Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans

Toxicology and Applied Pharmacology

Volumn 253, Issue 3, 2011, Pages 203-234

  Chiu, Weihsueh A ^a   Ginsberg, Gary L ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b CDC   (United States)

Author keywords

Glutathione conjugation; Metabolism; Oxidation; Physiologically based pharmacokinetic (PBPK) model; Risk assessment; Tetrachloroethylene; Trichloroethylene; Uncertainty; Variability

Indexed keywords

DICHLOROACETIC ACID; TETRACHLOROETHYLENE; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

AEROBIC METABOLISM; ARTICLE; BAYES THEOREM; CALIBRATION; CONTROLLED STUDY; FEMALE; GLUTATHIONE METABOLISM; HUMAN; MALE; MONTE CARLO METHOD; MOUSE; NONHUMAN; OXIDATION; RAT; TOXICOKINETICS; URINARY EXCRETION;

ANIMALS; BAYES THEOREM; FEMALE; GLUTATHIONE; HUMANS; MALE; MICE; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; RATS; SPECIES SPECIFICITY; TETRACHLOROETHYLENE;

MUS; RATTUS;

EID: 79956315889     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.03.020     Document Type: Article

References (107)

1. Abbas R., Fisher J.W. A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice. Toxicol. Appl. Pharmacol. 1997, 147:15-30.
2. Altmann L., Neuhann H.F., Kramer U., Witten J., Jermann E. Neurobehavioral and neurophysiological outcome of chronic low-level tetrachloroethene exposure measured in neighborhoods of dry cleaning shops. Environ. Res. 1995, 69:83-89.
3. Anders M.W., Lash L., Dekant W., Elfarra A.A., Dohn D. Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. Crit. Rev. Toxicol. 1988, 18:311-341.
4. Barter Z.E., Bayliss M.K., Beaune P.H., Boobis A.R., Carlile D.J., Edwards R.J., Houston J.B., Lake B.G., Lipscomb J.C., Pelkonen O.R., Tucker G.T., Rostami-Hodjegan A. Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver. Curr. Drug Metab. 2007, 8(1):33-45.
5. Belisle C.J.P. Convergence theorems for a class of simulated annealing algorithms on Rd. J. Appl. Prob. 1992, 29:885-895.
6. Bois F.Y., Zeise L., Tozer T.N. Precision and sensitivity of pharmacokinetic models for cancer risk assessment: tetrachloroethylene in mice, rats, and humans. Toxicol. Appl. Pharmacol. 1990, 102:300-315.
7. Bois F.Y., Gelman A., Jiang J., Maszle D.R., Zeise L., Alexeef G. Population toxicokinetics of tetrachloroethylene. Arch. Toxicol. 1996, 70:347-355.
8. Bong M., Laskowska-Klita T., Szymczyk T. Effect of the benzene fraction of petroleum on protein content in rat liver and kidney. Bull. Environ. Contam. Toxicol. 1985, 34(1):45-54.
9. Boyes W.K., Bercegeay M., Oshiro W.M., Krantz Q.T., Kenyon E.M., Bushnell P.J., Benignus V.A. Acute perchloroethylene exposure alters rat visual-evoked potentials in relation to brain concentrations. Toxicol. Sci. 2009, 108:159-172.
10. Brodkin C.A., Daniell W., Checkoway H., Echeverria D., Johnson J., Wang K., Sohaey R., Green D., Redlich C., Gretch D., Rosenstock L. Hepatic ultrasonic changes in workers exposed to perchloroethylene. Occup. Environ. Med. 1995, 52:679-685.
11. Brown R.P., Delp M.D., Lindstedt S.L., Rhomberg L.R., Beliles R.P. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 1997, 13:407-484.
12. Buben J.A., O'Flaherty E.J. Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study. Toxicol. Appl. Pharmacol. 1985, 78:105-122.
13. Bushnell P.J., Shafer T.J., Bale A.S., Boyes W.K., Simmons J.E., Eklund C., Jackson T.L. Developing an exposure dose response model for organic solvents: overview and progress on in vitro models and dosimetry. Environ. Toxicol. Pharmacol. 2005, 19:607-614.
14. Calvert G.M., Ruder A.M., Petersen M.R. Mortality and end-stage renal disease incidence among dry leaning workers. Occup. Environ. Med 2010, 10.1136/oem.2010.060665.
15. Chen C., Blancato J. Role of pharmacokinetic modeling in risk assessment: perchloroethylene as an example. Pharmacokinetics in Risk Assessment: Drinking Water and Health 1987, 369-390. National Academy Press, Washington, DC.
16. Chien, Y.C., 1997. The influences of exposure pattern and duration on elimination kinetics and exposure assessment of tetrachloroethylene in humans. PhD thesis, Rutgers University, New Brunswick, NJ.
17. Chiu W.A. Statistical issues in physiologically based pharmacokinetic modeling. Toxicokinetics and Risk Assessment 2007, Informa Healthcare, New York. J.C. Lipscomb, E.V. Ohanian (Eds.).
18. Chiu, W.A., in press. Trichloroacetic acid: updated estimates of its bioavailability and its contribution to trichloroethylene-induced mouse hepatomegaly. Toxicology. http://doi:10.1016/j.tox.2011.04.009.
19. Chiu W.A., Bois F.Y. Revisiting the population toxicokinetics of tetrachloroethylene. Arch. Toxicol. 2006, 80:382-385.
20. Chiu W.A., White P. Steady-state solutions to PBPK models and their applications to risk assessment I: route-to-route extrapolation of volatile chemicals. Risk Anal. 2006, 26(3):769-780.
21. Chiu W.A., Micallef S., Monster A.C., Bois F.Y. Toxicokinetics of inhaled trichloroethylene and tetrachloroethylene in humans at 1ppm: empirical results and comparisons with previous studies. Toxicol. Sci. 2007, 95:23-36.
22. Chiu W.A., Okino M.S., Evans M.V. Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach. Toxicol. Appl. Pharmacol. 2009, 241:36-60.
23. Clewell H.J., Gentry P.R., Kester J.E., Andersen M.E. Evaluation of physiologically based pharmacokinetic models in risk assessment: an example with perchloroethylene. Crit. Rev. Toxicol. 2005, 35:413-433.
24. Costa A.K., Ivanetich K.M. Tetrachloroethylene metabolism by the hepatic microsomal cytochrome P-450 system. Biochem. Pharmacol. 1980, 29:2863-2869.
25. Costa A.K., Ivanetich K.M. Chlorinated ethylenes: their metabolism and effect on DNA repair in rat hepatocytes. Carcinogenesis 1984, 5:1629-1636.
26. Covington T.R., Robinan Gentry P., Van Landingham C.B., Andersen M.E., Kester J.E., Clewell H.J. The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene. Regul. Toxicol. Pharmacol. 2007, 47:1-18.
27. Dallas C.E., Chen X.M., O'Barr K., Muralidhara S., Varkonyi P., Bruckner J.V. Development of a physiologically based pharmacokinetic model for perchloroethylene using tissue concentration-time data. Toxicol. Appl. Pharmacol. 1994, 128:50-59.
28. Dallas C.E., Muralidhara S., Chen X.M., Ramanathan R., Varkonyi P., Gallo J.M., Bruckner J.V. Use of a physiologically based model to predict systemic uptake and respiratory elimination of perchloroethylene. Toxicol. Appl. Pharmacol. 1994, 128:60-68. 10.1006/taap. 1994.1180.
29. Dallas C.E., Chen X.M., Muralidhara S., Varkonyi P., Tackett R.L., Bruckner J.V. Use of tissue disposition data from rats and dogs to determine species differences in input parameters for a physiological model for perchloroethylene. Environ. Res. 1994, 67:54-67.
30. Dallas C.E., Chen X.M., Muralidhara S., Varkonyi P., Tackett R.L., Bruckner J.V. Physiologically based pharmacokinetic model useful in prediction of the influence of species, dose, and exposure route on perchloroethylene pharmacokinetics. J. Toxicol. Environ. Health 1995, 44:301-317.
31. DeAngelo A.B., George M.H., House D.E. Hepatocarcinogenicity in the male B6C3F1 mouse following a lifetime exposure to dichloroacetic acid in the drinking water: dose-response determination and modes of action. J. Toxicol. Environ. Health A 1999, 58:485-507.
32. DeAngelo A.B., Daniel F.B., Wong D.M., George M.H. The induction of hepatocellular neoplasia by trichloroacetic acid administered in the drinking water of the male B6C3F1 mouse. J. Toxicol. Environ. Health A 2008, 71:1056-1068.
33. Dekant W. Toxicological review of trichloroethylene in support of the IRIS database (Draft of October 2009): comments of Prof. W. Dekant. submitted as part of Comments of the Halogenated Solvents Industry Alliance, Inc. 2010, url: http://www.regulations.gov/search/Regs/home.html#documentDetail?R=0900006480a8dd76.
34. Dekant W., Birner G., Werner M., Parker J. Glutathione conjugation of perchloroethene in subcellular fractions from rodent and human liver and kidney. Chem. Biol. Interact. 1998, 116(1-2):31-43.
35. Doherty A.T., Ellard S., Parry E.M., Parry J.M. An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells. Mutagenesis 1996, 11:247-274.
36. Echeverria D., White R.F., Sampaio C. A behavioral evaluation of PCE exposure in patients and dry cleaners: a possible relationship between clinical and preclinical effects. J. Occup. Environ. Med. 1995, 37:667-680.
37. Evans M.V., Chiu W.A., Okino M.S., Caldwell J.C. Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly. Toxicol. Appl. Pharmacol. 2009, 236:329-340.
38. Fernandez J., Guberan E., Caperos J. Experimental human exposures to tetrachloroethylene vapor and elimination in breath after inhalation. Am. Ind. Hyg. Assoc. J. 1976, 37:143-150.
39. Ferroni C., Selis L., Mutti A., Folli D., Bergamaschi E., Franchini I. Neurobehavioral and neuroendocrine effects of occupational exposure to perchloroethylene. Neurotoxicology 1992, 13:243-247.
40. Fisher J., Mahle D., Bankston L., Greene R., Gearhart J. Lactational transfer of volatile chemicals in breast milk. Am. Ind. Hyg. Assoc. J. 1997, 58(6):425-431.
41. Fisher J.W., Mahle D., Abbas R. A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol. Toxicol. Appl. Pharmacol. 1998, 152:339-359.
42. Franz S.W., Watanabe P.G. Tetrachloroethylene: balance and tissue distribution in male Sprague-Dawley rats by drinking-water administration. Toxicol. Appl. Pharmacol. 1983, 69:66-72.
43. Gargas, M.L. (1988). Tissue Solubilities and Biotransformation Rates of Halocarbons: Experimental Determinations and Quantitative Modeling. A dissertation submitted to Wright State University, Dayton, OH.
44. Gargas M.L., Burgess R.J., Voisard D.E., Cason G.H., Andersen M.E. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 1989, 98:87-99.
45. Gearhart J.M., Mahle D.A., Greene R.J., Seckel C.S., Flemming C.D., Fisher J.W., Clewell H.J. Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE). Toxicol. Lett. 1993, 68:131-144.
46. Gennari P., Naldi M., Motta R., Nucci M.C., Giacomini C., Violante F.S., Raffi G.B. gamma-Glutamyltransferase isoenzyme pattern in workers exposed to tetrachloroethylene. Am. J. Ind. Med. 1992, 21:661-671.
47. Ginsberg G., Smolenski S., Hattis D., Guyton K.Z., Johns D.O., Sonawane B. Genetic polymorphism in glutathione transferases (GST): population distribution of GSTM1, T1, and P1 conjugating activity. J. Toxicol. Environ. Health B Crit. Rev. 2009, 12:389-439.
48. Ginsberg G., Smolenski S., Neafsey P., Hattis D., Walker K., Guyton K.Z., Johns D.O., Sonawane B. The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes. J. Toxicol. Environ. Health B Crit. Rev. 2009, 12:307-333.
49. Green T. Perchloroethylene Induced Mouse Liver Tumours: Mode of Action Studies 2003, Central Toxicology Laboratory, Alderley Park Macclesfield, Cheshire, UK, Document number CTL/024741/RES/REPT-001, August 6, 2003.
50. Green T., Odum J., Nash J.A., Foster J.R. Perchloroethylene-induced rat kidney tumors: an investigation of the mechanisms involved and their relevance to humans. Toxicol. Appl. Pharmacol. 1990, 103(1):77-89.
51. Green T., Mainwaring G.W., Foster J.R. Trichloroethylene-induced mouse lung tumors: studies of the mode of action and comparisons between species. Fundam. Appl. Toxicol. 1997, 37:125-130.
52. Hack C.E., Chiu W.A., Jay Zhao Q., Clewell H.J. Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites. Regul. Toxicol. Pharmacol. 2006, 46:63-83.
53. Hake C.L., Stewart R.D. Human exposure to tetrachloroethylene: inhalation and skin contact. Environ. Health Perspect. 1977, 21:231-238.
54. Hejtmancik M.R., Trela B.A., Kurtz P.J., Persing R.L., Ryan M.J., Yarrington J.T., Chhabra R.S. Comparative gavage subchronic toxicity studies of o-chloroaniline and m-chloroaniline in F344 rats and B6C3F1 mice. Toxicol. Sci. 2002, 69:234-243.
55. Ikeda M., Ohtsuji H. A comparative study of the excretion of Fujiwara reaction-positive substances in urine of humans and rodents given trichloro-or tetrachloro-derivatives of ethane and ethylene. Br. J. Ind. Med. 1972, 29:99-104.
56. Ikeda M., Ohtsuji H., Imamura T., Komoike Y. Urinary excretion of total trichloro-compounds, trichloroethanol, and trichloroacetic acid as a measure of exposure to trichloroethylene and tetrachloroethylene. Br. J. Ind. Med. 1972, 29:328-333.
57. International Commission on Radiological Protection (ICRP) Basic anatomical and physiological data for use in radiological protection:reference values. Ann ICRP 2002, 32:5-265. ICRP Publication 89.
58. Japan Industrial Safety Association (JISA) Carcinogenicity Study of Tetrachloroethylene by Inhalation in Rats and Mice 1993, Japan Industrial Safety Association, Hadano, Japan.
59. Johanson G., Filser J.G. Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation. Arch. Toxicol. 1992, 66:291-295.
60. Juronen E., Tasa G., Uuskula M., Pooga M., Mikelaar A.V. Purification, characterization and tissue distribution of human class theta glutathione S-transferase S-transferse T1-1. Biochem. Mol. Biol. Int. 1996, 39:21-29.
61. Koizumi A. Potential of physiologically based pharmacokinetics to amalgamate kinetic data of trichloroethylene and tetrachloroethylene obtained in rats and man. Br. J. Ind. Med. 1989, 46:239-249.
62. Krause R.J., Lash L.H., Elfarra A.A. Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity. J. Pharmacol. Exp. Ther. 2003, 304:185-191.
63. Lash L.H., Parker J.C. Hepatic and renal toxicities associated with perchloroethylene. Pharmacol. Rev. 2001, 53:177-208.
64. Lash L.H., Qian W., Putt D.A., Desai K., Elfarra A.A., Sicuri A.R., Parker J.C. Glutathione conjugation of perchloroethylene in rats and mice in vitro: sex-, species-, and tissue-dependent differences. Toxicol. Appl. Pharmacol. 1998, 150:49-57.
65. Lash L.H., Lipscomb J.C., Putt D.C., Parker J.C. Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation. Drug Metab. Dispos. 1999, 27:351-359.
66. Lash L.H., Fisher J.W., Lipscomb J.C., Parker J.C. Metabolism of trichloroethylene. Environ. Health Perspect. 2000, 108(Suppl. 2):177-200.
67. Lash L.H., Putt D.A., Huang P., Hueni S.E., Parker J.C. Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione. Toxicology 2007, 235:11-26.
68. Lin J.H. Species similarities and differences in pharmacokinetics. Drug Metab. Dispos. 1995, 23:1008-1021.
69. Lipscomb J.C., Fisher J.W., Confer P.D., Byczkowski J.Z. In vitro to in vivo extrapolation for trichloroethylene metabolism in humans. Toxicol. Appl. Pharmacol. 1998, 152:376-387.
70. Lumpkin M.H., Bruckner J.V., Campbell J.L., Dallas C.E., White C.A., Fisher J.W. Plasma binding of trichloroacetic acid in mice, rats, and humans under cancer bioassay and environmental exposure conditions. Drug Metab. Dispos. 2003, 31:1203-1207.
71. Mahle D.A., Gearhart J.M., Grigsby C.C., Mattie D.R., Barton H.A., Lipscomb J.C., Cook R.S. Age-dependent partition coefficients for a mixture of volatile organic solvents in Sprague-Dawley rats and humans. J. Toxicol. Environ. Health A 2007, 70(20):1745-1751.
72. Mattie D.R., Bates G.D., Jepson G.W., Fisher J.W., McDougal J.N. Determinants of skin:air partition coefficients for volatile chemicals: experimental method and applications. Fundam. Appl. Toxicol. 1994, 22:51-57.
73. Monster A.C., Boersma G., Steenweg H. Kinetics of tetrachloroethylene in volunteers; influence of exposure concentration and work load. Int. Arch. Occup. Environ. Health 1979, 42:303-309.
74. Mutti A., Alinovi R., Bergamaschi E., Biagini C., Cavazzini S., Franchini I., Lauwerys R.R., Bernard A.M., Roels H., Gelpi E., Rosello J., Ramis I., Price R.G., Taylor S.A., De Broe M., Nuyts G.D., Stolte H., Fels L.M., Herbort C. Nephropathies and exposure to perchloroethylene in dry-cleaners. Lancet 1992, 340:189-193.
75. National Cancer Institute (NCI) Bioassay of tetrachloroethylene for possible carcinogenicity. DHEW Pub. (NIH) 77-813. Tech Rep Ser. 13 1977, National Toxicology Program, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA.
76. National Research Council (NRC) Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene 2010, National Academy Press, Washington, DC.
77. National Toxicology Program (NTP) NTP toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) (CAS No.127-18-4). 344/N rats and B6C3F1 mice. Tech Rep Ser 311 1986, National Toxicology Program, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA.
78. Nyengaard J.R., Flyvbjerg A., Rasch R. The impact of renal growth, regression and regrowth in experimental diabetes mellitus on number and size of proximal and distal tubular cells in the rat kidney. Diabetologia 1993, 36:1126-1131.
79. Odum J., Green T., Foster J.R., Hext P.M. The role of trichloracetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat. Toxicol. Appl. Pharmacol. 1988, 92:103-112.
80. Ohtsuki T., Sato K., Koizumi A., Kumai M., Ikeda M. Limited capacity of humans to metabolize tetrachloroethylene. Int. Arch. Occup. Environ. Health 1983, 51:381-390.
81. Pegg D.G., Zempel J.A., Braun W.H., Watanabe P.G. Disposition of tetrachloro(14C)ethylene following oral and inhalation exposure in rats. Toxicol. Appl. Pharmacol. 1979, 51:465-474.
82. Pereira M.A. Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice. Fundam. Appl. Toxicol. 1996, 31:192-199.
83. Philip B.K., Mumtaz M.M., Latendresse J.R., Mehendale H.M. Impact of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice. Toxicology 2007, 232:1-14.
84. Qiu J., Chien Y.C., Bruckner J.V., Fisher J.W. Bayesian analysis of a physiologically based pharmacokinetic model for perchloroethylene in humans. J. Toxicol. Environ. Health A 2010, 73(1):74-91.
85. Rao H.V., Brown D.R. A physiologically based pharmacokinetic assessment of tetrachloroethylene in groundwater for a bathing and showering determination. Risk Anal. 1993, 13:37-49.
86. Reitz R.H., Gargas M.L., Mendrala A.L., Schumann A.M. In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans. Toxicol. Appl. Pharmacol. 1996, 136:289-306.
87. Sarangapani R., Gentry P.R., Covington T.R., Teeguarden J.G., Clewell H.J. Evaluation of the potential impact of age- and gender-specific lung morphology and ventilation rate on the dosimetry of vapors. Inhal. Toxicol. 2003, 15:987-1016.
88. Sato A., Nakajima T. Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil. Br. J. Ind. Med. 1979, 36:231-234.
89. Savolainen H., Pfaffli P., Tengen M., Vainio H. Biochemical and behavioural effects of inhalation exposure to tetrachlorethylene and dichlormethane. J. Neuropathol. Exp. Neurol. 1977, 36:941-949.
90. Schreiber J.S., Hudnell H.K., Geller A.M., House D.E., Aldous K.M., Force M.S., Langguth K., Prohonic E.J., Parker J.C. Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity. Environ. Health Perspect. 2002, 110:655-664.
91. Schultz I.R., Merdink J.L., Gonzalez-Leon A., Bull R.J. Comparative toxicokinetics of chlorinated and brominated haloacetates in F344 rats. Toxicol. Appl. Pharmacol. 1999, 158:103-114.
92. Schumann A.M., Quast J.F., Watanabe P.G. The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats. Toxicol. Appl. Pharmacol. 1980, 55:207-219.
93. Seeber A. Neurobehavioral toxicity of long-term exposure to tetrachloroethylene. Neurotoxicol. Teratol. 1989, 11:579-583.
94. Sohlenius-Sternbeck A.K. Determination of the hepatocellularity number for human, dog, rabbit, rat and mouse livers from protein concentration measurements. Toxicol. In Vitro 2006, 20(8):1582-1586.
95. Stewart R.D., Gay H.H., Erley D.S., Hake C.L., Schaffer A.W. Human exposure to tetrachloroethylene vapor. Arch. Environ. Health 1961, 2:516-522.
96. Stewart R.D., Baretta E.D., Dodd H.C., Torkelson T.R. Experimental human exposure to tetrachloroethylene. Arch. Environ. Health 1970, 20(2):225-229.
97. Sweeney L.M., Kirman C.R., Gargas M.L., Dugard P.H. Contribution of trichloroacetic acid to liver tumors observed in perchloroethylene (perc)-exposed mice. Toxicology 2009, 260:77-83.
98. Templin M.V., Parker J.C., Bull R.J. Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice. Toxicol. Appl. Pharmacol. 1993, 123:1-8.
99. Templin M.V., Stevens D.K., Stenner R.D., Bonate P.L., Tuman D., Bull R.J. Factors affecting species differences in the kinetics of metabolites of trichloroethylene. J. Toxicol. Environ. Health 1995, 44:435-447.
100. Volkel W., Friedewald M., Lederer E., Pahler A., Parker J., Dekant W. Biotransformation of perchloroethene: dose-dependent excretion of trichloroacetic acid, dichloroacetic acid, and N-acetyl-S-(trichlorovinyl)-l-cysteine in rats and humans after inhalation. Toxicol. Appl. Pharmacol. 1998, 153:20-27.
101. Walker K., Ginsberg G., Hattis D., Johns D.O., Guyton K.Z., Sonawane B. Genetic polymorphism in N-Acetyltransferase (NAT): population distribution of NAT1 and NAT2 activity. J. Toxicol. Environ. Health B Crit. Rev. 2009, 12:440-472.
102. Ward R.C., Travis C.C., Hetrick D.M., Andersen M.E., Gargas M.L. Pharmacokinetics of tetrachloroethylene. Toxicol. Appl. Pharmacol. 1988, 93:108-117.
103. Warren D.A., Reigle T.G., Muralidhara S., Dallas C.E. Schedule-controlled operant behavior of rats following oral administration of perchloroethylene: time course and relationship to blood and brain solvent levels. J. Toxicol. Environ. Health 1996, 47:345-362.
104. Werner M., Birner G., Dekant W. Sulfoxidation of mercapturic acids derived from tri- and tetrachloroethene by cytochromes P450 3A: a bioactivation reaction in addition to deacetylation and cysteine conjugate beta-lyase mediated cleavage. Chem. Res. Toxicol. 1996, 9:41-49.
105. Wheeler J.B., Stourman N.V., Their R., Dommermuth A., Vuilleumier S., Rose J.A., Armstrong R.N., Guengerich F.P. Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and dihalomethanes. Chem. Res. Toxicol. 2001, 14:1118-11127.
106. Yoshioka T., Krauser J.A., Guengerich F.P. Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine. Chem. Res. Toxicol. 2002, 15:1096-1105.
107. Yu K.O., Barton H.A., Mahle D.A., Frazier J.M. In vivo kinetics of trichloroacetate in male Fischer 344 rats. Toxicol. Sci. 2000, 54:302-311.