Predominant contribution of rat organic anion transporting polypeptide-2 (Oatp2) to hepatic uptake of β-lactam antibiotics

Pharmaceutical Research

Volumn 25, Issue 3, 2008, Pages 578-585

  Nakakariya, Masanori ^a   Shimada, Taiki ^a   Irokawa, Masanori ^a   Koibuchi, Hiroyuki ^a   Iwanaga, Takashi ^a   Yabuuchi, Hikaru ^b   Maeda, Tomoji ^a   Tamai, Ikumi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b GenoMembrane Inc   (Japan)

Author keywords

Biliary excretion; Hepatic uptake; Oatp; Organic anion; Transporter

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; BETA LACTAM ANTIBIOTIC; BROMSULFOPHTHALEIN; CARRIER PROTEIN; CEFADROXIL; CEFALEXIN; CEFAZOLIN; CEFMETAZOLE; CEFOPERAZONE; CEFOTAXIME; CEFSULODIN; CEFTRIAXONE; ESTRONE SULFATE; NAFCILLIN; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 4; TETRYLAMMONIUM;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; BILE FLOW; CONTROLLED STUDY; DRUG EXCRETION; DRUG PROTEIN BINDING; DRUG TRANSPORT; DRUG UPTAKE; IN VITRO STUDY; LIVER CELL; MALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; XENOPUS LAEVIS;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; ESTRONE; FEMALE; HEPATOCYTES; KINETICS; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NAFCILLIN; OOCYTES; ORGANIC ANION TRANSPORT POLYPEPTIDE C; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; RATS, WISTAR; SULFOBROMOPHTHALEIN; TETRAETHYLAMMONIUM; XENOPUS LAEVIS;

EID: 40549099757     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9427-9     Document Type: Article

References (36)

1. J. M. Brogard, F. Comte, and M. Pinget. Pharmacokinetics of cephalosporin antibiotics. Antibiot. Chemother. 25:123-162 (1978).
2. J. M Brogard, and F. Comte. Pharmacokinetics of the new cephalosporins. Antibiot. Chemother. 32:145-210 (1982).
3. J. M Glassman, G. H. Warren, S. B. Rosenman, H. P. K. Agersborg. Phrmacology and distribution of WY-3277 (nafcillin): 6-(2-ethoxy-1-naphthamido) penicillanic acid. Toxicol. Appl. Pharmacol. 6:220-231 (1964).
4. S. Srinivasan, E. L. Francke, H. C. Neu. Comparative pharmacokinetics of cefoperazone and cefamandole. Agents. Chemother. 19:298-301 (1981).
5. H. Matsui, K. Yano, T. Okuda. Pharmacokinetics of the cephalosporin SM-1652 in mice, rats, rabbits, dogs, and rhesus monkeys. Agents Chemother. 22:213-217 (1982).
6. G. Forti, M. C. Guerra, A. M. Barbaro, T. Rossi, G. L. Biagi. The influence of lipophillic character on the biliary excretion of penicillins in isolated perfused liver. Boll Soc Ital Biol Sper. 51:406-408 (1975).
7. W. E. Wright, V. D. Line. Biliary excretion of cephalosporins in rats: influence of molecular weight. Agents Chemother. 17:842-846 (1980).
8. I. Tamai, T. Terasaki, A. Tsuji. Evidence for the existence of a common transport system of β-lactam antibiotics in isolated rat hepatocytes. J. Antibiotics. 38:1774-1780 (1985).
9. A. Tsuji, T. Terasaki, K. Takanosu, I. Tamai, E. Nakashima Uptake of benzylpenicillin, cefpiramide and cefazolin by freshly prepared rat hepatocytes. Biochem. Pharmacol. 35:151-158 (1986).
10. T. Terasaki, I. Tamai, K. Takanosu, E. Nakashima, and A Tsuji. Kinetic evidence for a common transport route of benzylpenicillin and probenecid by freshly prepared hepatocytes in rats. Influence of sodium ion, organic anions, amino acids and peptides on benzylpenicillin uptake. J Pharmacobio-Dyn. 9:18-28 (1986).
11. I. Tamai, and A. Tsuji. Kinetics of benzylpenicillin metabolism in isolated rat hepatocytes. J. Antibiotics. 40:533-541 (1987.)
12. A. Tsuji, T. Terasaki, I. Tamai, and K. Takeda. In vivo evidence for carrier-mediated uptake of ß-lactam antibiotics through organic anion transport systems in rat kidney and liver. J. Pharmacol. Exp. Ther. 253:315-320 (1990).
13. I. Tamai, T. Maekawa, and A. Tsuji. Membrane potential-dependent and carrier-mediated transport of cefpiramide, a cephalosporin antibiotic, in canalicular rat liver plasma membrane vesicles. J. Pharmacol. Exp. Ther. 253:537-544 (1990).
14. K. Ito, H. Suzuki, T. Horie, and Y. Sugiyama. Apical/Basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm Res. 22:1559-1577 (2005).
15. T. Nozawa, S. Sugiura, M. Nakajima, A. Goto, T. Yokoi, A. Tsuji, and I. Tamai. Involvement of organic anion transporting polypeptide in the transport of troglitazone sulfate: Implications for understanding troglitazone hepatotoxicity. Drug. Metab. Dispos. 32:291-294 (2004).
16. M. Niemi, E. Schaeffeler, T. Lang, M. F. Fromm, M. Neuvonen, C. Kyrklund, J. T. Backman, R. Kerb, M. Schwab, P. J. Neuvonen, M. Eichelbaum, and K. T. Kivisto. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics 14:429-440 (2004).
17. M. Tsuda-Tsukimoto, T. Maeda, T. Iwanaga, T. Kume, I. Tamai. Characterization of Hepatobiliary Transport Systems of a Novel alpha4beta1/alpha4beta7 Dual Antagonist, TR-14035. Pharm. Res. 23:2646-2656 (2006).
18. P. J. Meier, U. Eckhardt, A. Schroeder, B. Hagenbuch, and B. Stieger. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology. 26:1667-1677 (1997).
19. G. D. Simonson, A. C. Vincent, K. J. Roberg, Y. Huang, and V. Iwanij. Molecular cloning and characterization of a novel liver-specific transport protein. J. Cell Sci. 107:1065-1072 (1994).
20. D. Grundemann, V. Gorboulev, S. Gambaryan, M. Veyhl, and H. Koepsell. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372:549-552 (1994).
21. T. Abe, M. Unno, T. Onogawa, T. Tokui, T. N. Kondo, R. Nakagomi, H. Adachi, K. Fijiwara, M. Okabe, T. Suzuki, K. Nunoki, E. Sato, M. Kakyo, T. Nishio, J. Sugita, N. Asano, M. Tanemoto, M. Seki, F. Date, K. Ono, Y. Kondo, K. Shiiba, M. Suzuki, H. Ohtani, T. Shimosegawa, K. Inuma, H. Nagura, S. Ito, S. Matsuno. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensivity in gastrointestinal cancers. Gastroenterology 120:1689-1699 (2001).
22. B. Hsiang, Y. Zhu, Z. Wang, Y. Wu, V. Sasseville, W.P. Yang, and T.G. Kirchgessner. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J. Biol. Chem. 274:37161-37168 (1999).
23. T. Nozawa, H. Minami, S. Sugiura, A. Tsuji, and I. Tamai. Role of organic anion transporter OATP-C in hepatic uptake of irinotecan and its active metabolite SN-38: In vitro evidence and effect of single nucleotide polymorphisms. Drug. Metab. Dispos. 33:434-439 (2005).
24. K. Ito, T. Koresawa, K. Nakano, and T. Horie. Mrp2 is involved in benzylpenicillin-induced choleresis. Am. J. Physiol. Gastrointest. Liver. Physiol. 287:42-49 (2004).
25. I. Tamai, J. Nezu, H. Uchino, Y. Sai, A. Oku, M. Shimane, and A. Tsuji. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 273:251-260 (2000).
26. H. Yabuuchi, I. Tamai, K. Morita, T. Kouda, K. Miyamoto, Takeda, E., Tsuji, A. Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1. J. Pharmacol. Exp. Ther. 286:1391-1396 (1998).
27. C.M. Stowe, and G.L. Plaa. Extrarenal excretion of drugs and chemicals. Annu. Rev. Pharmacol. 8:337-356 (1968)
28. C. Eng, and N. B. Javitt. Effect of nafcillin on hepatic excretory function. Biochem. Pharmacol. 32:3649-3651 (1983).
29. 5]-enkephalin. J. Pharm. Pharmacol. 55:1013-1020 (2003).
30. I. Tamai, T. Nozawa, M. Koshida, J. Nezu, Y. Sai, and A. Tsuji. Functional characterization of human organic anion transporting polypeptide OATP-B in comparison with liver-specific OATP-C. Pharm. Res. 18:1262-1269 (2001).
31. M. Hirano, K. Maeda, Y. Shitara, and Y. Sugiyama. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J. Pharmacol. Exp. Ther. 311:139-146 (2004).
32. V Cattori, B Hagenbuch, N Hagenbuch, B Stieger, R Ha, KE Winterhalter and PJ Meier. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver. FEBS Lett. 474:242-245 (2000).
33. B. Noe, B. Hagenbuch, B. Stiger, and P. J. Meier. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc. Natl. Acad. Sci. U. S. A. 94:10346-10350 (1997).
34. I. Tamai, A. Tsuji, and Y. Kin. Carrier-mediated transport of cefixime, a new cephalosporin antibiotic, via an organic anion transport system in the rat renal brush-border membrane. J. Pharmacol. Exp. Ther. 246:338-344 (1988).
35. Y. Uwai, H. Saito, and K. Inui. Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone. Drug Metab Pharmacokinet. 17:125-129 (2002).
36. H Uchino, I Tamai, H Yabuuchi, K China, K Miyamoto, E Takeda and A Tsuji. Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Npt1. Agents Chemother. 44:547-577 (2000).