Chronic pain may change the structure of the brain

Pain

Volumn 137, Issue 1, 2008, Pages 7-15

  May, Arne ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Brainstem; Chronic pain; Chronification; Cingulate cortex; Imaging; Neuroplasticity; Voxel based morphometry (VBM)

Indexed keywords

ANTICIPATION; BACKACHE; BRAIN; CHRONIC PAIN; CINGULATE GYRUS; FIBROMYALGIA; GENOTYPE; GRAY MATTER; HEADACHE; HUMAN; INSULA; IRRITABLE COLON; MIGRAINE; MORPHOLOGY; NERVE CELL PLASTICITY; NEUROIMAGING; NOCICEPTION; NONHUMAN; ORBITAL CORTEX; PHANTOM PAIN; PONS; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS;

ANIMALS; BRAIN; BRAIN MAPPING; CHRONIC DISEASE; HUMANS; NEURONAL PLASTICITY; PAIN; PAIN MEASUREMENT;

EID: 44749092515     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2008.02.034     Document Type: Review

References (81)

1. Afridi S.K., et al. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain 128 (2005) 932-939
2. Andersson G.B. Epidemiology of low back pain. Acta Orthop Scand Suppl 281 (1998) 28-31
3. Apkarian A.V., et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci 24 (2004) 10410-10415
4. Argall B.D., Saad Z.S., and Beauchamp M.S. Simplified intersubject averaging on the cortical surface using SUMA. Hum Brain Mapp 27 (2006) 14-27
5. Ashburner J., et al. Computer-assisted imaging to assess brain structure in healthy and diseased brains. Lancet Neurol 2 (2003) 79-88
6. Bantick S.J., et al. Imaging how attention modulates pain in humans using functional MRI. Brain 125 (2002) 310-319
7. Bingel U., et al. Habituation to painful stimulation involves the antinociceptive system. Pain (2007)
8. DaSilva A.F., et al. Thickening in the somatosensory cortex of patients with migraine. Neurology 69 (2007) 1990-1995
9. Davis K.D., et al. Cortical thinning in IBS: implications for homeostatic, attention, and pain processing. Neurology 70 (2008) 153-154
10. Davis K.D., et al. Activation of the anterior cingulate cortex by thalamic stimulation in patients with chronic pain: a positron emission tomography study. J Neurosurg 92 (2000) 64-69
11. Derbyshire S.W. Meta-analysis of thirty-four independent samples studied using PET reveals a significantly attenuated central response to noxious stimulation in clinical pain patients. Curr Rev Pain 3 (1999) 265-280
12. Desmeules J.A., et al. Neurophysiologic evidence for a central sensitization in patients with fibromyalgia. Arthritis Rheum 48 (2003) 1420-1429
13. Dettmers C., et al. Increased excitability in the primary motor cortex and supplementary motor area in patients with phantom limb pain after upper limb amputation. Neurosci Lett 307 (2001) 109-112
14. Draganski B., et al. Neuroplasticity: changes in grey matter induced by training. Nature 427 (2004) 311-312
15. Draganski B., et al. Decrease of thalamic gray matter following limb amputation. NeuroImage 31 (2006) 951-957
16. Duncan G.H., Bushnell M.C., and Marchand S. Deep brain stimulation: a review of basic research and clinical studies. Pain 45 (1991) 49-59
17. Elbert T., et al. Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury. NeuroReport 5 (1994) 2593-2597
18. Faymonville M.E., et al. Neural mechanisms of antinociceptive effects of hypnosis. Anesthesiology 92 (2000) 1257-1267
19. Fjell A.M., et al. Selective increase of cortical thickness in high-performing elderly--structural indices of optimal cognitive aging. NeuroImage 29 (2006) 984-994
20. Flor H. Cortical reorganisation and chronic pain: implications for rehabilitation. J Rehabil Med (2003) 66-72
21. Flor H., et al. Extensive reorganization of primary somatosensory cortex in chronic back pain patients. Neurosci Lett 224 (1997) 5-8
22. Flor H., et al. Effect of sensory discrimination training on cortical reorganisation and phantom limb pain. Lancet 357 (2001) 1763-1764
23. Flor H., et al. Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 375 (1995) 482-484
24. Flor H., Knost B., and Birbaumer N. The role of operant conditioning in chronic pain: an experimental investigation. Pain 95 (2002) 111-118
25. Flor H., Nikolajsen L., and Staehelin Jensen T. Phantom limb pain: a case of maladaptive CNS plasticity?. Nat Rev Neurosci 7 (2006) 873-881
26. Florence S.L., Taub H.B., and Kaas J.H. Large-scale sprouting of cortical connections after peripheral injury in adult macaque monkeys. Science 282 (1998) 1117-1121
27. Friston KJ, et al., SPM99. World Wide Web, 1999. Available from: .
28. FSL. Available from: .
29. Good C.D., et al. A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 14 (2001) 21-36
30. Gordh T., Chu H., and Sharma H.S. Spinal nerve lesion alters blood-spinal cord barrier function and activates astrocytes in the rat. Pain 124 (2006) 211-221
31. Gracely R.H., et al. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 46 (2002) 1333-1343
32. Granziera C., et al. Anatomical alterations of the visual motion processing network in migraine with and without Aura. PLoS Med 3 (2006)
33. Grusser S.M., et al. Remote activation of referred phantom sensation and cortical reorganization in human upper extremity amputees. Exp Brain Res 154 (2004) 97-102
34. Grusser S.M., et al. The relationship of perceptual phenomena and cortical reorganization in upper extremity amputees. Neuroscience 102 (2001) 263-272
35. Gureje O. Psychiatric aspects of pain. Curr Opin Psychiatry 20 (2007) 42-46
36. Gybels J., and Kupers R. Deep brain stimulation in the treatment of chronic pain in man: where and why?. Neurophysiol Clin 20 (1990) 389-398
37. Headache classification committee of the international headache society, the international classification of headache disorders. 2nd ed. Cephalalgia 2004;24:1-160.
38. Jones E.G. Cortical and subcortical contributions to activity-dependent plasticity in primate somatosensory cortex. Annu Rev Neurosci 23 (2000) 1-37
39. Jones E.G., and Pons T.P. Thalamic and brainstem contributions to large-scale plasticity of primate somatosensory cortex. Science 282 (1998) 1121-1125
40. Julius D., and Basbaum A.I. Molecular mechanisms of nociception. Nature 413 (2001) 203-210
41. Katz J., and Melzack R. Pain 'memories' in phantom limbs: review and clinical observations. Pain 43 (1990) 319-336
42. Koltzenburg M. The changing sensitivity in the life of the nociceptor. Pain (1999) S93-S102
43. Kuchinad A., et al. Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain?. J Neurosci 27 (2007) 4004-4007
44. Kupers R., Faymonville M.E., and Laureys S. The cognitive modulation of pain: hypnosis- and placebo-induced analgesia. Prog Brain Res 150 (2005) 251-269
45. Kwan C.L., et al. Abnormal forebrain activity in functional bowel disorder patients with chronic pain. Neurology 65 (2005) 1268-1277
46. Lotze M., et al. Phantom movements and pain. An fMRI study in upper limb amputees. Brain 124 (2001) 2268-2277
47. Luders E., et al. A curvature-based approach to estimate local gyrification on the cortical surface. NeuroImage 29 (2006) 1224-1230
48. Maihofner C., et al. Patterns of cortical reorganization in complex regional pain syndrome. Neurology 61 (2003) 1707-1715
49. Maihofner C., et al. Cortical reorganization during recovery from complex regional pain syndrome. Neurology 63 (2004) 693-701
50. Marchand F., Perretti M., and McMahon S.B. Role of the immune system in chronic pain. Nat Rev Neurosci 6 (2005) 521-532
51. Matharu M.S., et al. No change in the structure of the brain in migraine: a voxel-based morphometric study. Eur J Neurol 10 (2003) 53-57
52. May A. The role of imaging in the pathophysiology and diagnosis of headache. Curr Opin Neurol 18 (2005) 293-297
53. May A., et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 5 (1999) 836-838
54. May A., and Gaser C. Magnetic resonance-based morphometry: a window into structural plasticity of the brain. Curr Opin Neurol 19 (2006) 407-411
55. May A., et al. Structural brain alterations following 5 days of intervention: dynamic aspects of neuroplasticity. Cereb Cortex 17 (2007) 205-210
56. Melzack R., et al. Central neuroplasticity and pathological pain. Ann NY Acad Sci 933 (2001) 157-174
57. Petrovic P., et al. Placebo and opioid analgesia - imaging a shared neuronal network. Science 295 (2002) 1737-1740
58. Peyron R., Laurent B., and Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin 30 (2000) 263-288
59. Pleger B., et al. Mean sustained pain levels are linked to hemispherical side-to-side differences of primary somatosensory cortex in the complex regional pain syndrome I. Exp Brain Res (2004)
60. Ploghaus A., et al. Dissociating pain from its anticipation in the human brain. Science 284 (1999) 1979-1981
61. Pons T.P., et al. Massive cortical reorganization after sensory deafferentation in adult macaques. Science 252 (1991) 1857-1860
62. Porro C.A., et al. Does anticipation of pain affect cortical nociceptive systems?. J Neurosci 22 (2002) 3206-3214
63. Porro C.A., et al. Functional activity mapping of the mesial hemispheric wall during anticipation of pain. NeuroImage 19 (2003) 1738-1747
64. Rainville P., et al. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277 (1997) 968-971
65. Rocca M.A., et al. Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study. Stroke 37 (2006) 1765-1770
66. Schmidt-Wilcke T., et al. Subtle grey matter changes between migraine patients and healthy controls. Cephalalgia 28 (2008) 1-4
67. Schmidt-Wilcke T., et al. Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients. Pain 125 (2006) 89-97
68. Schmidt-Wilcke T., et al. Gray matter decrease in patients with chronic tension type headache. Neurology 65 (2005) 1483-1486
69. Schmidt-Wilcke T., et al. Striatal grey matter increase in patients suffering from fibromyalgia - a voxel-based morphometry study. Pain (2007)
70. Scholz J., and Woolf C.J. The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 10 (2007) 1361-1368
71. Smith S.M., et al. Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23 (2004) S208-S219
72. Suzuki R., et al. Enlargement of the receptive field size to low intensity mechanical stimulation in the rat spinal nerve ligation model of neuropathy. Exp Neurol 163 (2000) 408-413
73. Thompson P.M., et al. Abnormal cortical complexity and thickness profiles mapped in Williams syndrome. J Neurosci 25 (2005) 4146-4158
74. Valfre W., et al. Voxel-based morphometry reveals gray matter abnormalities in migraine. Headache 48 (2008) 109-117
75. Wall P., and Melzack R. Textbook of pain. 4 th ed. (1999), Churchill Livingstone, Edingburgh, London, Madrid
76. Wei F., Li P., and Zhuo M. Loss of synaptic depression in mammalian anterior cingulate cortex after amputation. J Neurosci 19 (1999) 9346-9354
77. Weiss T., et al. Rapid functional plasticity of the somatosensory cortex after finger amputation. Exp Brain Res 134 (2000) 199-203
78. Welch K.M., and Goadsby P.J. Chronic daily headache: nosology and pathophysiology. Curr Opin Neurol 15 (2002) 287-295
79. Welch K.M., et al. Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness?. Headache 41 (2001) 629-637
80. Woolf C.J., and Salter M.W. Neuronal plasticity: increasing the gain in pain. Science 288 (2000) 1765-1769
81. Zhang Y.Q., et al. Inhibitory effects of electrically evoked activation of ventrolateral orbital cortex on the tail-flick reflex are mediated by periaqueductal gray in rats. Pain 72 (1997) 127-135