model is dependent upon genetic background Nephrol Dial Transplant 25 1059 1066 19846395 10.1093/ndt/gfp553 1:CAS:528:DC%2BC3cXjvF2ht7c%3D