Characterisation of [125I]-apamin binding sites in rat brain membranes and HEK293 cells transfected with SK channel subtypes

Neuropharmacology

Volumn 41, Issue 3, 2001, Pages 341-350

  Finlayson, K ^a   McLuckie, J ^a   Hern, J ^a   Aramori, I ^b   Olverman, H J ^a   Kelly, J S ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

125I apamin binding; Neuropharmacology; Rat brain; SK1 SK3; Small conductance Ca2+ activated K+ (SK) channels

Indexed keywords

4 AMINOPYRIDINE; APAMIN; BICUCULLINE; DEQUALINIUM; GALLAMINE; IODINE 125; LINOPIRDINE; PANCURONIUM; POTASSIUM CHANNEL; POTASSIUM ION; TETRYLAMMONIUM; TUBOCURARINE CHLORIDE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN TISSUE; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APAMIN; BINDING SITES; BRAIN CHEMISTRY; CELL LINE; CEREBRAL CORTEX; HIPPOCAMPUS; HUMANS; IODINE RADIOISOTOPES; KINETICS; MALE; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034888066     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00067-3     Document Type: Article

References (40)

1. + channel
2. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: A candidate for schizophrenia and bipolar disorder?
3. 50) of an enzymatic reaction
4. Effects of apamin, quinine and neuromuscular blockers on calcium-activated potassium channels in guinea-pig hepatocytes
5. + channels by gallamine and novel bis-quaternary quinolinium cyclophane, UCL 1530
6. Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds
7. Detection of adenosine receptor antagonists in rat brain using a modified radioreceptor assay
8. + channel blockers: Investigation into the role of the substituent at position 4 of the quinoline ring
9. Ca channel blockers: Synthesis, pharmacological testing, and radioligand binding studies on mono-, bis-, and tris-quinolinium compounds
10. Neuromuscular blocking agents inhibit receptor-mediated increases in the potassium permeability of intestinal smooth muscle
11. 125I]iodoglyburide in the rat brain
12. + channels
13. 125I]-apamin binding sites in rat brain tissue with three small conductance calcium activated potassium (SK) channel subtypes
14. Cloning of an SK channel from rat sympathetic neurones
15. Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes
16. 125I]apamin binding sites in Alzheimer hippocampus: A quantitative autoradiographic study
17. Determinants of apamin and d-tubocurarine block in SK potassium channels
18. + channels in the human leukemic T cell line, Jurkat
19. hSK4, a member of a novel subfamily of calcium-activated potassium channels
20. 2+-activated potassium channels
21. Bicuculline block of small-conductance calcium-activated potassium channels
22. Small-conductance, calcium-activated potassium channels from mammalian brain
23. Modulation of spontaneous and stimulation-evoked transmitter release from rat sympathetic neurons by the cognition enhancer linopirdine: Insights into its mechanisms of action
24. + channels in a pituitary cell line
25. 2+ channels in hippocampal neurons
26. + channels in cultured rat adrenal chromaffin cells
27. AHP by a phosphatase-kinase balance under basal conditions in rat CA1 pyramidal neurons
28. + currents in neurones: Types, physiological roles and modulation
29. 3H]5-hydroxytryptamine in rat hippocampal slices
30. Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons
31. Recent advances in the pharmacology of quaternary salts of bicuculline
32. + channels expressed in mammalian cell lines
33. + current in hippocampal pyramidal neurons
34. + channel subunits, SK1, SK2 and SK3, in the adult rat central nervous system
35. + channels stably expressed in HEK 293 cells
36. Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: Role of the cytoplasmic halves of the fifth and sixth transmembrane segments
37. Calcium-activated potassium channels
38. + channels
39. 2+-activated potassium channels
40. Mechanism of calcium gating in small-conductance calcium-activated potassium channels