Total syntheses of colchicine in comparison: A journey through 50 years of synthetic organic chemistry

Angewandte Chemie - International Edition

Volumn 43, Issue 25, 2004, Pages 3230-3256

  Graening, Timm ^a   Schmalz, Hans Günther ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Alkaloids; Cycloaddition; Natural products; Synthesis design; Total synthesis

Indexed keywords

ORGANIC COMPOUNDS; SYNTHESIS (CHEMICAL);

NATURAL PRODUCTS; SYNTHETIC ORGANIC METHODOLOGY;

DRUG PRODUCTS;

ALKALOID DERIVATIVE; ANTIMITOTIC AGENT; COLCHICEINE; COLCHICINE DERIVATIVE; DESACETAMIDOCOLCHICEINE; EPOTHILONE DERIVATIVE; NATURAL PRODUCT; PACLITAXEL; TRIMETHYLCOLCHICINIC ACID; TUBULIN; UNCLASSIFIED DRUG;

CHEMICAL MODIFICATION; COMPARATIVE STUDY; DRUG DESIGN; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR INTERACTION; ORGANIC CHEMISTRY; REVIEW;

CHEMISTRY, ORGANIC; COLCHICINE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 4544286643     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200300615     Document Type: Review

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