Effect of salmeterol compared with beclomethasone on allergen-induced asthmatic and inflammatory responses

European Respiratory Journal

Volumn 9, Issue 3, 1996, Pages 449-455

  Pizzichini, M M M ^a   Kidney, J C ^a   Wong, B J O ^a   Morris, M M ^a   Efthimiadis, A ^a   Dolovich, J ^a   Hargreave, F E ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b ST JOSEPH S HOSPITAL   (Canada)

Author keywords

airway responsiveness; allergen inhalation; beclomethasone; salmeterol; serum eosinophil cationic protein; sputum cell count

Indexed keywords

ALLERGEN; BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; PLACEBO; SALMETEROL;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; MALE; PNEUMONIA; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

ADMINISTRATION, INHALATION; ADRENERGIC BETA-AGONISTS; ADULT; ALBUTEROL; ALLERGENS; ANTI-ASTHMATIC AGENTS; ASTHMA; BECLOMETHASONE; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTION; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EOSINOPHILS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; SPIROMETRY; SPUTUM; TREATMENT OUTCOME;

EID: 0029873307     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.96.09030449     Document Type: Article

References (32)

1. 2-agonist. Ann Pharmacother 1993; 27: 1478-1487.
2. 2-adrenoreceptor agonist: comparison with saibutamol in adult asthmatic patients. Thorax. 1988; 43: 674-678.
3. Rabe KF, Jörres R, Nowak D, Behr N, Magnussen H. Comparison of the effects of salmeterol and formoterol on airway tone and responsiveness over 24 hours in bronchial asthma. Am Rev Respir Dis 1993; 147: 1436-1441.
4. Gongora HC, Wisniewski AFZ, Tattersfield AE. A single-dose comparison of inhaled albuterol and two formulations of salmeterol on airways reactivity in asthmatic subjects. Am Rev Respir Dis 1991; 144: 626-629.
5. Kemp JP, Dockhorn RJ, Busse WW, Bleecker ER, Van As A. Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm. Am J Respir Crit Care Med 1994; 150: 1612-1615.
6. Cartier A, Ghezzo H, L'Archevêque, Trudeau RT, Malo JL. Duration and magnitude of action of 50 and 100 μg of inhaled salmeterol in protecting against bronchoconstriction induced by hyperventilation of dry cold air in subjects with asthma. J Allergy Clin Immunol 1993; 92: 488-492.
7. Butchers PR, Vardey CJ, Johnson M. Salmeterol: a potent long-acting inhibitor of inflammatory mediator release from human lung. Br J Pharmacol 1991; 104: 672-676.
8. Baker AJ, Fuller RW. Anti-inflammatory effect of salmeterol on human alveolar macrophages. Am Rev Respir Dis 1990; 141: A394.
9. Whelan CJ, Johnson M. Salmeterol inhibits granulocyte accumulation in guinea-pig lung. Br J Pharmacol 1991; 102: 176P.
10. Twentyman OP, Finnerty JP, Harris A, Palmer J, Holgate ST. Protection against allergen-induced asthma by salmeterol. Lancet 1990; 336: 1338-1342.
11. Taylor IK, O'Shaughnessy KM, Choudry NB, Adachi M, Palmer JBD, Fuller RW. A comparative study in atopic subjects of the effects of salmeterol and salbutamol on allergen-induced bronchoconstriction, increase in airway responsiveness, and increase in urinary leukotriene excretion. J Allergy Clin Immunol 1992; 89: 575-583.
12. Pedersen B, Dahl R, Larsen BB, Venge P. The effect of salmeterol on the early- and late-phase reaction to bronchial allergen and postchallenge variation in bronchial reactivity, blood eosinophils, serum eosinophil cationic protein, and serum eosinophil protein X. Allergy 1993; 48: 377-382.
13. Weersink EJM, Aalbers R, Koëter GH, Kauffman HF, De Monchy JGR, Postma DS. Partial inhibition of the early and late asthmatic response by a single dose of salmeterol. Am J Respir Crit Care Med 1994; 150: 1262-1267.
14. 2-agonists in asthma. Lancet 1991; 337: 46.
15. Pin I, Freitag AP, O' Byrne PM, et al. Changes in the cellular profile of induced sputum after allergen-induced asthmatic responses. Am Rev Respir Dis 1992; 145: 1265-1269.
16. American Thoracic Society. Standardization of spirometry: 1987 update. Am Rev Respir Dis 1987; 136: 1285-1298.
17. Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meets ATS recommendation. Am Rev Respir Dis 1981; 123: 659-694.
18. Juniper EF, Cockcroft DW, Hargreave FE. Histamine and methacholine inhalation tests: a laboratory tidal breath-ing protocol. 2nd edn. Astra Diaco AB, Lund, Sweden, 1994.
19. Pepys J. Skin test in diagnosis. In: Gell PGH, Coombs RRA, Lachmann PJ, eds. Clinical aspects of immunology. 3rd edn. Oxford, Blackwell Scientific Publications, 1975; pp. 55-80.
20. Cockcroft DW, Murdock KY, Kirby J, Hargreave FE. Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. Am Rev Respir Dis 1987; 135: 264-267.
21. Wong BJ, Dolovich J, Ramsdale EH, et al. Formoterol compared with beclomethasone and placebo on allergen-induced asthmatic responses. Am Rev Respir Dis 1992; 146: 1156-1160.
22. Pin I, Gibson PG, Kolendowicz R, et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992; 47: 25-29.
23. Popov TA, Gottschalk R, Kolendowicz R, Dolovich J, Powers P, Hargreave FE. The evaluation of a cell dispersion method of sputum examination. Clin Exp Allergy 1994; 24: 778-783.
24. Glantz SA, Slinker BKL Repeated Measures. In: Glantz SA, Slinker BK, eds. Primer of Applied Regression and Analysis of Variance. New York, McGraw-Hill Inc., Health Professions Division, 1990; pp. 381-420.
25. Norman GR, Streiner DL. Repeated-measures ANOVA and reliability of measurement. In: Norman GR, Streiner DL, eds. Biostatistics: The Bare Essentials. St. Louis, Mosby Year Book Inc., 1994; pp. 90.
26. Popov TA, Pizzichini MMM, Pizzichini E, et al. Some technical factors influencing the induction of sputum for cell analysis. Eur Respir J 1995; 8: 559-565.
27. Pizzichini E, Morris MM, Efthimiadis A, et al. Reproducibility and validity of sputum fluid phase measurements. Am J Respir Crit Care Med 1995; 151: A385.
28. Fahy JV, Liu J, Wong H, Boushey HA. Analysis of cellular and biochemical constituents of induced sputum after allergen challenge: a method for studying allergic airway inflammation. J Allergy Clin Immunol 1994; 93: 1031-1039.
29. Gauvreau GM, Doctor J, Watson RM, Jordana M, O'Byrne PM. Effect of inhaled budesonide on allergen-induced airway and inflammatory responses. Am J Respir Crit Care Med 1995; 151: A41.
30. Dahl R, Pedersen B, Venge P. Bronchoalveolar lavage studies. Eur Respir Rev 1991; 1: 272-275.
31. Gardiner PV, Ward C, Booth H. Allison A, Hendrick DJ, Walters EH. Effect of eight weeks of treatment with salmeterol on bronchoalveolar lavage inflammatory indices in asthmatics. Am J Respir Crit Care Med 1994; 150: 1006-1011.
32. Boulet LP, Turcotte H, Dubé J, Gagnon M, Laviolette M, Bouter M. Influence of salmeterol on chronic and acute antigen-induced airway inflammation. Am J Respir Crit Care Med 1994; 149: A804.