Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 2, 2009, Pages 440-446

  Ma, Hongda ^a,b   Wang, Yongjun ^b   Guo, Tao ^a   He, Zhonggui ^b   Chang, Xinyu ^b   Pu, Xiaohui ^b  

^a SHENYANG NORTHERN HOSPITAL   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

LC ESI MS; Palmatine; Pharmacokinetics; Protopine; Tetrahydropalmatine

Indexed keywords

DICHLOROMETHANE; PALMATINE; PHENACETIN; PLANT EXTRACT; PROTOPINE; RHIZOMA CORYDALIS DECUMBENTIS EXTRACT; TETRAHYDROPALMATINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ABSORPTION; ANIMALS; AREA UNDER CURVE; BENZOPHENANTHRIDINES; BERBERINE ALKALOIDS; CALIBRATION; CHROMATOGRAPHY, LIQUID; CORYDALIS; DRUG STABILITY; DRUG STORAGE; DRUGS, CHINESE HERBAL; FREEZING; GUIDELINES AS TOPIC; HALF-LIFE; MALE; MASS SPECTROMETRY; MEDICINE, CHINESE TRADITIONAL; MOLECULAR STRUCTURE; PHARMACOPOEIAS AS TOPIC; PLANT EXTRACTS; PLANT ROOTS; POWDERS; RATS; RATS, WISTAR; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 59049084145     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.11.019     Document Type: Article

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