Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1α

Cancer Research

Volumn 65, Issue 7, 2005, Pages 2520-2525

  Bae, Moon Kyoung ^a,b   Jeong, Joo Won ^a   Kim, Se Hee ^a   Kim, Soo Young ^a   Hye, Jin Kang ^a   Kim, Dong Min ^a   Bae, Soo Kyung ^c   Yun, Il ^b   Trentin, Grace A ^d   Rozakis Adcock, Maria ^d   Kim, Kyu Won ^a  

^a Seoul National University   (South Korea)

^b Pusan National University   (South Korea)

^c Pusan National University School of Medicine   (South Korea)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; TUMOR SUPPRESSOR PROTEIN; TUMOROUS IMAGINAL DISC 1 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ANGIOGENESIS; ARTICLE; CANCER INHIBITION; CHICK EMBRYO; CONTROLLED STUDY; DROSOPHILA; EMBRYO; GENETIC SCREENING; HUMAN; HUMAN CELL; HYBRID; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SEQUENCE HOMOLOGY; YEAST;

CHORIOALLANTOIC MEMBRANE; DOWN-REGULATION; ENDOTHELIAL CELLS; HEAT-SHOCK PROTEINS; HELA CELLS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOVASCULARIZATION, PHYSIOLOGIC; PLASMIDS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 20144387547     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2735     Document Type: Article

References (20)

1. Kaelin WG Jr, Maher ER. The VHL tumour-suppressor gene paradigm. Trends Genet 1998;14:423-6.
2. Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999;399:271-5.
3. Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 2002;277:4656-62.
4. Lisztwan J, Imbert G, Wirbelauer C, Gstaiger M, Krek W. The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev 1999;13:1822-33.
5. Bunn HF, Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 1996;76:839-85.
6. Kurzik-Dumke U, Gundacker D, Renthrop M, Gateff E. Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog. Dev Genet 1995;16:64-76.
7. Syken J, De Medina T, Munger K. TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions. Proc Natl Acad Sci U S A 1999;96:8499-504.
8. Jeong JW, Bae MK, Ahn MY, et al. Regulation and destabilization of HIF-1a by ARD1-mediated acetylation. Cell 2002;111:709-20.
9. Lee SW, Kim WJ, Choi YK, et al. SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nat Med 2003;9:900-06.
10. Tanimoto K, Makino Y, Pereira T, Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein. EMBO J 2000;19:4298-309.
11. Kurzik-Dumke U, Gundacker D, Renthrop M, Gateff E. Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog. Dev Genet 1995;16:64-76.
12. Schilling B, De Medina T, Syken J, Vidal M, Munger K. A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein. Virology 1998;247:74-85.
13. Trentin GA, Yin X, Tahir S, et al. A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein. J Biol Chem 2001;276:13087-95.
14. Cheng H, Cenciarelli C, Tao M, Parks WP, Cheng-Mayer C. HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of IκB kinase β subunit. J Biol Chem 2002;277:20605-10.
15. Sarkar S, Pollack BP, Lin KT, et al. hTid-1, a human DnaJ protein, modulates the interferon signaling pathway. J Biol Chem 2001;276:49034-42.
16. Georgopoulos C, Welch WJ. Role of the major heat shock proteins as molecular chaperones. Annu Rev Cell Dev Biol 1993;9:601-34.
17. Cyr DM, Langer T, Douglas MG. DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70. Trends Biochem Sci 1994;19:176-81.
18. Huang J, Kontos CD. PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. J Biol Chem 2002;277:10760-6.
19. Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J, Iruela-Arispe ML. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proc Natl Acad Sci U S A 2001;98:12485-90.
20. Zhang L, Yu D, Hu M, et al. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res 2000;60:3655-61.