Design, synthesis, and antitumor activity of 4-halocolchicines and their pro-drugs activated by cathepsin B

ACS Medicinal Chemistry Letters

Volumn 2, Issue 5, 2011, Pages 348-352

  Yasobu, Naoko ^a   Kitajima, Mariko ^a   Kogure, Noriyuki ^a   Shishido, Yoshiyuki ^b   Matsuzaki, Takeshi ^b   Nagaoka, Masato ^b   Takayama, Hiromitsu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

Alkaloid; bioactivity; cathepsin B; colchicine; pro drug; structure modification

Indexed keywords

4 AMINOCOLCHICINE; 4 BROMOCOLCHICINE; 4 CHLOROCOLCHICINE; 4 FLUOROCOLCHICINE; 4 FLUORODEACETYLCOLCHICINE; 4 FORMYLCOLCHICINE; 4 HYDROXYCOLCHICINE; 4 IODOCOLCHICINE; 4 NITROCOLCHICINE; ANTINEOPLASTIC AGENT; CATHEPSIN B; COLCHICINE; COLCHICINE 4 CARBOXYLIC ACID; COLCHICINE DERIVATIVE; DEACETYLCOLCHICINE; DIPEPTIDE; MAGNESIUM BIS(MONOPEROXYPHTHALATE); PHENYLALANYLLYSYL PABC 4 FLUORODEACETYLCOLCHICINE; PHENYLALANYLLYSYL PABC DEACETYLCOLCHICINE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG ACTIVATION; DRUG DESIGN; DRUG SYNTHESIS; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY; TUMOR CELL;

MUS;

EID: 79956105142     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100287y     Document Type: Article

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