PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy

Journal of Controlled Release

Volumn 122, Issue 3, 2007, Pages 252-260

  Miyata, Kanjiro ^a   Fukushima, Shigeto ^a   Nishiyama, Nobuhiro ^a,b   Yamasaki, Yuichi ^a   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Block copolymer; Gene delivery; Nonviral; PEG; Polyplex micelle

Indexed keywords

GENE DELIVERY; POLYPLEX MICELLE; TRANSFECTION EFFICACY;

AMINO ACIDS; CYTOTOXICITY; DNA; GENE EXPRESSION; MICELLES; POLYETHYLENE GLYCOLS;

BLOCK COPOLYMERS;

ASPARTIC ACID DERIVATIVE; BLOCK CATIOMER; COPOLYMER; DNA; LYSINE; POLY(ETHYLENEGLYCOL) BLOCK CATIONIC POLY[LYSYLASPARTATE (DIETHYLENETRIAMINE)]; POLYCATION; POLYPLEX; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; ENDOSOME; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; MICELLE; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STOICHIOMETRY; STRUCTURE ANALYSIS;

CATIONS; DNA; DRUG CARRIERS; DRUG STABILITY; ENDOSOMES; HELA CELLS; HUMANS; LUCIFERASES; MICELLES; POLYETHYLENE GLYCOLS; TRANSFECTION;

EID: 34548654993     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.06.020     Document Type: Article

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