메뉴 건너뛰기




Volumn 65, Issue 2, 2011, Pages 344-352

Red ginseng deregulates hypoxia-induced genes by dissociating the HIF-1 dimer

Author keywords

Hypoxia; Hypoxia inducible factor 1; Red ginseng; Tumor

Indexed keywords

ANTINEOPLASTIC AGENT; DIMER; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RG 2; GINSENOSIDE RG 3; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; KOREAN RED GINSENG EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

EID: 79956290841     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-010-0504-8     Document Type: Article
Times cited : (13)

References (30)
  • 1
    • 2442521050 scopus 로고    scopus 로고
    • Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds
    • Yun TK, Lee YS, Lee YH, Kim SI, Yun HY (2001) Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. J Korean Med Sci 16:6-18
    • (2001) J Korean Med Sci , vol.16 , pp. 6-18
    • Yun, T.K.1    Lee, Y.S.2    Lee, Y.H.3    Kim, S.I.4    Yun, H.Y.5
  • 2
    • 37549015237 scopus 로고    scopus 로고
    • 2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia
    • DOI 10.1016/j.jep.2007.10.026, PII S0378874107005454
    • Zhang G, Liu A, Zhou Y, San X, Jin T, Jin Y (2008) Panax ginseng ginsenoside-Rg2 protects memory impairment via antiapoptosis in a rat model with vascular dementia. J Ethnopharmacol 115:441-448 (Pubitemid 50017508)
    • (2007) Journal of Ethnopharmacology , vol.115 , Issue.3 , pp. 441-448
    • Zhang, G.1    Liu, A.2    Zhou, Y.3    San, X.4    Jin, T.5    Jin, Y.6
  • 3
    • 59449090299 scopus 로고    scopus 로고
    • Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-γ, GLUT4 and LPL in ob/ob mice
    • Mollah ML, Kim GS, Moon HK, Chung SK, Cheon YP, Kim JK, Kim KS (2009) Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-γ, GLUT4 and LPL in ob/ob mice. Phytother Res 23:220-225
    • (2009) Phytother Res , vol.23 , pp. 220-225
    • Mollah, M.L.1    Kim, G.S.2    Moon, H.K.3    Chung, S.K.4    Cheon, Y.P.5    Kim, J.K.6    Kim, K.S.7
  • 4
    • 70349571741 scopus 로고    scopus 로고
    • Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage
    • Park BJ, Lim YS, Lee HJ, Eum WS, Park J, Han KH, Choi SY, Lee KS (2009) Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage. BMB Rep 42:500-505
    • (2009) BMB Rep , vol.42 , pp. 500-505
    • Park, B.J.1    Lim, Y.S.2    Lee, H.J.3    Eum, W.S.4    Park, J.5    Han, K.H.6    Choi, S.Y.7    Lee, K.S.8
  • 5
    • 33746080868 scopus 로고    scopus 로고
    • Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice
    • DOI 10.1038/sj.bjp.0706794, PII 0706794
    • Kimura Y, Sumiyoshi M, Kawahira K, Sakanaka M (2006) Effect of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice. Br J Pharmacol 148:860-870 (Pubitemid 44079416)
    • (2006) British Journal of Pharmacology , vol.148 , Issue.6 , pp. 860-870
    • Kimura, Y.1    Sumiyoshi, M.2    Kawahira, K.3    Sakanaka, M.4
  • 7
    • 0035653529 scopus 로고    scopus 로고
    • Chemistry and cancer preventing activities of Ginseng saponins and some related triterpenoid compounds
    • Shibata S (2001) Chemistry and cancer preventing activities of Ginseng saponins and some related triterpenoid compounds. J Korean Med Sci 16:28-37
    • (2001) J Korean Med Sci , vol.16 , pp. 28-37
    • Shibata, S.1
  • 8
    • 0029034101 scopus 로고
    • Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 pairs
    • Yun TK, Choi SY (1995) Preventive effect of ginseng intake against various human cancers: a case-control study on 1987 pairs. Cancer Epidemiol Biomarkers Prev 4:401-408
    • (1995) Cancer Epidemiol Biomarkers Prev , vol.4 , pp. 401-408
    • Yun, T.K.1    Choi, S.Y.2
  • 9
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47 (Pubitemid 37328806)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 11
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL (1995) Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 13
    • 0032538797 scopus 로고    scopus 로고
    • Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α
    • Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L (1998) Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J 17:6573-6586 (Pubitemid 28521792)
    • (1998) EMBO Journal , vol.17 , Issue.22 , pp. 6573-6586
    • Kallio, P.J.1    Okamoto, K.2    O'Brien, S.3    Carrero, P.4    Makino, Y.5    Tanaka, H.6    Poellinger, L.7
  • 14
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157:411-421 (Pubitemid 30626905)
    • (2000) American Journal of Pathology , vol.157 , Issue.2 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 16
    • 0035205085 scopus 로고    scopus 로고
    • A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses
    • Chun YS, Choi E, Yeo YJ, Lee JH, Kim MS, Park JW (2001) A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1- mediated hypoxic response. J Cell Sci 114:4051-4061 (Pubitemid 33115026)
    • (2001) Journal of Cell Science , vol.114 , Issue.22 , pp. 4051-4061
    • Chun, Y.-S.1    Choi, E.2    Yeo, E.-J.3    Lee, J.H.4    Kim, M.-S.5    Park, J.-W.6
  • 17
  • 19
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1- mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1- mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3:177-185
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 20
    • 58149102376 scopus 로고    scopus 로고
    • Current insights on the biology and clinical aspects of VEGF regulation
    • Birk DM, Barbato J, Mureebe L, Chaer RA (2008) Current insights on the biology and clinical aspects of VEGF regulation. Vasc Endovasc Surg 42:517-530
    • (2008) Vasc Endovasc Surg , vol.42 , pp. 517-530
    • Birk, D.M.1    Barbato, J.2    Mureebe, L.3    Chaer, R.A.4
  • 21
    • 33846013596 scopus 로고    scopus 로고
    • Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and β-catenin/T-cell factor-dependent pathway in human endothelial cells
    • DOI 10.1074/jbc.M606698200
    • Leung KW, Pon YL, Wong RN, Wong AS (2006) Ginsenoside- Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and β-catenin/T-cell factor-dependent pathway in human endothelial cells. J Biol Chem 47:36280-36288 (Pubitemid 46041363)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.47 , pp. 36280-36288
    • Kar, W.L.1    Yuen, L.P.2    Wong, R.N.S.3    Wong, A.S.T.4
  • 30
    • 69849086292 scopus 로고    scopus 로고
    • Effect of gensenoside Rg3 on apoptosis of Hep-2 and expression of HIF-1alpha in human laryngeal cancer cell line under anoxic conditions
    • Wang BS, Zhang LS, Song DM, Zhang JH, Liu YM (2009) Effect of gensenoside Rg3 on apoptosis of Hep-2 and expression of HIF-1alpha in human laryngeal cancer cell line under anoxic conditions. Zhong Yao Cai 32:102-106
    • (2009) Zhong Yao Cai , vol.32 , pp. 102-106
    • Wang, B.S.1    Zhang, L.S.2    Song, D.M.3    Zhang, J.H.4    Liu, Y.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.