Role of cyclo-oxygenase-2 induction in interleukin-1β induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline

British Journal of Pharmacology

Volumn 125, Issue 6, 1998, Pages 1320-1328

  Pang, Linhua ^a   Holland, Elaine ^a   Knox, Alan J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Airway inflammation; Airway smooth muscle; Asthma; Cyclic AMP; Cyclo oxygenase; Interleukin 1 ; Isoprenaline; Prostaglandin E2; Prostanoids; adrenoceptor agonist

Indexed keywords

ARACHIDONIC ACID; BRONCHODILATING AGENT; CYCLIC AMP; CYCLOHEXIMIDE; CYCLOOXYGENASE 2; DACTINOMYCIN; DEXAMETHASONE; FLURBIPROFEN; INDOMETACIN; INTERLEUKIN 1BETA; ISOPRENALINE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; STEROID;

ADULT; AIRWAY; ARTICLE; CASE REPORT; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; SMOOTH MUSCLE;

EID: 0031743176     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702193     Document Type: Article

References (34)

1. BAI, T.R. (1991). Abnormalities in airway smooth muscle in fatal asthma: a comparison between trachea and bronchus. Am. Rev. Respir. Dis., 143, 441-443.
2. BARNES, P.J. (1995). Beta adrenergic receptors and their regulation. Am. J. Respir. Crit. Care Mad., 152, 838-860.
3. BARNES, P.J., DOLLERY, C.T. & MACDERMOT, J. (1980). Increased pulmonary alpha-adrenergic and reduced beta-adrenergic receptors in experimental asthma. Nature, 285, 569-571.
4. BELVISI, M.G., SAUNDERS, M.A., HADDAD, E.B., HIRST, S.J., YACOUB, M.H. & MITCHELL, J.A. (1997). Induction of cyclooxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type. Br. J. Pharmacol., 120, 910-916.
5. BROIDE, D.H., LOTZ, M., CUOMO, A.J., COBURN, D.A., FREDERMAN, E.C. & WASSERMAN, S.I. (1992). Cytokines in symptomatic asthma airways. J. Allergy Clin. Immunol., 89, 958-967.
6. CEMBRZYNSKA-NOWAK, M., SZKLARZ, E., INGLOT, A.D. & TEODORCZYK-INJEYAN, J.A. (1993). Elevated release of tumour necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma. Am. Rev. Respir. Dis., 147, 291-295.
7. CHUNG, M.K., GULICK, T.S., ROTONDO, R.E., SCHREINER, G.F. & LANGE, L.G. (1990). Mechanism of cytokine inhibition of β-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Circ. Res., 67, 753-763.
8. DE JONGSTE, J.C., MONS, H., BONTA, I.L. & KERREBIJN, K.F. (1987). Human asthmatic airway responses in vitro: a case report. Eur. J. Respir. Dis., 70, 23-29.
9. 2 by bovine cultured airway smooth muscle cells and its inhibition by cyclo-oxygenase inhibitors. Br. J. Pharmacol., 111, 983-988.
10. EMALA, C., BLACK, C., CURRY, C., LEVINE, M.A. & HIRSHMAN, C.A. (1993). Impaired β-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the Basenji-Grayhound dog model of airway hyperresponsiveness. Am. J. Respir. Cell Mol. Biol., 8, 668-675.
11. EMALA, C.W., KUHL, J., HUNGERFORD, C.L. & HIRSHMAN, C.A. (1997). TNF-α inhibits isoproterenol-stimulated adenylyl cyclase activity in cultured airway smooth muscle cells. Am. J. Physiol., 212, L644-L650.
12. GILMAN, A.G. (1970). A protein binding assay for adenosine 3′ : 5′-cyclic monophosphate. Proc. Natl. Acad. Sci., 67, 305-312.
13. GOLDIE, R.G., SPINA, D., HENRY, P.J., LULICH, K.M. & PATERSON, J.W. (1986). In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, β-adrenoceptor agonists and theophylline. Br. J. Pharmacol., 22, 669-676.
14. HAKONARSON, H., HERRICK, D.J., GONZALEZ SERRANO, P. & GRUNSTEIN, M.M. (1996). Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle. J. Clin. Invest., 97, 2593-2600.
15. HAKONARSON, H., HERRICK, D.J., GONZALEZ SERRANO, P. & GRUNSTEIN, M.M. (1997). Autocrine role of interleukin 1β in altered responsiveness of atopic asthmatic sensitized airway smooth muscle. J. Clin. Invest., 99, 117-124.
16. 2-adrenoceptor desensitization in cultured human airway smooth muscle. Clin. Sci., 84, 151-157.
17. HALL, I.P., WIDDOPS, S., TOWNSEND, P. & DAYKIN, K. (1992). Control of cyclic AMP levels in primary culture of human tracheal smooth muscle cells. Br. J. Pharmacol., 107, 422-428.
18. KELSEN, S.G., ANAKWE, O., ZHOU, S., BENOVIC, J. & AKSOY, M. (1995). Interleukins impair beta-adrenergic receptor adenylyl cyclase (βAR-AC) system function in human airway epithelial cells. Chest. 107(suppl): 138S-139S.
19. KHYM, J.X. (1975). An analytical system for the rapid separation of tissue nucleotide low pressure on conventional anion exchanges. Clin. Chem., 21, 1245-1252.
20. KIPS, J.C., TAVERNIER, J. & PAUWELS, R.A. (1992). Tumour necrosis factor (TNF) causes bronchial hyperresponsiveness in rats. Am. Rev. Respir. Dis., 145, 332-336.
21. 2 receptors in the heart are coupled to inhibition of adenylyl cyclase via a pertussis toxin sensitive G protein. Can. J. Physiol. Pharmacol., 70, 77-84.
22. NARUMIYA, S. (1994). Prostanoid receptors: Structure, function and distribution. Ann. NY Acad. Sci. U.S.A., 744, 126-138.
23. PANG, L.H., HOLLAND, E. & KNOX, A.J. (1998). Impaired cAMP production in human airway smooth muscle cells by bradykinin: role of cyclooxygenase products. Am. J. Physiol., 275, L322-L329.
24. PANG, L.H. & HOULT, J.R.S. (1996). Induction of cyclooxygenase and nitric oxide synthase in endotoxin-activated J774 macrophages is differentially regulated by indomethacin: Enhanced cyclooxygenase-2 protein expression but reduction of inducible nitric oxide synthase. Eur. J. Pharmacol., 317, 151-155.
25. PANG, L.H. & KNOX, A.J. (1997). Effect of interleukin-1β, tumour necrosis factor-α and interferon-γ on the induction of cyclooxygenase-2 in cultured human airway smooth muscle cells. Br. J. Pharmacol., 121, 579-587.
26. 2-adrenergic receptor in normal and asthmatic subjects. Am. J. Respir. Cell Mol. Biol., 8, 334-339.
27. SHARMA, R.K. & JEFFERY, P.K. (1990). Airway β-adrenoceptor number in cystic fibrosis and asthma. Clin. Sci., 78, 409-417.
28. SHORE, S.A., LAPORTE, J., HALL, I.P., HARDY, E. & PANETTIERI, R.A. JR, (1997). Effect of IL-1β on responses of cultured human airway smooth muscle cells to bronchodilator agonists. Am. J. Respir. Cell Mol. Biol., 16, 702-712.
29. SPINA, D., RIGBY, P.J., PATERSON, J.W. & GOLDIE, R.G. (1989). Autoradiographic localization of β-adrenoceptors in asthmatic human lung. Am. Rev. Respir. Dis., 140, 1410-1415.
30. SPSS INC. (1996). SPSS base for Windows user's guide. SPSS Inc. Chicago. 564 pp.
31. TORPHY, T.J. (1994). β-adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogma. Trends Physiol. Sci., 15, 370-374.
32. VANE, J.R. (1994). Pharmacology: towards a better aspirin. Nature, 367, 215-216.
33. 2 in human bronchial smooth-muscle cells. Am. J. Respir. Crit. Care Med., 155, 864-868.
34. WILLS-KARP, M., UCHIDA, Y., LEE, J.Y., JINOT, J., HIRATA, A. & HIRATA, F. (1993). Organ culture with proinflammatory cytokine reproduces impairment of the β-adrenoceptor-mediated relaxation in tracheas of a guinea pig antigen model. Am. J. Respir. Cell Mol. Biol., 8, 153-159.