Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure

Cardiovascular Research

Volumn 66, Issue 3, 2005, Pages 454-461

  Lionetti, Vincenzo ^a   Linke, Axel ^a   Chandler, Margaret P ^b   Young, Martin E ^c   Penn, Marc S ^d   Gupte, Sachin ^a   D'Agostino, Chiara ^a   Hintze, Thomas H ^a   Stanley, William C ^b   Recchia, Fabio A ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Cardiomyopathy; Hemodynamics; Lipid metabolism

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE INHIBITOR; CITRATE SYNTHASE; FATTY ACID; GELATINASE A; GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; OXFENICINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HEART FAILURE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE WALL; HEART PACING; HEART VENTRICLE; HEART VENTRICLE REMODELING; HEMODYNAMICS; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BLOTTING, WESTERN; CARDIAC PACING, ARTIFICIAL; CARNITINE O-PALMITOYLTRANSFERASE; DOGS; ENZYME INHIBITORS; FATTY ACIDS; GENE EXPRESSION; GLYCINE; HEART FAILURE, CONGESTIVE; MALE; MYOCARDIUM; OXIDATION-REDUCTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROKE VOLUME; TIME FACTORS; VENTRICULAR REMODELING;

EID: 21144453386     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2005.02.004     Document Type: Article

References (24)

1. W.C. Stanley, and M.P. Chandler Energy metabolism in the normal and failing heart: potential for therapeutic interventions Heart Fail Rev 7 2002 115 130
2. M.N. Sack, T.A. Rader, S. Park, J. Bastin, S.A. McCune, and D.P. Kelly FAO enzyme gene expression is downregulated in the failing heart Circulation 94 1996 2837 2842
3. J.C. Osorio, W.C. Stanley, A. Linke, M. Castellari, Q.N. Diep, and A.R. Panchal Impaired myocardial FAO and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure Circulation 106 2002 606 612
4. J.M. Huss, and D.P. Kelly Nuclear receptor signaling and cardiac energetics Circ Res 95 2004 568 578
5. M.E. Young, F.A. Laws, G.W. Goodwin, and H. Taegtmeyer Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart J Biol Chem 276 2001 44390 44395
6. M. Bristow Etomoxir: a new approach to treatment of chronic heart failure Lancet 356 2000 1621 1622
7. H. Rupp, and R. Vetter Sarcoplasmic reticulum function and carnitine palmitoyltransferase-1 inhibition during progression of heart failure Br J Pharmacol 131 2000 1748 1756
8. H. Rupp, A. Zarain-Herzberg, and B. Maisch The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure Herz 27 2002 621 636
9. F.A. Recchia, P.I. McConnell, R.D. Bernstein, T.R. Vogel, X. Xu, and T.H. Hintze Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog Circ Res 83 1998 969 979
10. P.W. Armstrong, T.P. Stopps, S.E. Ford, and A.J. de Bold Rapid ventricular pacing in the dog: pathophysiologic studies of heart failure Circulation 74 1986 1075 1084
11. F.G. Spinale, M.L. Coker, C.V. Thomas, J.D. Walker, R. Mukherjee, and L. Hebbar Time-dependent changes in matrix metalloproteinase activity and expression during the progression of congestive heart failure: relation to ventricular and myocyte function Circ Res 82 1998 482 495
12. A.J. Drake-Holland, and J.E. Passingham The effect of oxfenicine on cardiac carbohydrate metabolism in intact dogs Basic Res Cardiol 78 1983 19 27
13. G.G. Schwartz, C. Greyson, J.A. Wisneski, and J. Garcia Inhibition of fatty acid metabolism alters myocardial high-energy phosphates in vivo Am J Physiol 267 1994 H224 H231
14. P. Greaves, J. Martin, M.C. Michel, and P. Mompon Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism Arch Toxicol Suppl 7 1984 488 493
15. B. Lei, V. Lionetti, M.E. Young, M.P. Chandler, C. d'Agostino, and E.Y. Kang Paradoxical downregulation of glucose oxidation pathway despite enhanced flux in severe heart failure J Mol Cell Cardiol 36 2004 567 576
16. D.J. Sahn, A.N. De Maria, J. Kisslo, and A. Weyman Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements Circulation 58 1978 1072 1083
17. P. Razeghi, M.E. Young, J.L. Alcorn, C.S. Moravec, O.H. Frazier, and H. Taegtmeyer Metabolic gene expression in fetal and failing human heart Circulation 104 2001 2923 2931
18. F.G. Spinale Matrix metalloproteinases: regulation and dysregulation in the failing heart Circ Res 90 2002 520 530
19. A.T. Askari, M.L. Brennan, X. Zhou, J. Drinko, A. Morehead, and J.D. Thomas Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction J Exp Med 197 2003 615 624
20. H. Esterbauer, R.J. Schaur, and H. Zollner Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radic Biol Med 11 1991 81 128
21. M.P. Chandler, J. Kerner, H. Huang, E. Vazquez, A. Reszko, and W.Z. Martini Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation Am J Physiol 287 2004 H1538 H1543
22. S. Srivastava, B. Chandrasekar, A. Bhatnagar, and S.D. Prabhu Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase Am J Physiol 283 2002 H2612 H2619
23. Z. Wu, P. Puigserver, U. Andersson, C. Zhang, G. Adelmant, and V. Mootha Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 Cell 98 1999 115 124
24. J.N. Trochu, S. Mital, X. Zhang, X. Xu, M. Ochoa, and J.K. Liao Preservation of NO production by statins in the treatment of heart failure Cardiovasc Res 60 2003 250 258