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Volumn , Issue 5, 2008, Pages 895-913

Synthesis of "Trioxaquantel"® derivatives as potential new antischistosomal drugs

Author keywords

Artemether; Dual drug; Praziquantel; Schistosomiasis; Trioxane

Indexed keywords


EID: 53649101019     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200700975     Document Type: Article
Times cited : (48)

References (63)
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    • Cremophor belongs to the family of polyoxoethylene alkyl ethers and is commonly used as a pharmaceutical excipient, because of the efficient solubilizing effect of this nonionic surfactant. However, in previous studies, we observed a low but significant inhibition of parasitemia in malaria-infected mice treated with Cremophor alone. Since biological evaluations can be affected by Cremophor in some cases, we decided to abandon the use of this excipient (Palumed, unpublished results).
    • Cremophor belongs to the family of polyoxoethylene alkyl ethers and is commonly used as a pharmaceutical excipient, because of the efficient solubilizing effect of this nonionic surfactant. However, in previous studies, we observed a low but significant inhibition of parasitemia in malaria-infected mice treated with Cremophor alone. Since biological evaluations can be affected by Cremophor in some cases, we decided to abandon the use of this excipient (Palumed, unpublished results).
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.