Structures of the bacterial ribosome in classical and hybrid states of tRNA binding

Science

Volumn 332, Issue 6032, 2011, Pages 981-984

  Dunkle, Jack A ^a   Wang, Leyi ^b   Feldman, Michael B ^b,c   Pulk, Arto ^a   Chen, Vincent B ^d   Kapral, Gary J ^d   Noeske, Jonas ^a   Richardson, Jane S ^d   Blanchard, Scott C ^b   Cate, Jamie H Doudna ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; CAPREOMYCIN; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; RIBOSOME RECYCLING FACTOR; RNA 16S; TRANSFER RNA; VIOMYCIN;

CHEMICAL BINDING; COLIFORM BACTERIUM; CRYSTALLOGRAPHY; HYBRID; MITOCHONDRIAL DNA; TRANSLOCATION; X-RAY SPECTROSCOPY;

ANTICODON; ARTICLE; BACTERIAL CELL; BACTERIAL RIBOSOME; BINDING KINETICS; BINDING SITE; CELL STRUCTURE; CONFORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ESCHERICHIA COLI; HYBRID; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RIBOSOME; RIBOSOME SUBUNIT; RNA BINDING; RNA TRANSCRIPTION; STRUCTURE ANALYSIS; THERMUS THERMOPHILUS; X RAY CRYSTALLOGRAPHY;

ANTICODON; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEINS; RIBOSOME SUBUNITS, LARGE, BACTERIAL; RIBOSOME SUBUNITS, SMALL, BACTERIAL; RNA, BACTERIAL; RNA, MESSENGER; RNA, RIBOSOMAL, 16S; RNA, RIBOSOMAL, 23S; RNA, TRANSFER, AMINO ACYL; RNA, TRANSFER, PHE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 79956303529     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1202692     Document Type: Article

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52. 0). This work was funded by the National Institutes of Health (GM65050 to J.H.D.C., GM079238 to S.C.B, and GM074127-04S1, GM088674, and P01-GM63210 project IV to J.S.R.), National Cancer Institute grant CA92584 for the SIBYLS and 8.3.1 beam lines at the ALS, and National Center for Research Resources grant RR-15301 for the Northeastern Collaborative Access Team beam lines at 24-ID at APS, and by the U.S. Department of Energy (DE-AC03 76SF00098 for the SIBYLS and 8.3.1 beamlines at the ALS, and DE-AC02-06CH11357 for the APS). M.B.F. is a trainee in the Weill Cornell/Rockefeller University/Sloan- Kettering Tri-Institutional MD-PhD Program supported by NIH Medical Scientist Training Program grant GM07739. J.N. is supported by a Human Frontiers in Science Program Postdoctoral Fellowship.