Mice with mutations in Mahogunin Ring Finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis

Developmental Dynamics

Volumn 235, Issue 12, 2006, Pages 3438-3447

  Cota, Christina D ^a   Bagher, Pooneh ^a   Pelc, Piotr ^a   Smith, C Owen ^a   Bodner, Christina R ^a   Gunn, Teresa M ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Congenital heart defects; Left right patterning; Lefty; Mahoganoid; Mahogunin Ring Finger 1; Nodal; Situs inversus

Indexed keywords

PROTEIN NODAL; UBIQUITIN PROTEIN LIGASE;

ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONGENITAL HEART MALFORMATION; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENETIC CODE; LETHALITY; MAHOGUNIN RING FINGER 1 GENE; MORTALITY; MOUSE; MOUSE MUTANT; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SITUS INVERSUS; UBIQUITINATION;

ANIMALS; BASE SEQUENCE; BODY PATTERNING; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART DEFECTS, CONGENITAL; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED C3H; MICE, MUTANT STRAINS; MUTATION; PREGNANCY; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 33845366979     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.20992     Document Type: Article

References (41)

1. Bagher P, Jiao J, Smith OC, Cota CD, Gunn TM. 2006. Characterization of Mahogunin Ring Finger 1 expression in mice. Pigment Cell Res 19. DOI: 10.1111/j.1600-0749.2006.00340.x
2. Bowers PN, Brueckner M, Yost HJ. 1996. The genetics of left-right development and heterotaxia. Semin Perinatol 20:577-588.
3. Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS, Robertson EJ. 2001. Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411:965-969.
4. Collignon J, Varlet I, Robertson EJ. 1996. Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381:155-158.
5. Ferencz C, Rubin JD, McCarter RJ, Brenner JI, Neill CA, Perry LW, Hepner SI, Downing JW. 1985. Congenital heart disease: prevalence at livebirth. The Baltimore-Washington Infant Study. Am J Epidemiol 121:31-36.
6. Freed MD. 2001. The pathology, pathophysiology, recognition, and treatment of congenital heart disease. In: Fuster V, Alexander RW, O'Rourke RA, editors. Hurst's the heart. NY: McGraw-Hill. p 1837-1905.
7. Gillette TG, Gonzalez F, Delahodde A, Johnston SA, Kodadek T. 2004. Physical and functional association of RNA polymerase II and the proteasome. Proc Natl Acad Sci U S A 101:5904-5909.
8. Haglund K, Di Fiore PP, Dikic I. 2003. Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci 28:598-603.
9. Hamada H, Meno C, Watanabe D, Saijoh Y. 2002. Establishment of vertebrate left-right asymmetry. Nat Rev Genet 3:103-113.
10. He L, Lu XY, Jolly AF, Eldridge AG, Watson SJ, Jackson PK, Barsh GS, Gunn TM. 2003. Spongiform degeneration in mahoganoid mutant mice. Science 299:710-712.
11. Kathiriya IS, Srivastava D. 2000. Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease. Am J Med Genet 97:271-279.
12. Kirby ML, Waldo KL. 1995. Neural crest and cardiovascular patterning. Circ Res 77:211-215.
13. Krebs LT, Iwai N, Nonaka S, Welsh IC, Lan Y, Jiang R, Saijoh Y, O'Brien TP, Hamada H, Gridley T. 2003. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev 17:1207-1212.
14. Lane PW. 1960. New mutants. Mouse News Letter 22:35.
15. Lowe LA, Supp DM, Sampath K, Yokoyama T, Wright CV, Potter SS, Overbeek P, Kuehn MR. 1996. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 381:158-161.
16. McGrath J, Somlo S, Makova S, Tian X, Brueckner M. 2003. Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell 114:61-73.
17. Meno C, Saijoh Y, Fujii H, Ikeda M, Yokoyama T, Yokoyama M, Toyoda Y, Hamada H. 1996. Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. Nature 381:151-155.
18. Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H. 1998. lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94:287-297.
19. Meno C, Takeuchi J, Sakuma R, Koshiba-Takeuchi K, Ohishi S, Saijoh Y, Miyazaki J, ten Dijke P, Ogura T, Hamada H. 2001. Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev Cell 1:127-138.
20. Mercola M. 2003. Left-right asymmetry: nodal points. J Cell Sci 116:3251-3257.
21. Miller KA, Gunn TM, Carrasquillo MM, Lamoreux ML, Galbraith DB, Barsh GS. 1997. Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics 146:1407-1415.
22. Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N. 1998. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95:829-837.
23. Nonaka S, Shiratori H, Saijoh Y, Hamada H. 2002. Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 418:96-99.
24. Okada Y, Takeda S, Tanaka Y, Belmonte JC, Hirokawa N. 2005. Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis determination. Cell 121:633-644.
25. Pennekamp P, Karcher C, Fischer A, Schweickert A, Skryabin B, Horst J, Blum M, Dworniczak B. 2002. The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol 12:938-943.
26. Phan LK, Lin F, LeDuc CA, Chung WK, Leibel RL. 2002. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest 110:1449-1459.
27. Phillips RJ. 1963. New mutant: non-agouti curly. Mouse News Letter 29:38.
28. Phillips RJ. 1971. Non-agouti curly (nc). Mouse News Letter 45:25.
29. Pickart CM. 2004. Back to the future with ubiquitin. Cell 116:181-190.
30. Ramsdell AF. 2005. Left-right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left-right axis determination. Dev Biol 288:1-20.
31. Raya A, Kawakami Y, Rodriguez-Esteban C, Buscher D, Koth CM, Itoh T, Morita M, Raya RM, Dubova I, Bessa JG, de la Pompa JL, Belmonte JC. 2003. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev 17:1213-1218.
32. Raya A, Kawakami Y, Rodriguez-Esteban C, Ibanes M, Rasskin-Gutman D, Rodriguez-Leon J, Buscher D, Feijo JA, Izpisua Belmonte JC. 2004. Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination. Nature 427:121-128.
33. Stang E, Johannessen LE, Knardal SL, Madshus IH. 2000. Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation. J Biol Chem 275:13940-13947.
34. Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE. 2003. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res 31:278-281.
35. Sun ZW, Allis CD. 2002. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418:104-108.
36. Sweet H, Davisson M. 1995. Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313). Mouse Genome 93:1030-1034.
37. Tanaka Y, Okada Y, Hirokawa N. 2005. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 435:172-177.
38. Walmsley R, Hishitani T, Sandor GG, Lim K, Duncan W, Tessier F, Farquharson DF, Potts JE. 2004. Diagnosis and outcome of dextrocardia diagnosed in the fetus. Am J Cardiol 94:141-143.
39. Welsh IC, O'Brien TP. 2000. Loss of late primitive streak mesoderm and interruption of left-right morhogenesis in the Ednrbs-1Acrg mutant mouse. Dev Biol 225:151-168.
40. Yamamoto M, Mine N, Mochida K, Sakai Y, Saijoh Y, Meno C, Hamada H. 2003. Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 130:1795-1804.
41. Yoshioka H, Meno C, Koshiba K, Sugihara M, Itoh H, Ishimaru Y, Inoue T, Ohuchi H, Semina EV, Murray JC, Hamada H, Noji S. 1998. Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 94:299-305.