메뉴 건너뛰기




Volumn 17, Issue 4, 2011, Pages 459-469

Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis

Author keywords

Adoptive transfer model; Bifidobacterium; Colitis; Inflammation; Mice; Probiotics; Regulatory t cells

Indexed keywords

CELL MARKER; DRINKING WATER; PROBIOTIC AGENT; TRANSCRIPTION FACTOR FOXP3;

EID: 79955961537     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v17.i4.459     Document Type: Article
Times cited : (51)

References (68)
  • 1
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003; 3: 521-533
    • (2003) Nat Rev Immunol , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 3
    • 0032890396 scopus 로고    scopus 로고
    • Effector and regulatory lymphoid cells and cytokines in mucosal sites
    • MacDonald TT. Effector and regulatory lymphoid cells and cytokines in mucosal sites. Curr Top Microbiol Immunol 1999; 236: 113-135
    • (1999) Curr Top Microbiol Immunol , vol.236 , pp. 113-135
    • Macdonald, T.T.1
  • 4
    • 0032707898 scopus 로고    scopus 로고
    • Animal models of mucosal inflammation and their relation to human inflammatory bowel disease
    • Blumberg RS, Saubermann LJ, Strober W. Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr Opin Immunol 1999; 11: 648-656
    • (1999) Curr Opin Immunol , vol.11 , pp. 648-656
    • Blumberg, R.S.1    Saubermann, L.J.2    Strober, W.3
  • 6
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 2002; 20: 495-549
    • (2002) Annu Rev Immunol , vol.20 , pp. 495-549
    • Strober, W.1    Fuss, I.J.2    Blumberg, R.S.3
  • 7
    • 0036841277 scopus 로고    scopus 로고
    • Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease
    • Bamias G, Marini M, Moskaluk CA, Odashima M, Ross WG, Rivera-Nieves J, Cominelli F. Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease. J Immunol 2002; 169: 5308-5314
    • (2002) J Immunol , vol.169 , pp. 5308-5314
    • Bamias, G.1    Marini, M.2    Moskaluk, C.A.3    Odashima, M.4    Ross, W.G.5    Rivera-Nieves, J.6    Cominelli, F.7
  • 9
    • 0141858770 scopus 로고    scopus 로고
    • Intestinal microflora and homeostasis of the mucosal immune response: Implications for probiotic bacteria?
    • Blum S, Schiffrin EJ. Intestinal microflora and homeostasis of the mucosal immune response: implications for probiotic bacteria? Curr Issues Intest Microbiol 2003; 4: 53-60
    • (2003) Curr Issues Intest Microbiol , vol.4 , pp. 53-60
    • Blum, S.1    Schiffrin, E.J.2
  • 13
    • 33947189577 scopus 로고    scopus 로고
    • Probiotic effects on inflammatory bowel disease
    • Sheil B, Shanahan F, O'Mahony L. Probiotic effects on inflammatory bowel disease. J Nutr 2007; 137: 819S-824S
    • (2007) J Nutr , vol.137
    • Sheil, B.1    Shanahan, F.2    O'Mahony, L.3
  • 16
    • 44349095801 scopus 로고    scopus 로고
    • Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells
    • Pronio A, Montesani C, Butteroni C, Vecchione S, Mumolo G, Vestri A, Vitolo D, Boirivant M. Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells. Inflamm Bowel Dis 2008; 14: 662-668
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 662-668
    • Pronio, A.1    Montesani, C.2    Butteroni, C.3    Vecchione, S.4    Mumolo, G.5    Vestri, A.6    Vitolo, D.7    Boirivant, M.8
  • 18
    • 47849097120 scopus 로고    scopus 로고
    • Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells
    • Imaoka A, Shima T, Kato K, Mizuno S, Uehara T, Matsumoto S, Setoyama H, Hara T, Umesaki Y. Anti-inflammatory activity of probiotic Bifidobacterium: enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells. World J Gastroenterol 2008; 14: 2511-2516
    • (2008) World J Gastroenterol , vol.14 , pp. 2511-2516
    • Imaoka, A.1    Shima, T.2    Kato, K.3    Mizuno, S.4    Uehara, T.5    Matsumoto, S.6    Setoyama, H.7    Hara, T.8    Umesaki, Y.9
  • 19
    • 33947136296 scopus 로고    scopus 로고
    • Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation
    • Kim N, Kunisawa J, Kweon MN, Eog Ji G, Kiyono H. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin Immunol 2007; 123: 30-39
    • (2007) Clin Immunol , vol.123 , pp. 30-39
    • Kim, N.1    Kunisawa, J.2    Kweon, M.N.3    Eog, J.G.4    Kiyono, H.5
  • 20
    • 20444490871 scopus 로고    scopus 로고
    • Probiotic Lactobacillusinduced improvement in murine chronic inflammatory bowel disease is associated with the down-regulation of pro-inflammatory cytokines in lamina propria mononuclear cells
    • Matsumoto S, Hara T, Hori T, Mitsuyama K, Nagaoka M, Tomiyasu N, Suzuki A, Sata M. Probiotic Lactobacillusinduced improvement in murine chronic inflammatory bowel disease is associated with the down-regulation of pro-inflammatory cytokines in lamina propria mononuclear cells. Clin Exp Immunol 2005; 140: 417-426
    • (2005) Clin Exp Immunol , vol.140 , pp. 417-426
    • Matsumoto, S.1    Hara, T.2    Hori, T.3    Mitsuyama, K.4    Nagaoka, M.5    Tomiyasu, N.6    Suzuki, A.7    Sata, M.8
  • 21
    • 34848858207 scopus 로고    scopus 로고
    • Comparative study of the preventative effects exerted by three probiotics, Bifidobacterium lactis Lactobacillus casei and Lactobacillus acidophilus, in the TNBS model of rat colitis
    • Peran L, Camuesco D, Comalada M, Bailon E, Henriksson A, Xaus J, Zarzuelo A, Galvez J. A comparative study of the preventative effects exerted by three probiotics, Bifidobacterium lactis, Lactobacillus casei and Lactobacillus acidophilus, in the TNBS model of rat colitis. J Appl Microbiol 2007; 103: 836-844
    • (2007) J Appl Microbiol , vol.103 , pp. 836-844
    • Peran, L.1    Camuesco, D.2    Comalada, M.3    Bailon, E.4    Henriksson, A.5    Xaus, J.6    Zarzuelo, A.7    Galvez, J.A.8
  • 22
    • 0027163182 scopus 로고
    • CD4 T Cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells
    • Morrissey PJ, Charrier K, Braddy S, Liggitt D, Watson JD. CD4 T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells. J Exp Med 1993; 178: 237-244
    • (1993) J Exp Med , vol.178 , pp. 237-244
    • Morrissey, P.J.1    Charrier, K.2    Braddy, S.3    Liggitt, D.4    Watson, J.D.5
  • 24
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • Powrie F, Leach MW, Mauze S, Caddle LB, Coffman RL. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 1993; 5: 1461-1471
    • (1993) Int Immunol , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 25
    • 0033763306 scopus 로고    scopus 로고
    • Control of experimental inflammatory bowel disease by regulatory T cells
    • Asseman C, Fowler S, Powrie F. Control of experimental inflammatory bowel disease by regulatory T cells. Am J Respir Crit Care Med 2000; 162: S185-S189
    • (2000) Am J Respir Crit Care Med , vol.162
    • Asseman, C.1    Fowler, S.2    Powrie, F.3
  • 28
    • 0033571441 scopus 로고    scopus 로고
    • Nonlymphocyte- derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells
    • Corazza N, Eichenberger S, Eugster HP, Mueller C. Nonlymphocyte- derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells. J Exp Med 1999; 190: 1479-1492
    • (1999) J Exp Med , vol.190 , pp. 1479-1492
    • Corazza, N.1    Eichenberger, S.2    Eugster, H.P.3    Mueller, C.4
  • 30
    • 40449091849 scopus 로고    scopus 로고
    • Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions
    • Niess JH, Leithäuser F, Adler G, Reimann J. Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions. J Immunol 2008; 180: 559-568
    • (2008) J Immunol , vol.180 , pp. 559-568
    • Niess, J.H.1    Leithäuser, F.2    Adler, G.3    Reimann, J.4
  • 31
    • 0027080632 scopus 로고
    • Epithelial proliferation in response to gastrointestinal inflammation
    • MacDonald TT. Epithelial proliferation in response to gastrointestinal inflammation. Ann N Y Acad Sci 1992; 664: 202-209
    • (1992) Ann N Y Acad Sci , vol.664 , pp. 202-209
    • Macdonald, T.T.1
  • 32
    • 0030029222 scopus 로고    scopus 로고
    • Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
    • Stuber E, Strober W, Neurath M. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J Exp Med 1996; 183: 693-698
    • (1996) J Exp Med , vol.183 , pp. 693-698
    • Stuber, E.1    Strober, W.2    Neurath, M.3
  • 33
    • 0032955192 scopus 로고    scopus 로고
    • Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: Amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand- IgG fusion protein
    • Higgins LM, McDonald SA, Whittle N, Crockett N, Shields JG, MacDonald TT. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand- IgG fusion protein. J Immunol 1999; 162: 486-493
    • (1999) J Immunol , vol.162 , pp. 486-493
    • Higgins, L.M.1    McDonald, S.A.2    Whittle, N.3    Crockett, N.4    Shields, J.G.5    Macdonald, T.T.6
  • 36
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon RK, Tonkonogy S, Schultz M, Dieleman LA, Grenther W, Balish E, Rennick DM, Sartor RB. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun 1998; 66: 5224-5231
    • (1998) Infect Immun , vol.66 , pp. 5224-5231
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3    Dieleman, L.A.4    Grenther, W.5    Balish, E.6    Rennick, D.M.7    Sartor, R.B.8
  • 38
    • 0038105403 scopus 로고    scopus 로고
    • Use of mouse models to evaluate the persistence, safety, and immune modulation capacities of lactic acid bacteria
    • Pavan S, Desreumaux P, Mercenier A. Use of mouse models to evaluate the persistence, safety, and immune modulation capacities of lactic acid bacteria. Clin Diagn Lab Immunol 2003; 10: 696-701
    • (2003) Clin Diagn Lab Immunol , vol.10 , pp. 696-701
    • Pavan, S.1    Desreumaux, P.2    Mercenier, A.3
  • 42
    • 33646801637 scopus 로고    scopus 로고
    • Regulation of apoptosis during homeostasis and disease in the intestinal epithelium
    • Edelblum KL, Yan F, Yamaoka T, Polk DB. Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm Bowel Dis 2006; 12: 413-424
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 413-424
    • Edelblum, K.L.1    Yan, F.2    Yamaoka, T.3    Polk, D.B.4
  • 43
    • 0029114193 scopus 로고
    • Current concepts of the etiology and pathogen-esis of ulcerative colitis and Crohn's disease
    • Sartor RB. Current concepts of the etiology and pathogen-esis of ulcerative colitis and Crohn's disease. Gastroenterol Clin North Am 1995; 24: 475-507
    • (1995) Gastroenterol Clin North Am , vol.24 , pp. 475-507
    • Sartor, R.B.1
  • 44
    • 15444353992 scopus 로고    scopus 로고
    • Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factoralpha (TNF-alpha) and/or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2 expression
    • Koshiji M, Adachi Y, Sogo S, Taketani S, Oyaizu N, Than S, Inaba M, Phawa S, Hioki K, Ikehara S. Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factoralpha (TNF-alpha) and/or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2 expression. Clin Exp Immunol 1998; 111: 211-218
    • (1998) Clin Exp Immunol , vol.111 , pp. 211-218
    • Koshiji, M.1    Adachi, Y.2    Sogo, S.3    Taketani, S.4    Oyaizu, N.5    Than, S.6    Inaba, M.7    Phawa, S.8    Hioki, K.9    Ikehara, S.10
  • 45
    • 0034005581 scopus 로고    scopus 로고
    • Role of cytokines in the pathogenesis of inflammatory bowel disease
    • Papadakis KA, Targan SR. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med 2000; 51: 289-298
    • (2000) Annu Rev Med , vol.51 , pp. 289-298
    • Papadakis, K.A.1    Targan, S.R.2
  • 46
    • 34548190038 scopus 로고    scopus 로고
    • Il-6 signaling in inflammatory bowel disease: Pathophysiological role and clinical relevance
    • Mudter J, Neurath MF. Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm Bowel Dis 2007; 13: 1016-1023
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1016-1023
    • Mudter, J.1    Neurath, M.F.2
  • 47
    • 35348951458 scopus 로고    scopus 로고
    • Therapeutic strategies for targeting the IL-6/STAT3 cytokine signaling pathway in inflammatory bowel disease
    • Mitsuyama K, Matsumoto S, Masuda J, Yamasakii H, Kuwaki K, Takedatsu H, Sata M. Therapeutic strategies for targeting the IL-6/STAT3 cytokine signaling pathway in inflammatory bowel disease. Anticancer Res 2007; 27: 3749-3756
    • (2007) Anticancer Res , vol.27 , pp. 3749-3756
    • Mitsuyama, K.1    Matsumoto, S.2    Masuda, J.3    Yamasakii, H.4    Kuwaki, K.5    Takedatsu, H.6    Sata, M.7
  • 49
    • 33751222572 scopus 로고    scopus 로고
    • Interleukin-6 trans-signaling in inflammatory bowel disease
    • Mitsuyama K, Sata M, Rose-John S. Interleukin-6 trans-signaling in inflammatory bowel disease. Cytokine Growth Factor Rev 2006; 17: 451-461
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 451-461
    • Mitsuyama, K.1    Sata, M.2    Rose-John, S.3
  • 50
    • 27744496768 scopus 로고    scopus 로고
    • The biology of p38 kinase: A central role in inflammation
    • Schieven GL. The biology of p38 kinase: a central role in inflammation. Curr Top Med Chem 2005; 5: 921-928
    • (2005) Curr Top Med Chem , vol.5 , pp. 921-928
    • Schieven, G.L.1
  • 52
    • 33646902166 scopus 로고    scopus 로고
    • COX-2: A pivotal enzyme in mucosal protection and resolution of inflammation
    • Wallace JL. COX-2: a pivotal enzyme in mucosal protection and resolution of inflammation. ScientificWorldJournal 2006; 6: 577-588
    • (2006) ScientificWorldJournal , vol.6 , pp. 577-588
    • Wallace, J.L.1
  • 53
    • 33846687337 scopus 로고    scopus 로고
    • Healing impairment effect of cyclooxygenase inhibitors on dextran sulfate sodium-induced colitis in rats
    • Tsubouchi R, Hayashi S, Aoi Y, Nishio H, Terashima S, Kato S, Takeuchi K. Healing impairment effect of cyclooxygenase inhibitors on dextran sulfate sodium-induced colitis in rats. Digestion 2006; 74: 91-100
    • (2006) Digestion , vol.74 , pp. 91-100
    • Tsubouchi, R.1    Hayashi, S.2    Aoi, Y.3    Nishio, H.4    Terashima, S.5    Kato, S.6    Takeuchi, K.7
  • 54
    • 34548125720 scopus 로고    scopus 로고
    • Anti-inflammatory and side effects of cyclooxygenase inhibitors
    • Süleyman H, Demircan B, Karagöz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacol Rep 2007; 59: 247-258
    • (2007) Pharmacol Rep , vol.59 , pp. 247-258
    • Süleyman, H.1    Demircan, B.2    Karagöz, Y.3
  • 55
    • 25144490062 scopus 로고    scopus 로고
    • Suppression of colitis- related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands
    • Kohno H, Suzuki R, Sugie S, Tanaka T. Suppression of colitis- related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. BMC Cancer 2005; 5: 46
    • (2005) BMC Cancer , vol.5 , pp. 46
    • Kohno, H.1    Suzuki, R.2    Sugie, S.3    Tanaka, T.4
  • 56
    • 0030875018 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease
    • Hendel J, Nielsen OH. Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease. Am J Gastroenterol 1997; 92: 1170-1173
    • (1997) Am J Gastroenterol , vol.92 , pp. 1170-1173
    • Hendel, J.1    Nielsen, O.H.2
  • 57
    • 9144254058 scopus 로고    scopus 로고
    • Characterization of colonic and mesenteric lymph node dendritic cell subpopulations in a murine adoptive transfer model of inflammatory bowel disease
    • Karlis J, Penttila I, Tran TB, Jones B, Nobbs S, Zola H, Flesch IE. Characterization of colonic and mesenteric lymph node dendritic cell subpopulations in a murine adoptive transfer model of inflammatory bowel disease. Inflamm Bowel Dis 2004; 10: 834-847
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 834-847
    • Karlis, J.1    Penttila, I.2    Tran, T.B.3    Jones, B.4    Nobbs, S.5    Zola, H.6    Flesch, I.E.7
  • 58
    • 0035337241 scopus 로고    scopus 로고
    • CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice
    • Malmström V, Shipton D, Singh B, Al-Shamkhani A, Puklavec MJ, Barclay AN, Powrie F. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J Immunol 2001; 166: 6972-6981
    • (2001) J Immunol , vol.166 , pp. 6972-6981
    • Malmström, V.1    Shipton, D.2    Singh, B.3    Al-Shamkhani, A.4    Puklavec, M.J.5    Barclay, A.N.6    Powrie, F.7
  • 60
    • 0032923689 scopus 로고    scopus 로고
    • CD4 T cell traffic control: In vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles
    • Brocker T, Gulbranson-Judge A, Flynn S, Riedinger M, Raykundalia C, Lane P. CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur J Immunol 1999; 29: 1610-1616
    • (1999) Eur J Immunol , vol.29 , pp. 1610-1616
    • Brocker, T.1    Gulbranson-Judge, A.2    Flynn, S.3    Riedinger, M.4    Raykundalia, C.5    Lane, P.6
  • 64
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003; 4: 337-342
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 65
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-336
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 66
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 67
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express tolllike receptors and are activated by lipopolysaccharide
    • Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express tolllike receptors and are activated by lipopolysaccharide. J Exp Med 2003; 197: 403-411
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.