An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

Tetrahedron Letters

Volumn 45, Issue 47, 2004, Pages 8631-8633

  Hopkins, Corey R ^a   Collar, Nicola ^a  

^a SANOFI   (France)

Author keywords

6 Substituted 5H pyrrolo 2,3 b pyrazine; Cyclization; Heteroannulation; Microwave; Palladium

Indexed keywords

5H PYRROLO[2,3 B]PYRAZINE; PALLADIUM; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANNULATION REACTION; ARTICLE; CATALYSIS; CHEMICAL REACTION; DEPROTECTION REACTION; HEATING; MICROWAVE RADIATION; SYNTHESIS;

EID: 7044249545     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.09.152     Document Type: Article

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26. 3) δ ppm: 12.4 (s, 1H), 8.34 (d, 1H, J = 2.6 Hz), 8.18 (d, 1H, J = 2.6 Hz), 7.94 (d, 2H, J = 8.5 Hz), 7.52 (d, 2H, J = 8.5 Hz), 7.08 (d, 1H, J = 2.0 Hz), 1.33 (s, 9H)
27. The reaction was monitored at times: 5, 10, 15 and 20 min and the reaction was deemed complete at 20 min due to full consumption of the SM