Beta-2-receptor regulation of immunomodulatory proteins in airway smooth muscle

Frontiers in Bioscience - Scholar

Volumn 3 S, Issue 2, 2011, Pages 643-654

  Ameredes, Bill T ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

(R) Albuterol; (S) Albuterol; Albuterol; Antagonist; Beta Receptor; Beta Arrestin; Formoterol; GM CSF; Inverse Agonism; Levalbuterol; Ligand; Racemic Mixture; Review

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID DERIVATIVE; DEXAMETHASONE; EOTAXIN; FENOTEROL; FLUTICASONE; FORMOTEROL; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; ISOPRENALINE; PROPRANOLOL; RANTES; SALBUTAMOL; SALMETEROL; TUMOR NECROSIS FACTOR ALPHA; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CYTOKINE;

AIRWAY CONSTRICTION; AIRWAY SMOOTH MUSCLE; ALLERGIC AIRWAY INFLAMMATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BREATHING MUSCLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENANTIOMER; HUMAN; IMMUNOMODULATION; INVERSE AGONISM; SMOOTH MUSCLE; BIOLOGICAL MODEL; DRUG EFFECT; IMMUNOLOGY; METABOLISM; RESPIRATORY SYSTEM; REVIEW;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; BRONCHODILATOR AGENTS; CYTOKINES; HUMANS; MODELS, BIOLOGICAL; MUSCLE, SMOOTH; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED; RESPIRATORY SYSTEM;

EID: 79955967007     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s177     Document Type: Article

References (66)

1. Regard, J. B., I. T. Sato & S. R. Coughlin: Anatomical profiling of G protein-coupled receptor expression. Cell, 135, 561-71 (2008)
2. Johnson, M.: Molecular mechanisms of beta(2)- adrenergic receptor function, response, and regulation. J Allergy Clin Immunol, 117, 18-24; quiz 25 (2006)
3. Bjornsdottir, U. S. & D. M. Cypcar: Asthma: an inflammatory mediator soup. Allergy, 54 Suppl 49, 55-61 (1999)
4. Panettieri, R. A., Jr.: Airway smooth muscle: immunomodulatory cells that modulate airway remodeling? Respir Physiol Neurobiol, 137, 277-93 (2003)
5. Ameredes, B. T. & W. J. Calhoun: Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle. J Allergy Clin Immunol, 116, 65-72 (2005)
6. Hallsworth, M. P., C. H. Twort, T. H. Lee & S. J. Hirst: beta(2)-adrenoceptor agonists inhibit release of eosinophilactivating cytokines from human airway smooth muscle cells. Br J Pharmacol, 132, 729-41 (2001)
7. Ammit, A. J., A. L. Lazaar, C. Irani, G. M. O'Neill, N. D. Gordon, Y. Amrani, R. B. Penn & R. A. Panettieri, Jr.: Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. Am J Respir Cell Mol Biol, 26, 465-74 (2002)
8. Giembycz, M. A. & R. Newton: Beyond the dogma: novel beta2-adrenoceptor signalling in the airways. Eur Respir J, 27, 1286-306 (2006)
9. Howarth, P. H., A. J. Knox, Y. Amrani, O. Tliba, R. A. Panettieri, Jr. & M. Johnson: Synthetic responses in airway smooth muscle. J Allergy Clin Immunol, 114, S32-50 (2004)
10. Misior, A. M., D. A. Deshpande, M. J. Loza, R. M. Pascual, J. D. Hipp & R. B. Penn: Glucocorticoid- and Protein Kinase A- dependent Transcriptome Regulation in Airway Smooth Muscle. Am J Respir Cell Mol Biol (2008)
11. John, M., S. J. Hirst, P. J. Jose, A. Robichaud, N. Berkman, C. Witt, C. H. Twort, P. J. Barnes & K. F. Chung: Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. Journal of Immunology, 158, 1841-7 (1997)
12. Hallsworth, M. P., C. P. Soh, C. H. Twort, T. H. Lee & S. J. Hirst: Cultured human airway smooth muscle cells stimulated by interleukin-1beta enhance eosinophil survival. Am J Respir Cell Mol Biol, 19, 910-9 (1998)
13. Shore, S. A., J. Laporte, I. P. Hall, E. Hardy & R. A. Panettieri, Jr.: Effect of IL-1 beta on responses of cultured human airway smooth muscle cells to bronchodilator agonists. Am J Respir Cell Mol Biol, 16, 702-12 (1997)
14. Pang, L., E. Holland & A. J. Knox: Role of cyclooxygenase- 2 induction in interleukin-1beta induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline. Br J Pharmacol, 125, 1320-8 (1998)
15. Shore, S. A.: Cytokine regulation of beta-adrenergic responses in airway smooth muscle. J Allergy Clin Immunol, 110, S255-60 (2002)
16. Saunders, M. A., J. A. Mitchell, P. M. Seldon, M. H. Yacoub, P. J. Barnes, M. A. Giembycz & M. G. Belvisi: Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone. Br J Pharmacol, 120, 545-6 (1997)
17. Sukkar, M. B., J. M. Hughes, P. R. Johnson & C. L. Armour: GM-CSF production from human airway smooth muscle cells is potentiated by human serum. Mediators Inflamm, 9, 161-8 (2000)
18. Lalor, D. J., B. Truong, S. Henness, A. E. Blake, Q. Ge, A. J. Ammit, C. L. Armour & J. M. Hughes: Mechanisms of serum potentiation of GM-CSF production by human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 287, L1007-16 (2004)
19. Panettieri, R. A., R. K. Murray, L. R. DePalo, P. A. Yadvish & M. I. Kotlikoff: A human airway smooth muscle cell line that retains physiological responsiveness. Am J Physiol, 256, C329-35 (1989)
20. Gauvreau, G. M., R. M. Watson & P. M. O'Byrne: Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation. Am J Respir Crit Care Med, 160, 640-7 (1999)
21. Liang, Y., Y. Zhou & P. Shen: NF-kappaB and its regulation on the immune system. Cell Mol Immunol, 1, 343-50 (2004)
22. Nie, M., A. J. Knox & L. Pang: beta2-Adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation. J Immunol, 175, 478-86 (2005)
23. Lazzeri, N., M. G. Belvisi, H. J. Patel, K. F. Chung, M. H. Yacoub & J. A. Mitchell: RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol. Eur J Pharmacol, 433, 231-5 (2001)
24. Pang, L. & A. J. Knox: Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells. Am J Respir Cell Mol Biol, 23, 79-85 (2000)
25. Ibe, B. O., M. F. Abdallah & J. U. Raj: Mechanisms by which S-albuterol induces human bronchial smooth muscle cell proliferation. Int Arch Allergy Immunol, 146, 321-33 (2008)
26. Atabai, K., L. B. Ware, M. E. Snider, P. Koch, B. Daniel, T. J. Nuckton & M. A. Matthay: Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med, 28, 705-11 (2002)
27. Baramki, D., J. Koester, A. J. Anderson & L. Borish: Modulation of T-cell function by (R)- and (S)-isomers of albuterol: anti-inflammatory influences of (R)-isomers are negated in the presence of the (S)-isomer. J Allergy Clin Immunol, 109, 449-54 (2002)
28. Cho, S. H., J. Y. Hartleroad & C. K. Oh: (S)-albuterol increases the production of histamine and IL-4 in mast cells. Int Arch Allergy Immunol, 124, 478-84 (2001)
29. Ellis, C.: The state of GPCR research in 2004. Nat Rev Drug Discov, 3, 577-626 (2004)
30. Greener, M.: Driving Changes in Ligand Theory. The Scientist, 18, 32 (2004)
31. Milligan, G. & R. A. Bond: Inverse agonism and the regulation of receptor number. Trends Pharmacol Sci, 18, 468-74 (1997)
32. Baker, J. G.: The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol, 144, 317-22 (2005)
33. Penn, R. B., T. Frielle, J. R. McCullough, G. Aberg & J. L. Benovic: Comparison of R-, S-, and RS-albuterol interaction with human beta 1- and beta 2-adrenergic receptors. Clin Rev Allergy Immunol, 14, 37-45 (1996)
34. Agrawal, D. K., K. Ariyarathna & P. W. Kelbe: (S)- Albuterol activates pro-constrictory and pro-inflammatory pathways in human bronchial smooth muscle cells. J Allergy Clin Immunol, 113, 503-10 (2004)
35. Azzi, M., P. G. Charest, S. Angers, G. Rousseau, T. Kohout, M. Bouvier & G. Pineyro: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci USA, 100, 11406-11 (2003)
36. Shenoy, S. K. & R. J. Lefkowitz: Seven-transmembrane receptor signaling through beta-arrestin. Sci STKE, 2005, cm10 (2005)
37. Gumbhir-Shah, K., D. J. Kellerman, S. DeGraw, P. Koch & W. J. Jusko: Pharmacokinetic and pharmacodynamic characteristics and safety of inhaled albuterol enantiomers in healthy volunteers. J Clin Pharmacol, 38, 1096-106 (1998)
38. Morgan, D. J., J. D. Paull, B. H. Richmond, E. Wilson- Evered & S. P. Ziccone: Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate. Br J Clin Pharmacol, 22, 587-93 (1986)
39. Walle, U. K., G. R. Pesola & T. Walle: Stereoselective sulphate conjugation of salbutamol in humans: comparison of hepatic, intestinal and platelet activity. Br J Clin Pharmacol, 35, 413-8 (1993)
40. Eaton, E. A., U. K. Walle, H. M. Wilson, G. Aberg & T. Walle: Stereoselective sulphate conjugation of salbutamol by human lung and bronchial epithelial cells. Br J Clin Pharmacol, 41, 201-6 (1996)
41. Neeck, G.: Fifty years of experience with cortisone therapy in the study and treatment of rheumatoid arthritis. Ann N Y Acad Sci, 966, 28-38 (2002)
42. Barnes, P. J.: Drugs for asthma. Br J Pharmacol, 147 Suppl 1, S297-303 (2006)
43. Crompton, G.: A brief history of inhaled asthma therapy over the last fifty years. Prim Care Respir J, 15, 326-31 (2006)
44. Stahn, C., M. Lowenberg, D. W. Hommes & F. Buttgereit: Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists. Mol Cell Endocrinol, 275, 71-8 (2007)
45. Woolcock, A., B. Lundback, N. Ringdal & L. A. Jacques: Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med, 153, 1481-8 (1996)
46. Chung, K. F. & I. M. Adcock: Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma. Treat Respir Med, 3, 279-89 (2004)
47. Menezes, M. B., A. L. Teixeira, J. Terra Filho & E. O. Vianna: Inflammatory and functional effects of increasing asthma treatment with formoterol or double dose budesonide. Respir Med, 102, 1385-91 (2008)
48. Wallin, A., M. Sue-Chu, L. Bjermer, J. Ward, T. Sandstrom, A. Lindberg, B. Lundback, R. Djukanovic, S. Holgate & S. Wilson: Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma. J Allergy Clin Immunol, 112, 72-8 (2003)
49. Barnes, P. J.: Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J, 19, 182-91 (2002)
50. Goleva, E., A. Dunlap & D. Y. Leung: Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists. J Allergy Clin Immunol, 114, 183-91 (2004)
51. Pace, E., R. Gagliardo, M. Melis, S. La Grutta, M. Ferraro, L. Siena, G. Bonsignore, M. Gjomarkaj, J. Bousquet & A. M. Vignola: Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma. J Allergy Clin Immunol, 114, 1216-23 (2004)
52. Mak, J. C., M. Nishikawa & P. J. Barnes: Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung. Am J Physiol, 268, L41-6 (1995)
53. Mak, J. C., M. Nishikawa, H. Shirasaki, K. Miyayasu & P. J. Barnes: Protective effects of a glucocorticoid on downregulation of pulmonary beta 2- adrenergic receptors in vivo. J Clin Invest, 96, 99-106 (1995)
54. Baraniuk, J. N., M. Ali, D. Brody, J. Maniscalco, E. Gaumond, T. Fitzgerald, G. Wong, A. Yuta, J. C. Mak, P. J. Barnes, R. Bascom & T. Troost: Glucocorticoids induce beta2-adrenergic receptor function in human nasal mucosa. Am J Respir Crit Care Med, 155, 704-10 (1997)
55. Kaur, M., N. S. Holden, S. M. Wilson, M. B. Sukkar, K. F. Chung, P. J. Barnes, R. Newton & M. A. Giembycz: Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: A role for protein kinase A. Am J Physiol Lung Cell Mol Physiol, 295, L505-14 (2008)
56. Shenoy, S. K., M. T. Drake, C. D. Nelson, D. A. Houtz, K. Xiao, S. Madabushi, E. Reiter, R. T. Premont, O. Lichtarge & R. J. Lefkowitz: beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem, 281, 1261-73 (2006)
57. Israel, E., V. M. Chinchilli, J. G. Ford, H. A. Boushey, R. Cherniack, T. J. Craig, A. Deykin, J. K. Fagan, J. V. Fahy, J. Fish, M. Kraft, S. J. Kunselman, S. C. Lazarus, R. F. Lemanske, Jr., S. B. Liggett, R. J. Martin, N. Mitra, S. P. Peters, E. Silverman, C. A. Sorkness, S. J. Szefler, M. E. Wechsler, S. T. Weiss & J. M. Drazen: Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet, 364, 1505-12 (2004)
58. Israel, E., J. M. Drazen, S. B. Liggett, H. A. Boushey, R. M. Cherniack, V. M. Chinchilli, D. M. Cooper, J. V. Fahy, J. E. Fish, J. G. Ford, M. Kraft, S. Kunselman, S. C. Lazarus, R. F. Lemanske, R. J. Martin, D. E. McLean, S. P. Peters, E. K. Silverman, C. A. Sorkness, S. J. Szefler, S. T. Weiss & C. N. Yandava: The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med, 162, 75-80 (2000)
59. Kaczka, D. W., E. P. Ingenito, E. Israel & K. R. Lutchen: Airway and lung tissue mechanics in asthma. Effects of albuterol. Am J Respir Crit Care Med, 159, 169-78 (1999)
60. Wraight, J. M., A. D. Smith, J. O. Cowan, E. M. Flannery, G. P. Herbison & D. R. Taylor: Adverse effects of short-acting beta-agonists: potential impact when antiinflammatory therapy is inadequate. Respirology, 9, 215-21 (2004)
61. Nelson, H. S., S. T. Weiss, E. R. Bleecker, S. W. Yancey & P. M. Dorinsky: The Salmeterol Multicenter Asthma Research Trial: A comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest, 129, 15-26 (2006)
62. Lemanske, R. F., Jr., C. A. Sorkness, E. A. Mauger, S. C. Lazarus, H. A. Boushey, J. V. Fahy, J. M. Drazen, V. M. Chinchilli, T. Craig, J. E. Fish, J. G. Ford, E. Israel, M. Kraft, R. J. Martin, S. A. Nachman, S. P. Peters, J. D. Spahn & S. J. Szefler: Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: A randomized controlled trial. Jama, 285, 2594-603 (2001)
63. Prenner, B. M.: Role of long-acting beta2-adrenergic agonists in asthma management based on updated asthma guidelines. Curr Opin Pulm Med, 14, 57-63 (2008)
64. Pizzichini, M. M., J. C. Kidney, B. J. Wong, M. M. Morris, A. Efthimiadis, J. Dolovich & F. E. Hargreave: Effect of salmeterol compared with beclomethasone on allergen-induced asthmatic and inflammatory responses. Eur Respir J, 9, 449-55 (1996)
65. McIvor, R. A., E. Pizzichini, M. O. Turner, P. Hussack, F. E. Hargreave & M. R. Sears: Potential masking effects of salmeterol on airway inflammation in asthma. Am J Respir Crit Care Med, 158, 924-30 (1998)
66. Boulet, L. P., J. Chakir, J. Milot, M. Boutet & M. Laviolette: Effect of salmeterol on allergen-induced airway inflammation in mild allergic asthma. Clin Exp Allergy, 31, 430-7 (2001)