Enhanced glucose uptake via GLUT4 fuels recovery from calcium overload after ischaemiareperfusion injury in sevoflurane- but not propofol-treated hearts

British Journal of Anaesthesia

Volumn 106, Issue 6, 2011, Pages 792-800

  Lucchinetti, E ^a   Wang, L ^a   Ko, K W S ^a   Troxler, H ^b   Hersberger, M ^b   Zhang, L ^a   Omar, M A ^a   Lopaschuk, G D ^a   Clanachan, A S ^a   Zaugg, M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

anaesthetics i.v., propofol; anaesthetics inhalation, sevoflurane; energy metabolism; myocardial reperfusion injury; rats

Indexed keywords

ADENYLATE KINASE; CALCIUM; GLUCOSE TRANSPORTER 4; PROPOFOL; SEVOFLURANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG MECHANISM; ENERGY METABOLISM; GLUCOSE TRANSPORT; ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

EID: 79957472911     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aer065     Document Type: Article

References (41)

1. Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005; 85: 1093-129 (Pubitemid 40894649)
2. Lazar HL, Chipkin SR, Fitzgerald CA, Bao Y, Cabral H, Apstein CS. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation 2004; 109: 1497-502 (Pubitemid 38420177)
3. Wang L, Ko KWS, Lucchinetti E, et al. Metabolic profiling of hearts exposed to sevoflurane and propofol reveals distinct regulation of fatty acid and glucose oxidation. CD36 and pyruvate dehydrogenase as key regulators in anesthetic-induced fuel shift. Anesthesiology 2010; 113: 541-51
4. Lucchinetti E, Hofer C, Bestmann L, et al. Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: inhalational versus intravenous anesthetics. Anesthesiology 2007; 106: 444-57 (Pubitemid 46662209)
5. Julier K, da Silva R, Garcia C, et al. Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study. Anesthesiology 2003; 98: 1315-27 (Pubitemid 36622462)
6. Shao H, Li J, Zhou Y, et al. Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic/reperfused rat heart: role of cardiolipin. Br J Pharmacol 2008; 153: 1641-9 (Pubitemid 351536002)
7. Xia Z, Huang Z, Ansley DM. Large-dose propofol during cardiopulmonary bypass decreases biochemical markers of myocardial injury in coronary surgery patients: a comparison with isoflurane. Anesth Analg 2006; 103: 527-32 (Pubitemid 44542898)
8. Zaugg M, Lucchinetti E, Spahn DR, Pasch T, Schaub MC. Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways. Anesthesiology 2002; 97: 4-14 (Pubitemid 34733916)
9. Omar MA, Wang L, Clanachan AS. Cardioprotection by GSK-3 inhibition: role of enhanced glycogen synthesis and attenuation of calcium overload. Cardiovasc Res 2010; 86: 478-86
10. Dyck JR, Cheng JF, Stanley WC, et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ Res 2004; 94: e78-84
11. Constantin-Teodosiu D, Cederblad G, Hultman E. A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue. Anal Biochem 1991; 198: 347-51
12. Lopaschuk GD, Kelly DP. Signalling in cardiac metabolism. Cardiovasc Res 2008; 79: 205-7 (Pubitemid 351951619)
13. Liedtke AJ, DeMaison L, Eggleston AM, Cohen LM, Nellis SH. Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res 1988; 62: 535-42 (Pubitemid 18078693)
14. Liu B, Clanachan AS, Schulz R, Lopaschuk GD. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ Res 1996; 79: 940-8 (Pubitemid 26359235)
15. Kelly DP, Strauss AW. Inherited cardiomyopathies. N Engl J Med 1994; 330: 913-9 (Pubitemid 24094973)
16. Liao R, Jain M, Cui L, et al. Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation 2002; 106: 2125-31 (Pubitemid 35192820)
17. Kuang M, Febbraio M, Wagg C, Lopaschuk GD, Dyck JR. Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia. Circulation 2004; 109: 1550-7 (Pubitemid 38420185)
18. Lionetti V, Linke A, Chandler MP, et al. Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Cardiovasc Res 2005; 66: 454-61 (Pubitemid 40725757)
19. McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 1996; 93: 135-42 (Pubitemid 26007542)
20. Rigoulet M, Leverve X, Fontaine E, Ouhabi R, Guerin B. Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: dependence upon both fluxes and forces. Mol Cell Biochem 1998; 184: 35-52 (Pubitemid 28398599)
21. Nobes CD, Hay WW Jr, Brand MD. The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes. J Biol Chem 1990; 265: 12910-5
22. Liu Q, Docherty JC, Rendell JC, Clanachan AS, Lopaschuk GD. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J Am Coll Cardiol 2002; 39: 718-25 (Pubitemid 34158171)
23. Gonzalez-Munoz E, Lopez-Iglesias C, Calvo M, Palacin M, Zorzano A, Camps M. Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes. Endocrinology 2009; 150: 3493-502
24. Hue L, Rider MH. The AMP-activated protein kinase: more than an energy sensor. Essays Biochem 2007; 43: 121-37
25. Luiken JJ, Coort SL, Koonen DP, et al. Regulation of cardiac longchain fatty acid and glucose uptake by translocation of substrate transporters. Pflugers Arch 2004; 448: 1-15 (Pubitemid 38657200)
26. Hue L, Taegtmeyer H. The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab 2009; 297: E578-91
27. Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002; 277: 50230-6 (Pubitemid 36042170)
28. Stratford S, DeWald DB, Summers SA. Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation. Biochem J 2001; 354: 359-68 (Pubitemid 32209874)
29. Holland WL, Brozinick JT, Wang LP, et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab 2007; 5: 167-79
30. Der P, Cui J, Das DK. Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned hearts. J Mol Cell Cardiol 2006; 40: 313-20 (Pubitemid 43152387)
31. Carles M, Dellamonica J, Roux J, et al. Sevoflurane but not propofol increases interstitial glycolysis metabolites availability during tourniquet-induced ischaemia-reperfusion. Br J Anaesth 2008; 100: 29-35 (Pubitemid 351773419)
32. Kudoh A, Katagai H, Takazawa T. Sevoflurane increases glucose transport in skeletal muscle cells. Anesth Analg 2002; 95: 123-8, table of contents (Pubitemid 34705565)
33. Di Paola M, Cocco T, Lorusso M. Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry 2000; 39: 6660-8 (Pubitemid 30353998)
34. 2+-independent mechanism. J Bioenerg Biomembr 2004; 36: 165-70 (Pubitemid 39023633)
35. Su X, Han X, Mancuso DJ, Abendschein DR, Gross RW. Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics. Biochemistry 2005; 44: 5234-45 (Pubitemid 40471236)
36. Netticadan T, Yu L, Dhalla NS, Panagia V. Palmitoyl carnitine increases intracellular calcium in adult rat cardiomyocytes. J Mol Cell Cardiol 1999; 31: 1357-67 (Pubitemid 29335666)
37. Haruna T, Horie M, Takano M, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch 2000; 441: 200-7 (Pubitemid 32128158)
38. Kohro S, Hogan QH, Nakae Y, Yamakage M, Bosnjak ZJ. Repeated or prolonged isoflurane exposure reduces mitochondrial oxidizing effects. Anesthesiology 2003; 98: 275-8 (Pubitemid 36043440)
39. Feng J, Lucchinetti E, Ahuja P, Pasch T, Perriard JC, Zaugg M. Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta. Anesthesiology 2005; 103: 987-95 (Pubitemid 41552054)
40. Lamberts RR, Onderwater G, Hamdani N, et al. Reactive oxygen species-induced stimulation of 5'AMP-activated protein kinase mediates sevoflurane-induced cardioprotection. Circulation 2009; 120: S10-5
41. De Hert SG, Van der Linden PJ, Cromheecke S, et al. Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration. Anesthesiology 2004; 101: 299-310 (Pubitemid 38988484)