-NH-dansyl isocolchicine exhibits a significantly improved tubulin-binding affinity and microtubule inhibition in comparison to isocolchicine by binding tubulin through its A and B rings

Biochemistry

Volumn 44, Issue 9, 2005, Pages 3249-3258

  Das, Lalita ^a   Datta, Ajit B ^a   Gupta, Suvroma ^a   Poddar, Asim ^a   Sengupta, Suparna ^c   Janik, Mark E ^a,b   Bhattacharyya, Bhabatarak ^a  

^a BOSE INSTITUTE   (India)

^b STATE UNIVERSITY OF NEW YORK AT FREDONIA   (United States)

^c RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CONCENTRATION (PROCESS); DRUG PRODUCTS; KETONES; PROTEINS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

BINDING AFFINITY; BIOLOGICAL ACTIVITY; ISOCOLCHICINE; MICROTUBULES;

ETHERS;

COLCHICINE; GUANOSINE TRIPHOSPHATASE; ISOCOLCHICINE; LIGAND; TUBULIN;

ARTICLE; CHEMICAL STRUCTURE; HYDROPHOBICITY; KINETICS; MATHEMATICAL ANALYSIS; MICROTUBULE; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SCATCHARD PLOT; SPECTROFLUOROMETRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SYNTHESIS;

BINDING SITES; COLCHICINE; DANSYL COMPOUNDS; HELA CELLS; HUMANS; ISOMERISM; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM; TUBULIN; TUBULIN MODULATORS;

EID: 14644386838     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048211u     Document Type: Article

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