In vitro assay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis

Journal of Applied Toxicology

Volumn 29, Issue 4, 2009, Pages 356-363

  Fujimura, Hisako ^a   Murakami, Naoko ^b   Kurabe, Michie ^b   Toriumi, Wataru ^b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b NONE

Author keywords

BODIPY558 568 C12; Fluorescence assay; Gene expression, oxidative stress; Hepatosteatosis; PPAR agonists; Rat primary hepatocytes

Indexed keywords

4,4 DIFLUORO 5 (2 THIENYL) 4 BORA 3A,4A DIAZA INDACENE 3 DODECANOIC ACID; CARBON TETRACHLORIDE; CLOFIBRATE; CYCLOSPORIN A; FAT DROPLET; FATTY ACID DERIVATIVE; LIPID; N (4,4 DIFLUORO 5,7 DIMETHYL 4 BORA 3A,4A DIAZA INDACENE 3 PROPIONYL) 1,2 DIHEXADECANOYL GLYCERO 3 PHOSPHOETHANOLAMINE, TRIETHYLAMMONIUM SALT; TAMOXIFEN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ASSAY; CONFOCAL LASER MICROSCOPY; CYTOPLASM; DOWN REGULATION; ELECTRON MICROSCOPY; FATTY LIVER; FLUORESCENCE; FLUOROMETRY; GENE EXPRESSION; LIPID METABOLISM; LIPOGENESIS; LIVER CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; UPREGULATION;

ANIMALS; BORON COMPOUNDS; CELLS, CULTURED; FATTY LIVER; FLUORESCENT DYES; FLUOROMETRY; GENE EXPRESSION; HEPATOCYTES; IMAGE PROCESSING, COMPUTER-ASSISTED; LIPIDS; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 65649112138     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1420     Document Type: Article

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