Steady-state solutions to PBPK models and their applications to risk assessment I: Route-to-route extrapolation of volatile chemicals

Risk Analysis

Volumn 26, Issue 3, 2006, Pages 769-780

  Chiu, Weihsueh A ^a   White, Paul ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Physiologically based pharmacokinetic model; Risk assessment; Route to route extrapolation; Toxicokinetics

Indexed keywords

DATA REDUCTION; DOSIMETRY; EXTRAPOLATION; MATHEMATICAL MODELS; METABOLISM; PROBLEM SOLVING;

INTRASPECIES VARIABILITY; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS; ROUTE-TO-ROUTE EXTRAPOLATION; TOXICOKINETICS;

RISK ASSESSMENT;

VINYL CHLORIDE; VOLATILE AGENT;

CHEMICAL SUBSTANCE BY USE OR EFFECT; KINETICS; RISK ASSESSMENT; VOLATILE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; DOSE RESPONSE; DOSIMETRY; DRUG ADMINISTRATION ROUTE; DRUG CLEARANCE; DRUG EXPOSURE; EXHALATION; FEEDING; HUMAN; IN VIVO STUDY; INHALATION; LIVER BLOOD FLOW; LIVER METABOLISM; LUNG VENTILATION; METABOLIC RATE; MODEL; NONHUMAN; PARTITION COEFFICIENT; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL; RAT; REPRODUCIBILITY; RISK ASSESSMENT; SPECIES DIFFERENCE; STEADY STATE; TOXICOKINETICS;

AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; LIVER; MODELS, CHEMICAL; MODELS, STATISTICAL; MODELS, THEORETICAL; PHARMACEUTICAL PREPARATIONS; RISK; RISK ASSESSMENT; TISSUE DISTRIBUTION; VINYL CHLORIDE;

EID: 33745340354     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2006.00762.x     Document Type: Article

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