Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LC-MS/MS: Application for a pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 5, 2011, Pages 1024-1030

  Braga, Rodolpho C ^a   Tôrres, Andréa C B ^a   Persiano, Camille B ^a   Alves, Rosângela O ^a   Fraga, Carlos A M ^b   Barreiro, Eliezer J ^b   De Oliveira, Valéria ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Canine plasma; LASSBio 294; LC MS MS; Oral administration; Pharmacokinetics

Indexed keywords

2 THIENYLIDENE 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; AMMONIUM ACETATE; DRUG METABOLITE; L 294; METHANOL; PARACETAMOL; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; CONTROLLED STUDY; DOG; ELECTROSPRAY; FEMALE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PLASMA; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ACETATES; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BLOOD PROTEINS; CALIBRATION; CARDIOVASCULAR AGENTS; CHEMISTRY TECHNIQUES, ANALYTICAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DOGS; HYDRAZONES; MASS SPECTROMETRY; METHANOL; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TEMPERATURE; THIOPHENES;

EID: 79956101051     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.02.031     Document Type: Article

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22. mp 204-205°C; 1H NMR (200MHz): δ 11.56 (s, 1H, CONH-), 8.62 (s, 1H, CH), 7.64 (d, 1H, H2′, J=5.03Hz), 7.49 (dd, 1H, H6, Jax=8.1Hz, Jbx=1.8Hz), 7.44-7.41 (m, 2H, H4′ H2), 7.12 (dd, 1H, H3′, Jax=5.04Hz, Jbx=5.03Hz), 7.03 (d, 1H, H2′, J=8.1Hz), 6.18 (s, 2H, O-CH2-O).