Palmitoyl carnitine increases intracellular calcium in adult rat cardiomyocytes

Journal of Molecular and Cellular Cardiology

Volumn 31, Issue 7, 1999, Pages 1357-1367

  Netticadan, Thomas ^a   Liping, Yu ^a   Dhalla, Naranjan S ^a   Panagia, Vincenzo ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b ST BONIFACE GENERAL HOSPITAL RESEARCH CENTRE   (Canada)

Author keywords

Cardiomyocytes intracellular Ca2+ handling; L type Ca2+ channel; Lysophosphatidylcholine; Na+ K+ ATPase; Palmitoyl carnitine; Sarcolemmal Na+ Ca2+ exchange; Sarcoplasmic reticulum

Indexed keywords

AMILORIDE; CALCIUM ION; DILTIAZEM; NICKEL; OUABAIN; PALMITOYLCARNITINE; RYANODINE; SODIUM ION; THAPSIGARGIN; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM;

EID: 0033166291     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1999.0968     Document Type: Article

References (52)

1. +-ATPase and adenylate cyclase activity of cardiac sarcolemma. J Mol Cell Cardiol 16: 239-245.
2. 2+ transport. J Biol Chem 254: 12404-12410.
3. Antolini M, Trevisi L, Debetto P, Luciani S, 1993. Effect of amiloride on sodium-calcium exchange activity in rat cardiac myocytes. Pharmacol Res 27: 227-231.
4. Ashavaid TF, Colvin RA, Messineo FC, Macalister T, Katz AM, 1985. Effects of fatty acids on Na/Ca exchange in cardiac sarcolemmal membranes. J Mol Cell Cardiol 17: 851-861.
5. Barry WH, Bridge JH, 1993. Intracellular calcium homeostasis in cardiac myocytes. Circulation 87: 1806-1815.
6. Baydoun AR, Markham A, Morgan RM, Sweetman AJ, 1988. Palmitoyl carnitine: An endogenous promoter of calcium efflux from rat heart mitochondria. Biochem Pharmacol 37: 3103-3107.
7. Chen Q, Van Breemen C, 1993. The superficial buffer in venous smooth muscle: Sarcoplasmic reticulum refilling and unloading. Br J Pharmacol 109: 336-343.
8. 2+ concentration in isolated rat ventricular myocytes. J Physiol (Lond) 445: 369-388.
9. Classen J, Deuticke B, Haest CWM, 1989. Nonmediated flip-flop of phospholipid analogues in the erythrocyte membrane as probed by palmitoylcarnitine: Basic properties and influence of membrane modification. Jmembr Biol 111: 169-178.
10. Corr PB, Gross RW, Sobel BE, 1984. Amphipathic metabolites and membrane dysfunction in ischemic myocardium. Circ Res 55: 135-154.
11. Da Torre SD, Creer MH, Pogwizd SM, Corr PB, 1991. Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart. J Mol Cell Cardiol 23: 11-22.
12. i. Circ Res 78: 857-862.
13. 2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. Biophys J 65: 779-789.
14. Fabiato A, 1985. Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac purkinje cell. J Gen Physiol 85:247-289.
15. Frohlich J, Seccombe DW, Hahu P, Dodek P, Hynie I, 1978. Effect of fasting on free and esterified carnitine levels in human serum and urine: Correlation with serum levels of fatty acids and β-hydroxy butyrate. Metabolism 27: 555-561.
16. Gross RW, Drisdel RC, Sobel BE, 1983. Rabbit myocardial lysophospholipase-transacylase: Purification, characterization and inhibition by endogenous cardiac amphiphiles. J Biol Chem 258: 15165-15172.
17. Gross RW, Sobel BE, 1981. Inhibition of myocardial lysophosphatidyl choline transacylase by palmitoyl carnitine: Implications for arrhythmogenesis. Trans Assoc Am Physicians 94: 115-125.
18. Gross RW, Sobel BE, 1983. Rabbit myocardial cytosolic lysophospholipase: Purification, characterization and competitive inhibition by L-palmitoyl carnitine. J Biol Chem 258: 5221-5226.
19. Hansford RG, Lakatta EG, 1987. Ryanodine releases calcium from sarcoplasmic reticulum in calcium-tolerant rat cardiac myocytes. J Physiol (Lond) 390: 453-467.
20. Hara A, HAshizume H, Abiko Y, 1996. Dilazep and its derivative K-7259, attenuate mechanical derangement induced by palmitoyl-L-carnitine in the isolated, perfused heart. J Pharm Exp Ther 279: 32-38.
21. Haworth RA, Redon D, 1998. Calibration of intracellular ca transients of isolated adult heart cells labelled with fura-2 by acetoxymethyl ester loading. Cell Calcium 24: 263-273.
22. Katz AM, 1982. Membrane-derived lipids and the pathogenesis of ischemic myocardial damage. J Mol Cell Cardiol 14: 627-632.
23. 2+ exchange current in single ventricular cells of guinea-pig. J Physiol (Lond) 384: 199-222.
24. 2+ pump. J Biol Chem 267: 12545-12551.
25. Knabb MT, Saffitz JE, Corr PB, Sobel BE, 1986. The dependence of electrophysiological derangements on accumulation of endogenous long-chain acylcarnitine in hypoxic neonatal rat myocytes. Circ Res 58: 230-240.
26. Lee H-C, Mohabir R, Smith N, Franz MR, Clusin WT, 1988. Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing Indo-1. Correlation with monophasic action potentials and contraction. Circulation 78: 1047-1059.
27. Lee KS, Tsien RW, 1983. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialyzed heart cells. Nature 302: 790-794.
28. Liedtke AJ, 1988. Lipid burden in ischemic myocardium. J Mol Cell Cardiol 20: 65-74.
29. Liedtke AJ, Nellis S, Neely JR, 1978. Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine. Circ Res 43: 652-661.
30. Liu E, Goldhaber JI, Weiss JN, 1991. Effects of lysophosphatidylcholine on electrophysiological properties and excitation-contraction coupling in isolated guinea pig myocytes. J Clin Invest 88: 1819-1832.
31. Liu Q-Y, Rosenberg RL, 1996. Activation and inhibition of reconstituted cardiac L-type calcium channels by palmitoyl-L-carnitine. Biochem Biophys Res Commun 228:252-258.
32. Liu S-Y, Yu C-H, Hays J-A, Panagia V, Dhalla NS, 1997. Modification of heart sarcolemmal phosphoinositide pathway by lysophosphatidylcholine. Biochim Biophys Acta 1349: 264-274.
33. McHowat J, Yamada KA, Wu J, Yan G-X, Corr PB, 1993. Recent insights pertaining to sarcolemmal phospholipid alterations underlying arrhythmogenesis in the ischemic heart. J Cardiovasc Electrophysiol 4: 288-310.
34. Meszaros J, Pappano AJ, 1990. Electrophysiological effects of L-palmitoylcarnitine in single ventricular myocytes. Am J Physiol 258: H931-H938.
35. 2+ concentration in living single rat myocytes. Am J Physiol 261: H1123-H1134.
36. O'Neill SC, Valdeolmillos M, Eisner DA, 1988. The effects of nickel on contraction and membrane current in isolated rat myocytes. Quart J Exp Physiol 73: 1017-1020.
37. + ATPase activity of cardiac sarcolemma. Am J Physiol 242: H456-H461.
38. + ATPase. Am J Physiol 247: H840-H846.
39. Pitts BJR, Tate CA, Van Winkle BW, Wood JM, Entman ML, 1978. Palmitoyl carnitine inhibition of the calcium pump in cardiac sarcoplasmic reticulum: A possible role in myocardial ischemia. Life Sci 23: 391-402.
40. Regitz-Zagrosek V, Fleck E, 1995. Myocardial carnitine deficiency in human cardiomyopathy. In: de Jong JW, Ferrari R (eds). The Carnitine System. Dordrecht: Kluwer Academic Publishers, 145-166.
41. Steenbergen C, Murphy E, Watts JA, London RE, 1990. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in the perfused rat heart. Circ Res 66: 135-146.
42. Tanaka M, Gilbert J, Pappano Aj, 1992. Inhibition of sodium pump by l-palmitoylcarnitine in single guinea- pig ventricular myocytes. J Mol Cell Cardiol 24: 711-720.
43. 2+ exchange activity. Am J Physiol 256: C1273-C1276.
44. 2+ from a caffeine- and ryanodine-insensitive intracellular pool in rat atrial cells. J Biol Chem 265: 6782-6787.
45. 2+ exchange: Effects on mechanical and electrical function of guinea-pig myocardium. Pharmacol Toxicol 71: 95-102.
46. Wu J, Corr PB, 1992. Influence of long-chain acylcarnitines on voltage-dependent calcium current in adult ventricular myocytes. Am J Physiol 263: H410-H417.
47. Wu J, Corr PB, 1994. Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes. Am J Physiol 266: H1034-H1046.
48. Wu J, McHowat J, Saffitz JE, Yamada KA, Corr PB, 1993. Inhibition of gap junctional conductance by long-chain acyl carnitines and their preferential accumulation in junctional sarcolemma during hypoxia. Circ Res 72: 879-889.
49. 2+ and cardiac contractile force. Am J Physiol 271: H651-H659.
50. 2+ homeostasis in cardiomyocytes. Mol Cell Biochem 172: 149-157.
51. i transients in murine ventricular myocytes. Circ Res 82: 657-665.
52. Yu L, Netticadan T, Xu Y-J, Panagia V, Dhalla NS, 1998. Mechanisms of lysophosphatidylcholine-induced increase in intracellular calcium in rat cardiomyocytes. J Pharmacol Exp Ther 286: 1-8.