Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic-ischemic injury

Neurobiology of Disease

Volumn 3, Issue 1, 1996, Pages 64-71

  Ferriero, Donna M ^a,b   Holtzman, David M ^c   Black, Stephen M ^b   Sheldon, R Ann ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; HIPPOCAMPUS; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0029865660     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1996.0006     Document Type: Article

References (32)

1. Ashwal, S., Cole, D. J., Osborne, T. N., & Pearce, W. J. (1994) Dual effects of L-NAME during transient focal cerebral ischemia in spontaneously hypertensive rats. Am. J. Physiol. 267, H276-H284.
2. Barone, F. C., Globus, M. Y., Price, W. J., White, R. F., Storer, B. L., Feuerstein, G. Z., Busto, R., & Ohlstein, E. H. (1994) Endothelin levels increase in rat focal and global ischemia. J. Cereb. Blood Flow Metab. 14, 337-342.
3. Beckman, J. S. (1991) The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J. Dev. Physiol. 15, 53-59.
4. Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R., & Snyder, S. H. (1991) Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351, 714-718.
5. Bredt, D. S., & Snyder, S. H. (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. USA 86, 9030-9033.
6. Carreau, A., Duval, D., Poignet, H., Scatton, B., Vige, X., & Nowicki, J.-P. (1994) Neuroprotective efficacy of N-nitro-L-arginine after focal cerebral ischemia in the mouse and inhibition of cortical nitric oxide synthase. Eur. J. Pharmacol. 256, 241-249.
7. Dalkara, T., & Moskowitz, M. A. (1994) The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia. Brain Pathol. 4, 49-57.
8. Dawson, V., Dawson, T., London, E., Bredt, D., & Snyder, S. H. (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88, 6361-6371.
9. Dawson, V. L., Dawson, T. M., Bartley, D. A., Uhl, G. R., & Snyder, S. H. (1993) Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J. Neurosci. 13, 2651-2661.
10. Dinerman, J. L., Dawson, T. M., Schell, M. J., Snowman, A., & Snyder, S. H. (1994) Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: Implications for synaptic plasticity. Proc. Natl. Acad. Sci. USA 91, 4214-4218.
11. Ditelberg, J., Sheldon, R., Epstein, C., & Ferriero, D. (1996) Brain injury after perinatal hypoxia-ischemia is exacerbated in copper/ zinc superoxide dismutase transgenic mice. Pediatr. Res., 39, 204-208.
12. Ferriero, D. M., Sheldon, R. A., Black, S. M., & Chuai, J. (1995) Selective destruction of nitric oxide synthase neurons with quisqualate reduces damage after hypoxia-ischemia in the neonatal rat. Pediatr. Res. 38, 912-918.
13. Ferriero, D. M., Soberano, H., Simon, R. P., & Sharp, F. R. (1990) Hypoxia-ischemia induces heat shock protein-like (HSP72) immunoreactivity in neonatal rat brain. Dev. Brain Res. 53, 145-160.
14. Hamada, Y., Hayakawa, T., Hattori, H., & Mikawa, H. (1994) Inhibition of nitric oxide synthesis reduces hypoxic-ischemic brain damage in the neonatal rat. Pediatr. Res. 35, 10-14.
15. Hewett, S. J., Csernansky, C. A., & Choi, D. W. (1994) Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS. Neuron 13, 487-494.
16. Holtzman, D., Kilbridge, J., Bredt, D., Black, S., Li, Y., Clary, D., Reichardt, L., & Mobley, W. (1994) NOS induction by NGF in basal forebrain cholinergic neurones:Evidence for regulation of brain NOS by a neurotrophin. Neurobiol. Dis. 1, 51-60.
17. Huang, P. L., Dawson, T. M., Bredt, D. S., Snyder, S. H., & Fishman, M. C. (1993) Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75, 1273-1286.
18. Huang, Z., Huang, P. L., Panahian, N., Dalkara, T., Fishman, M. C., & Moskowitz, M. A. (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265, 1883-1885.
19. Iadecola, C., Xu, X., Zhang, F., El-Fakahany, E., & Ross, M. (1995a) Marked induction of calcium-independent nitric oxide synthase activity after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 15, 52-59.
20. Iadecola, C., Zhang, F., Xu, S., Casey, R., & Ross, M. (1995b) Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J. Cereb. Blood Flow Metab. 15, 378-384.
21. Iadecola, C., Zhang, F., & Xu, X. (1995c) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am. J. Physiol. 268, R286-R292.
22. Kadowaki, K., Kishimoto, J., Leng, G., & Emson, P. C. (1994) Up-regulation of nitric oxide synthase gene expression together with NOS activity in the rat hypothalamo-hypophysial system after chronic salt loading: Evidence of a neuromodulatory role of nitric oxide in arginine vasopressin and oxytocin secretion. Endocrinology 134, 1011-1017.
23. Kozniewska, E., Oseka, M., & Stys, T. (1992) Effects of endothelium-derived nitric oxide on cerebral circulation during normoxia and hypoxia in the rat. J. Cereb. Blood Flow Metab. 12, 311-317.
24. Kozniewska, E., Roberts, T., Tsuura, M., Mintorovitch, J., Moseley, M., & Kucharczyk, J. (1995) N-Nitro-L-arginine delays the development of brain injury during focal ischemia in rats. Stroke 26, 282-289.
25. Lamas, S., Marsden, P., Li, G., Tempst, P., & Michel, T. (1992) Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme. Proc. Natl. Acad. Sci. USA 89, 6348-6352.
26. Lees, G. J. (1993) The possible contribution of microglia and macrophages to delayed neuronal death after ischemia. J. Neurol. Sci. 114, 119-122.
27. Lowenstein, C. J., Glatt, C. S., Bredt, D. S., & Snyder, S. H. (1992) Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. USA 89, 6711-6715.
28. Malinski, T., Bailey, F., Zhang, Z. G., & Chopp, M. (1993) Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 13, 355-358.
29. Panahian, N., Yoshida, T., Huang, P., Hedley-white, T., Fishman, M., & Moskowitz, M. (1995) Attenuated hippocampal damage after global cerebral ischemia in knock-out mice deficient in neuronal nitric oxide synthase. J. Cereb. Blood Flow Metab. 15, S5.
30. Radomski, M. W., Vallance, P., Whitley, G., Foxwell, N., & Moncada, S. (1993) Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide. Cardiovasc. Res. 27, 1380-1382.
31. Sagar, S. M., & Ferriero, D. M. (1987) NADPH diaphorase activity in the posterior pituitary: Relation to neuronal function. Brain Res. 400, 348-352.
32. Zhang, Z. G., Chopp, M., Zaloga, C., Pollock, J. S., & Förstermann, U. (1993) Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats. Stroke 24, 2016-2022.