Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites

Biochemical Journal

Volumn 436, Issue 2, 2011, Pages 363-369

  Pappalardi, Melissa B ^a   McNulty, Dean E ^a   Martin, John D ^a   Fisher, Kelly E ^a   Jiang, Yong ^a   Burns, Matthew C ^a   Zhao, Huizhen ^a   Ho, Thau ^a   Sweitzer, Sharon ^a   Schwartz, Benjamin ^a   Annan, Roland S ^a   Copeland, Robert A ^a   Tummino, Peter J ^a   Luo, Lusong ^a,b  

^a GLAXOSMITHKLINE   (United States)

^b BeiGene   (China)

Author keywords

C terminal transactivation domain (CAD); Hypoxia response element; Hypoxia inducible factor (HIF); Prolyl hydroxylase domain (PHD); Substrate selectivity

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR HYDROXYLASE; OXYGENASE; PROLINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME KINETICS; ENZYME SUBSTRATE; HYDROXYLATION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STEADY STATE; TANDEM MASS SPECTROMETRY;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISOENZYMES; PROCOLLAGEN-PROLINE DIOXYGENASE; SUBSTRATE SPECIFICITY;

EID: 79955990630     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101201     Document Type: Article

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