New synthetic thiocolchicine derivatives as low-toxic anticancer agents

Archiv der Pharmazie

Volumn 338, Issue 12, 2005, Pages 582-589

  Lee, Sun Hee ^a   Park, Sun Kyoung ^a   Kim, Jeong Mi ^a   Kim, Myung Hwa ^b   Kim, Kwang Hee ^b   Chun, Kwang Woo ^b   Cho, Kyung Hea ^a   Youn, Ji Youn ^a   Namgoong, Sung Keon ^a  

^a Seoul Women University   (South Korea)

^b Jeil Pharmaceutical Co Ltd   (South Korea)

Author keywords

Anticancer activity; Colchicine; Synthetic derivatives; Thiocolchicine; Toxicity

Indexed keywords

ANTINEOPLASTIC AGENT; COLCHICINE DERIVATIVE; DOXORUBICIN; N (4 HYDROXY 3 METHOXYCINNAMYL)DEACETYL 10 THIOCOLCHICINE; N (DEXTRO GLUCONYL)DEACETYL 10 THIOCOLCHICINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHO CELLS; COLCHICINE; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50;

EID: 29244440370     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200500148     Document Type: Article

References (22)

1. O. Boye, A. Brossi, Alkaloids 1992, 41, 125-176.
2. S. B. Hastie, Pharmacol. Ther. 1991, 51, 377-401.
3. J. Guan, X-K. Zhu, Y. Tachibana, K. F. Bastow, A. Brossi, E. Hamel, K-H. Lee, Bioorg. Med. Chem. 1998, 6, 2127-2131.
4. X. Pan, W. Fang, Acta Pharmaceutica Sinica 2002, 37, 821-827.
5. R. Brecht, G. Seitz, D. Guenard, S. Thoret, Bioorg. Med Chem. 2000, 8, 557-562 and references cited therein.
6. Q. Shi, K. Chen, A. Brossi, P. Verdier-Pinard, E. Hamel, A. T. McPhail, K-H. Lee, Helv. Chim. Acta. 1998, 81, 1023-1037 and references cited therein.
7. Q. Shi, P. Verdier-Pinard, A. Brossi, E. Hamel, A. T. McPhail, K-H. Lee, J. Med. Chem. 1997, 40, 961-966.
8. R. Dumount, A. Brossi, C. F. Chignell, F. R. Quinn, M. Stiffness, J. Med. Chem. 1987, 30, 732-735.
9. H. J. C. Yeh, M. Chrzanowska, A. Brossi, FEBS Lett. 1988, 229, 82-86.
10. M. H. Gelb, F. Tamanoi, K. Yokoyama, F. Ghomashchi, K. Esson, M. N. Gould, Cancer Lett. 1995, 91, 169-175.
11. I. R. Hardcastle, M. G. Rowlands, A. M. Barber, Biochem. Pharmacol. 1999, 57, 801-809.
12. J. L. Sessler, A. Gebauer, E. Vogel in The Porphyrin Handbook, Vol. 2 (Eds.: K. M. Kadish, K. M. Smith, R. Guilard), Academic Press, San Diego, CA, 1999, chapter 8.
13. D. Lash, Angew. Chem. 2000, 112, 1833-1837.
14. R. J. Lee, P. S. Low, Biochimica Biophysica Acta 1995, 1233, 134-144.
15. M. Zerouga, W. Stillwell, L. J. Jenski, Anti-Cancer Drugs 2002, 13, 301-311.
16. A. Murakami, Y. Nakamura, K. Koshimizu, D. Takahashi, K. Matsumoto, K. Hagihara, H. Taniguch, E. Nomura, A. Hosoda, T. Tsuno, Y. Maruta, H-W. Kim, K. Kawabata, H. Ohigashi, Cancer Lett. 2002, 180, 121-129.
17. M. Macchia, S. Bertini, S. Fogli, E. Giovanetti, F. Minatolo, S. Rapposelli, R. Danesi, Farmaco 2003, 58, 205-203 and references cited therein.
18. T. K. Hoffmann, K. Leenen, D. Hafner, V. Balz, C. Gerharz, A. Grund, H. Ballo, U. Hauser, H. Bier, Anti-Cancer Drugs 2002, 13, 93-100.
19. M. C. Desai, L. M. Stephens-Stramiello, Tetrahedron Lett. 1993, 34, 7685-7688.
20. E. O. Kim, M.S. Thesis, Seoul Women's University, 2003.
21. H. M. Kim, S. B. Han, M. S. Kim, J. S. Kang, G. T. Oh, D. H. Hong, J. Pharmacol. Toxicol. Methods 1996, 36, 163-169.
22. L. Sun, H. Hamel, C. M. Lin, S. B. Hastie, A. Pyluck, K-H. Lee, J. Med. Chem. 1993, 36, 1474-1479.