DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2)

Journal of Biological Chemistry

Volumn 286, Issue 21, 2011, Pages 18938-18948

  Hansen, Jeffrey C ^a   Wexler, Brian B ^b,c   Rogers, Danielle J ^b   Hite, Kristopher C ^a   Panchenko, Tanya ^b   Ajith, Sandya ^b   Black, Ben E ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLETE EXCHANGE; CONFORMATIONAL FLEXIBILITY; DNA BINDING; DNA BINDING DOMAIN; FINE RESOLUTION; FULL-LENGTH PROTEINS; GLOBULAR PROTEINS; HYDROGEN/DEUTERIUM EXCHANGE; METHYL-CPG-BINDING; N-TERMINALS; ORDERS OF MAGNITUDE; POINT MUTATIONS; POLYPEPTIDE BACKBONES; POLYPEPTIDE CHAIN; RETT SYNDROME; TERTIARY STRUCTURES;

BELT DRIVES; MASS SPECTROMETRY; PROTEINS; STRUCTURAL DYNAMICS;

DNA;

AMINO TERMINAL TELOPEPTIDE; METHYL CPG BINDING PROTEIN 2;

ARTICLE; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; MOLECULAR DYNAMICS; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RETT SYNDROME;

AMINO ACID SUBSTITUTION; DNA; DNA METHYLATION; HUMANS; METHYL-CPG-BINDING PROTEIN 2; MUTATION, MISSENSE; PEPTIDE MAPPING; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STABILITY; RETT SYNDROME;

EID: 79956295425     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.234609     Document Type: Article

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