Incorporating receptor flexibility in the molecular design of protein interfaces

Protein Engineering, Design and Selection

Volumn 22, Issue 9, 2009, Pages 575-586

  Li, Liwei ^a,b   Liang, Shide ^a,b   Pilcher, Meaghan M ^a   Meroueh, Samy O ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Flexible backbone design; Free energy calculations; Molecular dynamics simulations; Protein engineering; Protein protein interaction

Indexed keywords

FLEXIBLE BACKBONE DESIGN; FREE ENERGY CALCULATIONS; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN ENGINEERING; PROTEIN-PROTEIN INTERACTION;

ANTIBODIES; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; COMPLEXATION; DESIGN; DYNAMICS; ENTROPY; ENZYMES; FREE ENERGY; GENETIC ENGINEERING; MOLECULAR DYNAMICS; SOLVATION; SOLVENTS; VAN DER WAALS FORCES;

BINDING ENERGY;

BARNASE; BARSTAR; CHEY PROTEIN; LYSOZYME; PROTEIN; RECEPTOR; TENASCIN; TRYPSIN;

ARTICLE; COMPLEX FORMATION; ENERGY; ENTROPY; MOLECULAR DYNAMICS; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STABILITY; RECEPTOR BINDING; SOLVATION;

ALANINE; ALGORITHMS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; LINEAR MODELS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEINS; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 75849162018     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzp042     Document Type: Article

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