Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors

Organic and Biomolecular Chemistry

Volumn 9, Issue 11, 2011, Pages 4144-4149

  Guasconi, Margherita ^a   Lu, Xiaoyun ^b,c   Massarotti, Alberto ^a   Caldarelli, Antonio ^a   Ciraolo, Elisa ^b   Tron, Gian Cesare ^a   Hirsch, Emilio ^b   Sorba, Giovanni ^a   Pirali, Tracey ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

KINASE INHIBITORS; MULTI-COMPONENT REACTIONS; MULTICOMPONENTS; NOVEL PROTEINS; NUCLEOPHILIC AROMATIC SUBSTITUTION; PRIMARY AND SECONDARY AMINE; PYRAZINES;

AROMATIC COMPOUNDS; CYANIDES; ENZYMES;

BIOSYNTHESIS;

IMIDAZOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRAZINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; STEREOISOMERISM; SYNTHESIS;

IMIDAZOLES; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZINES; STEREOISOMERISM;

EID: 79956289928     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/c1ob05336a     Document Type: Article

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