Th17 differentiation is the default program for DPP2-deficient T-cell differentiation

European Journal of Immunology

Volumn 41, Issue 6, 2011, Pages 1583-1593

  Mele, Deanna A ^a   Sampson, James F ^a   Huber, Brigitte T ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; Cell differentiation; Cellular proliferation

Indexed keywords

BIOLOGICAL MARKER; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 2; INTERLEUKIN 17; PROTEIN KINASE LCK; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE PRODUCTION; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NEWBORN; NONHUMAN; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; TH17 CELL; THYMOCYTE;

ANIMALS; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; IMMUNIZATION; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH17 CELLS;

EID: 79957540210     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201041157     Document Type: Article

References (41)

1. Underwood, R., Chiravuri, M., Lee, H., Schmitz, T., Kabcenell, A. K., Yardley, K. and Huber, B. T., Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. J. Biol. Chem. 1999. 274: 34053-34058.
2. Chiravuri, M., Agarraberes, F., Mathieu, S. L., Lee, H. and Huber, B. T., Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase. J. Immunol. 2000. 165: 5695-5702.
3. Bista, P., Mele, D. A., Baez, D. V. and Huber, B. T., Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1. Mol. Immunol. 2008. 45: 3618-3623.
4. Chiravuri, M., Schmitz, T., Yardley, K., Underwood, R., Dayal, Y. and Huber, B. T., A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. J. Immunol. 1999. 163: 3092-3099.
5. Mele, D. A., Bista, P., Velez-Baez, D. and Huber, B. T., Dipeptidyl peptidase 2 is an essental survival factor in the regulation of cell quiescence. Cell Cycle 2009. 8: 2425-2434.
6. Mosmann, T. R. and Coffman, R. L., TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989. 7: 145-173.
7. Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T. et al., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005. 201: 233-240.
8. - naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 2003. 198: 1875-1886.
9. Ghoreschi, K., Laurence, A., Yang, X. P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L. et al., Generation of pathogenic Th17 cells in the absence of TGF-β signaling. Nature 2010. 467: 967-971.
10. Dong, C., Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat. Rev. Immunol. 2006. 6: 329-333.
11. Glimcher, L. H. and Murphy, K. M., Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 2000. 14: 1693-1711.
12. Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G. and Glimcher, L. H., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000. 100: 655-669.
13. Kaplan, M. H., Sun, Y. L., Hoey, T. and Grusby, M. J., Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996. 382: 174-177.
14. Thierfelder, W. E., van Deursen, J. M., Yamamoto, K., Tripp, R. A., Sarawar, S. R., Carson, R. T., Sangster, M. Y. et al., Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996. 382: 171-174.
15. Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J. and Littman, D. R., The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+T helper cells. Cell 2006. 126: 1121-1133.
16. Kleinschek, M. A., Owyang, A. M., Joyce-Shaikh, B., Langrish, C. L., Chen, Y., Gorman, D. M., Blumenschein, W. M. et al., IL-25 regulates Th17 function in autoimmune inflammation. J. Exp. Med. 2007. 204: 161-170.
17. Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003. 299: 1057-1061.
18. Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y., Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003. 4: 330-336.
19. Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M. and Murphy, K. M., Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006. 24: 677-688.
20. Doreau, A., Belot, A., Bastid, J., Riche, B., Trescol-Biemont, M. C., Ranchin, B., Fabien, N. et al., Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat. Immunol. 2009. 10: 778-785.
21. O'Connor, W., Jr., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K. and Flavell, R. A., A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat. Immunol. 2009. 10: 603-609.
22. Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L. et al., T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 2008. 28: 29-39.
23. Ogawa, A., Andoh, A., Araki, Y., Bamba, T. and Fujiyama, Y., Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin. Immunol. 2004. 110: 55-62.
24. Ventura, A., Meissner, A., Dillon, C. P., McManus, M., Sharp, P. A., Van Parijs, L., Jaenisch, R. et al., Cre-lox-regulated conditional RNA interference from transgenes. Proc. Natl. Acad. Sci. USA 2004. 101: 10380-10385.
25. Lee, P. P., Fitzpatrick, D. R., Beard, C., Jessup, H. K., Lehar, S., Makar, K. W., Pérez-Melgosa, M. et al., A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 2001. 15: 763-774.
26. Maeurer, M. J. and Lotze, M. T., Interleukin-7 (IL-7) knockout mice. Implications for lymphopoiesis and organ-specific immunity. Int. Rev. Immunol. 1998. 16: 309-322.
27. Freitas, A. A. and Rocha, B., Peripheral T cell survival. Curr. Opin. Immunol. 1999. 11: 152-156.
28. Schluns, K. S., Kieper, W. C., Jameson, S. C. and Lefrancois, L., Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 2000. 1: 426-432.
29. Tan, J. T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K. I. and Surh, C. D., IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl. Acad. Sci. USA 2001. 98: 8732-8737.
30. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. and Weissman, I. L., Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 1997. 89: 1033-1041.
31. Barata, J. T., Cardoso, A. A., Nadler, L. M. and Boussiotis, V. A., Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1). Blood 2001. 98: 1524-1531.
32. Marrack, P. and Kappler, J., Control of T cell viability. Annu. Rev. Immunol. 2004. 22: 765-787.
33. Brocker, T., Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J. Exp. Med. 1997. 186: 1223-1232.
34. Tzachanis, D., Freeman, G. J., Hirano, N., van Puijenbroek, A. A., Delfs, M. W., Berezovskaya, A., Nadler, L. M. and Boussiotis, V. A., Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat. Immunol. 2001. 2: 1174-1182.
35. Buckley, A. F., Kuo, C. T. and Leiden, J. M., Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc - dependent pathway. Nat. Immunol. 2001. 2: 698-704.
36. Kolls, J. K. and Linden, A., Interleukin-17 family members and inflammation. Immunity 2004. 21: 467-476.
37. Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B. et al., Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007. 26: 371-381.
38. Korn, T., Bettelli, E., Oukka, M. and Kuchroo, V. K., IL-17 and Th17 Cells. Annu. Rev. Immunol. 2009. 27: 485-517.
39. Zhu, B., Symonds, A. L., Martin, J. E., Kioussis, D., Wraith, D. C., Li, S. and Wang, P., Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J. Exp. Med. 2008. 205: 2295-2307.
40. Pesu, M., Watford, W. T., Wei, L., Xu, L., Fuss, I., Strober, W., Andersson, J. et al., T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature 2008. 455: 246-250.
41. Rubinson, D. A., Dillon, C. P., Kwiatkowski, A. V., Sievers, C., Yang, L., Kopinja, J., Rooney, D. L. et al., A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 2003. 33: 401-406.