Mahoganoid and Mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein

Journal of Biological Chemistry

Volumn 286, Issue 21, 2011, Pages 18914-18929

  Overton, John D ^a   Leibel, Rudolph L ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; HAIR FOLLICLES; LIGAND BINDING; MOLECULAR BASIS; OVER-EXPRESSION; RECEPTOR TRAFFICKING;

CELL MEMBRANES; FETAL MONITORING; MAMMALS; SIGNALING;

NUTRITION;

AGOUTI PROTEIN; ALPHA INTERMEDIN; ATTRACTIN; CYCLIC AMP; MAHOGANY PROTEIN; MAHOGAOID PROTEIN; MAHOGUNIN RING FINGER PROTEIN 1; MELANOCORTIN 4 RECEPTOR; RING FINGER PROTEIN; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENDOSOME; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AGOUTI SIGNALING PROTEIN; ALPHA-MSH; ANIMALS; CYCLIC AMP; ENDOSOMES; GENE EXPRESSION; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MUTATION; OBESITY; PROTEIN TRANSPORT; RECEPTOR, MELANOCORTIN, TYPE 1; RECEPTOR, MELANOCORTIN, TYPE 4; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

AGOUTI; SWIETENIA;

EID: 79956336698     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.224592     Document Type: Article

References (62)

1. Gantz, I., Miwa, H., Konda, Y., Shimoto, Y., Tashiro, T., Watson, S. J., DelValle, J., and Yamada, T. (1993) J. Biol. Chem. 268, 15174-15179
2. Lu, D., Willard, D., Patel, I. R., Kadwell, S., Overton, L., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) Nature 371, 799-802
3. Abdel-Malek, Z. A. (2001) Cell. Mol. Life Sci. 58, 434-441
4. Artigas, R. A., Gonzalez, A., Riquelme, E., Carvajal, C. A., Cattani, A., Martínez-Aguayo, A., Kalergis, A. M., Pérez-Acle, T., and Fardella, C. E. (2008) J. Clin. Endocrinol. Metab. 93, 3097-3105
5. Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J., Funahashi, H., Williams, T., Ferreira, M., Tang, V., McGovern, R. A., Kenny, C. D., Christiansen, L. M., Edelstein, E., Choi, B., Boss, O., Aschkenasi, C., Zhang, C. Y., Mountjoy, K., Kishi, T., Elmquist, J. K., and Lowell, B. B. (2005) Cell 123, 493-505
6. Chen, W., Kelly, M. A., Opitz-Araya, X., Thomas, R. E., Low, M. J., and Cone, R. D. (1997) Cell 91, 789-798
7. Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., Smith, F. J., Campfield, L. A., Burn, P., and Lee, F. (1997) Cell 88, 131-141
8. Robbins, L. S., Nadeau, J. H., Johnson, K. R., Kelly, M. A., Roselli-Rehfuss, L., Baack, E., Mountjoy, K. G., and Cone, R. D. (1993) Cell 72, 827-834
9. Star, R. A., Rajora, N., Huang, J., Stock, R. C., Catania, A., and Lipton, J. M. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 8016-8020
10. Van der Ploeg, L. H., Martin, W. J., Howard, A. D., Nargund, R. P., Austin, C. P., Guan, X., Drisko, J., Cashen, D., Sebhat, I., Patchett, A. A., Figueroa, D. J., DiLella, A. G., Connolly, B. M., Weinberg, D. H., Tan, C. P., Palyha, O. C., Pong, S. S., MacNeil, T., Rosenblum, C., Vongs, A., Tang, R., Yu, H., Sailer, A. W., Fong, T. M., Huang, C., Tota, M. R., Chang, R. S., Stearns, R., Tamvakopoulos, C., Christ, G., Drazen, D. L., Spar, B. D., Nelson, R. J., and MacIntyre, D. E. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 11381-11386
11. Zhou, A., Bloomquist, B. T., and Mains, R. E. (1993) J. Biol. Chem. 268, 1763-1769
12. Barsh, G. S., Ollmann, M. M., Wilson, B. D., Miller, K. A., and Gunn, T. M. (1999) Ann. N.Y. Acad. Sci. 885, 143-152
13. Ollmann, M. M., Lamoreux, M. L., Wilson, B. D., and Barsh, G. S. (1998) Genes Dev. 12, 316-330
14. Ollmann, M. M., Wilson, B. D., Yang, Y. K., Kerns, J. A., Chen, Y., Gantz, I., and Barsh, G. S. (1997) Science 278, 135-138
15. Chai, B. X., Neubig, R. R., Millhauser, G. L., Thompson, D. A., Jackson, P. J., Barsh, G. S., Dickinson, C. J., Li, J. Y., Lai, Y. M., and Gantz, I. (2003) Peptides 24, 603-609
16. Millar, S. E., Miller, M. W., Stevens, M. E., and Barsh, G. S. (1995) Development 121, 3223-3232
17. Michaud, E. J., Bultman, S. J., Stubbs, L. J., and Woychik, R. P. (1993) Genes Dev. 7, 1203-1213
18. Miller, M. W., Duhl, D. M., Vrieling, H., Cordes, S. P., Ollmann, M. M., Winkes, B. M., and Barsh, G. S. (1993) Genes Dev. 7, 454-467
19. Lane, P. M. (1960) Mouse News Lett. 22, 35
20. Lane, P. W., and Green, M. C. (1960) J. Hered. 51, 228-230
21. Miller, K. A., Gunn, T. M., Carrasquillo, M. M., Lamoreux, M. L., Galbraith, D. B., and Barsh, G. S. (1997) Genetics 146, 1407-1415
22. Phan, L. K., Lin, F., LeDuc, C. A., Chung, W. K., and Leibel, R. L. (2002) J. Clin. Invest. 110, 1449-1459
23. Gunn, T. M., Miller, K. A., He, L., Hyman, R. W., Davis, R. W., Azarani, A., Schlossman, S. F., Duke-Cohan, J. S., and Barsh, G. S. (1999) Nature 398, 152-156
24. Nagle, D. L., McGrail, S. H., Vitale, J., Woolf, E. A., Dussault, B. J., Jr., DiRocco, L., Holmgren, L., Montagno, J., Bork, P., Huszar, D., Fairchild-Huntress, V., Ge, P., Keilty, J., Ebeling, C., Baldini, L., Gilchrist, J., Burn, P., Carlson, G. A., and Moore, K. J. (1999) Nature 398, 148-152
25. Duke-Cohan, J. S., Kim, J. H., and Azouz, A. (2004) J. Environ. Pathol. Toxicol. Oncol. 23, 1-11
26. He, L., Gunn, T. M., Bouley, D. M., Lu, X. Y., Watson, S. J., Schlossman, S. F., Duke-Cohan, J. S., and Barsh, G. S. (2001) Nat. Genet. 27, 40-47
27. He, L., Lu, X. Y., Jolly, A. F., Eldridge, A. G., Watson, S. J., Jackson, P. K., Barsh, G. S., and Gunn, T. M. (2003) Science 299, 710-712
28. Jiao, J., Sun, K., Walker, W. P., Bagher, P., Cota, C. D., and Gunn, T. M. (2009) Biochim. Biophys. Acta 1792, 1027-1035
29. Kim, B. Y., Olzmann, J. A., Barsh, G. S., Chin, L. S., and Li, L. (2007) Mol. Biol. Cell 18, 1129-1142
30. Lee, H. H., Elia, N., Ghirlando, R., Lippincott-Schwartz, J., and Hurley, J. H. (2008) Science 322, 576-580
31. Li, M., Brooks, C. L., Wu-Baer, F., Chen, D., Baer, R., and Gu, W. (2003) Science 302, 1972-1975
32. Lubrano-Berthelier, C., Durand, E., Dubern, B., Shapiro, A., Dazin, P., Weill, J., Ferron, C., Froguel, P., and Vaisse, C. (2003) Hum. Mol. Genet. 12, 145-153
33. Mohammad, S., Baldini, G., Granell, S., Narducci, P., Martelli, A. M., and Baldini, G. (2007) J. Biol. Chem. 282, 4963-4974
34. Shinyama, H., Masuzaki, H., Fang, H., and Flier, J. S. (2003) Endocrinology 144, 1301-1314
35. Bagher, P., Jiao, J., Owen Smith, C., Cota, C. D., and Gunn, T. M. (2006) Pigment Cell Res. 19, 635-643
36. Chakrabarti, O., and Hegde, R. S. (2009) Cell 137, 1136-1147
37. Jiao, J., Kim, H. Y., Liu, R. R., Hogan, C. A., Sun, K., Tam, L. M., and Gunn, T. M. (2009) Genesis 47, 524-534
38. Ollmann, M. M., and Barsh, G. S. (1999) J. Biol. Chem. 274, 15837-15846
39. Gao, Z., Lei, D., Welch, J., Le, K., Lin, J., Leng, S., and Duhl, D. (2003) J. Pharmacol. Exp. Ther. 307, 870-877
40. Jackson, P. J., Douglas, N. R., Chai, B., Binkley, J., Sidow, A., Barsh, G. S., and Millhauser, G. L. (2006) Chem. Biol. 13, 1297-1305
41. Hida, T., Wakamatsu, K., Sviderskaya, E. V., Donkin, A. J., Montoliu, L., Lynn Lamoreux, M., Yu, B., Millhauser, G. L., Ito, S., Barsh, G. S., Jimbow, K., and Bennett, D. C. (2009) Pigment Cell Melanoma Res. 22, 623-634
42. Siegrist, W., Willard, D. H., Wilkison, W. O., and Eberle, A. N. (1996) Biochem. Biophys. Res. Commun. 218, 171-175
43. Barsh, G. S., He, L., and Gunn, T. M. (2002) J. Recept. Signal. Transduct. Res. 22, 63-77
44. Phan, L. K., Chung, W. K., and Leibel, R. L. (2006) Am. J. Physiol. Endocrinol. Metab. 291, E611-E620
45. Breit, A., Wolff, K., Kalwa, H., Jarry, H., Büch, T., and Gudermann, T. (2006) J. Biol. Chem. 281, 37447-37456
46. Pérez-Oliva, A. B., Olivares, C., Jiménez-Cervantes, C., and García-Borrón, J. C. (2009) J. Biol. Chem. 284, 31714-31725
47. Creemers, J. W., Pritchard, L. E., Gyte, A., Le Rouzic, P., Meulemans, S., Wardlaw, S. L., Zhu, X., Steiner, D. F., Davies, N., Armstrong, D., Lawrence, C. B., Luckman, S. M., Schmitz, C. A., Davies, R. A., Brennand, J. C., and White, A. (2006) Endocrinology 147, 1621-1631
48. Milligan, G., Bond, R. A., and Lee, M. (1995) Trends Pharmacol. Sci. 16, 10-13
49. Azouz, A., Gunn, T. M., and Duke-Cohan, J. S. (2007) Exp. Cell Res. 313, 761-771
50. Oshikawa, J., Toya, Y., Fujita, T., Egawa, M., Kawabe, J., Umemura, S., and Ishikawa, Y. (2003) Am. J. Physiol. Cell Physiol. 285, C567-C574
51. Rodal, S. K., Skretting, G., Garred, O., Vilhardt, F., van Deurs, B., and Sandvig, K. (1999) Mol. Biol. Cell 10, 961-974
52. Haqq, A. M., René, P., Kishi, T., Khong, K., Lee, C. E., Liu, H., Friedman, J. M., Elmquist, J. K., and Cone, R. D. (2003) Biochem. J. 376, 595-605
53. Walker, W. P., Aradhya, S., Hu, C. L., Shen, S., Zhang, W., Azarani, A., Lu, X., Barsh, G. S., and Gunn, T. M. (2007) Genesis 45, 744-756
54. Gunn, T. M., Inui, T., Kitada, K., Ito, S., Wakamatsu, K., He, L., Bouley, D. M., Serikawa, T., and Barsh, G. S. (2001) Genetics 158, 1683-1695
55. Paz, J., Yao, H., Lim, H. S., Lu, X. Y., and Zhang, W. (2007) Neurobiol. Aging 28, 1446-1456
56. Sun, K., Johnson, B. S., and Gunn, T. M. (2007) Neurobiol. Aging 28, 1840-1852
57. Cota, C. D., Bagher, P., Pelc, P., Smith, C. O., Bodner, C. R., and Gunn, T. M. (2006) Dev. Dyn. 235, 3438-3447
58. Duke-Cohan, J. S., Gu, J., McLaughlin, D. F., Xu, Y., Freeman, G. J., and Schlossman, S. F. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 11336-11341
59. Tao, Y. X. (2010) Endocr. Rev. 31, 506-543
60. Raiborg, C., Rusten, T. E., and Stenmark, H. (2003) Curr. Opin. Cell Biol. 15, 446-455
61. Candille, S. I., Kaelin, C. B., Cattanach, B. M., Yu, B., Thompson, D. A., Nix, M. A., Kerns, J. A., Schmutz, S. M., Millhauser, G. L., and Barsh, G. S. (2007) Science 318, 1418-1423
62. Farooqi, I. S., Keogh, J. M., Yeo, G. S., Lank, E. J., Cheetham, T., and O'Rahilly, S. (2003) N. Engl. J. Med. 348, 1085-1095