Simultaneous determination of five lignan constituents of Wuzhi capsule in rat plasma by LC-MS/MS: Application to pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 5, 2010, Pages 741-746

  Wei, Hua ^a   Xu, Wen ^a   Cai, Fei ^a   Zhao, Gang ^a   Feng, Jin ^a   Sun, Lianna ^b   Chen, Wansheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Liquid chromatography tandem mass spectrometry; Pharmacokinetic; Rat plasma; Schisandra sphenanthera; Wuzhi capsule

Indexed keywords

ACETONITRILE; BIFENDATE; DEOXYSHISANDRIN; FORMIC ACID; GOMISIN A; LIGNAN DERIVATIVE; METHANOL; SCHISANDRIN; SCHISANHENOL; SCHISANTHERIN A; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG STABILITY; EXTRACTION; FLOW RATE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, LIQUID; LIGNANS; LIMIT OF DETECTION; MALE; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 77950859510     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.02.003     Document Type: Article

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